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Items: 9


Selective androgen receptor modulators (SARMs) negatively regulate triple-negative breast cancer growth and epithelial:mesenchymal stem cell signaling.

Narayanan R, Ahn S, Cheney MD, Yepuru M, Miller DD, Steiner MS, Dalton JT.

PLoS One. 2014 Jul 29;9(7):e103202. doi: 10.1371/journal.pone.0103202. eCollection 2014.


Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation.

Narayanan R, Yepuru M, Coss CC, Wu Z, Bauler MN, Barrett CM, Mohler ML, Wang Y, Kim J, Snyder LM, He Y, Levy N, Miller DD, Dalton JT.

PLoS One. 2013 Dec 26;8(12):e83380. doi: 10.1371/journal.pone.0083380. eCollection 2013.


Steroidogenic enzyme AKR1C3 is a novel androgen receptor-selective coactivator that promotes prostate cancer growth.

Yepuru M, Wu Z, Kulkarni A, Yin F, Barrett CM, Kim J, Steiner MS, Miller DD, Dalton JT, Narayanan R.

Clin Cancer Res. 2013 Oct 15;19(20):5613-25. doi: 10.1158/1078-0432.CCR-13-1151. Epub 2013 Aug 30.


Role of nuclear receptors in lipid dysfunction and obesity-related diseases.

Swanson HI, Wada T, Xie W, Renga B, Zampella A, Distrutti E, Fiorucci S, Kong B, Thomas AM, Guo GL, Narayanan R, Yepuru M, Dalton JT, Chiang JY.

Drug Metab Dispos. 2013 Jan;41(1):1-11. doi: 10.1124/dmd.112.048694. Epub 2012 Oct 4.


β-LGND2, an ERβ selective agonist, inhibits pathologic retinal neovascularization.

Giddabasappa A, Eswaraka JR, Barrett CM, Bauler MN, Wu Z, Yepuru M, Miller DD, Dalton JT.

Invest Ophthalmol Vis Sci. 2012 Jul 31;53(8):5066-75. doi: 10.1167/iovs.12-9627.


Estrogen receptor-{beta}-selective ligands alleviate high-fat diet- and ovariectomy-induced obesity in mice.

Yepuru M, Eswaraka J, Kearbey JD, Barrett CM, Raghow S, Veverka KA, Miller DD, Dalton JT, Narayanan R.

J Biol Chem. 2010 Oct 8;285(41):31292-303. doi: 10.1074/jbc.M110.147850. Epub 2010 Jul 23.


17-β estradiol protects ARPE-19 cells from oxidative stress through estrogen receptor-β.

Giddabasappa A, Bauler M, Yepuru M, Chaum E, Dalton JT, Eswaraka J.

Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5278-87. doi: 10.1167/iovs.10-5316. Epub 2010 May 12.


Discovery and mechanistic characterization of a novel selective nuclear androgen receptor exporter for the treatment of prostate cancer.

Narayanan R, Yepuru M, Szafran AT, Szwarc M, Bohl CE, Young NL, Miller DD, Mancini MA, Dalton JT.

Cancer Res. 2010 Jan 15;70(2):842-51. doi: 10.1158/0008-5472.CAN-09-3206. Epub 2010 Jan 12.


Steroidal androgens and nonsteroidal, tissue-selective androgen receptor modulator, S-22, regulate androgen receptor function through distinct genomic and nongenomic signaling pathways.

Narayanan R, Coss CC, Yepuru M, Kearbey JD, Miller DD, Dalton JT.

Mol Endocrinol. 2008 Nov;22(11):2448-65. doi: 10.1210/me.2008-0160. Epub 2008 Sep 18.


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