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RNF25 promotes gefitinib resistance in EGFR-mutant NSCLC cells by inducing NF-κB-mediated ERK reactivation.

Cho JH, You YM, Yeom YI, Lee DC, Kim BK, Won M, Cho BC, Kang M, Park S, Yang SJ, Kim JS, Kim JA, Park KC.

Cell Death Dis. 2018 May 22;9(6):587. doi: 10.1038/s41419-018-0651-5.


Metabolic Signaling to Epigenetic Alterations in Cancer.

Kim JA, Yeom YI.

Biomol Ther (Seoul). 2018 Jan 1;26(1):69-80. doi: 10.4062/biomolther.2017.185. Review.


Regulation of hypoxia responses by flavin adenine dinucleotide-dependent modulation of HIF-1α protein stability.

Yang SJ, Park YS, Cho JH, Moon B, An HJ, Lee JY, Xie Z, Wang Y, Pocalyko D, Lee DC, Sohn HA, Kang M, Kim JY, Kim E, Park KC, Kim JA, Yeom YI.

EMBO J. 2017 Apr 13;36(8):1011-1028. doi: 10.15252/embj.201694408. Epub 2017 Mar 9.


Genome-scale functional analysis of the human genes modulating p53 activity by regulating MDM2 expression in a p53-independent manner.

Kim DM, Choi SH, Yeom YI, Min SH, Kim IC.

Biochem Biophys Res Commun. 2016 Sep 16;478(2):976-81. doi: 10.1016/j.bbrc.2016.08.063. Epub 2016 Aug 11.


AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth.

Park YS, Kim DJ, Koo H, Jang SH, You YM, Cho JH, Yang SJ, Yu ES, Jung Y, Lee DC, Kim JA, Park ZY, Park KC, Yeom YI.

Oncotarget. 2016 Jul 26;7(30):48155-48167. doi: 10.18632/oncotarget.10179.


Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer.

Park SY, Lee SJ, Cho HJ, Kim TW, Kim JT, Kim JW, Lee CH, Kim BY, Yeom YI, Lim JS, Lee Y, Lee HG.

Oncotarget. 2016 Feb 23;7(8):9501-12. doi: 10.18632/oncotarget.7033.


High-resolution transcriptome analysis reveals neuropathic pain gene-expression signatures in spinal microglia after nerve injury.

Jeong H, Na YJ, Lee K, Kim YH, Lee Y, Kang M, Jiang BC, Yeom YI, Wu LJ, Gao YJ, Kim J, Oh SB.

Pain. 2016 Apr;157(4):964-76. doi: 10.1097/j.pain.0000000000000470.


Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity.

Kim DJ, Roh E, Lee MH, Oi N, Lim DY, Kim MO, Cho YY, Pugliese A, Shim JH, Chen H, Cho EJ, Kim JE, Kang SC, Paul S, Kang HE, Jung JW, Lee SY, Kim SH, Reddy K, Yeom YI, Bode AM, Dong Z.

Cancer Res. 2016 Mar 1;76(5):1146-1157. doi: 10.1158/0008-5472.CAN-15-0442. Epub 2015 Dec 16.


Homeobox A9 directly targeted by miR-196b regulates aggressiveness through nuclear Factor-kappa B activity in non-small cell lung cancer cells.

Yu SL, Lee DC, Sohn HA, Lee SY, Jeon HS, Lee JH, Park CG, Lee HY, Yeom YI, Son JW, Yoon YS, Kang J.

Mol Carcinog. 2016 Dec;55(12):1915-1926. doi: 10.1002/mc.22439. Epub 2015 Nov 20.


Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells.

Kim DJ, Park YS, Kang MG, You YM, Jung Y, Koo H, Kim JA, Kim MJ, Hong SM, Lee KB, Jang JJ, Park KC, Yeom YI.

Exp Cell Res. 2015 Aug 1;336(1):119-29. doi: 10.1016/j.yexcr.2015.05.017. Epub 2015 Jun 22.


NDRG3-mediated lactate signaling in hypoxia.

Park KC, Lee DC, Yeom YI.

BMB Rep. 2015 Jun;48(6):301-2.


A lactate-induced response to hypoxia.

Lee DC, Sohn HA, Park ZY, Oh S, Kang YK, Lee KM, Kang M, Jang YJ, Yang SJ, Hong YK, Noh H, Kim JA, Kim DJ, Bae KH, Kim DM, Chung SJ, Yoo HS, Yu DY, Park KC, Yeom YI.

Cell. 2015 Apr 23;161(3):595-609. doi: 10.1016/j.cell.2015.03.011. Epub 2015 Apr 16.


Recurrence-associated pathways in hepatitis B virus-positive hepatocellular carcinoma.

Kim BY, Choi DW, Woo SR, Park ER, Lee JG, Kim SH, Koo I, Park SH, Han CJ, Kim SB, Yeom YI, Yang SJ, Yu A, Lee JW, Jang JJ, Cho MH, Jeon WK, Park YN, Suh KS, Lee KH.

BMC Genomics. 2015 Apr 10;16:279. doi: 10.1186/s12864-015-1472-x.


A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxia.

Kim DJ, Park YS, Kim ND, Min SH, You YM, Jung Y, Koo H, Noh H, Kim JA, Park KC, Yeom YI.

Mol Cells. 2015 Apr;38(4):373-9. doi: 10.14348/molcells.2015.2314. Epub 2015 Mar 26.


Knockdown of anterior gradient 2 expression extenuates tumor-associated phenotypes of SNU-478 ampulla of Vater cancer cells.

Kim SJ, Jun S, Cho HY, Lee DC, Yeom YI, Kim JH, Kang D.

BMC Cancer. 2014 Nov 3;14:804. doi: 10.1186/1471-2407-14-804.


Nuclear expression of phosphorylated TRAF2- and NCK-interacting kinase in hepatocellular carcinoma is associated with poor prognosis.

Jin J, Jung HY, Wang Y, Xie J, Yeom YI, Jang JJ, Lee KB.

Pathol Res Pract. 2014 Oct;210(10):621-7. doi: 10.1016/j.prp.2013.10.007. Epub 2014 Feb 24.


The EF-hand calcium-binding protein tescalcin is a potential oncotarget in colorectal cancer.

Kang YH, Han SR, Kim JT, Lee SJ, Yeom YI, Min JK, Lee CH, Kim JW, Yoon SR, Yoon DY, Hong KS, Hwang GS, Kim HC, Lee YH, Lee HG.

Oncotarget. 2014 Apr 30;5(8):2149-60.


Donor-derived natural killer cells infused after human leukocyte antigen-haploidentical hematopoietic cell transplantation: a dose-escalation study.

Choi I, Yoon SR, Park SY, Kim H, Jung SJ, Jang YJ, Kang M, Yeom YI, Lee JL, Kim DY, Lee YS, Kang YA, Jeon M, Seol M, Lee JH, Lee JH, Kim HJ, Yun SC, Lee KH.

Biol Blood Marrow Transplant. 2014 May;20(5):696-704. doi: 10.1016/j.bbmt.2014.01.031. Epub 2014 Feb 11.


Cystatin SN neutralizes the inhibitory effect of cystatin C on cathepsin B activity.

Kim JT, Lee SJ, Kang MA, Park JE, Kim BY, Yoon DY, Yang Y, Lee CH, Yeom YI, Choe YK, Lee HG.

Cell Death Dis. 2013 Dec 19;4:e974. doi: 10.1038/cddis.2013.485.


SH3RF2 functions as an oncogene by mediating PAK4 protein stability.

Kim TW, Kang YK, Park ZY, Kim YH, Hong SW, Oh SJ, Sohn HA, Yang SJ, Jang YJ, Lee DC, Kim SY, Yoo HS, Kim E, Yeom YI, Park KC.

Carcinogenesis. 2014 Mar;35(3):624-34. doi: 10.1093/carcin/bgt338. Epub 2013 Oct 15.


Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g).

Kim JT, Lee SJ, Kim BY, Lee CH, Yeom YI, Choe YK, Yoon DY, Chae SK, Kim JW, Yang Y, Lim JS, Lee HG.

FEBS Lett. 2013 Nov 15;587(22):3668-74. doi: 10.1016/j.febslet.2013.09.027. Epub 2013 Sep 27.


Metabolic signature genes associated with susceptibility to pyruvate kinase, muscle type 2 gene ablation in cancer cells.

Jung Y, Jang YJ, Kang MH, Park YS, Oh SJ, Lee DC, Xie Z, Yoo HS, Park KC, Yeom YI.

Mol Cells. 2013 Apr;35(4):335-41. doi: 10.1007/s10059-013-2319-4. Epub 2013 Mar 18.


CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo.

Kim DJ, Lee MH, Reddy K, Li Y, Lim DY, Xie H, Lee SY, Yeom YI, Bode AM, Dong Z.

Carcinogenesis. 2013 May;34(5):1134-43. doi: 10.1093/carcin/bgt015. Epub 2013 Jan 25.


Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice.

Lee JS, Park AH, Lee SH, Lee SH, Kim JH, Yang SJ, Yeom YI, Kwak TH, Lee D, Lee SJ, Lee CH, Kim JM, Kim D.

PLoS One. 2012;7(10):e47122. doi: 10.1371/journal.pone.0047122. Epub 2012 Oct 11.


Overexpression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in colorectal cancer.

Kim KS, Kim JT, Lee SJ, Kang MA, Choe IS, Kang YH, Kim SY, Yeom YI, Lee YH, Kim JH, Kim KH, Kim CN, Kim JW, Nam MS, Lee HG.

Clin Chim Acta. 2013 Jan 16;415:12-9. doi: 10.1016/j.cca.2012.09.003. Epub 2012 Sep 10.


ESM-1 regulates cell growth and metastatic process through activation of NF-κB in colorectal cancer.

Kang YH, Ji NY, Han SR, Lee CI, Kim JW, Yeom YI, Kim YH, Chun HK, Kim JW, Chung JW, Ahn DK, Lee HG, Song EY.

Cell Signal. 2012 Oct;24(10):1940-9. doi: 10.1016/j.cellsig.2012.06.004. Epub 2012 Jun 23.


Liverome: a curated database of liver cancer-related gene signatures with self-contained context information.

Lee L, Wang K, Li G, Xie Z, Wang Y, Xu J, Sun S, Pocalyko D, Bhak J, Kim C, Lee KH, Jang YJ, Yeom YI, Yoo HS, Hwang S.

BMC Genomics. 2011 Nov 30;12 Suppl 3:S3. doi: 10.1186/1471-2164-12-S3-S3. Epub 2011 Nov 30.


Dysregulation of overexpressed IL-32α in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-κB and Bcl-2.

Kang YH, Park MY, Yoon DY, Han SR, Lee CI, Ji NY, Myung PK, Lee HG, Kim JW, Yeom YI, Jang YJ, Ahn DK, Kim JW, Song EY.

Cancer Lett. 2012 May 28;318(2):226-33. doi: 10.1016/j.canlet.2011.12.023. Epub 2011 Dec 23.


Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer.

Kim JT, Song EY, Chung KS, Kang MA, Kim JW, Kim SJ, Yeom YI, Kim JH, Kim KH, Lee HG.

Cancer. 2011 Jun 15;117(12):2608-19. doi: 10.1002/cncr.25841. Epub 2010 Dec 23.


Integrated analysis of prognostic gene expression profiles from hepatitis B virus-positive hepatocellular carcinoma and adjacent liver tissue.

Kim BY, Suh KS, Lee JG, Woo SR, Park IC, Park SH, Han CJ, Kim SB, Jeong SH, Yeom YI, Yang SJ, Kim CM, Cho SJ, Yoo YD, Cho MH, Jang JJ, Choi DW, Lee KH.

Ann Surg Oncol. 2012 Jul;19 Suppl 3:S328-38. doi: 10.1245/s10434-011-1709-0. Epub 2011 Apr 30.


Thalamic T-type Ca²+ channels mediate frontal lobe dysfunctions caused by a hypoxia-like damage in the prefrontal cortex.

Kim J, Woo J, Park YG, Chae S, Jo S, Choi JW, Jun HY, Yeom YI, Park SH, Kim KH, Shin HS, Kim D.

J Neurosci. 2011 Mar 16;31(11):4063-73. doi: 10.1523/JNEUROSCI.4493-10.2011.


Epigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations.

Kim YH, Lee HC, Kim SY, Yeom YI, Ryu KJ, Min BH, Kim DH, Son HJ, Rhee PL, Kim JJ, Rhee JC, Kim HC, Chun HK, Grady WM, Kim YS.

Ann Surg Oncol. 2011 Aug;18(8):2338-47. doi: 10.1245/s10434-011-1573-y. Epub 2011 Feb 5.


Thrombin-dependent MMP-2 activity is regulated by heparan sulfate.

Koo BH, Han JH, Yeom YI, Kim DS.

J Biol Chem. 2010 Dec 31;285(53):41270-9. doi: 10.1074/jbc.M110.171595. Epub 2010 Nov 1.


ESM-1 silencing decreased cell survival, migration, and invasion and modulated cell cycle progression in hepatocellular carcinoma.

Kang YH, Ji NY, Lee CI, Lee HG, Kim JW, Yeom YI, Kim DG, Yoon SK, Kim JW, Park PJ, Song EY.

Amino Acids. 2011 Mar;40(3):1003-13. doi: 10.1007/s00726-010-0729-6. Epub 2010 Sep 7.


Identification of endothelial cell-specific molecule-1 as a potential serum marker for colorectal cancer.

Ji NY, Kim YH, Jang YJ, Kang YH, Lee CI, Kim JW, Yeom YI, Chun HK, Choi YH, Kim JH, Kim JW, Lee HG, Song EY.

Cancer Sci. 2010 Oct;101(10):2248-53. doi: 10.1111/j.1349-7006.2010.01665.x. Epub 2010 Jul 30.


Differential modulatory effects of rosiglitazone and pioglitazone on white adipose tissue in db/db mice.

Yang KJ, Noh JR, Kim YH, Gang GT, Hwang JH, Yang SJ, Yeom YI, Lee CH.

Life Sci. 2010 Sep 25;87(13-14):405-10. doi: 10.1016/j.lfs.2010.08.002. Epub 2010 Aug 17.


Functional switching of TGF-beta1 signaling in liver cancer via epigenetic modulation of a single CpG site in TTP promoter.

Sohn BH, Park IY, Lee JJ, Yang SJ, Jang YJ, Park KC, Kim DJ, Lee DC, Sohn HA, Kim TW, Yoo HS, Choi JY, Bae YS, Yeom YI.

Gastroenterology. 2010 May;138(5):1898-908. doi: 10.1053/j.gastro.2009.12.044. Epub 2009 Dec 29.


Tristetraprolin regulates the stability of HIF-1alpha mRNA during prolonged hypoxia.

Kim TW, Yim S, Choi BJ, Jang Y, Lee JJ, Sohn BH, Yoo HS, Yeom YI, Park KC.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):963-8. doi: 10.1016/j.bbrc.2009.11.174. Epub 2009 Dec 4.


Gene delivery using a derivative of the protein transduction domain peptide, K-Antp.

Min SH, Kim DM, Kim MN, Ge J, Lee DC, Park IY, Park KC, Hwang JS, Cho CW, Yeom YI.

Biomaterials. 2010 Mar;31(7):1858-64. doi: 10.1016/j.biomaterials.2009.11.019. Epub 2009 Dec 1.


Gene expression profiling in mouse liver infected with Clonorchis sinensis metacercariae.

Kim DM, Ko BS, Ju JW, Cho SH, Yang SJ, Yeom YI, Kim TS, Won Y, Kim IC.

Parasitol Res. 2009 Dec;106(1):269-78. doi: 10.1007/s00436-009-1662-z. Epub 2009 Nov 10.


Evaluation of annexin II as a potential serum marker for hepatocellular carcinoma using a developed sandwich ELISA method.

Ji NY, Park MY, Kang YH, Lee CI, Kim DG, Yeom YI, Jang YJ, Myung PK, Kim JW, Lee HG, Kim JW, Lee K, Song EY.

Int J Mol Med. 2009 Dec;24(6):765-71.


Osteopontin splice variants differentially modulate the migratory activity of hepatocellular carcinoma cell lines.

Chae S, Jun HO, Lee EG, Yang SJ, Lee DC, Jung JK, Park KC, Yeom YI, Kim KW.

Int J Oncol. 2009 Dec;35(6):1409-16.


2'-Benzoyloxycinnamaldehyde inhibits tumor growth in H-ras12V transgenic mice via downregulation of metallothionein.

Lee HS, Lee SY, Ha HL, Han DC, Han JM, Jeong TS, Yu DY, Yeom YI, Kwon BM, Moon EY.

Nutr Cancer. 2009;61(5):723-34. doi: 10.1080/01635580902825613.


CIIA induces the epithelial-mesenchymal transition and cell invasion.

Han SY, Hwang HS, Chae JS, Yang SJ, Yoon JH, Yeom YI, Choi EJ.

Biochem Biophys Res Commun. 2009 Sep 25;387(3):548-52. doi: 10.1016/j.bbrc.2009.07.050. Epub 2009 Jul 15.


Upregulation of the cysteine protease inhibitor, cystatin SN, contributes to cell proliferation and cathepsin inhibition in gastric cancer.

Choi EH, Kim JT, Kim JH, Kim SY, Song EY, Kim JW, Kim SY, Yeom YI, Kim IH, Lee HG.

Clin Chim Acta. 2009 Aug;406(1-2):45-51. doi: 10.1016/j.cca.2009.05.008. Epub 2009 May 19.


Suppression of NF-kappaB activity by NDRG2 expression attenuates the invasive potential of highly malignant tumor cells.

Kim A, Kim MJ, Yang Y, Kim JW, Yeom YI, Lim JS.

Carcinogenesis. 2009 Jun;30(6):927-36. doi: 10.1093/carcin/bgp072. Epub 2009 Mar 31.


Planning the human variome project: the Spain report.

Kaput J, Cotton RG, Hardman L, Watson M, Al Aqeel AI, Al-Aama JY, Al-Mulla F, Alonso S, Aretz S, Auerbach AD, Bapat B, Bernstein IT, Bhak J, Bleoo SL, Blöcker H, Brenner SE, Burn J, Bustamante M, Calzone R, Cambon-Thomsen A, Cargill M, Carrera P, Cavedon L, Cho YS, Chung YJ, Claustres M, Cutting G, Dalgleish R, den Dunnen JT, Díaz C, Dobrowolski S, dos Santos MR, Ekong R, Flanagan SB, Flicek P, Furukawa Y, Genuardi M, Ghang H, Golubenko MV, Greenblatt MS, Hamosh A, Hancock JM, Hardison R, Harrison TM, Hoffmann R, Horaitis R, Howard HJ, Barash CI, Izagirre N, Jung J, Kojima T, Laradi S, Lee YS, Lee JY, Gil-da-Silva-Lopes VL, Macrae FA, Maglott D, Marafie MJ, Marsh SG, Matsubara Y, Messiaen LM, Möslein G, Netea MG, Norton ML, Oefner PJ, Oetting WS, O'Leary JC, de Ramirez AM, Paalman MH, Parboosingh J, Patrinos GP, Perozzi G, Phillips IR, Povey S, Prasad S, Qi M, Quin DJ, Ramesar RS, Richards CS, Savige J, Scheible DG, Scott RJ, Seminara D, Shephard EA, Sijmons RH, Smith TD, Sobrido MJ, Tanaka T, Tavtigian SV, Taylor GR, Teague J, Töpel T, Ullman-Cullere M, Utsunomiya J, van Kranen HJ, Vihinen M, Webb E, Weber TK, Yeager M, Yeom YI, Yim SH, Yoo HS; Contributors to the Human Variome Project Planning Meeting.

Hum Mutat. 2009 Apr;30(4):496-510. doi: 10.1002/humu.20972.


Gene expression analysis of terminal differentiation of human melanoma cells highlights global reductions in cell cycle-associated genes.

Huynh KM, Kim G, Kim DJ, Yang SJ, Park SM, Yeom YI, Fisher PB, Kang D.

Gene. 2009 Mar 15;433(1-2):32-9. doi: 10.1016/j.gene.2008.11.013. Epub 2008 Nov 24.


Upregulation of the cycline kinase subunit CKS2 increases cell proliferation rate in gastric cancer.

Kang MA, Kim JT, Kim JH, Kim SY, Kim YH, Yeom YI, Lee Y, Lee HG.

J Cancer Res Clin Oncol. 2009 Jun;135(6):761-9. doi: 10.1007/s00432-008-0510-3. Epub 2008 Nov 26.


LRRC3B, encoding a leucine-rich repeat-containing protein, is a putative tumor suppressor gene in gastric cancer.

Kim M, Kim JH, Jang HR, Kim HM, Lee CW, Noh SM, Song KS, Cho JS, Jeong HY, Hahn Y, Yeom YI, Yoo HS, Kim YS.

Cancer Res. 2008 Sep 1;68(17):7147-55. doi: 10.1158/0008-5472.CAN-08-0667.

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