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Items: 25

1.

Genetic basis and evolution of rapid cycling in railway populations of tetraploid Arabidopsis arenosa.

Baduel P, Hunter B, Yeola S, Bomblies K.

PLoS Genet. 2018 Jul 5;14(7):e1007510. doi: 10.1371/journal.pgen.1007510. eCollection 2018 Jul.

2.

Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation.

Pearlstein RA, MacCannell KA, Erdemli G, Yeola S, Helmlinger G, Hu QY, Farid R, Egan W, Whitebread S, Springer C, Beck J, Wang HR, Maciejewski M, Urban L, Duca JS.

Curr Top Med Chem. 2016;16(16):1792-818. Review.

PMID:
26975508
3.

Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.

Carson C, Raman P, Tullai J, Xu L, Henault M, Thomas E, Yeola S, Lao J, McPate M, Verkuyl JM, Marsh G, Sarber J, Amaral A, Bailey S, Lubicka D, Pham H, Miranda N, Ding J, Tang HM, Ju H, Tranter P, Ji N, Krastel P, Jain RK, Schumacher AM, Loureiro JJ, George E, Berellini G, Ross NT, Bushell SM, Erdemli G, Solomon JM.

PLoS One. 2015 Jun 22;10(6):e0127498. doi: 10.1371/journal.pone.0127498. eCollection 2015.

4.

NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic Caenorhabditis elegans DEG/ENaC channels.

Kamat S, Yeola S, Zhang W, Bianchi L, Driscoll M.

J Biol Chem. 2014 Apr 25;289(17):11916-26. doi: 10.1074/jbc.M113.533695. Epub 2014 Feb 24.

5.

Genetic and functional analysis of human P2X5 reveals a distinct pattern of exon 10 polymorphism with predominant expression of the nonfunctional receptor isoform.

Kotnis S, Bingham B, Vasilyev DV, Miller SW, Bai Y, Yeola S, Chanda PK, Bowlby MR, Kaftan EJ, Samad TA, Whiteside GT.

Mol Pharmacol. 2010 Jun;77(6):953-60. doi: 10.1124/mol.110.063636. Epub 2010 Mar 11.

PMID:
20223879
6.

Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns.

Meanwell NA, Wallace OB, Fang H, Wang H, Deshpande M, Wang T, Yin Z, Zhang Z, Pearce BC, James J, Yeung KS, Qiu Z, Kim Wright JJ, Yang Z, Zadjura L, Tweedie DL, Yeola S, Zhao F, Ranadive S, Robinson BA, Gong YF, Wang HG, Spicer TP, Blair WS, Shi PY, Colonno RJ, Lin PF.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):1977-81. doi: 10.1016/j.bmcl.2009.02.040. Epub 2009 Feb 13. Erratum in: Bioorg Med Chem Lett. 2010 Feb 15;20(4):1460. Spicer, Timothy P [added].

PMID:
19251416
7.

Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease.

Prasad CV, Zheng M, Vig S, Bergstrom C, Smith DW, Gao Q, Yeola S, Polson CT, Corsa JA, Guss VL, Loo A, Wang J, Sleczka BG, Dangler C, Robertson BJ, Hendrick JP, Roberts SB, Barten DM.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):4006-11. Epub 2007 Apr 30.

PMID:
17502137
8.

6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.

Wong H, Dockens RC, Pajor L, Yeola S, Grace JE Jr, Stark AD, Taub RA, Yocca FD, Zaczek RC, Li YW.

Drug Metab Dispos. 2007 Aug;35(8):1387-92. Epub 2007 May 9.

PMID:
17494642
9.

In vitro and in vivo metabolism of a gamma-secretase inhibitor BMS-299897 and generation of active metabolites in milligram quantities with a microbial bioreactor.

Zhang D, Hanson R, Roongta V, Dischino DD, Gao Q, Sloan CP, Polson C, Keavy D, Zheng M, Mitroka J, Yeola S.

Curr Drug Metab. 2006 Dec;7(8):883-96.

PMID:
17168689
10.

Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling.

Zhang D, Wang L, Raghavan N, Zhang H, Li W, Cheng PT, Yao M, Zhang L, Zhu M, Bonacorsi S, Yeola S, Mitroka J, Hariharan N, Hosagrahara V, Chandrasena G, Shyu WC, Humphreys WG.

Drug Metab Dispos. 2007 Jan;35(1):150-67. Epub 2006 Oct 24.

PMID:
17062777
11.

Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes.

Zhu M, Zhao W, Jimenez H, Zhang D, Yeola S, Dai R, Vachharajani N, Mitroka J.

Drug Metab Dispos. 2005 Apr;33(4):500-7. Epub 2005 Jan 7.

PMID:
15640381
12.

Aminotriazine 5-HT7 antagonists.

Mattson RJ, Denhart DJ, Catt JD, Dee MF, Deskus JA, Ditta JL, Epperson J, Dalton King H, Gao A, Poss MA, Purandare A, Tortolani D, Zhao Y, Yang H, Yeola S, Palmer J, Torrente J, Stark A, Johnson G.

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4245-8.

PMID:
15261279
13.

The synthesis and structure-activity relationships of 3-amino-4-benzylquinolin-2-ones; discovery of novel KCNQ2 channel openers.

Hewawasam P, Chen N, Ding M, Natale JT, Boissard CG, Yeola S, Gribkoff VK, Starrett J, Dworetzky SI.

Bioorg Med Chem Lett. 2004 Apr 5;14(7):1615-8.

PMID:
15026035
14.

Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition.

Wu YJ, Davis CD, Dworetzky S, Fitzpatrick WC, Harden D, He H, Knox RJ, Newton AE, Philip T, Polson C, Sivarao DV, Sun LQ, Tertyshnikova S, Weaver D, Yeola S, Zoeckler M, Sinz MW.

J Med Chem. 2003 Aug 28;46(18):3778-81.

PMID:
12930139
15.

Mutations throughout the S6 region of the hKv1.5 channel alter the stability of the activation gate.

Rich TC, Yeola SW, Tamkun MM, Snyders DJ.

Am J Physiol Cell Physiol. 2002 Jan;282(1):C161-71.

16.

Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels.

Gribkoff VK, Starrett JE Jr, Dworetzky SI, Hewawasam P, Boissard CG, Cook DA, Frantz SW, Heman K, Hibbard JR, Huston K, Johnson G, Krishnan BS, Kinney GG, Lombardo LA, Meanwell NA, Molinoff PB, Myers RA, Moon SL, Ortiz A, Pajor L, Pieschl RL, Post-Munson DJ, Signor LJ, Srinivas N, Taber MT, Thalody G, Trojnacki JT, Wiener H, Yeleswaram K, Yeola SW.

Nat Med. 2001 Apr;7(4):471-7.

PMID:
11283675
17.
18.
21.

Processing of procarboxypeptidase A and other zymogens in murine mast cells.

Dikov MM, Springman EB, Yeola S, Serafin WE.

J Biol Chem. 1994 Oct 14;269(41):25897-904.

22.

Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver.

Chaudhary AK, Nokubo M, Reddy GR, Yeola SN, Morrow JD, Blair IA, Marnett LJ.

Science. 1994 Sep 9;265(5178):1580-2.

PMID:
8079172
24.

Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes.

Schinazi RF, Chu CK, Peck A, McMillan A, Mathis R, Cannon D, Jeong LS, Beach JW, Choi WB, Yeola S, et al.

Antimicrob Agents Chemother. 1992 Mar;36(3):672-6.

25.

Fluorimetric studies of protein kinase C interactions with phospholipids.

Rodriguez-Paris JM, Shoji M, Yeola S, Liotta D, Vogler WR, Kuo JF.

Biochem Biophys Res Commun. 1989 Mar 15;159(2):495-500.

PMID:
2930525

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