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GDF15 mediates the effects of metformin on body weight and energy balance.

Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross J, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S.

Nature. 2019 Dec 25. doi: 10.1038/s41586-019-1911-y. [Epub ahead of print]


Angiogenic factors during pregnancy in Asian women with elevated blood pressure in early pregnancy and the risk of preeclampsia: a longitudinal cohort study.

Zhu J, Zhang J, Ng MJ, Chern B, Yeo GS, Tan KH.

BMJ Open. 2019 Dec 1;9(11):e032237. doi: 10.1136/bmjopen-2019-032237.


Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells.

Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GS, Goldspink DA, Kay RG, Gribble FM, Reimann F.

Mol Metab. 2019 Nov;29:158-169. doi: 10.1016/j.molmet.2019.09.001. Epub 2019 Sep 7.


Impaired Autophagy in CD11b+ Dendritic Cells Expands CD4+ Regulatory T Cells and Limits Atherosclerosis in Mice.

Clement M, Raffort J, Lareyre F, Tsiantoulas D, Newland S, Lu Y, Masters L, Harrison J, Saveljeva S, Ma MKL, Ozsvar-Kozma M, Lam BYH, Yeo GSH, Binder CJ, Kaser A, Mallat Z.

Circ Res. 2019 Nov 8;125(11):1019-1034. doi: 10.1161/CIRCRESAHA.119.315248. Epub 2019 Oct 15.


Prospective evaluation of screening performance of first-trimester prediction models for preterm preeclampsia in an Asian population.

Chaemsaithong P, Pooh RK, Zheng M, Ma R, Chaiyasit N, Tokunaka M, Shaw SW, Seshadri S, Choolani M, Wataganara T, Yeo GSH, Wright A, Leung WC, Sekizawa A, Hu Y, Naruse K, Saito S, Sahota D, Leung TY, Poon LC.

Am J Obstet Gynecol. 2019 Dec;221(6):650.e1-650.e16. doi: 10.1016/j.ajog.2019.09.041. Epub 2019 Oct 4.


Outcomes following selective fetoscopic laser ablation for twin-to-twin transfusion syndrome: a single-centre experience.

Loh M, Bhatia A, Tan KL, Thia E, Yeo GSH.

Singapore Med J. 2019 Sep 6. doi: 10.11622/smedj.2019107. [Epub ahead of print]


Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake.

Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F.

Cell Metab. 2019 Nov 5;30(5):987-996.e6. doi: 10.1016/j.cmet.2019.07.013. Epub 2019 Aug 22.


Are women in Singapore gaining weight appropriately during pregnancy: a prospective cohort study.

He S, Allen JC, Razali NS, Win NM, Zhang JJ, Ng MJ, Yeo GSH, Chern BSM, Tan KH.

BMC Pregnancy Childbirth. 2019 Aug 13;19(1):290. doi: 10.1186/s12884-019-2443-z.


Coverage and determinants of influenza vaccine among pregnant women: a cross-sectional study.

Offeddu V, Tam CC, Yong TT, Tan LK, Thoon KC, Lee N, Tan TC, Yeo GSH, Yung CF.

BMC Public Health. 2019 Jul 5;19(1):890. doi: 10.1186/s12889-019-7172-8.


Low socioeconomic status and severe obesity are linked to poor cognitive performance in Malaysian children.

Poh BK, Lee ST, Yeo GS, Tang KC, Noor Afifah AR, Siti Hanisa A, Parikh P, Wong JE, Ng ALO; SEANUTS Study Group.

BMC Public Health. 2019 Jun 13;19(Suppl 4):541. doi: 10.1186/s12889-019-6856-4.


Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment.

Wray JR, Davies A, Sefton C, Allen TJ, Adamson A, Chapman P, Lam BYH, Yeo GSH, Coll AP, Harno E, White A.

Mol Metab. 2019 Aug;26:5-17. doi: 10.1016/j.molmet.2019.05.008. Epub 2019 May 18.


Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling.

Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, Reimann F, Gribble FM.

Diabetes. 2019 May;68(5):1062-1072. doi: 10.2337/db18-0883. Epub 2019 Feb 7.


Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery.

Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A, Melvin A, Biggs EK, Ravn P, Davy K, Hornigold DC, Yeo GSH, Hardwick RH, Reimann F, Gribble FM.

Cell Rep. 2019 Feb 5;26(6):1399-1408.e6. doi: 10.1016/j.celrep.2019.01.047.


Does Low Birth Weight Vary Geospatially in Singapore?

Sasha SR, Saffari SE, Allen JC, Yeo GS, Tan KH.

Ann Acad Med Singapore. 2018 Sep;47(9):373-380.


Patient satisfaction with the cervical ripening balloon as a method for induction of labour: a randomised controlled trial.

Lim SE, Tan TL, Ng GYH, Tagore S, Kyaw EEP, Yeo GSH.

Singapore Med J. 2018 Aug;59(8):419-424. doi: 10.11622/smedj.2018097.


The association between serum progesterone level and preterm delivery.

Feng T, Allen JC, Ng MJ, Yeo GSH, Kwek KYC, Chern BSM, Tan KH.

Int J Gynaecol Obstet. 2018 Sep;142(3):308-314. doi: 10.1002/ijgo.12564. Epub 2018 Jun 28.


Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.

Polex-Wolf J, Lam BY, Larder R, Tadross J, Rimmington D, Bosch F, Cenzano VJ, Ayuso E, Ma MK, Rainbow K, Coll AP, O'Rahilly S, Yeo GS.

J Clin Invest. 2018 Mar 1;128(3):960-969. doi: 10.1172/JCI97007. Epub 2018 Jan 29.


Gender-Specific Reference Charts of Fetal Head Circumference in a Singaporean Population.

Yeo GS, Qi M, Du R, Mahavadi PL, Yung CF, Thoon KC, Thia EW, Tan KL, Lai FM, Lee NK.

Ann Acad Med Singapore. 2017 Oct;46(10):367-373.


Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty.

Howard SR, Guasti L, Poliandri A, David A, Cabrera CP, Barnes MR, Wehkalampi K, O'Rahilly S, Aiken CE, Coll AP, Ma M, Rimmington D, Yeo GSH, Dunkel L.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):649-659. doi: 10.1210/jc.2017-02147.


GDF15 and energy balance: homing in on a mechanism.

Cimino I, Coll AP, Yeo GSH.

Nat Med. 2017 Oct 6;23(10):1119-1120. doi: 10.1038/nm.4414. No abstract available.


Correlation of cord blood telomere length with birth weight.

Lee SP, Hande P, Yeo GS, Tan EC.

BMC Res Notes. 2017 Sep 8;10(1):469. doi: 10.1186/s13104-017-2791-6.


Selective rab11 transport and the intrinsic regenerative ability of CNS axons.

Koseki H, Donegá M, Lam BY, Petrova V, van Erp S, Yeo GS, Kwok JC, Ffrench-Constant C, Eva R, Fawcett JW.

Elife. 2017 Aug 8;6. pii: e26956. doi: 10.7554/eLife.26956.


Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.

Larder R, Sim MFM, Gulati P, Antrobus R, Tung YCL, Rimmington D, Ayuso E, Polex-Wolf J, Lam BYH, Dias C, Logan DW, Virtue S, Bosch F, Yeo GSH, Saudek V, O'Rahilly S, Coll AP.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9421-9426. doi: 10.1073/pnas.1707310114. Epub 2017 Aug 15.


Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management.

Challis BG, Powlson AS, Casey RT, Pearson C, Lam BY, Ma M, Pitfield D, Yeo GSH, Godfrey E, Cheow HK, Chatterjee VK, Carroll NR, Shaw A, Buscombe JR, Simpson HL.

Endocr Connect. 2017 Oct;6(7):540-548. doi: 10.1530/EC-17-0076. Epub 2017 Aug 7.


A complex association between DNA methylation and gene expression in human placenta at first and third trimesters.

Lim YC, Li J, Ni Y, Liang Q, Zhang J, Yeo GSH, Lyu J, Jin S, Ding C.

PLoS One. 2017 Jul 13;12(7):e0181155. doi: 10.1371/journal.pone.0181155. eCollection 2017.


Maternal plasma phosphatidylcholine polyunsaturated fatty acids during pregnancy and offspring growth and adiposity.

Bernard JY, Tint MT, Aris IM, Chen LW, Quah PL, Tan KH, Yeo GS, Fortier MV, Yap F, Shek L, Chong YS, Gluckman PD, Godfrey KM, Calder PC, Chong MFF, Kramer MS, Botton J, Lee YS.

Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:21-29. doi: 10.1016/j.plefa.2017.05.006. Epub 2017 Jun 9.


Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight.

Hameed S, Patterson M, Dhillo WS, Rahman SA, Ma Y, Holton C, Gogakos A, Yeo GSH, Lam BYH, Polex-Wolf J, Fenske W, Bell J, Anastasovska J, Samarut J, Bloom SR, Bassett JHD, Williams GR, Gardiner JV.

Cell Rep. 2017 Jun 13;19(11):2202-2209. doi: 10.1016/j.celrep.2017.05.066.


A Single Centre Experience with Selective Termination of Anomalous Foetus in Multifoetal Pregnancies.

Bhatia A, Thia EW, Yeo GS.

Ann Acad Med Singapore. 2017 May;46(5):207-209. No abstract available.


Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing.

Lam BYH, Cimino I, Polex-Wolf J, Nicole Kohnke S, Rimmington D, Iyemere V, Heeley N, Cossetti C, Schulte R, Saraiva LR, Logan DW, Blouet C, O'Rahilly S, Coll AP, Yeo GSH.

Mol Metab. 2017 Mar 1;6(5):383-392. doi: 10.1016/j.molmet.2017.02.007. eCollection 2017 May.


Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet.

Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z.

Nat Med. 2017 May;23(5):601-610. doi: 10.1038/nm.4315. Epub 2017 Apr 17.


Gestational age-specific reference intervals for serum thyroid hormone levels in a multi-ethnic population.

Ho CKM, Tan ETH, Ng MJ, Yeo GSH, Chern B, Tee NWS, Kwek KYC, Tan KH.

Clin Chem Lab Med. 2017 Oct 26;55(11):1777-1788. doi: 10.1515/cclm-2016-0790.


Prediction of neonatal respiratory morbidity by quantitative ultrasound lung texture analysis: a multicenter study.

Palacio M, Bonet-Carne E, Cobo T, Perez-Moreno A, Sabrià J, Richter J, Kacerovsky M, Jacobsson B, García-Posada RA, Bugatto F, Santisteve R, Vives À, Parra-Cordero M, Hernandez-Andrade E, Bartha JL, Carretero-Lucena P, Tan KL, Cruz-Martínez R, Burke M, Vavilala S, Iruretagoyena I, Delgado JL, Schenone M, Vilanova J, Botet F, Yeo GSH, Hyett J, Deprest J, Romero R, Gratacos E; Fetal Lung Texture Team.

Am J Obstet Gynecol. 2017 Aug;217(2):196.e1-196.e14. doi: 10.1016/j.ajog.2017.03.016. Epub 2017 Mar 23.


Genetics of obesity: can an old dog teach us new tricks?

Yeo GSH.

Diabetologia. 2017 May;60(5):778-783. doi: 10.1007/s00125-016-4187-x. Epub 2016 Dec 24. Review.


Impaired prohormone processing: a grand unified theory for features of Prader-Willi syndrome?

Polex-Wolf J, Yeo GS, O'Rahilly S.

J Clin Invest. 2017 Jan 3;127(1):98-99. doi: 10.1172/JCI91307. Epub 2016 Dec 12.


Maternal Obesity in Pregnancy Developmentally Programs Adipose Tissue Inflammation in Young, Lean Male Mice Offspring.

Alfaradhi MZ, Kusinski LC, Fernandez-Twinn DS, Pantaleão LC, Carr SK, Ferland-McCollough D, Yeo GS, Bushell M, Ozanne SE.

Endocrinology. 2016 Nov;157(11):4246-4256. Epub 2016 Sep 1.


Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues.

Zhou J, Lam B, Neogi SG, Yeo GS, Azizan EA, Brown MJ.

Hypertension. 2016 Dec;68(6):1424-1431. Epub 2016 Oct 24.


A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.

Kim HS, Cheon JH, Jung ES, Park J, Aum S, Park SJ, Eun S, Lee J, Rüther U, Yeo GSH, Ma M, Park KS, Naito T, Kakuta Y, Lee JH, Kim WH, Lee MG.

Gut. 2017 Nov;66(11):1926-1935. doi: 10.1136/gutjnl-2016-311921. Epub 2016 Aug 24.


Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.

Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM.

Diabetologia. 2016 Oct;59(10):2156-65. doi: 10.1007/s00125-016-4033-1. Epub 2016 Jul 7.


Zika Virus: An Evolving Public Health Threat.

Yung CF, Chong CY, Yeo KT, Liew C, Ng LC, Tan NW, Yeo GSh, Tee NW, Lin RT, Tan TC, Rajadurai VS, Chan JK, Thoon KC.

Ann Acad Med Singapore. 2016 Apr;45(4):148-51. No abstract available.


A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs.

Raffan E, Dennis RJ, O'Donovan CJ, Becker JM, Scott RA, Smith SP, Withers DJ, Wood CJ, Conci E, Clements DN, Summers KM, German AJ, Mellersh CS, Arendt ML, Iyemere VP, Withers E, Söder J, Wernersson S, Andersson G, Lindblad-Toh K, Yeo GS, O'Rahilly S.

Cell Metab. 2016 May 10;23(5):893-900. doi: 10.1016/j.cmet.2016.04.012. Epub 2016 May 3.


Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Tóth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H.

Cell Metab. 2016 May 10;23(5):821-36. doi: 10.1016/j.cmet.2016.04.003. Epub 2016 Apr 28.


Fetoscopic laser photocoagulation in twin-to-twin transfusion syndrome: experience from a single institution.

Thia E, Thain S, Yeo GS.

Singapore Med J. 2017 Jun;58(6):321-326. doi: 10.11622/smedj.2016067. Epub 2016 Apr 8.


Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.

Dalgaard K, Landgraf K, Heyne S, Lempradl A, Longinotto J, Gossens K, Ruf M, Orthofer M, Strogantsev R, Selvaraj M, Lu TT, Casas E, Teperino R, Surani MA, Zvetkova I, Rimmington D, Tung YC, Lam B, Larder R, Yeo GS, O'Rahilly S, Vavouri T, Whitelaw E, Penninger JM, Jenuwein T, Cheung CL, Ferguson-Smith AC, Coll AP, Körner A, Pospisilik JA.

Cell. 2016 Jan 28;164(3):353-64. doi: 10.1016/j.cell.2015.12.025.


5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats.

Martin-Gronert MS, Stocker CJ, Wargent ET, Cripps RL, Garfield AS, Jovanovic Z, D'Agostino G, Yeo GS, Cawthorne MA, Arch JR, Heisler LK, Ozanne SE.

Dis Model Mech. 2016 Apr;9(4):401-12. doi: 10.1242/dmm.023903. Epub 2016 Jan 14.


FTO Obesity Variant and Adipocyte Browning in Humans.

O'Rahilly S, Coll AP, Yeo GS.

N Engl J Med. 2016 Jan 14;374(2):191. doi: 10.1056/NEJMc1513316. No abstract available.


Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets.

Sandovici I, Hammerle CM, Cooper WN, Smith NH, Tarry-Adkins JL, Dunmore BJ, Bauer J, Andrews SR, Yeo GS, Ozanne SE, Constância M.

Diabetologia. 2016 Mar;59(3):502-11. doi: 10.1007/s00125-015-3837-8. Epub 2015 Dec 23.


Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study.

Loy SL, Lek N, Yap F, Soh SE, Padmapriya N, Tan KH, Biswas A, Yeo GS, Kwek K, Gluckman PD, Godfrey KM, Saw SM, Müller-Riemenschneider F, Chong YS, Chong MF, Chan JK; Growing Up in Singapore Towards Healthy Outcomes (GUSTO) study group.

PLoS One. 2015 Nov 16;10(11):e0142239. doi: 10.1371/journal.pone.0142239. eCollection 2015.


Incremental Cost-Effectiveness Analysis of Gestational Diabetes Mellitus Screening Strategies in Singapore.

Chen PY, Finkelstein EA, Ng MJ, Yap F, Yeo GS, Rajadurai VS, Chong YS, Gluckman PD, Saw SM, Kwek KY, Tan KH.

Asia Pac J Public Health. 2016 Jan;28(1):15-25. doi: 10.1177/1010539515612908. Epub 2015 Oct 28.


Ethnic Differences in Effects of Maternal Pre-Pregnancy and Pregnancy Adiposity on Offspring Size and Adiposity.

Lin X, Aris IM, Tint MT, Soh SE, Godfrey KM, Yeo GS, Kwek K, Chan JK, Gluckman PD, Chong YS, Yap F, Holbrook JD, Lee YS.

J Clin Endocrinol Metab. 2015 Oct;100(10):3641-50. doi: 10.1210/jc.2015-1728. Epub 2015 Jul 22.

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