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Items: 26


An Unexpected Species Determined by X-ray Crystallography that May Represent an Intermediate in the Reaction Catalyzed by Quinolinate Synthase.

Esakova OA, Silakov A, Grove TL, Warui DM, Yennawar NH, Booker SJ.

J Am Chem Soc. 2019 Aug 7. doi: 10.1021/jacs.9b02513. [Epub ahead of print]


Physicochemical interactions with (-)-epigallocatechin-3-gallate drive structural modification of celiac-associated peptide α2-gliadin (57-89) at physiological conditions.

Van Buiten CB, Yennawar NH, Pacheco CN, Hatzakis E, Elias RJ.

Food Funct. 2019 May 22;10(5):2997-3007. doi: 10.1039/c9fo00553f.


Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis.

Rose HR, Maggiolo AO, McBride MJ, Palowitch GM, Pandelia ME, Davis KM, Yennawar NH, Boal AK.

Biochemistry. 2019 Apr 9;58(14):1845-1860. doi: 10.1021/acs.biochem.8b01252. Epub 2019 Mar 22.


Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.

McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr.

Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13.


Molecular Mechanism for Folding Cooperativity of Functional RNAs in Living Organisms.

Leamy KA, Yennawar NH, Bevilacqua PC.

Biochemistry. 2018 May 22;57(20):2994-3002. doi: 10.1021/acs.biochem.8b00345. Epub 2018 May 7.


Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA.

DiMarzio M, Rusconi B, Yennawar NH, Eppinger M, Patterson AD, Dudley EG.

PLoS One. 2017 Sep 14;12(9):e0183564. doi: 10.1371/journal.pone.0183564. eCollection 2017.


Cooperative RNA Folding under Cellular Conditions Arises From Both Tertiary Structure Stabilization and Secondary Structure Destabilization.

Leamy KA, Yennawar NH, Bevilacqua PC.

Biochemistry. 2017 Jul 11;56(27):3422-3433. doi: 10.1021/acs.biochem.7b00325. Epub 2017 Jun 28.


The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme.

Bingaman JL, Zhang S, Stevens DR, Yennawar NH, Hammes-Schiffer S, Bevilacqua PC.

Nat Chem Biol. 2017 Apr;13(4):439-445. doi: 10.1038/nchembio.2300. Epub 2017 Feb 13.


Inhibition of pancreatic lipase by black tea theaflavins: Comparative enzymology and in silico modeling studies.

Glisan SL, Grove KA, Yennawar NH, Lambert JD.

Food Chem. 2017 Feb 1;216:296-300. doi: 10.1016/j.foodchem.2016.08.052. Epub 2016 Aug 18.


Structure of Quinolinate Synthase from Pyrococcus horikoshii in the Presence of Its Product, Quinolinic Acid.

Esakova OA, Silakov A, Grove TL, Saunders AH, McLaughlin MI, Yennawar NH, Booker SJ.

J Am Chem Soc. 2016 Jun 15;138(23):7224-7. doi: 10.1021/jacs.6b02708. Epub 2016 Jun 2.


A High-Throughput Biological Calorimetry Core: Steps to Startup, Run, and Maintain a Multiuser Facility.

Yennawar NH, Fecko JA, Showalter SA, Bevilacqua PC.

Methods Enzymol. 2016;567:435-60. doi: 10.1016/bs.mie.2015.07.024. Epub 2015 Sep 5.


Structural and Biochemical Characterizations of Methanoredoxin from Methanosarcina acetivorans, a Glutaredoxin-Like Enzyme with Coenzyme M-Dependent Protein Disulfide Reductase Activity.

Yenugudhati D, Prakash D, Kumar AK, Kumar RS, Yennawar NH, Yennawar HP, Ferry JG.

Biochemistry. 2016 Jan 19;55(2):313-21. doi: 10.1021/acs.biochem.5b00823. Epub 2015 Dec 30.


Structural and Biochemical Characterization of a Ferredoxin:Thioredoxin Reductase-like Enzyme from Methanosarcina acetivorans.

Kumar AK, Kumar RS, Yennawar NH, Yennawar HP, Ferry JG.

Biochemistry. 2015 May 19;54(19):3122-8.


Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves.

Guo F, Zhou W, Li P, Mao Z, Yennawar NH, French JB, Huang TJ.

Small. 2015 Jun;11(23):2733-7. doi: 10.1002/smll.201403262. Epub 2015 Feb 1.


Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases.

Wörsdörfer B, Lingaraju M, Yennawar NH, Boal AK, Krebs C, Bollinger JM Jr, Pandelia ME.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18874-9. doi: 10.1073/pnas.1315927110. Epub 2013 Nov 6.


Molecular crowding favors reactivity of a human ribozyme under physiological ionic conditions.

Strulson CA, Yennawar NH, Rambo RP, Bevilacqua PC.

Biochemistry. 2013 Nov 19;52(46):8187-97. doi: 10.1021/bi400816s. Epub 2013 Nov 4.


Structural basis for entropy-driven cellulose binding by a type-A cellulose-binding module (CBM) and bacterial expansin.

Georgelis N, Yennawar NH, Cosgrove DJ.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14830-5. doi: 10.1073/pnas.1213200109. Epub 2012 Aug 27.


Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a novel plant-type ferredoxin/thioredoxin reductase-like protein from Methanosarcina acetivorans.

Kumar AK, Yennawar NH, Yennawar HP, Ferry JG.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):775-8. doi: 10.1107/S1744309111017234. Epub 2011 Jun 30.


Structural basis for methyl transfer by a radical SAM enzyme.

Boal AK, Grove TL, McLaughlin MI, Yennawar NH, Booker SJ, Rosenzweig AC.

Science. 2011 May 27;332(6033):1089-92. doi: 10.1126/science.1205358. Epub 2011 Apr 28.


Kinetic and structural characterization of dihydrofolate reductase from Streptococcus pneumoniae.

Lee J, Yennawar NH, Gam J, Benkovic SJ.

Biochemistry. 2010 Jan 12;49(1):195-206. doi: 10.1021/bi901614m.


Expression, crystallization and preliminary X-ray diffraction studies of recombinant Clostridium perfringens beta 2-toxin.

Gurjar AA, Yennawar NH, Yennawar HP, Rajashankar KR, Hegde NV, Jayarao BM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):484-7. Epub 2007 May 5.


Human mitochondrial branched chain aminotransferase isozyme: structural role of the CXXC center in catalysis.

Yennawar NH, Islam MM, Conway M, Wallin R, Hutson SM.

J Biol Chem. 2006 Dec 22;281(51):39660-71. Epub 2006 Oct 18.


Crystal structure and activities of EXPB1 (Zea m 1), a beta-expansin and group-1 pollen allergen from maize.

Yennawar NH, Li LC, Dudzinski DM, Tabuchi A, Cosgrove DJ.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14664-71. Epub 2006 Sep 19.


Two-component signaling in the AAA + ATPase DctD: binding Mg2+ and BeF3- selects between alternate dimeric states of the receiver domain.

Park S, Meyer M, Jones AD, Yennawar HP, Yennawar NH, Nixon BT.

FASEB J. 2002 Dec;16(14):1964-6. Epub 2002 Oct 4.


Crystal structures of human mitochondrial branched chain aminotransferase reaction intermediates: ketimine and pyridoxamine phosphate forms.

Yennawar NH, Conway ME, Yennawar HP, Farber GK, Hutson SM.

Biochemistry. 2002 Oct 1;41(39):11592-601.


X-ray crystal structure of gamma-chymotrypsin in hexane.

Yennawar NH, Yennawar HP, Farber GK.

Biochemistry. 1994 Jun 14;33(23):7326-36.


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