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Non-alcoholic fatty liver disease and hypercholesterolemia: Roles of thyroid hormones, metabolites, and agonists.

Sinha RA, Bruinstroop E, Singh BK, Yen PM.

Thyroid. 2019 Aug 7. doi: 10.1089/thy.2018.0664. [Epub ahead of print]


A liver-specific thyromimetic, VK2809, decreases hepatosteatosis in glycogen storage disease type Ia (GSD Ia).

Zhou J, Waskowicz LR, Lim A, Liao XH, Lian B, Masamune H, Refetoff S, Tran B, Koeberl DD, Yen PM.

Thyroid. 2019 Jul 24. doi: 10.1089/thy.2019.0007. [Epub ahead of print]


Hyperthyroidism in the personalized medicine era: the rise of mathematical optimization.

Meng F, Li E, Yen PM, Leow MKS.

J R Soc Interface. 2019 Jun 28;16(155):20190083. doi: 10.1098/rsif.2019.0083. Epub 2019 Jun 26.


Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.

Widjaja AA, Singh BK, Adami E, Viswanathan S, Dong J, D'Agostino GA, Ng B, Lim WW, Tan J, Paleja BS, Tripathi M, Lim SY, Shekeran SG, Chothani SP, Rabes A, Sombetzki M, Bruinstroop E, Min LP, Sinha RA, Albani S, Yen PM, Schafer S, Cook SA.

Gastroenterology. 2019 May 9. pii: S0016-5085(19)40858-5. doi: 10.1053/j.gastro.2019.05.002. [Epub ahead of print]


Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels.

Siong Tan HW, Anjum B, Shen HM, Ghosh S, Yen PM, Sinha RA.

Autophagy. 2019 Aug;15(8):1455-1459. doi: 10.1080/15548627.2019.1609847. Epub 2019 Apr 28.


Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo.

Zhou J, Ng B, Ko NSJ, Fiedler LR, Khin E, Lim A, Sahib NE, Wu Y, Chothani SP, Schafer S, Bay BH, Sinha RA, Cook SA, Yen PM.

Hum Mol Genet. 2019 Jun 15;28(12):1971-1981. doi: 10.1093/hmg/ddz033.


PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction.

Zhou W, Ma D, Sun AX, Tran HD, Ma DL, Singh BK, Zhou J, Zhang J, Wang D, Zhao Y, Yen PM, Goh E, Tan EK.

Hum Mol Genet. 2019 Apr 1;28(7):1100-1116. doi: 10.1093/hmg/ddy413.


Novel Transcriptional Mechanisms for Regulating Metabolism by Thyroid Hormone.

Singh BK, Sinha RA, Yen PM.

Int J Mol Sci. 2018 Oct 22;19(10). pii: E3284. doi: 10.3390/ijms19103284. Review.


A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N 6-methyladenosine demethylase activity in cells.

Cheong A, Low JJA, Lim A, Yen PM, Woon ECY.

Chem Sci. 2018 Aug 7;9(36):7174-7185. doi: 10.1039/c8sc02163e. eCollection 2018 Sep 28.


Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia.

Waskowicz LR, Zhou J, Landau DJ, Brooks ED, Lim A, Yavarow ZA, Kudo T, Zhang H, Wu Y, Grant S, Young SP, Huat BB, Yen PM, Koeberl DD.

Hum Mol Genet. 2019 Jan 1;28(1):143-154. doi: 10.1093/hmg/ddy343.


Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.

Yau WW, Singh BK, Lesmana R, Zhou J, Sinha RA, Wong KA, Wu Y, Bay BH, Sugii S, Sun L, Yen PM.

Autophagy. 2019 Jan;15(1):131-150. doi: 10.1080/15548627.2018.1511263. Epub 2018 Sep 13.


Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.

Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Giguère V, Bay BH, Vanacker JM, Ghosh S, Gauthier K, Hollenberg AN, McDonnell DP, Yen PM.

Sci Signal. 2018 Jun 26;11(536). pii: eaam5855. doi: 10.1126/scisignal.aam5855.


Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro.

Zhou J, Sinha RA, Lesmana R, Yau WWY, Yen PM.

Methods Mol Biol. 2018;1801:111-122. doi: 10.1007/978-1-4939-7902-8_11.


Low-Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients With Type 2 Diabetes Mellitus and NAFLD.

Bruinstroop E, Dalan R, Cao Y, Bee YM, Chandran K, Cho LW, Soh SB, Teo EK, Toh SA, Leow MKS, Sinha RA, Sadananthan SA, Michael N, Stapleton HM, Leung C, Angus PW, Patel SK, Burrell LM, Lim SC, Sum CF, Velan SS, Yen PM.

J Clin Endocrinol Metab. 2018 Jul 1;103(7):2698-2706. doi: 10.1210/jc.2018-00475.


Direct effects of thyroid hormones on hepatic lipid metabolism.

Sinha RA, Singh BK, Yen PM.

Nat Rev Endocrinol. 2018 May;14(5):259-269. doi: 10.1038/nrendo.2018.10. Epub 2018 Feb 23. Review.


Increasing Dietary Medium-Chain Fatty Acid Ratio Mitigates High-fat Diet-Induced Non-Alcoholic Steatohepatitis by Regulating Autophagy.

Wang ME, Singh BK, Hsu MC, Huang C, Yen PM, Wu LS, Jong DS, Chiu CH.

Sci Rep. 2017 Oct 25;7(1):13999. doi: 10.1038/s41598-017-14376-y.


A clinician's guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoforms.

Singh BK, Yen PM.

Clin Diabetes Endocrinol. 2017 Sep 15;3:8. doi: 10.1186/s40842-017-0046-z. eCollection 2017.


Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia.

Farah BL, Landau DJ, Wu Y, Sinha RA, Loh A, Bay BH, Koeberl DD, Yen PM.

Mol Genet Metab. 2017 Nov;122(3):95-98. doi: 10.1016/j.ymgme.2017.08.013. Epub 2017 Sep 1.


Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet.

Iannucci LF, Cioffi F, Senese R, Goglia F, Lanni A, Yen PM, Sinha RA.

Sci Rep. 2017 May 17;7(1):2023. doi: 10.1038/s41598-017-02205-1.


Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature.

Flamant F, Cheng SY, Hollenberg AN, Moeller LC, Samarut J, Wondisford FE, Yen PM, Refetoff S.

Endocrinology. 2017 Jul 1;158(7):2052-2057. doi: 10.1210/en.2017-00250.


Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.

Ohba K, Sinha RA, Singh BK, Iannucci LF, Zhou J, Kovalik JP, Liao XH, Refetoff S, Sng JCG, Leow MK, Yen PM.

Thyroid. 2017 Jun;27(6):852-860. doi: 10.1089/thy.2016.0456. Epub 2017 May 24.


Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa).

Farah BL, Sinha RA, Wu Y, Singh BK, Lim A, Hirayama M, Landau DJ, Bay BH, Koeberl DD, Yen PM.

Sci Rep. 2017 Mar 20;7:44408. doi: 10.1038/srep44408.


Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging.

Zhou J, Chong SY, Lim A, Singh BK, Sinha RA, Salmon AB, Yen PM.

Aging (Albany NY). 2017 Feb 26;9(2):583-599. doi: 10.18632/aging.101181.


Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy.

Singh BK, Sinha RA, Ohba K, Yen PM.

Mol Cell Endocrinol. 2017 Dec 15;458:160-168. doi: 10.1016/j.mce.2017.02.018. Epub 2017 Feb 16. Review.


Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation.

Tripathi M, Zhang CW, Singh BK, Sinha RA, Moe KT, DeSilva DA, Yen PM.

Cell Death Dis. 2016 Dec 8;7(12):e2513. doi: 10.1038/cddis.2016.374.


Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis.

Sinha RA, Singh BK, Yen PM.

Endocr Rev. 2017 Feb 1;38(1):69-102. doi: 10.1210/er.2016-1103. Review.


Corrigendum to "Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells" [Biochem. Biophys. Res. Commun. 480 (2016) 461-467].

Iannucci LF, Sun J, Singh BK, Zhou J, Kaddai VA, Lanni A, Yen PM, Sinha RA.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1517. doi: 10.1016/j.bbrc.2016.11.116. Epub 2016 Nov 26. No abstract available.


Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.

Sinha RA, Singh BK, Zhou J, Xie S, Farah BL, Lesmana R, Ohba K, Tripathi M, Ghosh S, Hollenberg AN, Yen PM.

Autophagy. 2017 Jan 2;13(1):169-186. doi: 10.1080/15548627.2016.1235123. Epub 2016 Nov 15.


Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells.

Iannucci LF, Sun J, Singh BK, Zhou J, Kaddai VA, Lanni A, Yen PM, Sinha RA.

Biochem Biophys Res Commun. 2016 Nov 18;480(3):461-467. doi: 10.1016/j.bbrc.2016.10.072. Epub 2016 Oct 20. Erratum in: Biochem Biophys Res Commun. 2017 Jan 22;482(4):1517.


Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity.

Lim A, Zhou J, Sinha RA, Singh BK, Ghosh S, Lim KH, Chow PK, Woon ECY, Yen PM.

Biochem Biophys Res Commun. 2016 Oct 21;479(3):476-481. doi: 10.1016/j.bbrc.2016.09.086. Epub 2016 Sep 17.


TSHβv-A New Bone to Pick.

Yen PM.

Endocrinology. 2016 Sep;157(9):3402-4. doi: 10.1210/en.2016-1519. No abstract available.


Physiological and Metabolic Changes During the Transition from Hyperthyroidism to Euthyroidism in Graves' Disease.

Chng CL, Lim AY, Tan HC, Kovalik JP, Tham KW, Bee YM, Lim W, Acharyya S, Lai OF, Chong MF, Yen PM.

Thyroid. 2016 Oct;26(10):1422-1430. Epub 2016 Sep 7.


Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD.

Sinha RA, Yen PM.

Cell Biosci. 2016 Jul 19;6:46. doi: 10.1186/s13578-016-0113-7. eCollection 2016. Review.


Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice.

Ohba K, Leow MK, Singh BK, Sinha RA, Lesmana R, Liao XH, Ghosh S, Refetoff S, Sng JC, Yen PM.

Endocrinology. 2016 Apr;157(4):1660-72. doi: 10.1210/en.2015-1848. Epub 2016 Feb 11.


Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle.

Lesmana R, Sinha RA, Singh BK, Zhou J, Ohba K, Wu Y, Yau WW, Bay BH, Yen PM.

Endocrinology. 2016 Jan;157(1):23-38. doi: 10.1210/en.2015-1632. Epub 2015 Nov 12.


Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency.

Farah BL, Landau DJ, Sinha RA, Brooks ED, Wu Y, Fung SYS, Tanaka T, Hirayama M, Bay BH, Koeberl DD, Yen PM.

J Hepatol. 2016 Feb;64(2):370-379. doi: 10.1016/j.jhep.2015.10.008. Epub 2015 Oct 20.


Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.

Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM.

J Biol Chem. 2016 Jan 1;291(1):198-214. doi: 10.1074/jbc.M115.668673. Epub 2015 Oct 9.


Classical nuclear hormone receptor activity as a mediator of complex biological responses: a look at health and disease.

Yen PM.

Best Pract Res Clin Endocrinol Metab. 2015 Aug;29(4):517-28. doi: 10.1016/j.beem.2015.07.005. Epub 2015 Jul 16. Review.


Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling.

Sinha RA, Singh BK, Zhou J, Wu Y, Farah BL, Ohba K, Lesmana R, Gooding J, Bay BH, Yen PM.

Autophagy. 2015;11(8):1341-57. doi: 10.1080/15548627.2015.1061849.


Cellular Action of Thyroid Hormone.

Sinha R, Yen PM.

In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-.
2018 Jun 20.


An integrative approach identified genes associated with drug response in gastric cancer.

Zhou J, Yong WP, Yap CS, Vijayaraghavan A, Sinha RA, Singh BK, Xiu S, Manesh S, Ngo A, Lim A, Ang C, Xie C, Wong FY, Lin SJ, Wan WK, Tan IB, Flotow H, Tan P, Lim KH, Yen PM, Goh LK.

Carcinogenesis. 2015 Apr;36(4):441-51. doi: 10.1093/carcin/bgv014. Epub 2015 Mar 5.


Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism.

Sinha RA, Singh BK, Yen PM.

Trends Endocrinol Metab. 2014 Oct;25(10):538-45. doi: 10.1016/j.tem.2014.07.001. Epub 2014 Aug 12. Review.


β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver.

Farah BL, Sinha RA, Wu Y, Singh BK, Zhou J, Bay BH, Yen PM.

PLoS One. 2014 Jun 20;9(6):e98155. doi: 10.1371/journal.pone.0098155. eCollection 2014.


Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism.

Refetoff S, Bassett JH, Beck-Peccoz P, Bernal J, Brent G, Chatterjee K, De Groot LJ, Dumitrescu AM, Jameson JL, Kopp PA, Murata Y, Persani L, Samarut J, Weiss RE, Williams GR, Yen PM.

Eur Thyroid J. 2014 Mar;3(1):7-9. doi: 10.1159/000358180. Epub 2014 Mar 4. No abstract available.


Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism.

Refetoff S, Bassett JH, Beck-Peccoz P, Bernal J, Brent G, Chatterjee K, De Groot LJ, Dumitrescu AM, Jameson JL, Kopp PA, Murata Y, Persani L, Samarut J, Weiss RE, Williams GR, Yen PM.

J Clin Endocrinol Metab. 2014 Mar;99(3):768-70. doi: 10.1210/jc.2013-3393. No abstract available.


Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells.

Aw DK, Sinha RA, Xie SY, Yen PM.

Biochem Biophys Res Commun. 2014 May 16;447(4):569-73. doi: 10.1016/j.bbrc.2014.04.031. Epub 2014 Apr 13.


Studies of molecular mechanisms associated with increased deiodinase 3 expression in a case of consumptive hypothyroidism.

Aw DK, Sinha RA, Tan HC, Loh LM, Salvatore D, Yen PM.

J Clin Endocrinol Metab. 2014 Nov;99(11):3965-71. doi: 10.1210/jc.2013-3408. Epub 2014 Mar 19.


Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism.

Refetoff S, Bassett JH, Beck-Peccoz P, Bernal J, Brent G, Chatterjee K, De Groot LJ, Dumitrescu AM, Jameson JL, Kopp PA, Murata Y, Persani L, Samarut J, Weiss RE, Williams GR, Yen PM.

Thyroid. 2014 Mar;24(3):407-9. doi: 10.1089/thy.2013.3393.nomen. Epub 2014 Mar 4. No abstract available.


Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance.

Zhou J, Farah BL, Sinha RA, Wu Y, Singh BK, Bay BH, Yang CS, Yen PM.

PLoS One. 2014 Jan 29;9(1):e87161. doi: 10.1371/journal.pone.0087161. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e96884.

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