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Items: 1 to 50 of 425

1.

Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors (GISTs) and Acute Myeloid Leukemia (AML).

Lin WH, Wu S, Yeh TK, Chen CT, Song JS, Shiao HY, Kuo CC, Hsu T, Lu CT, Wang PC, Wu TS, Peng YH, Lin HY, Chen CP, Weng YL, Kung FC, Wu MH, Su YC, Huang KW, Chou LH, Hsueh CC, Yen KJ, Kuo PC, Huang CL, Chen LT, Shih C, Tsai HJ, Jiaang WT.

J Med Chem. 2019 Nov 13. doi: 10.1021/acs.jmedchem.9b01229. [Epub ahead of print]

PMID:
31721578
2.

Subconjunctival abscess formation after strabismus surgery.

Wu F, Edmond J, Yen K, Ram R, Coats D, Herce H, Chilakapati M.

J AAPOS. 2019 Sep 30. pii: S1091-8531(19)30495-1. doi: 10.1016/j.jaapos.2019.08.273. [Epub ahead of print]

PMID:
31580892
3.

The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity.

Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P.

Physiol Rep. 2019 Jul;7(13):e14171. doi: 10.14814/phy2.14171.

4.

Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment.

Mehta HH, Xiao J, Ramirez R, Miller B, Kim SJ, Cohen P, Yen K.

Metabolomics. 2019 Jun 6;15(6):88. doi: 10.1007/s11306-019-1549-7.

5.

Band keratopathy in children previously treated with diode laser for type 1 retinopathy of prematurity.

Ali SF, Edmond JC, Suelflow JR, Coats DK, Yen KG.

J AAPOS. 2019 Aug;23(4):232-234. doi: 10.1016/j.jaapos.2019.04.004. Epub 2019 May 30.

PMID:
31153950
6.

Prediction of local relapse and distant metastasis in patients with definitive chemoradiotherapy-treated cervical cancer by deep learning from [18F]-fluorodeoxyglucose positron emission tomography/computed tomography.

Shen WC, Chen SW, Wu KC, Hsieh TC, Liang JA, Hung YC, Yeh LS, Chang WC, Lin WC, Yen KY, Kao CH.

Eur Radiol. 2019 Dec;29(12):6741-6749. doi: 10.1007/s00330-019-06265-x. Epub 2019 May 27.

PMID:
31134366
7.

Predicting Hemolytic Uremic Syndrome and Renal Failure in Shiga Toxin-Producing Escherichia coli Infected Children.

McKee RS, Schnadower D, Tarr PI, Xie J, Finkelstein Y, Desai N, Lane RD, Bergmann KR, Kaplan RL, Hariharan S, Cruz AT, Cohen DM, Dixon A, Ramgopal S, Rominger A, Powell EC, Kilgar J, Michelson KA, Beer D, Bitzan M, Pruitt CM, Yen K, Meckler GD, Plint AC, Bradin S, Abramo TJ, Gouin S, Kam AJ, Schuh A, Balamuth F, Hunley TE, Kanegaye JT, Jones NE, Avva U, Porter R, Fein DM, Louie JP, Freedman SB; Pediatric Emergency Medicine Collaborative Research Committee (PEMCRC); Pediatric Emergency Research Canada (PERC).

Clin Infect Dis. 2019 May 24. pii: ciz432. doi: 10.1093/cid/ciz432. [Epub ahead of print]

PMID:
31125419
8.

Cortical Visual Impairment in Congenital Cytomegalovirus Infection.

Jin HD, Demmler-Harrison GJ, Miller J, Edmond JC, Coats DK, Paysse EA, Bhatt AR, Yen KG, Klingen JT, Steinkuller P; Congenital CMV Longitudinal Group.

J Pediatr Ophthalmol Strabismus. 2019 May 22;56(3):194-202. doi: 10.3928/01913913-20190311-01.

PMID:
31116869
9.

Comparing the Utility of Mitochondrial and Nuclear DNA to Adjust for Genetic Ancestry in Association Studies.

Miller B, Arpawong TE, Jiao H, Kim SJ, Yen K, Mehta HH, Wan J, Carpten JC, Cohen P.

Cells. 2019 Apr 3;8(4). pii: E306. doi: 10.3390/cells8040306.

10.

Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression.

Breton CV, Song AY, Xiao J, Kim SJ, Mehta HH, Wan J, Yen K, Sioutas C, Lurmann F, Xue S, Morgan TE, Zhang J, Cohen P.

Mitochondrion. 2019 May;46:22-29. doi: 10.1016/j.mito.2019.04.001. Epub 2019 Apr 10.

PMID:
30980914
11.

GRSF1 is an age-related regulator of senescence.

Kim SJ, Chun M, Wan J, Lee C, Yen K, Cohen P.

Sci Rep. 2019 Apr 3;9(1):5546. doi: 10.1038/s41598-019-42064-6.

12.

Outcomes of Unilateral Cataracts in Infants and Toddlers 7 to 24 Months of Age: Toddler Aphakia and Pseudophakia Study (TAPS).

Bothun ED, Wilson ME, Traboulsi EI, Diehl NN, Plager DA, Vanderveen DK, Freedman SF, Yen KG, Weil NC, Loh AR, Morrison D, Anderson JS, Lambert SR; Toddler Aphakia and Pseudophakia Study Group (TAPS).

Ophthalmology. 2019 Aug;126(8):1189-1195. doi: 10.1016/j.ophtha.2019.03.011. Epub 2019 Mar 14.

PMID:
30880109
13.

Tongue Flap for Keratinized Soft Tissue Coverage Around Dental Implants: A Case Report and Discussion.

Yen K, Lazow S, Segal J.

J Oral Implantol. 2019 Jun;45(3):223-226. doi: 10.1563/aaid-joi-D-18-00140. Epub 2019 Mar 15.

PMID:
30875271
14.

MOTS-c: an equal opportunity insulin sensitizer.

Kim SJ, Miller B, Kumagai H, Yen K, Cohen P.

J Mol Med (Berl). 2019 Apr;97(4):487-490. doi: 10.1007/s00109-019-01758-0. Epub 2019 Feb 20. No abstract available.

PMID:
30788534
15.

Ectopically Expressed IL-34 Can Efficiently Induce Macrophage Migration to the Liver in Zebrafish.

Jiang Y, Chen J, Yen K, Xu J.

Zebrafish. 2019 Apr;16(2):165-170. doi: 10.1089/zeb.2018.1685. Epub 2019 Feb 6.

PMID:
30724719
16.

Molecular remission and response patterns in patients with mutant-IDH2 acute myeloid leukemia treated with enasidenib.

Stein EM, DiNardo CD, Fathi AT, Pollyea DA, Stone RM, Altman JK, Roboz GJ, Patel MR, Collins R, Flinn IW, Sekeres MA, Stein AS, Kantarjian HM, Levine RL, Vyas P, MacBeth KJ, Tosolini A, VanOostendorp J, Xu Q, Gupta I, Lila T, Risueno A, Yen KE, Wu B, Attar EC, Tallman MS, de Botton S.

Blood. 2019 Feb 14;133(7):676-687. doi: 10.1182/blood-2018-08-869008. Epub 2018 Dec 3.

17.

Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia.

Brunner AM, Neuberg DS, Wander SA, Sadrzadeh H, Ballen KK, Amrein PC, Attar E, Hobbs GS, Chen YB, Perry A, Connolly C, Joseph C, Burke M, Ramos A, Galinsky I, Yen K, Yang H, Straley K, Agresta S, Adamia S, Borger DR, Iafrate A, Graubert TA, Stone RM, Fathi AT.

Cancer. 2019 Feb 15;125(4):541-549. doi: 10.1002/cncr.31729. Epub 2018 Nov 13.

PMID:
30422308
18.

Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.

Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P.

Sci Rep. 2018 Sep 21;8(1):14212. doi: 10.1038/s41598-018-32616-7.

19.

JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.

McKenney AS, Lau AN, Somasundara AVH, Spitzer B, Intlekofer AM, Ahn J, Shank K, Rapaport FT, Patel MA, Papalexi E, Shih AH, Chiu A, Freinkman E, Akbay EA, Steadman M, Nagaraja R, Yen K, Teruya-Feldstein J, Wong KK, Rampal R, Vander Heiden MG, Thompson CB, Levine RL.

J Clin Invest. 2018 Oct 1;128(10):4743. doi: 10.1172/JCI124920. Epub 2018 Sep 17. No abstract available.

20.

Textural features of cervical cancers on FDG-PET/CT associate with survival and local relapse in patients treated with definitive chemoradiotherapy.

Chen SW, Shen WC, Hsieh TC, Liang JA, Hung YC, Yeh LS, Chang WC, Lin WC, Yen KY, Kao CH.

Sci Rep. 2018 Aug 8;8(1):11859. doi: 10.1038/s41598-018-30336-6.

21.

Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib.

Quek L, David MD, Kennedy A, Metzner M, Amatangelo M, Shih A, Stoilova B, Quivoron C, Heiblig M, Willekens C, Saada V, Alsafadi S, Vijayabaskar MS, Peniket A, Bernard OA, Agresta S, Yen K, MacBeth K, Stein E, Vassiliou GS, Levine R, De Botton S, Thakurta A, Penard-Lacronique V, Vyas P.

Nat Med. 2018 Aug;24(8):1167-1177. doi: 10.1038/s41591-018-0115-6. Epub 2018 Jul 16.

PMID:
30013198
22.

Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice.

Qin Q, Mehta H, Yen K, Navarrete G, Brandhorst S, Wan J, Delrio S, Zhang X, Lerman LO, Cohen P, Lerman A.

Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1127-H1136. doi: 10.1152/ajpheart.00685.2017. Epub 2018 Jul 13.

23.

Metabolic Imaging Phenotype Using Radiomics of [18F]FDG PET/CT Associated with Genetic Alterations of Colorectal Cancer.

Chen SW, Shen WC, Chen WT, Hsieh TC, Yen KY, Chang JG, Kao CH.

Mol Imaging Biol. 2019 Feb;21(1):183-190. doi: 10.1007/s11307-018-1225-8.

PMID:
29948642
24.

Perspectives of Nanoemulsion Strategies in The Improvement of Oral, Parenteral and Transdermal Chemotherapy.

Pandey M, Choudhury H, Yeun OC, Yin HM, Lynn TW, Tine CLY, Wi NS, Yen KCC, Phing CS, Kesharwani P, Bhattamisra SK, Gorain B.

Curr Pharm Biotechnol. 2018;19(4):276-292. doi: 10.2174/1389201019666180605125234. Review.

PMID:
29874994
25.

Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML.

DiNardo CD, Stein EM, de Botton S, Roboz GJ, Altman JK, Mims AS, Swords R, Collins RH, Mannis GN, Pollyea DA, Donnellan W, Fathi AT, Pigneux A, Erba HP, Prince GT, Stein AS, Uy GL, Foran JM, Traer E, Stuart RK, Arellano ML, Slack JL, Sekeres MA, Willekens C, Choe S, Wang H, Zhang V, Yen KE, Kapsalis SM, Yang H, Dai D, Fan B, Goldwasser M, Liu H, Agresta S, Wu B, Attar EC, Tallman MS, Stone RM, Kantarjian HM.

N Engl J Med. 2018 Jun 21;378(25):2386-2398. doi: 10.1056/NEJMoa1716984. Epub 2018 Jun 2.

26.

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers.

Popovici-Muller J, Lemieux RM, Artin E, Saunders JO, Salituro FG, Travins J, Cianchetta G, Cai Z, Zhou D, Cui D, Chen P, Straley K, Tobin E, Wang F, David MD, Penard-Lacronique V, Quivoron C, Saada V, de Botton S, Gross S, Dang L, Yang H, Utley L, Chen Y, Kim H, Jin S, Gu Z, Yao G, Luo Z, Lv X, Fang C, Yan L, Olaharski A, Silverman L, Biller S, Su SM, Yen K.

ACS Med Chem Lett. 2018 Jan 19;9(4):300-305. doi: 10.1021/acsmedchemlett.7b00421. eCollection 2018 Apr 12.

27.

Integrated computer-aided forensic case analysis, presentation, and documentation based on multimodal 3D data.

Bornik A, Urschler M, Schmalstieg D, Bischof H, Krauskopf A, Schwark T, Scheurer E, Yen K.

Forensic Sci Int. 2018 Jun;287:12-24. doi: 10.1016/j.forsciint.2018.03.031. Epub 2018 Mar 23.

28.

Efficacy and safety of lebrikizumab in adult patients with mild-to-moderate asthma not receiving inhaled corticosteroids.

Korenblat P, Kerwin E, Leshchenko I, Yen K, Holweg CTJ, Anzures-Cabrera J, Martin C, Putnam WS, Governale L, Olsson J, Matthews JG.

Respir Med. 2018 Jan;134:143-149. doi: 10.1016/j.rmed.2017.12.006. Epub 2017 Dec 13.

29.

JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.

McKenney AS, Lau AN, Somasundara AVH, Spitzer B, Intlekofer AM, Ahn J, Shank K, Rapaport FT, Patel MA, Papalexi E, Shih AH, Chiu A, Freinkman E, Akbay EA, Steadman M, Nagaraja R, Yen K, Teruya-Feldstein J, Wong KK, Rampal R, Vander Heiden MG, Thompson CB, Levine RL.

J Clin Invest. 2018 Feb 1;128(2):789-804. doi: 10.1172/JCI94516. Epub 2018 Jan 22. Erratum in: J Clin Invest. 2018 Oct 1;128(10):4743.

30.

Efficacy and safety of lebrikizumab (an anti-IL-13 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical corticosteroids: A randomized, placebo-controlled phase II trial (TREBLE).

Simpson EL, Flohr C, Eichenfield LF, Bieber T, Sofen H, Taïeb A, Owen R, Putnam W, Castro M, DeBusk K, Lin CY, Voulgari A, Yen K, Omachi TA.

J Am Acad Dermatol. 2018 May;78(5):863-871.e11. doi: 10.1016/j.jaad.2018.01.017. Epub 2018 Jan 17.

31.

Associations of Tumor PD-1 Ligands, Immunohistochemical Studies, and Textural Features in 18F-FDG PET in Squamous Cell Carcinoma of the Head and Neck.

Chen RY, Lin YC, Shen WC, Hsieh TC, Yen KY, Chen SW, Kao CH.

Sci Rep. 2018 Jan 8;8(1):105. doi: 10.1038/s41598-017-18489-2.

32.

Dipeptidyl peptidase-4 inhibitor decreases the risk of atrial fibrillation in patients with type 2 diabetes: a nationwide cohort study in Taiwan.

Chang CY, Yeh YH, Chan YH, Liu JR, Chang SH, Lee HF, Wu LS, Yen KC, Kuo CT, See LC.

Cardiovasc Diabetol. 2017 Dec 19;16(1):159. doi: 10.1186/s12933-017-0640-5.

33.

Knowledge, competencies and attitudes regarding external post-mortem physical examination: A survey among German post-graduate trainees in general practice.

Valentini J, Goetz K, Yen K, Szecsenyi J, Dettling A, Joos S, Steinhaeuser J, Flum E.

Eur J Gen Pract. 2018 Dec;24(1):26-31. doi: 10.1080/13814788.2017.1389884. Epub 2017 Nov 23.

34.

Immunohistochemical biomarkers and volumetric parameters for predicting radiotherapy-based outcomes in patients with p16-negative pharyngeal cancer.

Chen RY, Lin YC, Chen SW, Lin TY, Hsieh TC, Yen KY, Liang JA, Yang SN, Wang YC, Chen YH, Chiang SF, Kao CH.

Oncotarget. 2017 Aug 21;8(42):72342-72351. doi: 10.18632/oncotarget.20374. eCollection 2017 Sep 22.

35.

Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment.

Kim SJ, Xiao J, Cohen P, Yen K.

J Vis Exp. 2017 Sep 25;(127). doi: 10.3791/56496.

36.

The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity.

Okada AK, Teranishi K, Lobo F, Isas JM, Xiao J, Yen K, Cohen P, Langen R.

Sci Rep. 2017 Aug 10;7(1):7802. doi: 10.1038/s41598-017-08372-5.

37.

Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.

Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR.

Cell Metab. 2017 Jun 6;25(6):1320-1333.e5. doi: 10.1016/j.cmet.2017.05.003.

38.

Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia.

Stein EM, DiNardo CD, Pollyea DA, Fathi AT, Roboz GJ, Altman JK, Stone RM, DeAngelo DJ, Levine RL, Flinn IW, Kantarjian HM, Collins R, Patel MR, Frankel AE, Stein A, Sekeres MA, Swords RT, Medeiros BC, Willekens C, Vyas P, Tosolini A, Xu Q, Knight RD, Yen KE, Agresta S, de Botton S, Tallman MS.

Blood. 2017 Aug 10;130(6):722-731. doi: 10.1182/blood-2017-04-779405. Epub 2017 Jun 6.

39.

Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response.

Amatangelo MD, Quek L, Shih A, Stein EM, Roshal M, David MD, Marteyn B, Farnoud NR, de Botton S, Bernard OA, Wu B, Yen KE, Tallman MS, Papaemmanuil E, Penard-Lacronique V, Thakurta A, Vyas P, Levine RL.

Blood. 2017 Aug 10;130(6):732-741. doi: 10.1182/blood-2017-04-779447. Epub 2017 Jun 6.

40.

Mitochondrially derived peptides as novel regulators of metabolism.

Kim SJ, Xiao J, Wan J, Cohen P, Yen K.

J Physiol. 2017 Nov 1;595(21):6613-6621. doi: 10.1113/JP274472. Epub 2017 Jul 18. Review.

41.

Characteristics of Anterior Lens Opacities in Children.

Dixit L, Puente M, Yen KG.

Open Ophthalmol J. 2017 Apr 28;11:84-88. doi: 10.2174/1874364101711010084. eCollection 2017.

42.

Outcomes of Cataract Surgery in Children with Down Syndrome.

Saifee M, Kong L, Yen KG.

J Ophthalmic Vis Res. 2017 Apr-Jun;12(2):243-244. doi: 10.4103/jovr.jovr_212_16. No abstract available.

43.

Long-term Outcomes of Primary Intraocular Lens Implantation in Patients Aged 7 to 24 Months.

Yeh AG, Kong L, Yen KG.

J Pediatr Ophthalmol Strabismus. 2017 May 1;54(3):149-155. doi: 10.3928/01913913-20170206-02.

PMID:
28537643
44.

Peripheral complement interactions with amyloid β peptide: Erythrocyte clearance mechanisms.

Brubaker WD, Crane A, Johansson JU, Yen K, Garfinkel K, Mastroeni D, Asok P, Bradt B, Sabbagh M, Wallace TL, Glavis-Bloom C, Tenner AJ, Rogers J.

Alzheimers Dement. 2017 Dec;13(12):1397-1409. doi: 10.1016/j.jalz.2017.03.010. Epub 2017 May 2.

45.

Visual outcomes of patients presenting with bilateral infantile cataracts and nystagmus.

Crockett C, Camero KA, Kong L, Yen KG.

Can J Ophthalmol. 2017 Apr;52(2):203-206. doi: 10.1016/j.jcjo.2016.08.021. Epub 2016 Oct 27.

PMID:
28457292
46.

[18]Fluorodeoxyglucose Positron Emission Tomography for the Textural Features of Cervical Cancer Associated with Lymph Node Metastasis and Histological Type.

Shen WC, Chen SW, Liang JA, Hsieh TC, Yen KY, Kao CH.

Eur J Nucl Med Mol Imaging. 2017 Sep;44(10):1721-1731. doi: 10.1007/s00259-017-3697-1. Epub 2017 Apr 14.

PMID:
28409221
47.

Long-term Visual and Ocular Sequelae in Patients With Congenital Cytomegalovirus Infection.

Jin HD, Demmler-Harrison GJ, Coats DK, Paysse EA, Bhatt A, Edmond JC, Yen KG, Steinkuller P, Miller J; Congenital CMV Longitudinal Study Group.

Pediatr Infect Dis J. 2017 Sep;36(9):877-882. doi: 10.1097/INF.0000000000001599.

48.

A pharmacogenomic approach validates AG-221 as an effective and on-target therapy in IDH2 mutant AML.

Kats LM, Vervoort SJ, Cole R, Rogers AJ, Gregory GP, Vidacs E, Li J, Nagaraja R, Yen KE, Johnstone RW.

Leukemia. 2017 Jun;31(6):1466-1470. doi: 10.1038/leu.2017.84. Epub 2017 Mar 10. No abstract available.

PMID:
28280273
49.

Detection and volume estimation of artificial hematomas in the subcutaneous fatty tissue: comparison of different MR sequences at 3.0 T.

Ogris K, Petrovic A, Scheicher S, Sprenger H, Urschler M, Hassler EM, Yen K, Scheurer E.

Forensic Sci Med Pathol. 2017 Jun;13(2):135-144. doi: 10.1007/s12024-017-9847-8. Epub 2017 Mar 1.

50.

Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia.

Shih AH, Meydan C, Shank K, Garrett-Bakelman FE, Ward PS, Intlekofer AM, Nazir A, Stein EM, Knapp K, Glass J, Travins J, Straley K, Gliser C, Mason CE, Yen K, Thompson CB, Melnick A, Levine RL.

Cancer Discov. 2017 May;7(5):494-505. doi: 10.1158/2159-8290.CD-16-1049. Epub 2017 Feb 13.

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