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Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma.

Konteatis Z, Artin E, Nicolay B, Straley K, Padyana AK, Jin L, Chen Y, Narayaraswamy R, Tong S, Wang F, Zhou D, Cui D, Cai Z, Luo Z, Fang C, Tang H, Lv X, Nagaraja R, Yang H, Su SM, Sui Z, Dang L, Yen K, Popovici-Muller J, Codega P, Campos C, Mellinghoff IK, Biller SA.

ACS Med Chem Lett. 2020 Jan 22;11(2):101-107. doi: 10.1021/acsmedchemlett.9b00509. eCollection 2020 Feb 13.


Outcomes of Bilateral Cataracts Removed in Infants 1 to 7 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry.

Bothun ED, Wilson ME, Vanderveen DK, Plager DA, Freedman SF, Trivedi RH, Traboulsi EI, Anderson JS, Loh AR, Yen KG, Weil NC, Morrison D, Lambert SR.

Ophthalmology. 2019 Nov 9. pii: S0161-6420(19)32214-6. doi: 10.1016/j.ophtha.2019.10.039. [Epub ahead of print]


Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia.

Roboz GJ, DiNardo CD, Stein EM, de Botton S, Mims AS, Prince GT, Altman JK, Arellano ML, Donnellan W, Erba HP, Mannis GN, Pollyea DA, Stein AS, Uy GL, Watts JM, Fathi AT, Kantarjian HM, Tallman MS, Choe S, Dai D, Fan B, Wang H, Zhang V, Yen KE, Kapsalis SM, Hickman D, Liu H, Agresta SV, Wu B, Attar EC, Stone RM.

Blood. 2019 Dec 16. pii: blood.2019002140. doi: 10.1182/blood.2019002140. [Epub ahead of print]


Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.

Wang Y, Lu T, Sun G, Zheng Y, Yang S, Zhang H, Hao S, Liu Y, Ma S, Zhang H, Ru Y, Gao S, Yen K, Cheng H, Cheng T.

Nat Commun. 2019 Dec 6;10(1):5594. doi: 10.1038/s41467-019-13411-y.


Assessing the Utility of Urine Testing in Febrile Infants 2 to 12 Months of Age With Bronchiolitis.

Elkhunovich MA, Wang VJ, Pham P, Arpilleda JC, Clingenpeel JM, Mansour K, Riech T, Yen K, Liu DR.

Pediatr Emerg Care. 2019 Dec 3. doi: 10.1097/PEC.0000000000001912. [Epub ahead of print]


Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.

Lin WH, Wu SY, Yeh TK, Chen CT, Song JS, Shiao HY, Kuo CC, Hsu T, Lu CT, Wang PC, Wu TS, Peng YH, Lin HY, Chen CP, Weng YL, Kung FC, Wu MH, Su YC, Huang KW, Chou LH, Hsueh CC, Yen KJ, Kuo PC, Huang CL, Chen LT, Shih C, Tsai HJ, Jiaang WT.

J Med Chem. 2019 Dec 26;62(24):11135-11150. doi: 10.1021/acs.jmedchem.9b01229. Epub 2019 Dec 6.


Subconjunctival abscess formation after strabismus surgery.

Wu F, Edmond J, Yen K, Ram R, Coats D, Herce H, Chilakapati M.

J AAPOS. 2019 Dec;23(6):349-351. doi: 10.1016/j.jaapos.2019.08.273. Epub 2019 Sep 30.


The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity.

Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P.

Physiol Rep. 2019 Jul;7(13):e14171. doi: 10.14814/phy2.14171.


Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment.

Mehta HH, Xiao J, Ramirez R, Miller B, Kim SJ, Cohen P, Yen K.

Metabolomics. 2019 Jun 6;15(6):88. doi: 10.1007/s11306-019-1549-7.


Band keratopathy in children previously treated with diode laser for type 1 retinopathy of prematurity.

Ali SF, Edmond JC, Suelflow JR, Coats DK, Yen KG.

J AAPOS. 2019 Aug;23(4):232-234. doi: 10.1016/j.jaapos.2019.04.004. Epub 2019 May 30.


Prediction of local relapse and distant metastasis in patients with definitive chemoradiotherapy-treated cervical cancer by deep learning from [18F]-fluorodeoxyglucose positron emission tomography/computed tomography.

Shen WC, Chen SW, Wu KC, Hsieh TC, Liang JA, Hung YC, Yeh LS, Chang WC, Lin WC, Yen KY, Kao CH.

Eur Radiol. 2019 Dec;29(12):6741-6749. doi: 10.1007/s00330-019-06265-x. Epub 2019 May 27.


Predicting Hemolytic Uremic Syndrome and Renal Failure in Shiga Toxin-Producing Escherichia coli Infected Children.

McKee RS, Schnadower D, Tarr PI, Xie J, Finkelstein Y, Desai N, Lane RD, Bergmann KR, Kaplan RL, Hariharan S, Cruz AT, Cohen DM, Dixon A, Ramgopal S, Rominger A, Powell EC, Kilgar J, Michelson KA, Beer D, Bitzan M, Pruitt CM, Yen K, Meckler GD, Plint AC, Bradin S, Abramo TJ, Gouin S, Kam AJ, Schuh A, Balamuth F, Hunley TE, Kanegaye JT, Jones NE, Avva U, Porter R, Fein DM, Louie JP, Freedman SB; Pediatric Emergency Medicine Collaborative Research Committee (PEMCRC); Pediatric Emergency Research Canada (PERC).

Clin Infect Dis. 2019 May 24. pii: ciz432. doi: 10.1093/cid/ciz432. [Epub ahead of print]


Cortical Visual Impairment in Congenital Cytomegalovirus Infection.

Jin HD, Demmler-Harrison GJ, Miller J, Edmond JC, Coats DK, Paysse EA, Bhatt AR, Yen KG, Klingen JT, Steinkuller P; Congenital CMV Longitudinal Group.

J Pediatr Ophthalmol Strabismus. 2019 May 22;56(3):194-202. doi: 10.3928/01913913-20190311-01.


Comparing the Utility of Mitochondrial and Nuclear DNA to Adjust for Genetic Ancestry in Association Studies.

Miller B, Arpawong TE, Jiao H, Kim SJ, Yen K, Mehta HH, Wan J, Carpten JC, Cohen P.

Cells. 2019 Apr 3;8(4). pii: E306. doi: 10.3390/cells8040306.


Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression.

Breton CV, Song AY, Xiao J, Kim SJ, Mehta HH, Wan J, Yen K, Sioutas C, Lurmann F, Xue S, Morgan TE, Zhang J, Cohen P.

Mitochondrion. 2019 May;46:22-29. doi: 10.1016/j.mito.2019.04.001. Epub 2019 Apr 10.


GRSF1 is an age-related regulator of senescence.

Kim SJ, Chun M, Wan J, Lee C, Yen K, Cohen P.

Sci Rep. 2019 Apr 3;9(1):5546. doi: 10.1038/s41598-019-42064-6.


Outcomes of Unilateral Cataracts in Infants and Toddlers 7 to 24 Months of Age: Toddler Aphakia and Pseudophakia Study (TAPS).

Bothun ED, Wilson ME, Traboulsi EI, Diehl NN, Plager DA, Vanderveen DK, Freedman SF, Yen KG, Weil NC, Loh AR, Morrison D, Anderson JS, Lambert SR; Toddler Aphakia and Pseudophakia Study Group (TAPS).

Ophthalmology. 2019 Aug;126(8):1189-1195. doi: 10.1016/j.ophtha.2019.03.011. Epub 2019 Mar 14.


Tongue Flap for Keratinized Soft Tissue Coverage Around Dental Implants: A Case Report and Discussion.

Yen K, Lazow S, Segal J.

J Oral Implantol. 2019 Jun;45(3):223-226. doi: 10.1563/aaid-joi-D-18-00140. Epub 2019 Mar 15.


MOTS-c: an equal opportunity insulin sensitizer.

Kim SJ, Miller B, Kumagai H, Yen K, Cohen P.

J Mol Med (Berl). 2019 Apr;97(4):487-490. doi: 10.1007/s00109-019-01758-0. Epub 2019 Feb 20. No abstract available.


Ectopically Expressed IL-34 Can Efficiently Induce Macrophage Migration to the Liver in Zebrafish.

Jiang Y, Chen J, Yen K, Xu J.

Zebrafish. 2019 Apr;16(2):165-170. doi: 10.1089/zeb.2018.1685. Epub 2019 Feb 6.


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