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Statins and increases in Lp(a): an inconvenient truth that needs attention.

Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL.

Eur Heart J. 2020 Jan 1;41(1):192-193. doi: 10.1093/eurheartj/ehz776. No abstract available.


Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis.

Boffa MB, Marar TT, Yeang C, Viney NJ, Xia S, Witztum JL, Koschinsky ML, Tsimikas S.

J Lipid Res. 2019 Dec;60(12):2082-2089. doi: 10.1194/jlr.P094763. Epub 2019 Sep 24.


Correction: Exploring candidate biological functions by Boolean Function Networks for Saccharomyces cerevisiae.

Simak M, Yeang CH, Lu HH.

PLoS One. 2019 Aug 22;14(8):e0221703. doi: 10.1371/journal.pone.0221703. eCollection 2019.


Statin therapy increases lipoprotein(a) levels.

Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL.

Eur Heart J. 2019 May 20. pii: ehz310. doi: 10.1093/eurheartj/ehz310. [Epub ahead of print]


Modelling bistable tumour population dynamics to design effective treatment strategies.

Akhmetzhanov AR, Kim JW, Sullivan R, Beckman RA, Tamayo P, Yeang CH.

J Theor Biol. 2019 Aug 7;474:88-102. doi: 10.1016/j.jtbi.2019.05.005. Epub 2019 May 9.


MGSEA - a multivariate Gene set enrichment analysis.

Tiong KL, Yeang CH.

BMC Bioinformatics. 2019 Mar 18;20(1):145. doi: 10.1186/s12859-019-2716-6.


Lipoprotein(a) in Patients Undergoing Transcatheter Aortic Valve Replacement.

Ma GS, Wilkinson MJ, Reeves RR, Yeang C, DeMaria AN, Cotter B, Patel M, Mahmud E, Tsimikas S.

Angiology. 2019 Apr;70(4):332-336. doi: 10.1177/0003319719826461. Epub 2019 Jan 30.


Association of Mild to Moderate Aortic Valve Stenosis Progression With Higher Lipoprotein(a) and Oxidized Phospholipid Levels: Secondary Analysis of a Randomized Clinical Trial.

Capoulade R, Yeang C, Chan KL, Pibarot P, Tsimikas S.

JAMA Cardiol. 2018 Dec 1;3(12):1212-1217. doi: 10.1001/jamacardio.2018.3798.


Explaining cancer type specific mutations with transcriptomic and epigenomic features in normal tissues.

Tiong KL, Yeang CH.

Sci Rep. 2018 Jul 30;8(1):11456. doi: 10.1038/s41598-018-29861-1.


Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.

Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL.

Nature. 2018 Sep;561(7724):E43. doi: 10.1038/s41586-018-0313-x.


Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.

Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL.

Nature. 2018 Jun;558(7709):301-306. doi: 10.1038/s41586-018-0198-8. Epub 2018 Jun 6. Erratum in: Nature. 2018 Sep;561(7724):E43.


Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids.

Yeang C, Hasanally D, Que X, Hung MY, Stamenkovic A, Chan D, Chaudhary R, Margulets V, Edel AL, Hoshijima M, Gu Y, Bradford W, Dalton N, Miu P, Cheung DY, Jassal DS, Pierce GN, Peterson KL, Kirshenbaum LA, Witztum JL, Tsimikas S, Ravandi A.

Cardiovasc Res. 2019 Jan 1;115(1):179-189. doi: 10.1093/cvr/cvy136.


Relationship between "LDL-C", estimated true LDL-C, apolipoprotein B-100, and PCSK9 levels following lipoprotein(a) lowering with an antisense oligonucleotide.

Viney NJ, Yeang C, Yang X, Xia S, Witztum JL, Tsimikas S.

J Clin Lipidol. 2018 May - Jun;12(3):702-710. doi: 10.1016/j.jacl.2018.02.014. Epub 2018 Mar 1.


PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis.

Senders ML, Que X, Cho YS, Yeang C, Groenen H, Fay F, Calcagno C, Meerwaldt AE, Green S, Miu P, Lobatto ME, Reiner T, Fayad ZA, Witztum JL, Mulder WJM, Pérez-Medina C, Tsimikas S.

J Am Coll Cardiol. 2018 Jan 23;71(3):321-335. doi: 10.1016/j.jacc.2017.11.036.


Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis.

Torzewski M, Ravandi A, Yeang C, Edel A, Bhindi R, Kath S, Twardowski L, Schmid J, Yang X, Franke UFW, Witztum JL, Tsimikas S.

JACC Basic Transl Sci. 2017 Jun;2(3):229-240. doi: 10.1016/j.jacbts.2017.02.004. Epub 2017 Jun 26.


Exploring candidate biological functions by Boolean Function Networks for Saccharomyces cerevisiae.

Simak M, Yeang CH, Lu HH.

PLoS One. 2017 Oct 5;12(10):e0185475. doi: 10.1371/journal.pone.0185475. eCollection 2017. Erratum in: PLoS One. 2019 Aug 22;14(8):e0221703.


Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

Kim JW, Abudayyeh OO, Yeerna H, Yeang CH, Stewart M, Jenkins RW, Kitajima S, Konieczkowski DJ, Medetgul-Ernar K, Cavazos T, Mah C, Ting S, Van Allen EM, Cohen O, Mcdermott J, Damato E, Aguirre AJ, Liang J, Liberzon A, Alexe G, Doench J, Ghandi M, Vazquez F, Weir BA, Tsherniak A, Subramanian A, Meneses-Cime K, Park J, Clemons P, Garraway LA, Thomas D, Boehm JS, Barbie DA, Hahn WC, Mesirov JP, Tamayo P.

Cell Syst. 2017 Aug 23;5(2):105-118.e9. doi: 10.1016/j.cels.2017.08.002.


Novel Lipoprotein(a) Catabolism Pathway via Apolipoprotein(a) Recycling: Adding the Plasminogen Receptor PlgRKT to the List.

Yeang C, Gordts PL, Tsimikas S.

Circ Res. 2017 Mar 31;120(7):1050-1052. doi: 10.1161/CIRCRESAHA.117.310700. No abstract available.


A quantitative model for the rate-limiting process of UGA alternative assignments to stop and selenocysteine codons.

Chen YF, Lin HC, Chuang KN, Lin CH, Yen HS, Yeang CH.

PLoS Comput Biol. 2017 Feb 8;13(2):e1005367. doi: 10.1371/journal.pcbi.1005367. eCollection 2017 Feb.


The Prevalence of Lipoprotein(a) Measurement and Degree of Elevation Among 2710 Patients With Calcific Aortic Valve Stenosis in an Academic Echocardiography Laboratory Setting.

Wilkinson MJ, Ma GS, Yeang C, Ang L, Strachan M, DeMaria AN, Tsimikas S, Cotter B.

Angiology. 2017 Oct;68(9):795-798. doi: 10.1177/0003319716688415. Epub 2017 Jan 10.


Lipoprotein(a)-cholesterol levels estimated by vertical auto profile correlate poorly with Lp(a) mass in hyperlipidemic subjects: Implications for clinical practice interpretation of Lp(a)-mediated risk.

Yeang C, Clopton PC, Tsimikas S.

J Clin Lipidol. 2016 Nov - Dec;10(6):1389-1396. doi: 10.1016/j.jacl.2016.09.012. Epub 2016 Sep 28.


Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans.

van der Valk FM, Bekkering S, Kroon J, Yeang C, Van den Bossche J, van Buul JD, Ravandi A, Nederveen AJ, Verberne HJ, Scipione C, Nieuwdorp M, Joosten LA, Netea MG, Koschinsky ML, Witztum JL, Tsimikas S, Riksen NP, Stroes ES.

Circulation. 2016 Aug 23;134(8):611-24. doi: 10.1161/CIRCULATIONAHA.116.020838. Epub 2016 Aug 5.


Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a).

Yeang C, Hung MY, Byun YS, Clopton P, Yang X, Witztum JL, Tsimikas S.

J Clin Lipidol. 2016 May-Jun;10(3):594-603. doi: 10.1016/j.jacl.2016.01.005. Epub 2016 Mar 8.


Lipoprotein(a) and oxidized phospholipids in calcific aortic valve stenosis.

Yeang C, Wilkinson MJ, Tsimikas S.

Curr Opin Cardiol. 2016 Jul;31(4):440-50. doi: 10.1097/HCO.0000000000000300. Review.


Detection of 22q11.2 microduplication by cell-free DNA screening and chromosomal microarray in fetus with multiple anomalies.

Wu WJ, Ma GC, Lin YS, Yeang CH, Ni YH, Li WC, Tsai HD, Shur-Fen Gau S, Chen M.

Ultrasound Obstet Gynecol. 2016 Oct;48(4):530-532. doi: 10.1002/uog.15965. Epub 2016 Sep 13. No abstract available.


PCSK9 Association With Lipoprotein(a).

Tavori H, Christian D, Minnier J, Plubell D, Shapiro MD, Yeang C, Giunzioni I, Croyal M, Duell PB, Lambert G, Tsimikas S, Fazio S.

Circ Res. 2016 Jun 24;119(1):29-35. doi: 10.1161/CIRCRESAHA.116.308811. Epub 2016 Apr 27.


The role of lipoprotein(a) in progression of renal disease: Causality or reverse causality?

Yeang C, Tsimikas S.

J Diabetes Complications. 2016 Jul;30(5):755-7. doi: 10.1016/j.jdiacomp.2016.04.001. Epub 2016 Apr 7. No abstract available.


Analysis of spatial-temporal gene expression patterns reveals dynamics and regionalization in developing mouse brain.

Chou SJ, Wang C, Sintupisut N, Niou ZX, Lin CH, Li KC, Yeang CH.

Sci Rep. 2016 Jan 20;6:19274. doi: 10.1038/srep19274.


Experimental Animal Models Evaluating the Causal Role of Lipoprotein(a) in Atherosclerosis and Aortic Stenosis.

Yeang C, Cotter B, Tsimikas S.

Cardiovasc Drugs Ther. 2016 Feb;30(1):75-85. doi: 10.1007/s10557-015-6634-1. Review.


Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis.

Capoulade R, Chan KL, Yeang C, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Mahmut A, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S.

J Am Coll Cardiol. 2015 Sep 15;66(11):1236-1246. doi: 10.1016/j.jacc.2015.07.020.


Putative effectors for prognosis in lung adenocarcinoma are ethnic and gender specific.

Woolston A, Sintupisut N, Lu TP, Lai LC, Tsai MH, Chuang EY, Yeang CH.

Oncotarget. 2015 Aug 14;6(23):19483-99.


HDL-C, ABCA1-mediated cholesterol efflux, and lipoprotein(a): insights into a potential novel physiologic role of lipoprotein(a).

Yeang C, Tsimikas S.

J Lipid Res. 2015 Jul;56(7):1241-4. doi: 10.1194/jlr.E060947. Epub 2015 May 26. No abstract available.


'LDL-C' = LDL-C + Lp(a)-C: implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowering.

Yeang C, Witztum JL, Tsimikas S.

Curr Opin Lipidol. 2015 Jun;26(3):169-78. doi: 10.1097/MOL.0000000000000171. Review.


Imaging of oxidation-specific epitopes with targeted nanoparticles to detect high-risk atherosclerotic lesions: progress and future directions.

Briley-Saebo K, Yeang C, Witztum JL, Tsimikas S.

J Cardiovasc Transl Res. 2014 Nov;7(8):719-36. doi: 10.1007/s12265-014-9590-4. Epub 2014 Oct 9. Review.


Nonstandard personalized medicine strategies for cancer may lead to improved patient outcomes.

Beckman RA, Yeang CH.

Per Med. 2014 Sep;11(7):705-719. doi: 10.2217/pme.14.57.


Genome-wide normalized score: a novel algorithm to detect fetal trisomy 21 during non-invasive prenatal testing.

Yeang CH, Ma GC, Hsu HW, Lin YS, Chang SM, Cheng PJ, Chen CA, Ni YH, Chen M.

Ultrasound Obstet Gynecol. 2014 Jul;44(1):25-30. doi: 10.1002/uog.13377. Epub 2014 Jun 12.


Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells.

Lin IY, Chiu FL, Yeang CH, Chen HF, Chuang CY, Yang SY, Hou PS, Sintupisut N, Ho HN, Kuo HC, Lin KI.

Stem Cell Reports. 2014 Jan 23;2(2):189-204. doi: 10.1016/j.stemcr.2013.12.009. eCollection 2014 Feb 11.


An integrative characterization of recurrent molecular aberrations in glioblastoma genomes.

Sintupisut N, Liu PL, Yeang CH.

Nucleic Acids Res. 2013 Oct;41(19):8803-21. doi: 10.1093/nar/gkt656. Epub 2013 Jul 31.


Functional characterization of motif sequences under purifying selection.

Chen DH, Chang AY, Liao BY, Yeang CH.

Nucleic Acids Res. 2013 Feb 1;41(4):2105-20. doi: 10.1093/nar/gks1456. Epub 2013 Jan 8.


Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia.

Hoyer S, Nguon S, Kim S, Habib N, Khim N, Sum S, Christophel EM, Bjorge S, Thomson A, Kheng S, Chea N, Yok S, Top S, Ros S, Sophal U, Thompson MM, Mellor S, Ariey F, Witkowski B, Yeang C, Yeung S, Duong S, Newman RD, Menard D.

PLoS One. 2012;7(10):e45797. doi: 10.1371/journal.pone.0045797. Epub 2012 Oct 1.


Evolution of domain architectures and catalytic functions of enzymes in metabolic systems.

Suen S, Lu HH, Yeang CH.

Genome Biol Evol. 2012;4(9):976-93. doi: 10.1093/gbe/evs072. Epub 2012 Aug 30.


Impact of genetic dynamics and single-cell heterogeneity on development of nonstandard personalized medicine strategies for cancer.

Beckman RA, Schemmann GS, Yeang CH.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14586-91. doi: 10.1073/pnas.1203559109. Epub 2012 Aug 13.


Genome-wide gene expression analysis implicates the immune response and lymphangiogenesis in the pathogenesis of fetal chylothorax.

Yeang CH, Ma GC, Shih JC, Yang YS, Chen CP, Chang SP, Wu SH, Liu CS, Kuo SJ, Chou HC, Hwu WL, Cameron AD, Ginsberg NA, Lin YS, Chen M.

PLoS One. 2012;7(4):e34901. doi: 10.1371/journal.pone.0034901. Epub 2012 Apr 18.


Subcellular targeting domains of sphingomyelin synthase 1 and 2.

Yeang C, Ding T, Chirico WJ, Jiang XC.

Nutr Metab (Lond). 2011 Dec 14;8:89. doi: 10.1186/1743-7075-8-89.


Deciphering causal and statistical relations of molecular aberrations and gene expressions in NCI-60 cell lines.

Li SD, Tagami T, Ho YF, Yeang CH.

BMC Syst Biol. 2011 Nov 4;5:186. doi: 10.1186/1752-0509-5-186.


Role of phospholipid transfer protein in high-density lipoprotein- mediated reverse cholesterol transport.

Yazdanyar A, Yeang C, Jiang XC.

Curr Atheroscler Rep. 2011 Jun;13(3):242-8. doi: 10.1007/s11883-011-0172-5. Review.


Sphingomyelin synthase 2 (SMS2) deficiency attenuates LPS-induced lung injury.

Gowda S, Yeang C, Wadgaonkar S, Anjum F, Grinkina N, Cutaia M, Jiang XC, Wadgaonkar R.

Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L430-40. doi: 10.1152/ajplung.00208.2010. Epub 2010 Dec 29.


An integrated analysis of molecular aberrations in NCI-60 cell lines.

Yeang CH.

BMC Bioinformatics. 2010 Oct 6;11:495. doi: 10.1186/1471-2105-11-495.


Integration of metabolic reactions and gene regulation.

Yeang CH.

Mol Biotechnol. 2011 Jan;47(1):70-82. doi: 10.1007/s12033-010-9325-y. Review.


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