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Structural basis of ligand binding modes at the human formyl peptide receptor 2.

Chen T, Xiong M, Zong X, Ge Y, Zhang H, Wang M, Won Han G, Yi C, Ma L, Ye RD, Xu Y, Zhao Q, Wu B.

Nat Commun. 2020 Mar 5;11(1):1208. doi: 10.1038/s41467-020-15009-1.


The Rho guanine nucleotide exchange factor P-Rex1 as a potential drug target for cancer metastasis and inflammatory diseases.

Ye RD.

Pharmacol Res. 2020 Mar;153:104676. doi: 10.1016/j.phrs.2020.104676. Epub 2020 Jan 30. Review.


Serum amyloid A3 confers protection against acute lung injury in Pseudomonas aeruginosa-infected mice.

Fan Y, Zhang G, Vong CT, Ye RD.

Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L314-L322. doi: 10.1152/ajplung.00309.2019. Epub 2019 Dec 18.


Detection of Intact Transcription Factors in Human Neutrophils.

McDonald PP, Ye RD.

Methods Mol Biol. 2020;2087:261-275. doi: 10.1007/978-1-0716-0154-9_20.


Targeted Delivery of a Ligand-Drug Conjugate via Formyl Peptide Receptor 1 through Cholesterol-Dependent Endocytosis.

Wang J, Chen M, Li S, Ye RD.

Mol Pharm. 2019 Jun 3;16(6):2636-2647. doi: 10.1021/acs.molpharmaceut.9b00188. Epub 2019 May 22.


MLN4924 protects against interleukin-17A-induced pulmonary inflammation by disrupting ACT1-mediated signaling.

Hao R, Song Y, Li R, Wu Y, Yang X, Li X, Qian F, Ye RD, Sun L.

Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1070-L1080. doi: 10.1152/ajplung.00349.2018. Epub 2019 Mar 20.


Fpr2 Deficiency Alleviates Diet-Induced Insulin Resistance Through Reducing Body Weight Gain and Inhibiting Inflammation Mediated by Macrophage Chemotaxis and M1 Polarization.

Chen X, Zhuo S, Zhu T, Yao P, Yang M, Mei H, Li N, Ma F, Wang JM, Chen S, Ye RD, Li Y, Le Y.

Diabetes. 2019 Jun;68(6):1130-1142. doi: 10.2337/db18-0469. Epub 2019 Mar 12.


The Kinesin Light Chain-Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes.

Arabi-Derkawi R, O'Dowd Y, Cheng N, Rolas L, Boussetta T, Raad H, Marzaioli V, Pintard C, Fasseu M, Kroviarski Y, Belambri SA, Dang PM, Ye RD, Gougerot-Pocidalo MA, El-Benna J.

J Immunol. 2019 Mar 1;202(5):1549-1558. doi: 10.4049/jimmunol.1800610. Epub 2019 Jan 21.


In vitro immunomodulatory effects of human milk oligosaccharides on murine macrophage RAW264.7 cells.

Zhang W, Yan J, Wu L, Yu Y, Ye RD, Zhang Y, Liang X.

Carbohydr Polym. 2019 Mar 1;207:230-238. doi: 10.1016/j.carbpol.2018.11.039. Epub 2018 Nov 28.


A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver Ischemia/Reperfusion Injury.

Sun L, Wu Q, Nie Y, Cheng N, Wang R, Wang G, Zhang D, He H, Ye RD, Qian F.

Front Immunol. 2018 Nov 13;9:2610. doi: 10.3389/fimmu.2018.02610. eCollection 2018.


Formyl Peptide Receptor 2 Deficiency Improves Cognition and Attenuates Tau Hyperphosphorylation and Astrogliosis in a Mouse Model of Alzheimer's Disease.

Zhang H, Wang D, Gong P, Lin A, Zhang Y, Ye RD, Yu Y.

J Alzheimers Dis. 2019;67(1):169-179. doi: 10.3233/JAD-180823.


Identification of Alkaloids from Corydalis yanhusuo W. T. Wang as Dopamine D₁ Receptor Antagonists by Using CRE-Luciferase Reporter Gene Assay.

Wu L, Zhang W, Qiu X, Wang C, Liu Y, Wang Z, Yu Y, Ye RD, Zhang Y.

Molecules. 2018 Oct 10;23(10). pii: E2585. doi: 10.3390/molecules23102585.


Serum amyloid A promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury.

Cheng N, Liang Y, Du X, Ye RD.

EMBO Rep. 2018 Oct;19(10). pii: e45517. doi: 10.15252/embr.201745517. Epub 2018 Aug 20.


A CRISPR-Cpf1-Assisted Non-Homologous End Joining Genome Editing System of Mycobacterium smegmatis.

Sun B, Yang J, Yang S, Ye RD, Chen D, Jiang Y.

Biotechnol J. 2018 Sep;13(9):e1700588. doi: 10.1002/biot.201700588. Epub 2018 Aug 6.


Elevated Expression of Serum Amyloid A 3 Protects Colon Epithelium Against Acute Injury Through TLR2-Dependent Induction of Neutrophil IL-22 Expression in a Mouse Model of Colitis.

Zhang G, Liu J, Wu L, Fan Y, Sun L, Qian F, Chen D, Ye RD.

Front Immunol. 2018 Jun 29;9:1503. doi: 10.3389/fimmu.2018.01503. eCollection 2018.


FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell proliferation and differentiation.

Zheng C, Chen D, Zhang Y, Bai Y, Huang S, Zheng D, Liang W, She S, Peng X, Wang P, Mo X, Song Q, Lv P, Huang J, Ye RD, Wang Y.

FASEB J. 2018 May 25:fj201800020RRR. doi: 10.1096/fj.201800020RRR. [Epub ahead of print]


MK2 mediates macrophage activation and acute lung injury by regulating let-7e miRNA.

Wu Y, He H, Ding Y, Liu S, Zhang D, Wang J, Jiang H, Zhang D, Sun L, Ye RD, Qian F.

Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L371-L381. doi: 10.1152/ajplung.00019.2018. Epub 2018 May 17.


SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrity.

Liu J, Li D, Zhang T, Tong Q, Ye RD, Lin L.

Cell Death Dis. 2017 Oct 26;8(10):e3158. doi: 10.1038/cddis.2017.564.


4'-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice.

Fan C, Wu LH, Zhang GF, Xu F, Zhang S, Zhang X, Sun L, Yu Y, Zhang Y, Ye RD.

PLoS One. 2017 Aug 8;12(8):e0181191. doi: 10.1371/journal.pone.0181191. eCollection 2017.


The Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer.

Li SQ, Su N, Gong P, Zhang HB, Liu J, Wang D, Sun YP, Zhang Y, Qian F, Zhao B, Yu Y, Ye RD.

Sci Rep. 2017 Jul 19;7(1):5918. doi: 10.1038/s41598-017-06368-9.


4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-ones as N-formyl peptide receptor 1 (FPR1) antagonists.

Kirpotina LN, Schepetkin IA, Khlebnikov AI, Ruban OI, Ge Y, Ye RD, Kominsky DJ, Quinn MT.

Biochem Pharmacol. 2017 Oct 15;142:120-132. doi: 10.1016/j.bcp.2017.07.004. Epub 2017 Jul 8.


Suppression of Lipopolysaccharide-Induced Inflammatory Response by Fragments from Serum Amyloid A.

Zhou H, Chen M, Zhang G, Ye RD.

J Immunol. 2017 Aug 1;199(3):1105-1112. doi: 10.4049/jimmunol.1700470. Epub 2017 Jul 3.


Nedd8 modification of Cullin-5 regulates lipopolysaccharide-induced acute lung injury.

Zhu Z, Sun L, Hao R, Jiang H, Qian F, Ye RD.

Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L104-L114. doi: 10.1152/ajplung.00410.2016. Epub 2017 May 18.


An Exploration of Traditional Chinese Medicinal Plants with Anti-Inflammatory Activities.

Fan C, Jin HZ, Wu L, Zhang Y, Ye RD, Zhang W, Zhang Y.

Evid Based Complement Alternat Med. 2017;2017:1231820. doi: 10.1155/2017/1231820. Epub 2017 Apr 4.


AKT2 Regulates Pulmonary Inflammation and Fibrosis via Modulating Macrophage Activation.

Nie Y, Sun L, Wu Y, Yang Y, Wang J, He H, Hu Y, Chang Y, Liang Q, Zhu J, Ye RD, Christman JW, Qian F.

J Immunol. 2017 Jun 1;198(11):4470-4480. doi: 10.4049/jimmunol.1601503. Epub 2017 Apr 28.


Selenium-mediated protection in reversing the sensitivity of bacterium to the bactericidal antibiotics.

Li Z, Tan J, Shao L, Dong X, Ye RD, Chen D.

J Trace Elem Med Biol. 2017 May;41:23-31. doi: 10.1016/j.jtemb.2017.02.007. Epub 2017 Feb 12.


The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition.

He HQ, Ye RD.

Molecules. 2017 Mar 13;22(3). pii: E455. doi: 10.3390/molecules22030455. Review.


Licocoumarone isolated from Glycyrrhiza uralensis selectively alters LPS-induced inflammatory responses in RAW 264.7 macrophages.

Wu L, Fan Y, Fan C, Yu Y, Sun L, Jin Y, Zhang Y, Ye RD.

Eur J Pharmacol. 2017 Apr 15;801:46-53. doi: 10.1016/j.ejphar.2017.02.049. Epub 2017 Mar 2.


[Operational models of allosteric modulation of G protein-coupled receptors].

Gong H, Zhang S, Ye RD.

Yao Xue Xue Bao. 2016 Dec;51(12):1829-37. Review. Chinese.


Synthesis of Five- and Six-Membered N-Phenylacetamido Substituted Heterocycles as Formyl Peptide Receptor Agonists.

Vergelli C, Schepetkin IA, Ciciani G, Cilibrizzi A, Crocetti L, Giovannoni MP, Guerrini G, Iacovone A, Kirpotina LN, Ye RD, Quinn MT.

Drug Dev Res. 2017 Feb;78(1):49-62. doi: 10.1002/ddr.21370. Epub 2016 Nov 18.


Cutting Edge: A Cullin-5-TRAF6 Interaction Promotes TRAF6 Polyubiquitination and Lipopolysaccharide Signaling.

Zhu Z, Wang L, Hao R, Zhao B, Sun L, Ye RD.

J Immunol. 2016 Jul 1;197(1):21-6. doi: 10.4049/jimmunol.1600447. Epub 2016 May 27.


Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis.

Liang Q, Cheng N, Zhang G, Liang Y, Qian F, Wu D, Ye RD.

Sci Rep. 2016 May 13;6:25785. doi: 10.1038/srep25785.


2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists.

Vergelli C, Schepetkin IA, Ciciani G, Cilibrizzi A, Crocetti L, Giovannoni MP, Guerrini G, Iacovone A, Kirpotina LN, Khlebnikov AI, Ye RD, Quinn MT.

Bioorg Med Chem. 2016 Apr 8. pii: S0968-0896(16)30253-X. doi: 10.1016/j.bmc.2016.04.019. [Epub ahead of print]


Serum amyloid A1: Structure, function and gene polymorphism.

Sun L, Ye RD.

Gene. 2016 May 25;583(1):48-57. doi: 10.1016/j.gene.2016.02.044. Epub 2016 Mar 3. Review.


Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A.

Liu J, Wang D, Li SQ, Yu Y, Ye RD.

J Neuroinflammation. 2016 Feb 2;13:28. doi: 10.1186/s12974-016-0493-y.


Shikonin Derivative DMAKO-05 Inhibits Akt Signal Activation and Melanoma Proliferation.

Yang YY, He HQ, Cui JH, Nie YJ, Wu YX, Wang R, Wang G, Zheng JN, Ye RD, Wu Q, Li SS, Qian F.

Chem Biol Drug Des. 2016 Jun;87(6):895-904. doi: 10.1111/cbdd.12722. Epub 2016 Feb 18.


Hydroxycinnamic acid amides from Scopolia tangutica inhibit the activity of M1 muscarinic acetylcholine receptor in vitro.

Zhang Y, Long Z, Guo Z, Wang Z, Zhang X, Ye RD, Liang X, Civelli O.

Fitoterapia. 2016 Jan;108:9-12. doi: 10.1016/j.fitote.2015.11.007. Epub 2015 Nov 14.


Deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of Alzheimer's disease.

Li SQ, Yu Y, Han JZ, Wang D, Liu J, Qian F, Fan GH, Bucala R, Ye RD.

J Neuroinflammation. 2015 Sep 17;12:177. doi: 10.1186/s12974-015-0396-3.


Emerging functions of serum amyloid A in inflammation.

Ye RD, Sun L.

J Leukoc Biol. 2015 Dec;98(6):923-9. doi: 10.1189/jlb.3VMR0315-080R. Epub 2015 Jun 30. Review.


Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases.

Qian F, Deng J, Wang G, Ye RD, Christman JW.

Curr Protein Pept Sci. 2016;17(4):332-42. Review.


Ex vivo and in vitro effect of serum amyloid a in the induction of macrophage M2 markers and efferocytosis of apoptotic neutrophils.

Sun L, Zhou H, Zhu Z, Yan Q, Wang L, Liang Q, Ye RD.

J Immunol. 2015 May 15;194(10):4891-900. doi: 10.4049/jimmunol.1402164. Epub 2015 Apr 13.


Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient.

Liu X, Yang T, Suzuki K, Tsukita S, Ishii M, Zhou S, Wang G, Cao L, Qian F, Taylor S, Oh MJ, Levitan I, Ye RD, Carnegie GK, Zhao Y, Malik AB, Xu J.

J Exp Med. 2015 Feb 9;212(2):267-80. doi: 10.1084/jem.20140508. Epub 2015 Jan 19.


New erythromycin derivatives enhance β-lactam antibiotics against methicillin-resistant Staphylococcus aureus.

Li Z, He M, Dong X, Lin H, Ge H, Shen S, Li J, Ye RD, Chen D.

Lett Appl Microbiol. 2015 Apr;60(4):352-8. doi: 10.1111/lam.12378. Epub 2015 Jan 14.


Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones.

Schepetkin IA, Kirpotina LN, Khlebnikov AI, Cheng N, Ye RD, Quinn MT.

Biochem Pharmacol. 2014 Dec 15;92(4):627-41. doi: 10.1016/j.bcp.2014.09.027. Epub 2014 Oct 17.


Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension.

Tang H, Chen J, Fraidenburg DR, Song S, Sysol JR, Drennan AR, Offermanns S, Ye RD, Bonini MG, Minshall RD, Garcia JG, Machado RF, Makino A, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L208-20. doi: 10.1152/ajplung.00242.2014. Epub 2014 Nov 21.


Design, synthesis and characterization of fMLF-mimicking AApeptides.

Hu Y, Cheng N, Wu H, Kang S, Ye RD, Cai J.

Chembiochem. 2014 Nov 3;15(16):2420-6. doi: 10.1002/cbic.201402396. Epub 2014 Sep 15.


Serum amyloid A1 isoforms display different efficacy at Toll-like receptor 2 and formyl peptide receptor 2.

Chen M, Zhou H, Cheng N, Qian F, Ye RD.

Immunobiology. 2014 Dec;219(12):916-23. doi: 10.1016/j.imbio.2014.08.002. Epub 2014 Aug 10.


Microglial Aβ receptors in Alzheimer's disease.

Yu Y, Ye RD.

Cell Mol Neurobiol. 2015 Jan;35(1):71-83. doi: 10.1007/s10571-014-0101-6. Epub 2014 Aug 23. Review.


The chemerin receptor CMKLR1 is a functional receptor for amyloid-β peptide.

Peng L, Yu Y, Liu J, Li S, He H, Cheng N, Ye RD.

J Alzheimers Dis. 2015;43(1):227-42. doi: 10.3233/JAD-141227.


Serum amyloid A induces interleukin-33 expression through an IRF7-dependent pathway.

Sun L, Zhu Z, Cheng N, Yan Q, Ye RD.

Eur J Immunol. 2014 Jul;44(7):2153-64. doi: 10.1002/eji.201344310. Epub 2014 May 22.

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