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Items: 7


Immunoproteasome inhibition and bioactivity of thiasyrbactins.

Bakas NA, Schultz CR, Yco LP, Roberts CC, Chang CA, Bachmann AS, Pirrung MC.

Bioorg Med Chem. 2018 Jan 15;26(2):401-412. doi: 10.1016/j.bmc.2017.11.048. Epub 2017 Dec 7.


Syrbactin Structural Analog TIR-199 Blocks Proteasome Activity and Induces Tumor Cell Death.

Bachmann AS, Opoku-Ansah J, Ibarra-Rivera TR, Yco LP, Ambadi S, Roberts CC, Chang CE, Pirrung MC.

J Biol Chem. 2016 Apr 15;291(16):8350-62. doi: 10.1074/jbc.M115.710053. Epub 2016 Feb 23.


Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target.

Yco LP, Geerts D, Mocz G, Koster J, Bachmann AS.

BMC Cancer. 2015 Jun 21;15:477. doi: 10.1186/s12885-015-1447-y.


Withaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple Myeloma.

Yco LP, Mocz G, Opoku-Ansah J, Bachmann AS.

Biochem Insights. 2014 Nov 9;7:1-13. doi: 10.4137/BCI.S18863. eCollection 2014.


AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport.

Samal K, Zhao P, Kendzicky A, Yco LP, McClung H, Gerner E, Burns M, Bachmann AS, Sholler G.

Int J Cancer. 2013 Sep 15;133(6):1323-33. doi: 10.1002/ijc.28139. Epub 2013 May 30.


PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma.

Yco LP, Geerts D, Koster J, Bachmann AS.

Int J Oncol. 2013 Apr;42(4):1408-16. doi: 10.3892/ijo.2013.1836. Epub 2013 Feb 21.


Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma.

Koomoa DL, Yco LP, Borsics T, Wallick CJ, Bachmann AS.

Cancer Res. 2008 Dec 1;68(23):9825-31. doi: 10.1158/0008-5472.CAN-08-1865.

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