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Loss of Ing3 Expression Results in Growth Retardation and Embryonic Death.

Fink D, Yau T, Nabbi A, Wagner B, Wagner C, Hu SM, Lang V, Handschuh S, Riabowol K, Rülicke T.

Cancers (Basel). 2019 Dec 29;12(1). pii: E80. doi: 10.3390/cancers12010080.


Precise annotation of human, chimpanzee, rhesus macaque and mouse mitochondrial genomes leads to insight into mitochondrial transcription in mammals.

Jin X, Cheng Z, Wang B, Yau TO, Chen Z, Barker SC, Chen D, Bu W, Sun D, Gao S.

RNA Biol. 2020 Jan 10:1-8. doi: 10.1080/15476286.2019.1709746. [Epub ahead of print]


Regorafenib in Chinese patients with metastatic colorectal cancer: subgroup analysis of the phase 3 CONCUR trial.

Xu J, Xu RH, Qin S, Pan H, Bai Y, Chi Y, Wang L, Bi F, Cheng Y, Liu T, Ma D, Shen L, Ba Y, Liang J, Wang X, Yau TCC, Ma BB, Yeh KH, Lin JK, Kappeler C, Shapiro JA, Kalmus J, Li J.

J Gastroenterol Hepatol. 2020 Jan 3. doi: 10.1111/jgh.14974. [Epub ahead of print]


Long-Term Sequelae of Smoking and Cessation in Spontaneously Hypertensive Rats.

Wu CW, Yau T, Fulgar CC, Mack SM, Revilla AM, Kenyon NJ, Pinkerton KE.

Toxicol Pathol. 2019 Dec 24:192623319893312. doi: 10.1177/0192623319893312. [Epub ahead of print]


A phase II study of the efficacy and safety of the MET inhibitor capmatinib (INC280) in patients with advanced hepatocellular carcinoma.

Qin S, Chan SL, Sukeepaisarnjaroen W, Han G, Choo SP, Sriuranpong V, Pan H, Yau T, Guo Y, Chen M, Ren Z, Xu J, Yen CJ, Lin ZZ, Manenti L, Gu Y, Sun Y, Tiedt R, Hao L, Song W, Tanwandee T.

Ther Adv Med Oncol. 2019 Dec 11;11:1758835919889001. doi: 10.1177/1758835919889001. eCollection 2019.


Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial.

Finn RS, Ryoo BY, Merle P, Kudo M, Bouattour M, Lim HY, Breder V, Edeline J, Chao Y, Ogasawara S, Yau T, Garrido M, Chan SL, Knox J, Daniele B, Ebbinghaus SW, Chen E, Siegel AB, Zhu AX, Cheng AL; KEYNOTE-240 investigators.

J Clin Oncol. 2020 Jan 20;38(3):193-202. doi: 10.1200/JCO.19.01307. Epub 2019 Dec 2.


A novel faecal Lachnoclostridium marker for the non-invasive diagnosis of colorectal adenoma and cancer.

Liang JQ, Li T, Nakatsu G, Chen YX, Yau TO, Chu E, Wong S, Szeto CH, Ng SC, Chan FKL, Fang JY, Sung JJY, Yu J.

Gut. 2019 Nov 27. pii: gutjnl-2019-318532. doi: 10.1136/gutjnl-2019-318532. [Epub ahead of print]


Corrigendum to "Nivolumab in advanced hepatocellular carcinoma: Sorafenib-experienced Asian cohort analysis" [J Hepatol 71 (2019) 543-552].

Yau T, Hsu C, Kim TY, Choo SP, Kang YK, Hou MM, Numata K, Yeo W, Chopra A, Ikeda M, Kuromatsu R, Moriguchi M, Chao Y, Zhao H, Anderson J, Dela Cruz C, Kudo M.

J Hepatol. 2019 Dec;71(6):1278. doi: 10.1016/j.jhep.2019.09.013. Epub 2019 Oct 25. No abstract available.


Progression of glucose intolerance and cardiometabolic risk factors over a decade in Chinese women with polycystic ovary syndrome: A case-control study.

Ng NYH, Jiang G, Cheung LP, Zhang Y, Tam CHT, Luk AOY, Quan J, Lau ESH, Yau TTL, Chan MHM, Ho CS, Lim CKP, Ozaki R, Huang J, Liu KH, Tam WH, Sahota DS, Chu WCW, Goggins W, Woo J, Li TC, Chow CC, Chan JCN, Ma RCW.

PLoS Med. 2019 Oct 25;16(10):e1002953. doi: 10.1371/journal.pmed.1002953. eCollection 2019 Oct.


Precision treatment in colorectal cancer: Now and the future.

Yau TO.

JGH Open. 2019 Feb 8;3(5):361-369. doi: 10.1002/jgh3.12153. eCollection 2019 Oct. Review.


First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant FGF19 Signaling as a Driver Event in Hepatocellular Carcinoma.

Kim RD, Sarker D, Meyer T, Yau T, Macarulla T, Park JW, Choo SP, Hollebecque A, Sung MW, Lim HY, Mazzaferro V, Trojan J, Zhu AX, Yoon JH, Sharma S, Lin ZZ, Chan SL, Faivre S, Feun LG, Yen CJ, Dufour JF, Palmer DH, Llovet JM, Manoogian M, Tugnait M, Stransky N, Hagel M, Kohl NE, Lengauer C, Sherwin CA, Schmidt-Kittler O, Hoeflich KP, Shi H, Wolf BB, Kang YK.

Cancer Discov. 2019 Dec;9(12):1696-1707. doi: 10.1158/2159-8290.CD-19-0555. Epub 2019 Oct 1.


The effects of marijuana smoking on lung function in older people.

Tan WC, Bourbeau J, Aaron SD, Hogg JC, Maltais F, Hernandez P, Marciniuk DD, Chapman KR, To T, FitzGerald JM, Walker BL, Road J, Zheng L, Zhou G, Yau T, Benedetti A, O'Donnell D, Sin DD; CanCOLD Collaborative Research Group; Members of the CanCOLD Collaborative Research Group not listed as authors:.

Eur Respir J. 2019 Dec 19;54(6). pii: 1900826. doi: 10.1183/13993003.00826-2019. Print 2019 Dec.


Survival analysis of breast cancer liver metastasis treated by hepatectomy: A propensity score analysis for Chinese women in Hong Kong.

Cheung TT, Chok KS, Chan AC, Tsang SH, Dai WC, Yau TC, Kwong A, Lo CM.

Hepatobiliary Pancreat Dis Int. 2019 Oct;18(5):452-457. doi: 10.1016/j.hbpd.2019.08.001. Epub 2019 Aug 22.


Role of the Nephro-Hospitalist.

Yau TT, Humphreys BD.

Clin J Am Soc Nephrol. 2019 Sep 6;14(9):1405-1407. doi: 10.2215/CJN.03890319. Epub 2019 Aug 9. No abstract available.


Overexpression of Pin1 and rho signaling partners correlates with metastatic behavior and poor recurrence-free survival of hepatocellular carcinoma patients.

Ng L, Kwan V, Chow A, Yau TC, Poon RT, Pang R, Law WL.

BMC Cancer. 2019 Jul 19;19(1):713. doi: 10.1186/s12885-019-5919-3.


Faecal microRNAs as a non-invasive tool in the diagnosis of colonic adenomas and colorectal cancer: A meta-analysis.

Yau TO, Tang CM, Harriss EK, Dickins B, Polytarchou C.

Sci Rep. 2019 Jul 1;9(1):9491. doi: 10.1038/s41598-019-45570-9.


Evaluating the effectiveness and cost-effectiveness of the Smoking Treatment Optimisation in Pharmacies (STOP) intervention: protocol for a cluster randomised controlled trial.

Sohanpal R, Jumbe S, James WY, Steed L, Yau T, Rivas C, Madurasinghe V, Houlihan C, Berdunisov V, Taylor M, Taylor SJC, Griffiths C, Eldridge S, Walton R.

Trials. 2019 Jun 10;20(1):337. doi: 10.1186/s13063-019-3368-6.


Nivolumab in advanced hepatocellular carcinoma: Sorafenib-experienced Asian cohort analysis.

Yau T, Hsu C, Kim TY, Choo SP, Kang YK, Hou MM, Numata K, Yeo W, Chopra A, Ikeda M, Kuromatsu R, Moriguchi M, Chao Y, Zhao H, Anderson J, Cruz CD, Kudo M.

J Hepatol. 2019 Sep;71(3):543-552. doi: 10.1016/j.jhep.2019.05.014. Epub 2019 Jun 7. Erratum in: J Hepatol. 2019 Dec;71(6):1278.


A Mobile Lifestyle Management Program (GlycoLeap) for People With Type 2 Diabetes: Single-Arm Feasibility Study.

Koot D, Goh PSC, Lim RSM, Tian Y, Yau TY, Tan NC, Finkelstein EA.

JMIR Mhealth Uhealth. 2019 May 24;7(5):e12965. doi: 10.2196/12965.


Evaluating NHS Stop Smoking Service engagement in community pharmacies using simulated smokers: fidelity assessment of a theory-based intervention.

Jumbe S, James WY, Madurasinghe V, Steed L, Sohanpal R, Yau TK, Taylor S, Eldridge S, Griffiths C, Walton R.

BMJ Open. 2019 May 19;9(5):e026841. doi: 10.1136/bmjopen-2018-026841.


Knockout of Canopy 2 activates p16INK4a pathway to impair cardiac repair.

Yin W, Guo J, Zhang C, Alibhai FJ, Li SH, Billia P, Wu J, Yau TM, Weisel RD, Li RK.

J Mol Cell Cardiol. 2019 Jul;132:36-48. doi: 10.1016/j.yjmcc.2019.04.018. Epub 2019 Apr 29.


Novel mediators of aneurysm progression in bicuspid aortic valve disease.

Tobin SW, Alibhai FJ, Lee MM, Yeganeh A, Wu J, Li SH, Guo J, Tsang K, Tumiati L, Rocha R, Butany J, Yau TM, Ouzounian M, David TE, Weisel RD, Li RK.

J Mol Cell Cardiol. 2019 Jul;132:71-83. doi: 10.1016/j.yjmcc.2019.04.022. Epub 2019 Apr 29.


Changing pattern of recurrences in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy in the era of dual anti-HER2 therapy.

Chiu JW, Leung R, Tang V, Cheuk WY, Lo J, Kwok GW, Wong H, Suen D, Cheung P, Wong TT, Yau T, Kwong A.

Postgrad Med J. 2019 Mar;95(1121):155-161. doi: 10.1136/postgradmedj-2018-135739. Epub 2019 Apr 19.


Intramyocardial Injection of Mesenchymal Precursor Cells and Successful Temporary Weaning From Left Ventricular Assist Device Support in Patients With Advanced Heart Failure: A Randomized Clinical Trial.

Yau TM, Pagani FD, Mancini DM, Chang HL, Lala A, Woo YJ, Acker MA, Selzman CH, Soltesz EG, Kern JA, Maltais S, Charbonneau E, Pan S, Marks ME, Moquete EG, O'Sullivan KL, Taddei-Peters WC, McGowan LK, Green C, Rose EA, Jeffries N, Parides MK, Weisel RD, Miller MA, Hung J, O'Gara PT, Moskowitz AJ, Gelijns AC, Bagiella E, Milano CA; Cardiothoracic Surgical Trials Network.

JAMA. 2019 Mar 26;321(12):1176-1186. doi: 10.1001/jama.2019.2341. Erratum in: JAMA. 2019 Sep 3;322(9):895.


Increased Serum Levels of Cortisol and Inflammatory Cytokines in People With Depression.

Jia Y, Liu L, Sheng C, Cheng Z, Cui L, Li M, Zhao Y, Shi T, Yau TO, Li F, Chen L.

J Nerv Ment Dis. 2019 Apr;207(4):271-276. doi: 10.1097/NMD.0000000000000957. Erratum in: J Nerv Ment Dis. 2019 Jul;207(7):610.


Transcriptomic analysis of different tissue layers in antler growth Center in Sika Deer (Cervus nippon).

Ba H, Wang D, Yau TO, Shang Y, Li C.

BMC Genomics. 2019 Mar 5;20(1):173. doi: 10.1186/s12864-019-5560-1.


Persistence and outcomes of non-vitamin K antagonist oral anticoagulants versus warfarin in patients with non-valvular atrial fibrillation.

Wu S, Xie S, Xu Y, Que D, Yau TO, Wang L, Huang Y.

J Clin Nurs. 2019 May;28(9-10):1839-1846. doi: 10.1111/jocn.14797. Epub 2019 Feb 12.


An Open-Label, Multicenter, Phase I, Dose Escalation Study with Phase II Expansion Cohort to Determine the Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Intravenous TKM-080301 in Subjects with Advanced Hepatocellular Carcinoma.

El Dika I, Lim HY, Yong WP, Lin CC, Yoon JH, Modiano M, Freilich B, Choi HJ, Chao TY, Kelley RK, Brown J, Knox J, Ryoo BY, Yau T, Abou-Alfa GK.

Oncologist. 2019 Jun;24(6):747-e218. doi: 10.1634/theoncologist.2018-0838. Epub 2018 Dec 31.


Historical investigation of medical treatment for adult congenital heart disease: A Canadian perspective.

Lapum JL, Fredericks S, Bailey B, Yau TM, Graham J, Marelli AJ.

Congenit Heart Dis. 2019 Mar;14(2):185-192. doi: 10.1111/chd.12716. Epub 2018 Nov 19.


A revision of the genus Bromeloecia Spuler (Diptera: Sphaeroceridae: Limosininae).

Yau T, Marshall SA.

Zootaxa. 2018 Jul 13;4445(1):1-115. doi: 10.11646/zootaxa.4445.1.1.


Comprehensive inventory of true flies (Diptera) at a tropical site.

Brown BV, Borkent A, Adler PH, Amorim DS, Barber K, Bickel D, Boucher S, Brooks SE, Burger J, Burington ZL, Capellari RS, Costa DNR, Cumming JM, Curler G, Dick CW, Epler JH, Fisher E, Gaimari SD, Gelhaus J, Grimaldi DA, Hash J, Hauser M, Hippa H, Ibáñez-Bernal S, Jaschhof M, Kameneva EP, Kerr PH, Korneyev V, Korytkowski CA, Kung GA, Kvifte GM, Lonsdale O, Marshall SA, Mathis W, Michelsen V, Naglis S, Norrbom AL, Paiero S, Pape T, Pereira-Colavite A, Pollet M, Rochefort S, Rung A, Runyon JB, Savage J, Silva VC, Sinclair BJ, Skevington JH, Stireman Iii JO, Swann J, Thompson FC, Vilkamaa P, Wheeler T, Whitworth T, Wong M, Wood DM, Woodley N, Yau T, Zavortink TJ, Zumbado MA.

Commun Biol. 2018 Mar 22;1:21. doi: 10.1038/s42003-018-0022-x. eCollection 2018.


Phase II Studies with Refametinib or Refametinib plus Sorafenib in Patients with RAS-Mutated Hepatocellular Carcinoma.

Lim HY, Merle P, Weiss KH, Yau T, Ross P, Mazzaferro V, Blanc JF, Ma YT, Yen CJ, Kocsis J, Choo SP, Sukeepaisarnjaroen W, Gérolami R, Dufour JF, Gane EJ, Ryoo BY, Peck-Radosavljevic M, Dao T, Yeo W, Lamlertthon W, Thongsawat S, Teufel M, Roth K, Reis D, Childs BH, Krissel H, Llovet JM.

Clin Cancer Res. 2018 Oct 1;24(19):4650-4661. doi: 10.1158/1078-0432.CCR-17-3588. Epub 2018 Jun 27.


Comparison of propofol-based versus volatile-based anaesthesia and postoperative sedation in cardiac surgical patients: a prospective, randomized, study.

Wąsowicz M, Jerath A, Luksun W, Sharma V, Mitsakakis N, Meineri M, Katznelson R, Yau T, Rao V, Beattie WS.

Anaesthesiol Intensive Ther. 2018;50(3):200-209. doi: 10.5603/AIT.a2018.0012. Epub 2018 Jun 18.


Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway.

Ng L, Chow AKM, Man JHW, Yau TCC, Wan TMH, Iyer DN, Kwan VHT, Poon RTP, Pang RWC, Law WL.

BMC Cancer. 2018 Jun 1;18(1):621. doi: 10.1186/s12885-018-4326-5.


Polypyrrole-chitosan conductive biomaterial synchronizes cardiomyocyte contraction and improves myocardial electrical impulse propagation.

Cui Z, Ni NC, Wu J, Du GQ, He S, Yau TM, Weisel RD, Sung HW, Li RK.

Theranostics. 2018 Apr 9;8(10):2752-2764. doi: 10.7150/thno.22599. eCollection 2018.


Remarkable fly (Diptera) diversity in a patch of Costa Rican cloud forest: Why inventory is a vital science.

Borkent A, Brown BV, Adler PH, Amorim DS, Barber K, Bickel D, Boucher S, Brooks SE, Burger J, Burington ZL, Capellari RS, Costa DNR, Cumming JM, Curler G, Dick CW, Epler JH, Fisher E, Gaimari SD, Gelhaus J, Grimaldi DA, Hash J, Hauser M, Hippa H, IbÁÑez-Bernal S, Jaschhof M, Kameneva EP, Kerr PH, Korneyev V, Korytkowski CA, Kung GA, Kvifte GM, Lonsdale O, Marshall SA, Mathis WN, Michelsen V, Naglis S, Norrbom AL, Paiero S, Pape T, Pereira-Colavite A, Pollet M, Rochefort S, Rung A, Runyon JB, Savage J, Silva VC, Sinclair BJ, Skevington JH, Stireman JOI, Swann J, Vilkamaa P, Wheeler T, Whitworth T, Wong M, Wood DM, Woodley N, Yau T, Zavortink TJ, Zumbado MA.

Zootaxa. 2018 Mar 27;4402(1):53-90. doi: 10.11646/zootaxa.4402.1.3.


Optimising endocrine therapy in postmenopausal women with advanced breast cancer.

Yau THL, Cheung KL.

Endocr Relat Cancer. 2018 Jul;25(7):705-721. doi: 10.1530/ERC-18-0021. Epub 2018 Apr 19.


Hong Kong Consensus Statements for the Management of Unresectable Hepatocellular Carcinoma.

Cheung TT, Kwok PC, Chan S, Cheung CC, Lee AS, Lee V, Cheng HC, Chia NH, Chong CCN, Lai TW, Law ALY, Luk MY, Tong CC, Yau TCC.

Liver Cancer. 2018 Mar;7(1):40-54. doi: 10.1159/000485984. Epub 2018 Jan 25.


Evolution of Diabetes Care in Hong Kong: From the Hong Kong Diabetes Register to JADE-PEARL Program to RAMP and PEP Program.

Ng IHY, Cheung KKT, Yau TTL, Chow E, Ozaki R, Chan JCN.

Endocrinol Metab (Seoul). 2018 Mar;33(1):17-32. doi: 10.3803/EnM.2018.33.1.17. Review.


Factors predicting patient satisfaction in women with advanced breast cancer: a prospective study.

Lam WWT, Kwong A, Suen D, Tsang J, Soong I, Yau TK, Yeo W, Suen J, Ho WM, Wong KY, Sze WK, Ng AWY, Fielding R.

BMC Cancer. 2018 Feb 7;18(1):162. doi: 10.1186/s12885-018-4085-3.


Practical valvular issues in patients requiring ventricular assist devices.

Badiwala M, Yau T.

Curr Opin Cardiol. 2018 Mar;33(2):162-167. doi: 10.1097/HCO.0000000000000500. Review.


Tranexamic Acid Dosing for Cardiac Surgical Patients With Chronic Renal Dysfunction: A New Dosing Regimen.

Jerath A, Yang QJ, Pang KS, Looby N, Reyes-Garces N, Vasiljevic T, Bojko B, Pawliszyn J, Wijeysundera D, Beattie WS, Yau TM, Wąsowicz M.

Anesth Analg. 2018 Dec;127(6):1323-1332. doi: 10.1213/ANE.0000000000002724.


The feasibility of assessing swallowing physiology following prolonged intubation after cardiovascular surgery.

Skoretz SA, Yau TM, Granton JT, Martino R.

Pilot Feasibility Stud. 2017 Nov 21;3:62. doi: 10.1186/s40814-017-0199-7. eCollection 2017.


Polycystic ovary syndrome: a common reproductive syndrome with long-term metabolic consequences.

Yau TT, Ng NY, Cheung LP, Ma RC.

Hong Kong Med J. 2017 Dec;23(6):622-34. doi: 10.12809/hkmj176308. Epub 2017 Nov 24. Review.


Surgical Enlargement of the Aortic Root Does Not Increase the Operative Risk of Aortic Valve Replacement.

Rocha RV, Manlhiot C, Feindel CM, Yau TM, Mueller B, David TE, Ouzounian M.

Circulation. 2018 Apr 10;137(15):1585-1594. doi: 10.1161/CIRCULATIONAHA.117.030525. Epub 2017 Nov 22.


Early pneumopericardium after heart transplantation.

Duero Posada JG, Moayedi Y, Alhussein M, Bunce PE, Yau TM, Ross HJ.

Transpl Infect Dis. 2018 Feb;20(1). doi: 10.1111/tid.12800. Epub 2017 Dec 13.


Cell therapies: The next-generation clinical trials.

Yau TM, Noiseux N, Der Sarkissian S.

J Thorac Cardiovasc Surg. 2017 Aug;154(2):556-557. doi: 10.1016/j.jtcvs.2017.04.018. No abstract available.


Left ventricular assist device exchange: the Toronto General Hospital experience.

Tsubota H, Ribeiro RVP, Billia F, Cusimano RJ, Yau TM, Badiwala MV, Stansfield WE, Rao V.

Can J Surg. 2017 Aug;60(4):253-259.


Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial.

El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, Kim TY, Choo SP, Trojan J, Welling TH Rd, Meyer T, Kang YK, Yeo W, Chopra A, Anderson J, Dela Cruz C, Lang L, Neely J, Tang H, Dastani HB, Melero I.

Lancet. 2017 Jun 24;389(10088):2492-2502. doi: 10.1016/S0140-6736(17)31046-2. Epub 2017 Apr 20.


Skin-derived precursors from human subjects with Type 2 diabetes yield dysfunctional vascular smooth muscle cells.

Steinbach SK, Yau TM, Ouzounian M, Abdel-Qadir H, Chandy M, Waddell TK, Husain M.

Clin Sci (Lond). 2017 Jul 5;131(15):1801-1814. doi: 10.1042/CS20170239. Print 2017 Aug 1.


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