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Items: 1 to 50 of 105


Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions.

Sindrewicz P, Li X, Yates EA, Turnbull JE, Lian LY, Yu LG.

Sci Rep. 2019 Aug 14;9(1):11851. doi: 10.1038/s41598-019-47658-8.


SimpleDSFviewer: A tool to analyze and view differential scanning fluorimetry data for characterizing protein thermal stability and interactions.

Sun C, Li Y, Yates EA, Fernig DG.

Protein Sci. 2019 Aug 8. doi: 10.1002/pro.3703. [Epub ahead of print]


A further unique chondroitin sulfate from the shrimp Litopenaeus vannamei with antithrombin activity that modulates acute inflammation.

Palhares LCGF, Brito AS, de Lima MA, Nader HB, London JA, Barsukov IL, Andrade GPV, Yates EA, Chavante SF.

Carbohydr Polym. 2019 Oct 15;222:115031. doi: 10.1016/j.carbpol.2019.115031. Epub 2019 Jun 28.


Sulfated polysaccharides interact with fibroblast growth factors and protect from denaturation.

Sun C, Liu M, Sun P, Yang M, Yates EA, Guo Z, Fernig DG.

FEBS Open Bio. 2019 Aug;9(8):1477-1487. doi: 10.1002/2211-5463.12696. Epub 2019 Jul 16.


Multivariate analysis applied to complex biological medicines.

Rudd TR, Mauri L, Marinozzi M, Stancanelli E, Yates EA, Naggi A, Guerrini M.

Faraday Discuss. 2019 Aug 15;218(0):303-316. doi: 10.1039/c9fd00009g.


A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease.

Mycroft-West CJ, Cooper LC, Devlin AJ, Procter P, Guimond SE, Guerrini M, Fernig DG, Lima MA, Yates EA, Skidmore MA.

Mar Drugs. 2019 May 16;17(5). pii: E293. doi: 10.3390/md17050293.


Molecular Recognition of Structures Is Key in the Polymerization of Patterned Barnacle Adhesive Sequences.

So CR, Yates EA, Estrella LA, Fears KP, Schenck AM, Yip CM, Wahl KJ.

ACS Nano. 2019 May 28;13(5):5172-5183. doi: 10.1021/acsnano.8b09194. Epub 2019 Apr 26.


By-Products of Heparin Production Provide a Diverse Source of Heparin-like and Heparan Sulfate Glycosaminoglycans.

Taylor SL, Hogwood J, Guo W, Yates EA, Turnbull JE.

Sci Rep. 2019 Feb 25;9(1):2679. doi: 10.1038/s41598-019-39093-6.


Low sulfated heparins target multiple proteins for central nervous system repair.

McCanney GA, McGrath MA, Otto TD, Burchmore R, Yates EA, Bavington CD, Willison HJ, Turnbull JE, Barnett SC.

Glia. 2019 Apr;67(4):668-687. doi: 10.1002/glia.23562. Epub 2018 Dec 26.


Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease.

Mycroft-West CJ, Yates EA, Skidmore MA.

Biochem Soc Trans. 2018 Aug 20;46(4):919-929. doi: 10.1042/BST20170404. Epub 2018 Jul 19. Review.


New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors.

Byrne DP, Li Y, Ramakrishnan K, Barsukov IL, Yates EA, Eyers CE, Papy-Garcia D, Chantepie S, Pagadala V, Liu J, Wells C, Drewry DH, Zuercher WJ, Berry NG, Fernig DG, Eyers PA.

Biochem J. 2018 Aug 14;475(15):2417-2433. doi: 10.1042/BCJ20180265.


Potential role for Streptococcus gordonii-derived hydrogen peroxide in heme acquisition by Porphyromonas gingivalis.

Brown JL, Yates EA, Bielecki M, Olczak T, Smalley JW.

Mol Oral Microbiol. 2018 Aug;33(4):322-335. doi: 10.1111/omi.12229.


Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection.

Vicenzi E, Pagani I, Ghezzi S, Taylor SL, Rudd TR, Lima MA, Skidmore MA, Yates EA.

Biochem Soc Trans. 2018 Jun 19;46(3):609-617. doi: 10.1042/BST20170399. Epub 2018 Apr 20. Review.


Walking the Path Together: Indigenous Health Data at ICES.

Pyper E, Henry D, Yates EA, Mecredy G, Ratnasingham S, Slegers B, Walker JD.

Healthc Q. 2018 Jan;20(4):6-9. doi: 10.12927/hcq.2018.25431.


A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence.

Skidmore MA, Mustaffa KMF, Cooper LC, Guimond SE, Yates EA, Craig AG.

PLoS One. 2017 Oct 18;12(10):e0186276. doi: 10.1371/journal.pone.0186276. eCollection 2017.


Insights into the role of 3-O-sulfotransferase in heparan sulfate biosynthesis.

Meneghetti MCZ, Gesteira Ferreira T, Tashima AK, Chavante SF, Yates EA, Liu J, Nader HB, Lima MA.

Org Biomol Chem. 2017 Aug 16;15(32):6792-6799. doi: 10.1039/c7ob01533j.


Molecular Origins of the Compatibility between Glycosaminoglycans and Aβ40 Amyloid Fibrils.

Stewart KL, Hughes E, Yates EA, Middleton DA, Radford SE.

J Mol Biol. 2017 Aug 4;429(16):2449-2462. doi: 10.1016/j.jmb.2017.07.003. Epub 2017 Jul 10.


The nature of the conserved basic amino acid sequences found among 437 heparin binding proteins determined by network analysis.

Rudd TR, Preston MD, Yates EA.

Mol Biosyst. 2017 May 2;13(5):852-865. doi: 10.1039/c6mb00857g.


Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells.

Ghezzi S, Cooper L, Rubio A, Pagani I, Capobianchi MR, Ippolito G, Pelletier J, Meneghetti MCZ, Lima MA, Skidmore MA, Broccoli V, Yates EA, Vicenzi E.

Antiviral Res. 2017 Apr;140:13-17. doi: 10.1016/j.antiviral.2016.12.023. Epub 2017 Jan 5.


Coupling of vinculin to F-actin demands Syndecan-4 proteoglycan.

Cavalheiro RP, Lima MA, Jarrouge-Bouças TR, Viana GM, Lopes CC, Coulson-Thomas VJ, Dreyfuss JL, Yates EA, Tersariol ILS, Nader HB.

Matrix Biol. 2017 Nov;63:23-37. doi: 10.1016/j.matbio.2016.12.006. Epub 2017 Jan 4.


Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors.

Macchi E, Rudd TR, Raman R, Sasisekharan R, Yates EA, Naggi A, Guerrini M, Elli S.

Biochemistry. 2016 Dec 6;55(48):6605-6616. Epub 2016 Nov 23.


19F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy.

Lima MA, Cavalheiro RP, M Viana G, Meneghetti MCZ, Rudd TR, Skidmore MA, Powell AK, Yates EA.

Glycoconj J. 2017 Jun;34(3):405-410. doi: 10.1007/s10719-016-9723-x. Epub 2016 Aug 15.


Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity.

Ahmed YA, Yates EA, Moss DJ, Loeven MA, Hussain SA, Hohenester E, Turnbull JE, Powell AK.

Mol Biosyst. 2016 Oct 20;12(10):3166-75. doi: 10.1039/c6mb00432f. Epub 2016 Aug 9.


Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-β Fibrils.

Stewart KL, Hughes E, Yates EA, Akien GR, Huang TY, Lima MA, Rudd TR, Guerrini M, Hung SC, Radford SE, Middleton DA.

J Am Chem Soc. 2016 Jul 13;138(27):8328-31. doi: 10.1021/jacs.6b02816. Epub 2016 Jul 5.


Recent innovations in the structural analysis of heparin.

Yates EA, Rudd TR.

Int J Cardiol. 2016 Jun;212 Suppl 1:S5-9. doi: 10.1016/S0167-5273(16)12002-9. Review.


Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification.

Li Y, Sun C, Yates EA, Jiang C, Wilkinson MC, Fernig DG.

Open Biol. 2016 Mar;6(3). pii: 150275. doi: 10.1098/rsob.150275.


Heparan sulfate and heparin interactions with proteins.

Meneghetti MC, Hughes AJ, Rudd TR, Nader HB, Powell AK, Yates EA, Lima MA.

J R Soc Interface. 2015 Sep 6;12(110):0589. doi: 10.1098/rsif.2015.0589. Review.


Differentiation of generic enoxaparins marketed in the United States by employing NMR and multivariate analysis.

Guerrini M, Rudd TR, Mauri L, Macchi E, Fareed J, Yates EA, Naggi A, Torri G.

Anal Chem. 2015 Aug 18;87(16):8275-83. doi: 10.1021/acs.analchem.5b01366. Epub 2015 Aug 6.


Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis.

Duckworth CA, Guimond SE, Sindrewicz P, Hughes AJ, French NS, Lian LY, Yates EA, Pritchard DM, Rhodes JM, Turnbull JE, Yu LG.

Oncotarget. 2015 Sep 15;6(27):23671-87.


Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding.

Solari V, Rudd TR, Guimond SE, Powell AK, Turnbull JE, Yates EA.

Org Biomol Chem. 2015 Jun 7;13(21):6066-72. doi: 10.1039/c5ob00564g.


Heparin derivatives for the targeting of multiple activities in the inflammatory response.

Veraldi N, Hughes AJ, Rudd TR, Thomas HB, Edwards SW, Hadfield L, Skidmore MA, Siligardi G, Cosentino C, Shute JK, Naggi A, Yates EA.

Carbohydr Polym. 2015 Mar 6;117:400-7. doi: 10.1016/j.carbpol.2014.09.079. Epub 2014 Oct 7.


Enhanced tumorigenic potential of colorectal cancer cells by extracellular sulfatases.

Vicente CM, Lima MA, Yates EA, Nader HB, Toma L.

Mol Cancer Res. 2015 Mar;13(3):510-23. doi: 10.1158/1541-7786.MCR-14-0372. Epub 2014 Dec 4.


Preparation protocols of aβ(1-40) promote the formation of polymorphic aggregates and altered interactions with lipid bilayers.

Yates EA, Legleiter J.

Biochemistry. 2014 Nov 18;53(45):7038-50. doi: 10.1021/bi500792f. Epub 2014 Nov 7.


Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry.

Nieves DJ, Azmi NS, Xu R, Lévy R, Yates EA, Fernig DG.

Chem Commun (Camb). 2014 Nov 7;50(86):13157-60. doi: 10.1039/c4cc05909c.


MYCN-dependent expression of sulfatase-2 regulates neuroblastoma cell survival.

Solari V, Borriello L, Turcatel G, Shimada H, Sposto R, Fernandez GE, Asgharzadeh S, Yates EA, Turnbull JE, DeClerck YA.

Cancer Res. 2014 Nov 1;74(21):5999-6009. doi: 10.1158/0008-5472.CAN-13-2513. Epub 2014 Aug 27.


Characterisation of the interaction of neuropilin-1 with heparin and a heparan sulfate mimetic library of heparin-derived sugars.

Uniewicz KA, Ori A, Ahmed YA, Yates EA, Fernig DG.

PeerJ. 2014 Jun 26;2:e461. doi: 10.7717/peerj.461. eCollection 2014.


Insights into the human glycan receptor conformation of 1918 pandemic hemagglutinin-glycan complexes derived from nuclear magnetic resonance and molecular dynamics studies.

Elli S, Macchi E, Rudd TR, Raman R, Sassaki G, Viswanathan K, Yates EA, Shriver Z, Naggi A, Torri G, Sasisekharan R, Guerrini M.

Biochemistry. 2014 Jul 1;53(25):4122-35. doi: 10.1021/bi500338r. Epub 2014 Jun 20.


Patterns of cigarillo use among Canadian young adults in two urban settings.

Yates EA, Dubray J, Schwartz R, Kirst M, Lacombe-Duncan A, Suwal J, Hatcher J.

Can J Public Health. 2014 Jan 6;105(1):e11-4.


A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential.

Brito AS, Cavalcante RS, Palhares LC, Hughes AJ, Andrade GP, Yates EA, Nader HB, Lima MA, Chavante SF.

Carbohydr Polym. 2014 Jan;99:372-8. doi: 10.1016/j.carbpol.2013.08.063. Epub 2013 Aug 29.


On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+.

Córdula CR, Lima MA, Shinjo SK, Gesteira TF, Pol-Fachin L, Coulson-Thomas VJ, Verli H, Yates EA, Rudd TR, Pinhal MA, Toma L, Dietrich CP, Nader HB, Tersariol IL.

Mol Biosyst. 2014 Jan;10(1):54-64. doi: 10.1039/c3mb70370c.


Human (α2→6) and avian (α2→3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution.

Sassaki GL, Elli S, Rudd TR, Macchi E, Yates EA, Naggi A, Shriver Z, Raman R, Sasisekharan R, Torri G, Guerrini M.

Biochemistry. 2013 Oct 15;52(41):7217-7230. doi: 10.1021/bi400677n. Epub 2013 Sep 27.


Unravelling structural information from complex mixtures utilizing correlation spectroscopy applied to HSQC spectra.

Rudd TR, Macchi E, Muzi L, Ferro M, Gaudesi D, Torri G, Casu B, Guerrini M, Yates EA.

Anal Chem. 2013 Aug 6;85(15):7487-93. doi: 10.1021/ac4014379. Epub 2013 Jul 29.


Specific domains of Aβ facilitate aggregation on and association with lipid bilayers.

Yates EA, Owens SL, Lynch MF, Cucco EM, Umbaugh CS, Legleiter J.

J Mol Biol. 2013 Jun 12;425(11):1915-1933. doi: 10.1016/j.jmb.2013.03.022. Epub 2013 Mar 21.


Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.

Burke KA, Yates EA, Legleiter J.

Front Neurol. 2013 Mar 1;4:17. doi: 10.3389/fneur.2013.00017. eCollection 2013.


Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network.

Xu R, Rudd TR, Hughes AJ, Siligardi G, Fernig DG, Yates EA.

FEBS J. 2013 May;280(10):2260-70. doi: 10.1111/febs.12201. Epub 2013 Mar 13.


Amyloid-forming proteins alter the local mechanical properties of lipid membranes.

Burke KA, Yates EA, Legleiter J.

Biochemistry. 2013 Feb 5;52(5):808-17. doi: 10.1021/bi301070v. Epub 2013 Jan 27.


Site-specific identification of an aβ fibril-heparin interaction site by using solid-state NMR spectroscopy.

Madine J, Pandya MJ, Hicks MR, Rodger A, Yates EA, Radford SE, Middleton DA.

Angew Chem Int Ed Engl. 2012 Dec 21;51(52):13140-3. doi: 10.1002/anie.201204459. Epub 2012 Nov 14.


Diversification of the structural determinants of fibroblast growth factor-heparin interactions: implications for binding specificity.

Xu R, Ori A, Rudd TR, Uniewicz KA, Ahmed YA, Guimond SE, Skidmore MA, Siligardi G, Yates EA, Fernig DG.

J Biol Chem. 2012 Nov 16;287(47):40061-73. doi: 10.1074/jbc.M112.398826. Epub 2012 Sep 27.


A zinc complex of heparan sulfate destabilises lysozyme and alters its conformation.

Hughes AJ, Hussain R, Cosentino C, Guerrini M, Siligardi G, Yates EA, Rudd TR.

Biochem Biophys Res Commun. 2012 Sep 7;425(4):794-9. doi: 10.1016/j.bbrc.2012.07.154. Epub 2012 Aug 3.


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