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Items: 1 to 50 of 119

1.

Impact of the Major Candida glabrata Triazole Resistance Determinants on the Activity of the Novel Investigational Tetrazoles VT-1598 and VT-1161.

Nishimoto AT, Whaley SG, Wiederhold NP, Zhang Q, Yates CM, Hoekstra WJ, Schotzinger RJ, Garvey EP, Rogers PD.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e01304-19. doi: 10.1128/AAC.01304-19. Print 2019 Oct.

PMID:
31383660
2.

Development of Highly Selective Pyrimidine-Based Aldosterone Synthase (CYP11B2) Inhibitors.

Sparks SM, Danger DP, Hoekstra WJ, Leesnitzer T, Schotzinger RJ, Yates CM, Becherer JD.

ACS Med Chem Lett. 2019 Jun 7;10(7):1056-1060. doi: 10.1021/acsmedchemlett.9b00152. eCollection 2019 Jul 11.

PMID:
31312408
3.

In Vitro Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of Candida albicans.

Nishimoto AT, Wiederhold NP, Flowers SA, Zhang Q, Kelly SL, Morschhäuser J, Yates CM, Hoekstra WJ, Schotzinger RJ, Garvey EP, Rogers PD.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00341-19. doi: 10.1128/AAC.00341-19. Print 2019 Jun.

PMID:
30910896
4.

The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris.

Wiederhold NP, Lockhart SR, Najvar LK, Berkow EL, Jaramillo R, Olivo M, Garvey EP, Yates CM, Schotzinger RJ, Catano G, Patterson TF.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e02233-18. doi: 10.1128/AAC.02233-18. Print 2019 Mar.

5.

The novel fungal CYP51 inhibitor VT-1598 is efficacious alone and in combination with liposomal amphotericin B in a murine model of cryptococcal meningitis.

Garvey EP, Sharp AD, Warn PA, Yates CM, Schotzinger RJ.

J Antimicrob Chemother. 2018 Oct 1;73(10):2815-2822. doi: 10.1093/jac/dky242.

PMID:
29947783
6.

VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice.

Break TJ, Desai JV, Healey KR, Natarajan M, Ferre EMN, Henderson C, Zelazny A, Siebenlist U, Yates CM, Cohen OJ, Schotzinger RJ, Perlin DS, Garvey EP, Lionakis MS.

J Antimicrob Chemother. 2018 Aug 1;73(8):2089-2094. doi: 10.1093/jac/dky170.

7.

The Novel Fungal Cyp51 Inhibitor VT-1598 Is Efficacious in Experimental Models of Central Nervous System Coccidioidomycosis Caused by Coccidioides posadasii and Coccidioides immitis.

Wiederhold NP, Shubitz LF, Najvar LK, Jaramillo R, Olivo M, Catano G, Trinh HT, Yates CM, Schotzinger RJ, Garvey EP, Patterson TF.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02258-17. doi: 10.1128/AAC.02258-17. Print 2018 Apr.

8.

Fungal-specific Cyp51 inhibitor VT-1598 demonstrates in vitro activity against Candida and Cryptococcus species, endemic fungi, including Coccidioides species, Aspergillus species and Rhizopus arrhizus.

Wiederhold NP, Patterson HP, Tran BH, Yates CM, Schotzinger RJ, Garvey EP.

J Antimicrob Chemother. 2018 Feb 1;73(2):404-408. doi: 10.1093/jac/dkx410.

PMID:
29190379
9.

Changes in the pattern of plasma extracellular vesicles after severe trauma.

Kuravi SJ, Yates CM, Foster M, Harrison P, Hazeldine J, Hampson P, Watson C, Belli A, Midwinter M, Nash GB.

PLoS One. 2017 Aug 24;12(8):e0183640. doi: 10.1371/journal.pone.0183640. eCollection 2017.

10.

Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors.

Yates CM, Garvey EP, Shaver SR, Schotzinger RJ, Hoekstra WJ.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3243-3248. doi: 10.1016/j.bmcl.2017.06.037. Epub 2017 Jun 15.

PMID:
28651982
11.

Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.

Hargrove TY, Garvey EP, Hoekstra WJ, Yates CM, Wawrzak Z, Rachakonda G, Villalta F, Lepesheva GI.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00570-17. doi: 10.1128/AAC.00570-17. Print 2017 Jul.

12.

Monocyte Subsets Coregulate Inflammatory Responses by Integrated Signaling through TNF and IL-6 at the Endothelial Cell Interface.

Chimen M, Yates CM, McGettrick HM, Ward LS, Harrison MJ, Apta B, Dib LH, Imhof BA, Harrison P, Nash GB, Rainger GE.

J Immunol. 2017 Apr 1;198(7):2834-2843. doi: 10.4049/jimmunol.1601281. Epub 2017 Feb 13.

13.

Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium.

Appleby SL, Mitrofan CG, Crosby A, Hoenderdos K, Lodge K, Upton PD, Yates CM, Nash GB, Chilvers ER, Morrell NW.

J Immunol. 2016 Oct 15;197(8):3302-3314. doi: 10.4049/jimmunol.1601219. Epub 2016 Sep 19.

14.

The interaction of PRC2 with RNA or chromatin is mutually antagonistic.

Beltran M, Yates CM, Skalska L, Dawson M, Reis FP, Viiri K, Fisher CL, Sibley CR, Foster BM, Bartke T, Ule J, Jenner RG.

Genome Res. 2016 Jul;26(7):896-907. doi: 10.1101/gr.197632.115. Epub 2016 May 9.

15.

The role of platelets in the recruitment of leukocytes during vascular disease.

Ed Rainger G, Chimen M, Harrison MJ, Yates CM, Harrison P, Watson SP, Lordkipanidzé M, Nash GB.

Platelets. 2015;26(6):507-20. doi: 10.3109/09537104.2015.1064881. Epub 2015 Jul 21. Review.

16.

The Phyre2 web portal for protein modeling, prediction and analysis.

Kelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJ.

Nat Protoc. 2015 Jun;10(6):845-58. doi: 10.1038/nprot.2015.053. Epub 2015 May 7.

17.

Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease.

Chimen M, McGettrick HM, Apta B, Kuravi SJ, Yates CM, Kennedy A, Odedra A, Alassiri M, Harrison M, Martin A, Barone F, Nayar S, Hitchcock JR, Cunningham AF, Raza K, Filer A, Copland DA, Dick AD, Robinson J, Kalia N, Walker LSK, Buckley CD, Nash GB, Narendran P, Rainger GE.

Nat Med. 2015 May;21(5):467-475. doi: 10.1038/nm.3842. Epub 2015 Apr 20.

18.

Presentations to the Emergency Department Following Cannabis use--a Multi-Centre Case Series from Ten European Countries.

Dines AM, Wood DM, Galicia M, Yates CM, Heyerdahl F, Hovda KE, Giraudon I, Sedefov R; Euro-DEN Research Group, Dargan PI.

J Med Toxicol. 2015 Dec;11(4):415-21. doi: 10.1007/s13181-014-0460-x.

19.

Design and optimization of highly-selective fungal CYP51 inhibitors.

Hoekstra WJ, Garvey EP, Moore WR, Rafferty SW, Yates CM, Schotzinger RJ.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3455-8. doi: 10.1016/j.bmcl.2014.05.068. Epub 2014 Jun 9.

PMID:
24948565
20.

SuSPect: enhanced prediction of single amino acid variant (SAV) phenotype using network features.

Yates CM, Filippis I, Kelley LA, Sternberg MJ.

J Mol Biol. 2014 Jul 15;426(14):2692-701. doi: 10.1016/j.jmb.2014.04.026. Epub 2014 May 5.

21.

Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease.

Yates CM, Calder PC, Ed Rainger G.

Pharmacol Ther. 2014 Mar;141(3):272-82. doi: 10.1016/j.pharmthera.2013.10.010. Epub 2013 Nov 4. Review.

PMID:
24201219
22.

Adhesion of tumor cells to matrices and endothelium.

Yates CM, McGettrick HM, Nash GB, Rainger GE.

Methods Mol Biol. 2014;1070:57-75. doi: 10.1007/978-1-4614-8244-4_5.

PMID:
24092432
23.

The effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on protein-protein interactions.

Yates CM, Sternberg MJ.

J Mol Biol. 2013 Nov 1;425(21):3949-63. doi: 10.1016/j.jmb.2013.07.012. Epub 2013 Jul 15. Review.

PMID:
23867278
24.

Proteins and domains vary in their tolerance of non-synonymous single nucleotide polymorphisms (nsSNPs).

Yates CM, Sternberg MJ.

J Mol Biol. 2013 Apr 26;425(8):1274-86. doi: 10.1016/j.jmb.2013.01.026. Epub 2013 Jan 25.

PMID:
23357174
25.

Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.

Liu F, Barsyte-Lovejoy D, Allali-Hassani A, He Y, Herold JM, Chen X, Yates CM, Frye SV, Brown PJ, Huang J, Vedadi M, Arrowsmith CH, Jin J.

J Med Chem. 2011 Sep 8;54(17):6139-50. doi: 10.1021/jm200903z. Epub 2011 Aug 5.

26.

Prostaglandin D2 regulates CD4+ memory T cell trafficking across blood vascular endothelium and primes these cells for clearance across lymphatic endothelium.

Ahmed SR, McGettrick HM, Yates CM, Buckley CD, Ratcliffe MJ, Nash GB, Rainger GE.

J Immunol. 2011 Aug 1;187(3):1432-9. doi: 10.4049/jimmunol.1100299. Epub 2011 Jun 29.

27.

Endovascular aneurysm repair reverses the increased titer and the inflammatory activity of interleukin-1α in the serum of patients with abdominal aortic aneurysm.

Yates CM, Abdelhamid M, Adam DJ, Nash GB, Bradbury AW, Rainger GE.

J Vasc Surg. 2011 Aug;54(2):497-503. doi: 10.1016/j.jvs.2011.02.061. Epub 2011 May 28.

28.

Docosahexaenoic acid inhibits the adhesion of flowing neutrophils to cytokine stimulated human umbilical vein endothelial cells.

Yates CM, Tull SP, Madden J, Calder PC, Grimble RF, Nash GB, Rainger GE.

J Nutr. 2011 Jul;141(7):1331-4. doi: 10.3945/jn.111.139287. Epub 2011 May 25.

PMID:
21613456
29.

Endothelial cell-borne platelet bridges selectively recruit monocytes in human and mouse models of vascular inflammation.

Kuckleburg CJ, Yates CM, Kalia N, Zhao Y, Nash GB, Watson SP, Rainger GE.

Cardiovasc Res. 2011 Jul 1;91(1):134-41. doi: 10.1093/cvr/cvr040. Epub 2011 Feb 1.

PMID:
21285294
30.

Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists.

Yates CM, Brown PJ, Stewart EL, Patten C, Austin RJ, Holt JA, Maglich JM, Angell DC, Sasse RZ, Taylor SJ, Uings IJ, Trump RP.

J Med Chem. 2010 Jun 10;53(11):4531-44. doi: 10.1021/jm100447c.

PMID:
20469868
31.

Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment.

Tull SP, Yates CM, Maskrey BH, O'Donnell VB, Madden J, Grimble RF, Calder PC, Nash GB, Rainger GE.

PLoS Biol. 2009 Aug;7(8):e1000177. doi: 10.1371/journal.pbio.1000177. Epub 2009 Aug 25.

32.

Catalytic asymmetric acylation of (silyloxy)nitrile anions.

Nicewicz DA, Yates CM, Johnson JS.

Angew Chem Int Ed Engl. 2004 May 10;43(20):2652-5. No abstract available.

PMID:
18629980
33.

The interaction between dam methylation sites and Xba1 restriction digest sites in Escherichia coli O157:H7 EDL933.

Sales J, Vali L, Hoyle DV, Yates CM, Amyes SG, McKendrick IJ.

J Appl Microbiol. 2007 Mar;102(3):820-5.

34.

Modelling the epidemiology and transmission of Verocytotoxin-producing Escherichia coli serogroups O26 and O103 in two different calf cohorts.

Liu WC, Shaw DJ, Matthews L, Hoyle DV, Pearce MC, Yates CM, Low JC, Amyes SG, Gunn GJ, Woolhouse ME.

Epidemiol Infect. 2007 Nov;135(8):1316-23. Epub 2007 Jan 15.

35.

Enhancement of bacterial competitive fitness by apramycin resistance plasmids from non-pathogenic Escherichia coli.

Yates CM, Shaw DJ, Roe AJ, Woolhouse ME, Amyes SG.

Biol Lett. 2006 Sep 22;2(3):463-5.

36.

Erythropoietin in thyroid cancer.

Yates CM, Patel A, Oakley K, Helms A, Tuttle RM, Francis GL.

J Endocrinol Invest. 2006 Apr;29(4):320-9.

PMID:
16699298
37.

Molecular characterisation of bovine faecal Escherichia coli shows persistence of defined ampicillin resistant strains and the presence of class 1 integrons on an organic beef farm.

Hoyle DV, Davison HC, Knight HI, Yates CM, Dobay O, Gunn GJ, Amyes SG, Woolhouse ME.

Vet Microbiol. 2006 Jun 15;115(1-3):250-7. Epub 2006 Feb 21.

PMID:
16490325
38.

Molecular epidemiology of antimicrobial-resistant commensal Escherichia coli strains in a cohort of newborn calves.

Hoyle DV, Yates CM, Chase-Topping ME, Turner EJ, Davies SE, Low JC, Gunn GJ, Woolhouse ME, Amyes SG.

Appl Environ Microbiol. 2005 Nov;71(11):6680-8.

39.

Metallophosphite-induced nucleophilic acylation of alpha,beta-unsaturated amides: facilitated catalysis by a diastereoselective retro [1,4] Brook rearrangement.

Nahm MR, Linghu X, Potnick JR, Yates CM, White PS, Johnson JS.

Angew Chem Int Ed Engl. 2005 Apr 15;44(16):2377-9. No abstract available. Erratum in: Angew Chem Int Ed Engl. 2005 Jul 25;44(30):4660.

40.
41.

High frequency transfer and horizontal spread of apramycin resistance in calf faecal Escherichia coli.

Yates CM, Pearce MC, Woolhouse ME, Amyes SG.

J Antimicrob Chemother. 2004 Aug;54(2):534-7. Epub 2004 Jul 1.

PMID:
15231771
42.

Detection of TEM-52 in Salmonella enterica serovar Enteritidis isolated in Scotland.

Yates CM, Brown DJ, Edwards GF, Amyes SG.

J Antimicrob Chemother. 2004 Feb;53(2):407-8. Epub 2003 Dec 19. No abstract available.

PMID:
14688043
43.

Alternative approaches to predicting methane emissions from dairy cows.

Mills JA, Kebreab E, Yates CM, Crompton LA, Cammell SB, Dhanoa MS, Agnew RE, France J.

J Anim Sci. 2003 Dec;81(12):3141-50.

PMID:
14677870
44.
45.

Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism.

Graf WD, Unis AS, Yates CM, Sulzbacher S, Dinulos MB, Jack RM, Dugaw KA, Paddock MN, Parson WW.

Neurology. 2001 Aug 14;57(3):410-6.

PMID:
11502905
46.

Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease.

Seckl JR, French KL, O'Donnell D, Meaney MJ, Nair NP, Yates CM, Fink G.

Brain Res Mol Brain Res. 1993 May;18(3):239-45.

PMID:
8497185
47.
48.

Mutation in codon 713 of the beta amyloid precursor protein gene presenting with schizophrenia.

Jones CT, Morris S, Yates CM, Moffoot A, Sharpe C, Brock DJ, St Clair D.

Nat Genet. 1992 Jul;1(4):306-9.

PMID:
1307241
49.

A response to nonaversive behavior management and "Default" technologies.

Yates CM.

Behav Anal. 1991 Fall;14(2):217-8. No abstract available.

50.

Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.

Yates CM, Butterworth J, Tennant MC, Gordon A.

J Neurochem. 1990 Nov;55(5):1624-30.

PMID:
2213015

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