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Items: 1 to 50 of 113

1.

A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis.

Takezaki A, Tsukumo SI, Setoguchi Y, Ledford JG, Goto H, Hosomichi K, Uehara H, Nishioka Y, Yasutomo K.

J Exp Med. 2019 Oct 10. pii: jem.20182351. doi: 10.1084/jem.20182351. [Epub ahead of print]

PMID:
31601679
2.

The Significance of MicroRNA-449a and Its Potential Target HDAC1 in Patients With Colorectal Cancer.

Ishikawa D, Takasu C, Kashihara H, Nishi M, Tokunaga T, Higashijima J, Yoshikawa K, Yasutomo K, Shimada M.

Anticancer Res. 2019 Jun;39(6):2855-2860. doi: 10.21873/anticanres.13414.

PMID:
31177123
3.

Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.

Ishifune C, Tsukumo SI, Maekawa Y, Hozumi K, Chung DH, Motozono C, Yamasaki S, Nakano H, Yasutomo K.

PLoS Biol. 2019 May 9;17(5):e3000262. doi: 10.1371/journal.pbio.3000262. eCollection 2019 May.

4.

Dysregulation of immunoproteasomes in autoinflammatory syndromes.

Yasutomo K.

Int Immunol. 2019 Sep 18;31(10):631-637. doi: 10.1093/intimm/dxy059.

PMID:
30169676
5.

Regulation of CD8+ T Cells and Antitumor Immunity by Notch Signaling.

Tsukumo SI, Yasutomo K.

Front Immunol. 2018 Jan 30;9:101. doi: 10.3389/fimmu.2018.00101. eCollection 2018. Review.

6.

Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.

Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, Takeda K.

Cell Rep. 2017 Nov 14;21(7):1824-1838. doi: 10.1016/j.celrep.2017.10.082.

7.

SIRPα+ dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen.

Saito Y, Respatika D, Komori S, Washio K, Nishimura T, Kotani T, Murata Y, Okazawa H, Ohnishi H, Kaneko Y, Yui K, Yasutomo K, Nishigori C, Nojima Y, Matozaki T.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10151-E10160. doi: 10.1073/pnas.1711345114. Epub 2017 Nov 6.

8.

MicroRNA-449a deficiency promotes colon carcinogenesis.

Niki M, Nakajima K, Ishikawa D, Nishida J, Ishifune C, Tsukumo SI, Shimada M, Nagahiro S, Mitamura Y, Yasutomo K.

Sci Rep. 2017 Sep 6;7(1):10696. doi: 10.1038/s41598-017-10500-0.

9.

Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression.

Zaman TS, Arimochi H, Maruyama S, Ishifune C, Tsukumo SI, Kitamura A, Yasutomo K.

J Immunol. 2017 Sep 15;199(6):1989-1997. doi: 10.4049/jimmunol.1700645. Epub 2017 Aug 4.

10.

Corrigendum: Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.

Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Häger C, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP.

Nat Commun. 2017 May 3;8:15486. doi: 10.1038/ncomms15486. No abstract available.

11.

Survival of mature T cells depends on signaling through HOIP.

Okamura K, Kitamura A, Sasaki Y, Chung DH, Kagami S, Iwai K, Yasutomo K.

Sci Rep. 2016 Oct 27;6:36135. doi: 10.1038/srep36135.

12.

Transmission of survival signals through Delta-like 1 on activated CD4+ T cells.

Furukawa T, Ishifune C, Tsukumo SI, Hozumi K, Maekawa Y, Matsui N, Kaji R, Yasutomo K.

Sci Rep. 2016 Sep 23;6:33692. doi: 10.1038/srep33692.

13.

Treatment with DHA/EPA ameliorates atopic dermatitis-like skin disease by blocking LTB4 production.

Yoshida S, Yasutomo K, Watanabe T.

J Med Invest. 2016;63(3-4):187-91. doi: 10.2152/jmi.63.187.

14.

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.

Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP.

Nat Commun. 2016 Aug 31;7:12597. doi: 10.1038/ncomms12597.

15.

Dysfunctional immunoproteasomes in autoinflammatory diseases.

Arimochi H, Sasaki Y, Kitamura A, Yasutomo K.

Inflamm Regen. 2016 May 28;36:13. doi: 10.1186/s41232-016-0011-8. eCollection 2016. Review.

16.

Differentiation of preadipocytes and mature adipocytes requires PSMB8.

Arimochi H, Sasaki Y, Kitamura A, Yasutomo K.

Sci Rep. 2016 May 26;6:26791. doi: 10.1038/srep26791.

17.

An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned.

Seed TM, Xiao S, Manley N, Nikolich-Zugich J, Pugh J, Van den Brink M, Hirabayashi Y, Yasutomo K, Iwama A, Koyasu S, Shterev I, Sempowski G, Macchiarini F, Nakachi K, Kunugi KC, Hammer CG, Dewerd LA.

Int J Radiat Biol. 2016;92(2):59-70. doi: 10.3109/09553002.2015.1106024. Epub 2015 Nov 17.

18.

CD98 Heavy Chain Is a Potent Positive Regulator of CD4+ T Cell Proliferation and Interferon-γ Production In Vivo.

Kurihara T, Arimochi H, Bhuyan ZA, Ishifune C, Tsumura H, Ito M, Ito Y, Kitamura A, Maekawa Y, Yasutomo K.

PLoS One. 2015 Oct 7;10(10):e0139692. doi: 10.1371/journal.pone.0139692. eCollection 2015.

19.

Notch 1 and Notch 2 synergistically regulate the differentiation and function of invariant NKT cells.

Oh SJ, Ahn S, Jin YH, Ishifune C, Kim JH, Yasutomo K, Chung DH.

J Leukoc Biol. 2015 Nov;98(5):781-9. doi: 10.1189/jlb.1A0914-459RR. Epub 2015 Jul 17.

PMID:
26188077
20.

Notch controls the survival of memory CD4+ T cells by regulating glucose uptake.

Maekawa Y, Ishifune C, Tsukumo S, Hozumi K, Yagita H, Yasutomo K.

Nat Med. 2015 Jan;21(1):55-61. doi: 10.1038/nm.3758. Epub 2014 Dec 15.

PMID:
25501905
21.

An inherited mutation in NLRC4 causes autoinflammation in human and mice.

Kitamura A, Sasaki Y, Abe T, Kano H, Yasutomo K.

J Exp Med. 2014 Nov 17;211(12):2385-96. doi: 10.1084/jem.20141091. Epub 2014 Nov 10.

22.

Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling.

Ishifune C, Maruyama S, Sasaki Y, Yagita H, Hozumi K, Tomita T, Kishihara K, Yasutomo K.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5986-91. doi: 10.1073/pnas.1401671111. Epub 2014 Apr 7.

23.

Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells.

Bhuyan ZA, Asanoma M, Iwata A, Ishifune C, Maekawa Y, Shimada M, Yasutomo K.

PLoS One. 2014 Feb 28;9(2):e89266. doi: 10.1371/journal.pone.0089266. eCollection 2014.

24.

CD98hc regulates the development of experimental colitis by controlling effector and regulatory CD4(+) T cells.

Bhuyan ZA, Arimochi H, Nishida J, Kataoka K, Kurihara T, Ishifune C, Tsumura H, Ito M, Ito Y, Kitamura A, Yasutomo K.

Biochem Biophys Res Commun. 2014 Feb 21;444(4):628-33. doi: 10.1016/j.bbrc.2014.01.144. Epub 2014 Jan 31.

PMID:
24491544
25.

Feasibility of reduced-intensity conditioning followed by unrelated cord blood transplantation for primary hemophagocytic lymphohistiocytosis: a nationwide retrospective analysis in Japan.

Sawada A, Ohga S, Ishii E, Inoue M, Okada K, Inagaki J, Goto H, Suzuki N, Koike K, Atsuta Y, Suzuki R, Yabe H, Kawa K, Kato K, Yasutomo K.

Int J Hematol. 2013 Aug;98(2):223-30. doi: 10.1007/s12185-013-1391-z. Epub 2013 Jul 11.

PMID:
23843148
26.

The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ⁺CD8αα⁺ cells.

Nakajima K, Maekawa Y, Kataoka K, Ishifune C, Nishida J, Arimochi H, Kitamura A, Yoshimoto T, Tomita S, Nagahiro S, Yasutomo K.

Nat Commun. 2013;4:2112. doi: 10.1038/ncomms3112.

PMID:
23836150
27.

Mariner-based transposon mutagenesis for Bacteroides species.

Ichimura M, Uchida K, Nakayama-Imaohji H, Hirakawa H, Tada T, Morita H, Yasutomo K, Okazaki K, Kuwahara T.

J Basic Microbiol. 2014 Jun;54(6):558-67. doi: 10.1002/jobm.201200763. Epub 2013 May 20.

PMID:
23686946
28.

PhoB regulates the survival of Bacteroides fragilis in peritoneal abscesses.

Wakimoto S, Nakayama-Imaohji H, Ichimura M, Morita H, Hirakawa H, Hayashi T, Yasutomo K, Kuwahara T.

PLoS One. 2013;8(1):e53829. doi: 10.1371/journal.pone.0053829. Epub 2013 Jan 15.

29.

Dll4-Fc, an inhibitor of Dll4-notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-κB activity.

Kuramoto T, Goto H, Mitsuhashi A, Tabata S, Ogawa H, Uehara H, Saijo A, Kakiuchi S, Maekawa Y, Yasutomo K, Hanibuchi M, Akiyama S, Sone S, Nishioka Y.

Mol Cancer Ther. 2012 Dec;11(12):2578-87. doi: 10.1158/1535-7163.MCT-12-0640. Epub 2012 Sep 18.

30.

Reduced diversity and imbalance of fecal microbiota in patients with ulcerative colitis.

Nemoto H, Kataoka K, Ishikawa H, Ikata K, Arimochi H, Iwasaki T, Ohnishi Y, Kuwahara T, Yasutomo K.

Dig Dis Sci. 2012 Nov;57(11):2955-64. doi: 10.1007/s10620-012-2236-y. Epub 2012 May 24.

PMID:
22623042
31.

Reduced-intensity conditioning in unrelated donor cord blood transplantation for familial hemophagocytic lymphohistiocytosis.

Nishi M, Nishimura R, Suzuki N, Sawada A, Okamura T, Fujita N, Kanai R, Yano J, Adachi S, Yasumi T, Sato E, Yasutomo K, Ishii E, Ohga S.

Am J Hematol. 2012 Jun;87(6):637-9. doi: 10.1002/ajh.23190. Epub 2012 Apr 10.

32.

Notch2 regulates the development of marginal zone B cells through Fos.

Iwahashi S, Maekawa Y, Nishida J, Ishifune C, Kitamura A, Arimochi H, Kataoka K, Chiba S, Shimada M, Yasutomo K.

Biochem Biophys Res Commun. 2012 Feb 24;418(4):701-7. doi: 10.1016/j.bbrc.2012.01.082. Epub 2012 Jan 24.

PMID:
22293205
33.

Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice.

Lian G, Arimochi H, Kitamura A, Nishida J, Li S, Kishihara K, Maekawa Y, Yasutomo K.

J Immunol. 2012 Mar 1;188(5):2227-34. doi: 10.4049/jimmunol.1102586. Epub 2012 Jan 30.

34.

High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice.

Shiota A, Taketani Y, Maekawa Y, Yasutomo K, Sata M, Sakai T, Mizuno R, Isshiki M, Yamamoto H, Takeda E.

J Clin Biochem Nutr. 2011 Sep;49(2):109-14. doi: 10.3164/jcbn.10-150. Epub 2011 May 25.

35.

Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production.

Xu M, Morishima N, Mizoguchi I, Chiba Y, Fujita K, Kuroda M, Iwakura Y, Cua DJ, Yasutomo K, Mizuguchi J, Yoshimoto T.

Eur J Immunol. 2011 Oct;41(10):2828-39. doi: 10.1002/eji.201141291. Epub 2011 Aug 31.

36.

Low-dose lipopolysaccharide affects lung allergic responses by regulating Jagged1 expression on antigen-pulsed dendritic cells.

Okamoto M, Takeda K, Lucas JJ, Joetham A, Yasutomo K, Gelfand EW.

Int Arch Allergy Immunol. 2012;157(1):65-72. doi: 10.1159/000324836. Epub 2011 Sep 6.

37.

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans.

Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley DM, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, Yasutomo K.

J Clin Invest. 2011 Oct;121(10):4150-60. doi: 10.1172/JCI58414. Epub 2011 Sep 1.

38.

The lifestyle of the segmented filamentous bacterium: a non-culturable gut-associated immunostimulating microbe inferred by whole-genome sequencing.

Kuwahara T, Ogura Y, Oshima K, Kurokawa K, Ooka T, Hirakawa H, Itoh T, Nakayama-Imaohji H, Ichimura M, Itoh K, Ishifune C, Maekawa Y, Yasutomo K, Hattori M, Hayashi T.

DNA Res. 2011 Aug;18(4):291-303. doi: 10.1093/dnares/dsr022. Epub 2011 Jul 26.

39.

Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus.

Ishifune C, Maekawa Y, Nishida J, Kitamura A, Tanigaki K, Yagita H, Yasutomo K.

Eur J Immunol. 2011 May;41(5):1309-20. doi: 10.1002/eji.201041159. Epub 2011 Apr 12.

40.

Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.

Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S.

Blood. 2011 Jan 6;117(1):128-34. doi: 10.1182/blood-2010-07-289611. Epub 2010 Oct 22.

PMID:
20971948
41.

Notch2 signaling is required for potent antitumor immunity in vivo.

Sugimoto K, Maekawa Y, Kitamura A, Nishida J, Koyanagi A, Yagita H, Kojima H, Chiba S, Shimada M, Yasutomo K.

J Immunol. 2010 May 1;184(9):4673-8. doi: 10.4049/jimmunol.0903661. Epub 2010 Mar 29.

42.

Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor.

Alam MS, Maekawa Y, Kitamura A, Tanigaki K, Yoshimoto T, Kishihara K, Yasutomo K.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5943-8. doi: 10.1073/pnas.0911755107. Epub 2010 Mar 15.

43.

Protein-tyrosine phosphatase-kappa regulates CD4+ T cell development through ERK1/2-mediated signaling.

Erdenebayar N, Maekawa Y, Nishida J, Kitamura A, Yasutomo K.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):489-93. doi: 10.1016/j.bbrc.2009.09.117. Epub 2009 Oct 1.

PMID:
19800317
44.

Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production.

Okamoto M, Matsuda H, Joetham A, Lucas JJ, Domenico J, Yasutomo K, Takeda K, Gelfand EW.

J Immunol. 2009 Sep 1;183(5):2995-3003. doi: 10.4049/jimmunol.0900692. Epub 2009 Aug 10.

45.

Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading.

Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T.

Mol Cell Biol. 2009 Sep;29(17):4798-811. doi: 10.1128/MCB.01347-08. Epub 2009 Jun 22.

46.

Notch activation induces the generation of functional NK cells from human cord blood CD34-positive cells devoid of IL-15.

Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S.

J Immunol. 2009 May 15;182(10):6168-78. doi: 10.4049/jimmunol.0803036.

47.

Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese.

Nishimoto K, Kochi Y, Ikari K, Yamamoto K, Suzuki A, Shimane K, Nakamura Y, Yano K, Iikuni N, Tsukahara S, Kamatani N, Okamoto H, Kaneko H, Kawaguchi Y, Hara M, Toyama Y, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Yamanaka H, Momohara S.

Ann Rheum Dis. 2010 Feb;69(2):368-73. doi: 10.1136/ard.2008.104315. Epub 2009 Mar 30.

PMID:
19336421
48.

Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells.

Kijima M, Iwata A, Maekawa Y, Uehara H, Izumi K, Kitamura A, Yagita H, Chiba S, Shiota H, Yasutomo K.

J Immunol. 2009 Mar 15;182(6):3566-72. doi: 10.4049/jimmunol.0803765.

49.

Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.

Maekawa Y, Minato Y, Ishifune C, Kurihara T, Kitamura A, Kojima H, Yagita H, Sakata-Yanagimoto M, Saito T, Taniuchi I, Chiba S, Sone S, Yasutomo K.

Nat Immunol. 2008 Oct;9(10):1140-7. doi: 10.1038/ni.1649. Epub 2008 Aug 24.

PMID:
18724371
50.

Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population.

Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, Nakamura Y, Toyama Y, Mochizuki T, Tsukahara S, Kawaguchi Y, Terai C, Hara M, Tomatsu T, Yamanaka H, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Okamoto H, Kamatani N, Momohara S.

Arthritis Rheum. 2008 Jul;58(7):1940-6. doi: 10.1002/art.23494.

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