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Items: 1 to 50 of 121

1.

High Salt Intake Worsens Aortic Dissection in Mice: Involvement of IL (Interleukin)-17A-Dependent ECM (Extracellular Matrix) Metabolism.

Nishida N, Aoki H, Ohno-Urabe S, Nishihara M, Furusho A, Hirakata S, Hayashi M, Ito S, Yamada H, Hirata Y, Yasukawa H, Imaizumi T, Tanaka H, Fukumoto Y.

Arterioscler Thromb Vasc Biol. 2019 Nov 7:ATVBAHA119313336. doi: 10.1161/ATVBAHA.119.313336. [Epub ahead of print]

PMID:
31694392
2.

Collaborative Study for Analysis of Subvisible Particles Using Flow Imaging and Light Obscuration: Experiences in Japanese Biopharmaceutical Consortium.

Kiyoshi M, Shibata H, Harazono A, Torisu T, Maruno T, Akimaru M, Asano Y, Hirokawa M, Ikemoto K, Itakura Y, Iwura T, Kikitsu A, Kumagai T, Mori N, Murase H, Nishimura H, Oda A, Ogawa T, Ojima T, Okabe S, Saito S, Saitoh S, Suetomo H, Takegami K, Takeuchi M, Yasukawa H, Uchiyama S, Ishii-Watabe A.

J Pharm Sci. 2019 Feb;108(2):832-841. doi: 10.1016/j.xphs.2018.08.006. Epub 2018 Aug 16.

3.

Taurine is an amino acid with the ability to activate autophagy in adipocytes.

Kaneko H, Kobayashi M, Mizunoe Y, Yoshida M, Yasukawa H, Hoshino S, Itagawa R, Furuichi T, Okita N, Sudo Y, Imae M, Higami Y.

Amino Acids. 2018 May;50(5):527-535. doi: 10.1007/s00726-018-2550-6. Epub 2018 Mar 9.

PMID:
29523960
4.

Role of Macrophage Socs3 in the Pathogenesis of Aortic Dissection.

Ohno-Urabe S, Aoki H, Nishihara M, Furusho A, Hirakata S, Nishida N, Ito S, Hayashi M, Yasukawa H, Imaizumi T, Akashi H, Tanaka H, Fukumoto Y.

J Am Heart Assoc. 2018 Jan 17;7(2). pii: e007389. doi: 10.1161/JAHA.117.007389.

5.

Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways.

Mizunoe Y, Kobayashi M, Sudo Y, Watanabe S, Yasukawa H, Natori D, Hoshino A, Negishi A, Okita N, Komatsu M, Higami Y.

Redox Biol. 2018 May;15:115-124. doi: 10.1016/j.redox.2017.09.007. Epub 2017 Sep 20.

6.

Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice.

Mizunoe Y, Sudo Y, Okita N, Hiraoka H, Mikami K, Narahara T, Negishi A, Yoshida M, Higashibata R, Watanabe S, Kaneko H, Natori D, Furuichi T, Yasukawa H, Kobayashi M, Higami Y.

Autophagy. 2017 Apr 3;13(4):642-653. doi: 10.1080/15548627.2016.1274850. Epub 2017 Jan 25.

7.

In Vitro Transformation of Chlorinated Parabens by the Liver S9 Fraction: Kinetics, Metabolite Identification, and Aryl Hydrocarbon Receptor Agonist Activity.

Terasaki M, Wada T, Nagashima S, Makino M, Yasukawa H.

Chem Pharm Bull (Tokyo). 2016;64(6):650-4. doi: 10.1248/cpb.c15-00977.

8.

Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias.

Hara M, Takahashi T, Mitsumasu C, Igata S, Takano M, Minami T, Yasukawa H, Okayama S, Nakamura K, Okabe Y, Tanaka E, Takemura G, Kosai K, Yamashita Y, Matsuishi T.

Sci Rep. 2015 Jun 15;5:11204. doi: 10.1038/srep11204.

9.

Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules.

Nagata T, Yasukawa H, Kyogoku S, Oba T, Takahashi J, Nohara S, Minami T, Mawatari K, Sugi Y, Shimozono K, Pradervand S, Hoshijima M, Aoki H, Fukumoto Y, Imaizumi T.

PLoS One. 2015 May 26;10(5):e0127942. doi: 10.1371/journal.pone.0127942. eCollection 2015.

10.

Coformulation of a Novel Human α-Galactosidase A With the Pharmacological Chaperone AT1001 Leads to Improved Substrate Reduction in Fabry Mice.

Xu S, Lun Y, Brignol N, Hamler R, Schilling A, Frascella M, Sullivan S, Boyd RE, Chang K, Soska R, Garcia A, Feng J, Yasukawa H, Shardlow C, Churchill A, Ketkar A, Robertson N, Miyamoto M, Mihara K, Benjamin ER, Lockhart DJ, Hirato T, Fowles S, Valenzano KJ, Khanna R.

Mol Ther. 2015 Jul;23(7):1169-1181. doi: 10.1038/mt.2015.87. Epub 2015 Apr 27.

11.

Renal Nerve-Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning.

Oba T, Yasukawa H, Nagata T, Kyogoku S, Minami T, Nishihara M, Ohshima H, Mawatari K, Nohara S, Takahashi J, Sugi Y, Igata S, Iwamoto Y, Kai H, Matsuoka H, Takano M, Aoki H, Fukumoto Y, Imaizumi T.

Circ J. 2015;79(7):1557-67. doi: 10.1253/circj.CJ-14-1171. Epub 2015 Mar 31.

12.

ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells.

Morita R, Suzuki M, Kasahara H, Shimizu N, Shichita T, Sekiya T, Kimura A, Sasaki K, Yasukawa H, Yoshimura A.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):160-5. doi: 10.1073/pnas.1413234112. Epub 2014 Dec 24.

13.

Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms.

Kataoka Y, Shibata R, Ohashi K, Kambara T, Enomoto T, Uemura Y, Ogura Y, Yuasa D, Matsuo K, Nagata T, Oba T, Yasukawa H, Numaguchi Y, Sone T, Murohara T, Ouchi N.

J Am Coll Cardiol. 2014 Jun 24;63(24):2722-33. doi: 10.1016/j.jacc.2014.03.032. Epub 2014 Apr 23.

14.

Protective role of JAK/STAT signaling against renal fibrosis in mice with unilateral ureteral obstruction.

Koike K, Ueda S, Yamagishi S, Yasukawa H, Kaida Y, Yokoro M, Fukami K, Yoshimura A, Okuda S.

Clin Immunol. 2014 Jan;150(1):78-87. doi: 10.1016/j.clim.2013.11.003. Epub 2013 Nov 13.

PMID:
24333535
15.

Alterations in coxsackievirus and adenovirus receptor confer susceptibility to ventricular arrhythmia with an ischemic event.

Yasukawa H, Oba T, Fukumoto Y.

J Am Coll Cardiol. 2014 Feb 18;63(6):560-2. doi: 10.1016/j.jacc.2013.12.001. Epub 2013 Dec 8. No abstract available.

16.

Identification of photoactivated adenylyl cyclases in Naegleria australiensis and BLUF-containing protein in Naegleria fowleri.

Yasukawa H, Sato A, Kita A, Kodaira K, Iseki M, Takahashi T, Shibusawa M, Watanabe M, Yagita K.

J Gen Appl Microbiol. 2013;59(5):361-9.

17.

SOCS3: A novel therapeutic target for cardioprotection.

Yasukawa H, Nagata T, Oba T, Imaizumi T.

JAKSTAT. 2012 Oct 1;1(4):234-40. doi: 10.4161/jkst.22435. Review.

18.

Screening for Fabry disease in patients with left ventricular hypertrophy.

Mawatari K, Yasukawa H, Oba T, Nagata T, Togawa T, Tsukimura T, Kyogoku S, Ohshima H, Minami T, Sugi Y, Sakuraba H, Imaizumi T.

Int J Cardiol. 2013 Aug 10;167(3):1059-61. doi: 10.1016/j.ijcard.2012.10.076. Epub 2012 Nov 18. No abstract available.

PMID:
23168011
19.

Photomanipulation of antibiotic susceptibility and biofilm formation of Escherichia coli heterologously expressing photoactivated adenylyl cyclase.

Yasukawa H, Konno N, Haneda Y, Yamamori B, Iseki M, Shibusawa M, Ono Y, Kodaira K, Funada H, Watanabe M.

J Gen Appl Microbiol. 2012;58(3):183-90.

20.

Transient reduction and activation of circulating dendritic cells in patients with acute myocardial infarction.

Fukui D, Yasukawa H, Sugi Y, Oba T, Nagata T, Kyogoku S, Futamata N, Yokoyama T, Yokoyama S, Kai H, Ueno T, Kage M, Imaizumi T.

Int J Cardiol. 2012 Oct 18;160(3):216-9. doi: 10.1016/j.ijcard.2012.06.070. Epub 2012 Jul 27.

PMID:
22841473
21.

Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice.

Ohmura H, Yasukawa H, Minami T, Sugi Y, Oba T, Nagata T, Kyogoku S, Ohshima H, Aoki H, Imaizumi T.

Hypertens Res. 2012 Nov;35(11):1063-8. doi: 10.1038/hr.2012.92. Epub 2012 Jul 5.

PMID:
22763477
22.

SOCS, Inflammation, and Autoimmunity.

Yoshimura A, Suzuki M, Sakaguchi R, Hanada T, Yasukawa H.

Front Immunol. 2012 Mar 12;3:20. doi: 10.3389/fimmu.2012.00020. eCollection 2012.

23.

JAK's SOCS: a mechanism of inhibition.

Yoshimura A, Yasukawa H.

Immunity. 2012 Feb 24;36(2):157-9. doi: 10.1016/j.immuni.2012.01.010.

24.

Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction.

Oba T, Yasukawa H, Hoshijima M, Sasaki K, Futamata N, Fukui D, Mawatari K, Nagata T, Kyogoku S, Ohshima H, Minami T, Nakamura K, Kang D, Yajima T, Knowlton KU, Imaizumi T.

J Am Coll Cardiol. 2012 Feb 28;59(9):838-52. doi: 10.1016/j.jacc.2011.10.887.

25.

Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130-dependent manner accompanied by contractile dysfunction and ventricular arrhythmias.

Yajima T, Murofushi Y, Zhou H, Park S, Housman J, Zhong ZH, Nakamura M, Machida M, Hwang KK, Gu Y, Dalton ND, Yajima T, Yasukawa H, Peterson KL, Knowlton KU.

Circulation. 2011 Dec 13;124(24):2690-701. doi: 10.1161/CIRCULATIONAHA.111.028498. Epub 2011 Nov 14.

26.

Pioglitazone attenuates atherosclerotic plaque inflammation in patients with impaired glucose tolerance or diabetes a prospective, randomized, comparator-controlled study using serial FDG PET/CT imaging study of carotid artery and ascending aorta.

Mizoguchi M, Tahara N, Tahara A, Nitta Y, Kodama N, Oba T, Mawatari K, Yasukawa H, Kaida H, Ishibashi M, Hayabuchi N, Harada H, Ikeda H, Yamagishi S, Imaizumi T.

JACC Cardiovasc Imaging. 2011 Oct;4(10):1110-8. doi: 10.1016/j.jcmg.2011.08.007.

27.

Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction.

Hiwatashi K, Tamiya T, Hasegawa E, Fukaya T, Hashimoto M, Kakoi K, Kashiwagi I, Kimura A, Inoue N, Morita R, Yasukawa H, Yoshimura A.

Cancer Lett. 2011 Sep 28;308(2):172-80. doi: 10.1016/j.canlet.2011.04.024. Epub 2011 May 31.

PMID:
21624767
28.

Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: regulation of T-cell inflammation by SOCS1 and SOCS3.

Tamiya T, Kashiwagi I, Takahashi R, Yasukawa H, Yoshimura A.

Arterioscler Thromb Vasc Biol. 2011 May;31(5):980-5. doi: 10.1161/ATVBAHA.110.207464. Review.

PMID:
21508344
29.

Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling.

Metlakunta AS, Sahu M, Yasukawa H, Dhillon SS, Belsham DD, Yoshimura A, Sahu A.

Am J Physiol Regul Integr Comp Physiol. 2011 May;300(5):R1185-93. doi: 10.1152/ajpregu.00794.2010. Epub 2011 Feb 16.

30.

Factors associated with plasma ghrelin level in Japanese general population.

Nanjo Y, Adachi H, Hirai Y, Enomoto M, Fukami A, Otsuka M, Yoshikawa K, Yokoi K, Ogata K, Tsukagawa E, Kasahara A, Murayama K, Yasukawa H, Kojima M, Imaizumi T.

Clin Endocrinol (Oxf). 2011 Apr;74(4):453-8. doi: 10.1111/j.1365-2265.2010.03938.x.

PMID:
21092051
31.

Silent information regulator 2 proteins encoded by Cryptosporidium parasites.

Yasukawa H, Yagita K.

Parasitol Res. 2010 Aug;107(3):707-12. doi: 10.1007/s00436-010-1925-8. Epub 2010 Jun 19.

PMID:
20563732
32.

Reduction and activation of circulating dendritic cells in patients with decompensated heart failure.

Sugi Y, Yasukawa H, Kai H, Fukui D, Futamata N, Mawatari K, Oba T, Nagata N, Kyougoku S, Koga M, Imaizumi T.

Int J Cardiol. 2011 Mar 3;147(2):258-64. doi: 10.1016/j.ijcard.2009.09.524. Epub 2009 Nov 17.

PMID:
19923020
33.

Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats.

Takemiya K, Kai H, Yasukawa H, Tahara N, Kato S, Imaizumi T.

Basic Res Cardiol. 2010 May;105(3):409-17. doi: 10.1007/s00395-009-0065-8. Epub 2009 Oct 17.

PMID:
19838762
34.

Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis.

Taleb S, Romain M, Ramkhelawon B, Uyttenhove C, Pasterkamp G, Herbin O, Esposito B, Perez N, Yasukawa H, Van Snick J, Yoshimura A, Tedgui A, Mallat Z.

J Exp Med. 2009 Sep 28;206(10):2067-77. doi: 10.1084/jem.20090545. Epub 2009 Sep 8.

35.

Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis.

Taniguchi K, Sasaki K, Watari K, Yasukawa H, Imaizumi T, Ayada T, Okamoto F, Ishizaki T, Kato R, Kohno R, Kimura H, Sato Y, Ono M, Yonemitsu Y, Yoshimura A.

PLoS One. 2009;4(5):e5467. doi: 10.1371/journal.pone.0005467. Epub 2009 May 8.

36.

Analysis of Sir2E in the cellular slime mold Dictyostelium discoideum: cellular localization, spatial expression and overexpression.

Katayama T, Yasukawa H.

Dev Growth Differ. 2008 Oct;50(8):645-52. doi: 10.1111/j.1440-169X.2008.01062.x. Epub 2008 Aug 13.

PMID:
18707607
37.

Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis.

Torisu T, Nakaya M, Watanabe S, Hashimoto M, Yoshida H, Chinen T, Yoshida R, Okamoto F, Hanada T, Torisu K, Takaesu G, Kobayashi T, Yasukawa H, Yoshimura A.

Hepatology. 2008 May;47(5):1644-54. doi: 10.1002/hep.22214.

PMID:
18393318
38.

Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads.

Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A.

J Immunol. 2008 Mar 15;180(6):3746-56.

39.
40.

Postnatal blocking of interferon-gamma function prevented atherosclerotic plaque formation in apolipoprotein E-knockout mice.

Koga M, Kai H, Yasukawa H, Kato S, Yamamoto T, Kawai Y, Kusaba K, Seki Y, Kai M, Egashira K, Kataoka Y, Imaizumi T.

Hypertens Res. 2007 Mar;30(3):259-67.

PMID:
17510508
41.

Inhibition of progression and stabilization of plaques by postnatal interferon-gamma function blocking in ApoE-knockout mice.

Koga M, Kai H, Yasukawa H, Yamamoto T, Kawai Y, Kato S, Kusaba K, Kai M, Egashira K, Kataoka Y, Imaizumi T.

Circ Res. 2007 Aug 17;101(4):348-56. Epub 2007 May 10.

PMID:
17495225
42.

Inhibition of intrinsic interferon-gamma function prevents neointima formation after balloon injury.

Kusaba K, Kai H, Koga M, Takayama N, Ikeda A, Yasukawa H, Seki Y, Egashira K, Imaizumi T.

Hypertension. 2007 Apr;49(4):909-15. Epub 2007 Feb 19.

PMID:
17309951
43.

Interleukin-6-induced activation of signal transducer and activator of transcription-3 in ruptured rotator cuff tendon.

Nakama K, Gotoh M, Yamada T, Mitsui Y, Yasukawa H, Imaizumi T, Higuchi F, Nagata K.

J Int Med Res. 2006 Nov-Dec;34(6):624-31.

PMID:
17294994
44.

Pressure overload-induced transient oxidative stress mediates perivascular inflammation and cardiac fibrosis through angiotensin II.

Kai H, Mori T, Tokuda K, Takayama N, Tahara N, Takemiya K, Kudo H, Sugi Y, Fukui D, Yasukawa H, Kuwahara F, Imaizumi T.

Hypertens Res. 2006 Sep;29(9):711-8.

PMID:
17249527
45.

Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling.

Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton KU.

Circulation. 2006 Nov 28;114(22):2364-73. Epub 2006 Nov 13.

PMID:
17101849
46.

Comedolytic effect of topically applied active vitamin D3 analogue on pseudocomedones in the rhino mouse.

Hayashi N, Watanabe H, Yasukawa H, Uratsuji H, Kanazawa H, Ishimaru M, Kotera N, Akatsuka M, Kawashima M.

Br J Dermatol. 2006 Nov;155(5):895-901.

PMID:
17034516
47.

Decrease in rat internal anal pressure with the use of a topical ointment containing a killed E. coli culture suspension.

Kido H, Yasukawa H, Hirota T, Shindo A, Naruse T.

Int J Colorectal Dis. 2007 Mar;22(3):271-6. Epub 2006 Apr 21.

PMID:
16628409
48.

Platelet P-selectin plays an important role in arterial thrombogenesis by forming large stable platelet-leukocyte aggregates.

Yokoyama S, Ikeda H, Haramaki N, Yasukawa H, Murohara T, Imaizumi T.

J Am Coll Cardiol. 2005 Apr 19;45(8):1280-6.

49.

HMG-CoA reductase inhibitor protects against in vivo arterial thrombosis by augmenting platelet-derived nitric oxide release in rats.

Yokoyama S, Ikeda H, Haramaki N, Yasukawa H, Katoh A, Imaizumi T.

J Cardiovasc Pharmacol. 2005 Apr;45(4):375-81.

PMID:
15772528
50.

Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats.

Tahara N, Kai H, Niiyama H, Mori T, Sugi Y, Takayama N, Yasukawa H, Numaguchi Y, Matsui H, Okumura K, Imaizumi T.

Hum Gene Ther. 2004 Dec;15(12):1270-8.

PMID:
15684702

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