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Items: 1 to 50 of 89

1.

A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.

Ding H, Kiguchi N, Yasuda D, Daga PR, Polgar WE, Lu JJ, Czoty PW, Kishioka S, Zaveri NT, Ko MC.

Sci Transl Med. 2018 Aug 29;10(456). pii: eaar3483. doi: 10.1126/scitranslmed.aar3483.

PMID:
30158150
2.

[Hit-to-Lead in Academia: Discovery of a Protein-Protein Interaction Inhibitor of Keap1-Nrf2].

Yasuda D, Obata R, Takahashi K, Ohe T, Mashino T.

Yakugaku Zasshi. 2018;138(8):1059-1065. doi: 10.1248/yakushi.17-00211-5. Review. Japanese.

3.

[Young Innovators Driving the Next Generation of Academic Drug Discovery].

Matsumaru T, Yasuda D.

Yakugaku Zasshi. 2018;138(8):1025-1026. doi: 10.1248/yakushi.17-00211-F. Japanese. No abstract available.

4.

A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis.

Niino T, Tago K, Yasuda D, Takahashi K, Mashino T, Tamura H, Funakoshi-Tago M.

Biochem Pharmacol. 2018 Sep;155:182-197. doi: 10.1016/j.bcp.2018.06.021. Epub 2018 Jun 22.

PMID:
29940171
5.

Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor.

Yasuda D, Yuasa A, Obata R, Nakajima M, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T.

Bioorg Med Chem Lett. 2017 Nov 15;27(22):5006-5009. doi: 10.1016/j.bmcl.2017.10.008. Epub 2017 Oct 6.

PMID:
29037947
6.

Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling.

Tanishima M, Takashima S, Honda A, Yasuda D, Tanikawa T, Ishii S, MaruYama T.

J Biol Chem. 2017 Oct 20;292(42):17250-17257. doi: 10.1074/jbc.M117.813899. Epub 2017 Sep 7.

PMID:
28882891
7.

Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact.

Takara K, Eino D, Ando K, Yasuda D, Naito H, Tsukada Y, Iba T, Wakabayashi T, Muramatsu F, Kidoya H, Fukuhara S, Mochizuki N, Ishii S, Kishima H, Takakura N.

Cell Rep. 2017 Aug 29;20(9):2072-2086. doi: 10.1016/j.celrep.2017.07.080.

8.

The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats.

Yuan M, Malagon AM, Yasuda D, Belluzzi JD, Leslie FM, Zaveri NT.

Behav Brain Res. 2017 Aug 30;333:251-257. doi: 10.1016/j.bbr.2017.07.004. Epub 2017 Jul 8.

9.

Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption.

Kallupi M, Shen Q, de Guglielmo G, Yasuda D, Journigan VB, Zaveri NT, Ciccocioppo R.

Addict Biol. 2018 Mar;23(2):585-595. doi: 10.1111/adb.12513. Epub 2017 Jun 21.

10.

Preparation and antioxidant/pro-oxidant activities of 3-monosubstituted 5-hydroxyoxindole derivatives.

Yasuda D, Takahashi K, Ohe T, Nakamura S, Mashino T.

J Clin Biochem Nutr. 2016 Nov;59(3):165-173. Epub 2016 Aug 24.

11.

Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity.

Yasuda D, Nakajima M, Yuasa A, Obata R, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T.

Bioorg Med Chem Lett. 2016 Dec 15;26(24):5956-5959. doi: 10.1016/j.bmcl.2016.10.083. Epub 2016 Oct 27.

PMID:
27839920
12.

In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations.

Ferrari F, Cerlesi MC, Malfacini D, Asth L, Gavioli EC, Journigan BV, Kamakolanu UG, Meyer ME, Yasuda D, Polgar WE, Rizzi A, Guerrini R, Ruzza C, Zaveri NT, Calo G.

Eur J Pharmacol. 2016 Dec 15;793:1-13. doi: 10.1016/j.ejphar.2016.10.025. Epub 2016 Oct 22.

13.

Efficacy and safety of repaglinide added to sitagliptin in Japanese patients with type 2 diabetes: A randomized 24-week open-label clinical trial.

Nishimura A, Usui S, Kumashiro N, Uchino H, Yamato A, Yasuda D, Nagasawa K, Okubo M, Mori Y, Hirose T.

Endocr J. 2016 Dec 30;63(12):1087-1098. doi: 10.1507/endocrj.EJ16-0291. Epub 2016 Sep 17.

14.

Comparison of serum lipid management between elderly and non-elderly patients with and without coronary heart disease (CHD).

Shimizu R, Torii H, Yasuda D, Hiraoka Y, Furukawa Y, Yoshimoto A, Iwakura T, Matsuoka N, Tomii K, Kohara N, Hashida T, Kume N.

Prev Med Rep. 2016 Jun 8;4:192-8. doi: 10.1016/j.pmedr.2016.06.006. eCollection 2016 Dec.

15.

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.

Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T, Motohashi H, Waguri S, Soga T, Yamamoto M, Tanaka K, Komatsu M.

Nat Commun. 2016 Jun 27;7:12030. doi: 10.1038/ncomms12030.

16.

Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice.

Vang D, Paul JA, Nguyen J, Tran H, Vincent L, Yasuda D, Zaveri NT, Gupta K.

Haematologica. 2015 Dec;100(12):1517-25. doi: 10.3324/haematol.2015.128736. Epub 2015 Aug 20.

17.

High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice.

Khroyan TV, Yasuda D, Toll L, Polgar WE, Zaveri NT.

Biochem Pharmacol. 2015 Oct 15;97(4):531-541. doi: 10.1016/j.bcp.2015.08.083. Epub 2015 Aug 7.

18.

The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells.

Igarashi H, Akahoshi N, Ohto-Nakanishi T, Yasuda D, Ishii S.

Sci Rep. 2015 Jun 19;5:11410. doi: 10.1038/srep11410.

19.

Relationship between sleep disordered breathing and diabetic retinopathy: Analysis of 136 patients with diabetes.

Nishimura A, Kasai T, Tamura H, Yamato A, Yasuda D, Nagasawa K, Okubo M, Narui K, Mori Y.

Diabetes Res Clin Pract. 2015 Aug;109(2):306-11. doi: 10.1016/j.diabres.2015.05.015. Epub 2015 May 12.

PMID:
26028572
20.

Serum Lipid Goal Attainment in Chronic Kidney Disease (CKD) Patients under the Japan Atherosclerosis Society (JAS) 2012 Guidelines.

Shimizu R, Torii H, Yasuda D, Hiraoka Y, Kitada N, Hashida T, Yoshimoto A, Kita T, Kume N.

J Atheroscler Thromb. 2015;22(9):949-57. doi: 10.5551/jat.29165. Epub 2015 Apr 4.

21.

The atypical N-glycosylation motif, Asn-Cys-Cys, in human GPR109A is required for normal cell surface expression and intracellular signaling.

Yasuda D, Imura Y, Ishii S, Shimizu T, Nakamura M.

FASEB J. 2015 Jun;29(6):2412-22. doi: 10.1096/fj.14-267096. Epub 2015 Feb 17.

22.

AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology.

Cippitelli A, Wu J, Gaiolini KA, Mercatelli D, Schoch J, Gorman M, Ramirez A, Ciccocioppo R, Khroyan TV, Yasuda D, Zaveri NT, Pascual C, Xie XS, Toll L.

Br J Pharmacol. 2015 Apr;172(7):1834-45. doi: 10.1111/bph.13034. Epub 2015 Jan 23.

23.

Biomechanical factors associated with mandibular cantilevers: analysis with three-dimensional finite element models.

Gonda T, Yasuda D, Ikebe K, Maeda Y.

Int J Oral Maxillofac Implants. 2014 Nov-Dec;29(6):e275-82. doi: 10.11607/jomi.3663.

PMID:
25397809
24.

Functional characterization of AT-1001, an α3β4 nicotinic acetylcholine receptor ligand, at human α3β4 and α4β2 nAChR.

Zaveri NT, Bertrand S, Yasuda D, Bertrand D.

Nicotine Tob Res. 2015 Mar;17(3):361-7. doi: 10.1093/ntr/ntu170. Epub 2014 Sep 1.

25.

[Specific ligands rescue cell-surface expression of ER-retained GPCR].

Yasuda D, Nakamura M.

Seikagaku. 2013 Nov;85(11):1007-12. Review. Japanese. No abstract available.

PMID:
24364255
26.

Antioxidant activities of 5-hydroxyoxindole and its 3-hydroxy-3-phenacyl derivatives: the suppression of lipid peroxidation and intracellular oxidative stress.

Yasuda D, Takahashi K, Ohe T, Nakamura S, Mashino T.

Bioorg Med Chem. 2013 Dec 15;21(24):7709-14. doi: 10.1016/j.bmc.2013.10.021. Epub 2013 Oct 30.

PMID:
24216095
27.

Amino acid residues of G-protein-coupled receptors critical for endoplasmic reticulum export and trafficking.

Nakamura M, Yasuda D, Hirota N, Yamamoto T, Yamaguchi S, Shimizu T, Nagamune T.

Methods Enzymol. 2013;521:203-16. doi: 10.1016/B978-0-12-391862-8.00011-9.

PMID:
23351741
28.

Characterization of brassinosteroid-regulated proteins in a nuclear-enriched fraction of Arabidopsis suspension-cultured cells.

Shigeta T, Yasuda D, Mori T, Yoshimitsu Y, Nakamura Y, Yoshida S, Asami T, Okamoto S, Matsuo T.

Plant Physiol Biochem. 2011 Sep;49(9):985-95. doi: 10.1016/j.plaphy.2011.04.012. Epub 2011 May 4.

PMID:
21571540
29.

Randomized controlled trial: roxatidine vs omeprazole for non-erosive reflux disease.

Nakamura K, Akiho H, Ochiai T, Motomura Y, Higuchi N, Okamoto R, Matsui N, Yasuda D, Akahoshi K, Kabemura T, Ihara E, Harada N, Ito T, Takayanagi R.

Hepatogastroenterology. 2010 May-Jun;57(99-100):497-500.

PMID:
20698216
30.

Specific ligands as pharmacological chaperones: The transport of misfolded G-protein coupled receptors to the cell surface.

Nakamura M, Yasuda D, Hirota N, Shimizu T.

IUBMB Life. 2010 Jun;62(6):453-9. doi: 10.1002/iub.344. Review.

31.

A SNP of NPC1L1 affects cholesterol absorption in Japanese.

Maeda T, Honda A, Ishikawa T, Kinoshita M, Mashimo Y, Takeoka Y, Yasuda D, Kusano J, Tsukamoto K, Matsuzaki Y, Teramoto T.

J Atheroscler Thromb. 2010 Apr 30;17(4):356-60. Epub 2010 Apr 7.

32.

Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor.

Hirota N, Yasuda D, Hashidate T, Yamamoto T, Yamaguchi S, Nagamune T, Nagase T, Shimizu T, Nakamura M.

J Biol Chem. 2010 Feb 19;285(8):5931-40. doi: 10.1074/jbc.M109.066282. Epub 2009 Dec 10.

33.

Natural course of the remnant hepatic functional reserve as estimated by technetium-99m-galactosyl human serum albumin scintigraphy after a hepatectomy.

Shimizu Y, Aoki T, Kusano T, Matsuda K, Enami Y, Yasuda D, Koizumi T, Niiya T, Murai N, Kato H, Kusano M, Murakami M.

J Gastroenterol. 2010 Mar;45(3):308-16. doi: 10.1007/s00535-009-0144-5. Epub 2009 Nov 7.

PMID:
19894018
34.

Intraoperative fluorescent imaging using indocyanine green for liver mapping and cholangiography.

Aoki T, Murakami M, Yasuda D, Shimizu Y, Kusano T, Matsuda K, Niiya T, Kato H, Murai N, Otsuka K, Kusano M, Kato T.

J Hepatobiliary Pancreat Sci. 2010 Sep;17(5):590-4. doi: 10.1007/s00534-009-0197-0. Epub 2009 Oct 21.

PMID:
19844652
35.

Hepatoprotective amide constituents from the fruit of Piper chaba: Structural requirements, mode of action, and new amides.

Matsuda H, Ninomiya K, Morikawa T, Yasuda D, Yamaguchi I, Yoshikawa M.

Bioorg Med Chem. 2009 Oct 15;17(20):7313-23. doi: 10.1016/j.bmc.2009.08.050. Epub 2009 Aug 29.

PMID:
19775895
36.

Increased serum apolipoprotein B48 concentration in patients with metabolic syndrome.

Kinoshita M, Ohnishi H, Maeda T, Yoshimura N, Takeoka Y, Yasuda D, Kusano J, Mashimo Y, Saito S, Shimamoto K, Teramoto T.

J Atheroscler Thromb. 2009 Aug;16(4):517-22. Epub 2009 Aug 27.

37.

Characterization of start-up performance and archaeal community shifts during anaerobic self-degradation of waste-activated sludge.

Kobayashi T, Yasuda D, Li YY, Kubota K, Harada H, Yu HQ.

Bioresour Technol. 2009 Nov;100(21):4981-8. doi: 10.1016/j.biortech.2009.05.043. Epub 2009 Jun 24.

PMID:
19556123
38.

[Dislipidemia and steatohepatitis with visceral fat].

Yasuda D, Maeda T, Teramoto T.

Nihon Rinsho. 2009 Feb;67(2):344-9. Japanese.

PMID:
19202910
39.

Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum.

Yasuda D, Okuno T, Yokomizo T, Hori T, Hirota N, Hashidate T, Miyano M, Shimizu T, Nakamura M.

FASEB J. 2009 May;23(5):1470-81. doi: 10.1096/fj.08-125385. Epub 2009 Jan 6.

PMID:
19126593
40.

Sentinel node mapping guided by indocyanine green fluorescence imaging in gastric cancer.

Tajima Y, Yamazaki K, Masuda Y, Kato M, Yasuda D, Aoki T, Kato T, Murakami M, Miwa M, Kusano M.

Ann Surg. 2009 Jan;249(1):58-62. doi: 10.1097/SLA.0b013e3181927267.

PMID:
19106676
41.

Cold preservation of the liver with oxygenation by a two-layer method.

Odaira M, Aoki T, Miyamoto Y, Yasuhara R, Jin Z, Yu J, Nishino N, Yamada K, Kusano T, Hayashi K, Yasuda D, Koizumi T, Mitamura K, Enami Y, Niiya T, Murai N, Kato H, Shimizu Y, Kamijyo R, Kusano M.

J Surg Res. 2009 Apr;152(2):209-17. doi: 10.1016/j.jss.2008.03.034. Epub 2008 Apr 23.

PMID:
18701117
42.

Myo-inositol treatment increases serum plasmalogens and decreases small dense LDL, particularly in hyperlipidemic subjects with metabolic syndrome.

Maeba R, Hara H, Ishikawa H, Hayashi S, Yoshimura N, Kusano J, Takeoka Y, Yasuda D, Okazaki T, Kinoshita M, Teramoto T.

J Nutr Sci Vitaminol (Tokyo). 2008 Jun;54(3):196-202.

43.

Medicinal foodstuffs. XXXIV. Structures of new prenylchalcones and prenylflavanones with TNF-alpha and aminopeptidase N inhibitory activities from Boesenbergia rotunda.

Morikawa T, Funakoshi K, Ninomiya K, Yasuda D, Miyagawa K, Matsuda H, Yoshikawa M.

Chem Pharm Bull (Tokyo). 2008 Jul;56(7):956-62.

44.

Image-guided liver mapping using fluorescence navigation system with indocyanine green for anatomical hepatic resection.

Aoki T, Yasuda D, Shimizu Y, Odaira M, Niiya T, Kusano T, Mitamura K, Hayashi K, Murai N, Koizumi T, Kato H, Enami Y, Miwa M, Kusano M.

World J Surg. 2008 Aug;32(8):1763-7. doi: 10.1007/s00268-008-9620-y.

PMID:
18543027
45.

Intranasal hemangiosarcoma in a dog.

Fujita M, Takaishi Y, Yasuda D, Hasegawa D, Taniguchi A, Takahashi K, Orima H.

J Vet Med Sci. 2008 May;70(5):525-8.

46.

Cyst wall resection and ablation by hand-assisted laparoscopic surgery combined with argon plasma coagulator for huge hepatic cysts.

Aoki T, Kato T, Yasuda D, Shimizu Y, Murai N, Sato A, Koizumi T, Otsuka K, Kusano T, Hayashi K, Murakami M, Kusano M.

Int Surg. 2007 Nov-Dec;92(6):361-6.

PMID:
18402132
47.

Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-alpha-induced cell death in mouse hepatocytes.

Matsuda H, Ninomiya K, Morikawa T, Yasuda D, Yamaguchi I, Yoshikawa M.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2038-42. doi: 10.1016/j.bmcl.2008.01.101. Epub 2008 Jan 31.

PMID:
18289853
48.

Microencapsule technique protects hepatocytes from cryoinjury.

Kusano T, Aoki T, Yasuda D, Matsumoto S, Jin Z, Nishino N, Hayashi K, Odaira M, Yamada K, Koizumi T, Izumida Y, Mitamura K, Enami Y, Niiya T, Murai N, Kato H, Shimizu Y, Kou K, Furukawa Y, Matsusita M, Todo S, Shioda S, Kusano M.

Hepatol Res. 2008 Jun;38(6):593-600. Epub 2007 Dec 7.

PMID:
18070054
49.

Hepatocyte transplantation from steatotic liver in a rat model.

Hayashi K, Aoki T, Jin Z, Wang H, Nishino N, Kusano T, Yasuda D, Koizumi T, Enami Y, Odaira M, Yamada K, Mitamura K, Niiya T, Murai N, Kato H, Shimizu Y, Kusano M.

J Surg Res. 2007 Sep;142(1):104-12. Epub 2007 Jun 29.

PMID:
17604052
50.

Long-term maintenance of the drug transport activity in cryopreservation of microencapsulated rat hepatocytes.

Koizumi T, Aoki T, Kobayashi Y, Yasuda D, Izumida Y, Jin Z, Nishino N, Shimizu Y, Kato H, Murai N, Niiya T, Enami Y, Mitamura K, Yamamoto T, Kusano M.

Cell Transplant. 2007;16(1):67-73.

PMID:
17436856

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