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Items: 36


Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate-Two randomized Phase II clinical trials in 18 to 49 and ≥50 years old adults.

Pillet S, Couillard J, Trépanier S, Poulin JF, Yassine-Diab B, Guy B, Ward BJ, Landry N.

PLoS One. 2019 Jun 5;14(6):e0216533. doi: 10.1371/journal.pone.0216533. eCollection 2019.


The effect of dielectrophoresis on living cells: crossover frequencies and deregulation in gene expression.

Nerguizian V, Stiharu I, Al-Azzam N, Yassine-Diab B, Alazzam A.

Analyst. 2019 Jun 21;144(12):3853-3860. doi: 10.1039/c9an00320g. Epub 2019 May 17.


Humoral and cell-mediated immune responses to H5N1 plant-made virus-like particle vaccine are differentially impacted by alum and GLA-SE adjuvants in a Phase 2 clinical trial.

Pillet S, Aubin É, Trépanier S, Poulin JF, Yassine-Diab B, Ter Meulen J, Ward BJ, Landry N.

NPJ Vaccines. 2018 Jan 23;3:3. doi: 10.1038/s41541-017-0043-3. eCollection 2018.


Tn-MUC1 DC Vaccination of Rhesus Macaques and a Phase I/II Trial in Patients with Nonmetastatic Castrate-Resistant Prostate Cancer.

Scheid E, Major P, Bergeron A, Finn OJ, Salter RD, Eady R, Yassine-Diab B, Favre D, Peretz Y, Landry C, Hotte S, Mukherjee SD, Dekaban GA, Fink C, Foster PJ, Gaudet J, Gariepy J, Sekaly RP, Lacombe L, Fradet Y, Foley R.

Cancer Immunol Res. 2016 Oct;4(10):881-892. Epub 2016 Sep 7.


A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults.

Pillet S, Aubin É, Trépanier S, Bussière D, Dargis M, Poulin JF, Yassine-Diab B, Ward BJ, Landry N.

Clin Immunol. 2016 Jul;168:72-87. doi: 10.1016/j.clim.2016.03.008. Epub 2016 Mar 14.


Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens.

Landry N, Pillet S, Favre D, Poulin JF, Trépanier S, Yassine-Diab B, Ward BJ.

Clin Immunol. 2014 Oct;154(2):164-77. doi: 10.1016/j.clim.2014.08.003. Epub 2014 Aug 14.


MMTV superantigens coerce an unconventional topology between the TCR and MHC class II.

Fortin JS, Genève L, Gauthier C, Shoukry NH, Azar GA, Younes S, Yassine-Diab B, Sékaly RP, Fremont DH, Thibodeau J.

J Immunol. 2014 Feb 15;192(4):1896-906. doi: 10.4049/jimmunol.1203130. Epub 2014 Jan 22.


Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection.

Breton G, Chomont N, Takata H, Fromentin R, Ahlers J, Filali-Mouhim A, Riou C, Boulassel MR, Routy JP, Yassine-Diab B, Sékaly RP.

J Immunol. 2013 Sep 1;191(5):2194-204. doi: 10.4049/jimmunol.1200646. Epub 2013 Aug 5.


Autologous HIV-1 clade-B Nef peptides elicit increased frequency, breadth and function of CD8+ T-cells compared to consensus peptides.

Doroudchi M, Yegorov O, Baumgartner T, Kernaleguen AE, Breton G, Ndongala ML, Boulassel MR, Routy JP, Bernard NF, Sékaly RP, Yassine-Diab B.

PLoS One. 2012;7(11):e49562. doi: 10.1371/journal.pone.0049562. Epub 2012 Nov 19.


CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction.

Peretz Y, He Z, Shi Y, Yassine-Diab B, Goulet JP, Bordi R, Filali-Mouhim A, Loubert JB, El-Far M, Dupuy FP, Boulassel MR, Tremblay C, Routy JP, Bernard N, Balderas R, Haddad EK, Sékaly RP.

PLoS Pathog. 2012;8(8):e1002840. doi: 10.1371/journal.ppat.1002840. Epub 2012 Aug 16.


Unique features of memory T cells in HIV elite controllers: a systems biology perspective.

Fonseca SG, Procopio FA, Goulet JP, Yassine-Diab B, Ancuta P, Sékaly RP.

Curr Opin HIV AIDS. 2011 May;6(3):188-96. doi: 10.1097/COH.0b013e32834589a1. Review.


Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy.

Routy JP, Boulassel MR, Yassine-Diab B, Nicolette C, Healey D, Jain R, Landry C, Yegorov O, Tcherepanova I, Monesmith T, Finke L, Sékaly RP.

Clin Immunol. 2010 Feb;134(2):140-7. doi: 10.1016/j.clim.2009.09.009. Epub 2009 Nov 4.


siRNA knockdown of PD-L1 and PD-L2 in monocyte-derived dendritic cells only modestly improves proliferative responses to Gag by CD8(+) T cells from HIV-1-infected individuals.

Breton G, Yassine-Diab B, Cohn L, Boulassel MR, Routy JP, Sékaly RP, Steinman RM.

J Clin Immunol. 2009 Sep;29(5):637-45. doi: 10.1007/s10875-009-9313-9. Epub 2009 Jun 27.


HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.

Chomont N, El-Far M, Ancuta P, Trautmann L, Procopio FA, Yassine-Diab B, Boucher G, Boulassel MR, Ghattas G, Brenchley JM, Schacker TW, Hill BJ, Douek DC, Routy JP, Haddad EK, Sékaly RP.

Nat Med. 2009 Aug;15(8):893-900. doi: 10.1038/nm.1972. Epub 2009 Jun 21.


Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells.

Streeck H, Jolin JS, Qi Y, Yassine-Diab B, Johnson RC, Kwon DS, Addo MM, Brumme C, Routy JP, Little S, Jessen HK, Kelleher AD, Hecht FM, Sekaly RP, Rosenberg ES, Walker BD, Carrington M, Altfeld M.

J Virol. 2009 Aug;83(15):7641-8. doi: 10.1128/JVI.00182-09. Epub 2009 May 20.


Cellular and molecular mechanisms of memory T-cell survival.

Tanel A, Fonseca SG, Yassine-Diab B, Bordi R, Zeidan J, Shi Y, Benne C, Sékaly RP.

Expert Rev Vaccines. 2009 Mar;8(3):299-312. doi: 10.1586/14760584.8.3.299. Review.


HIV Gag p24 specific responses secreting IFN-gamma and/or IL-2 in treatment-naïve individuals in acute infection early disease (AIED) are associated with low viral load.

Ndongala ML, Peretz Y, Boulet S, Doroudchi M, Yassine-Diab B, Boulassel MR, Rouleau D, Tremblay C, LeBlanc R, Routy JP, Sékaly RP, Bernard NF.

Clin Immunol. 2009 May;131(2):277-87. doi: 10.1016/j.clim.2008.11.006. Epub 2009 Jan 8.


Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses.

Gaucher D, Therrien R, Kettaf N, Angermann BR, Boucher G, Filali-Mouhim A, Moser JM, Mehta RS, Drake DR 3rd, Castro E, Akondy R, Rinfret A, Yassine-Diab B, Said EA, Chouikh Y, Cameron MJ, Clum R, Kelvin D, Somogyi R, Greller LD, Balderas RS, Wilkinson P, Pantaleo G, Tartaglia J, Haddad EK, Sékaly RP.

J Exp Med. 2008 Dec 22;205(13):3119-31. doi: 10.1084/jem.20082292. Epub 2008 Dec 1.


Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection.

Salha MD, Cheynier R, Halwani R, McGrath H, Langaee TY, Yassine Diab B, Fournier J, Parenteau M, Edgar J, Ko D, Sherring A, Bogdanovic D, Sekaly RP, Rud EW.

Virology. 2008 Aug 1;377(2):239-47. doi: 10.1016/j.virol.2008.04.031.


Therapeutic vaccination with simian immunodeficiency virus (SIV)-DNA + IL-12 or IL-15 induces distinct CD8 memory subsets in SIV-infected macaques.

Halwani R, Boyer JD, Yassine-Diab B, Haddad EK, Robinson TM, Kumar S, Parkinson R, Wu L, Sidhu MK, Phillipson-Weiner R, Pavlakis GN, Felber BK, Lewis MG, Shen A, Siliciano RF, Weiner DB, Sekaly RP.

J Immunol. 2008 Jun 15;180(12):7969-79.


T-cell exhaustion in HIV infection.

El-Far M, Halwani R, Said E, Trautmann L, Doroudchi M, Janbazian L, Fonseca S, van Grevenynghe J, Yassine-Diab B, Sékaly RP, Haddad EK.

Curr HIV/AIDS Rep. 2008 Feb;5(1):13-9. Review.


Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection.

van Grevenynghe J, Procopio FA, He Z, Chomont N, Riou C, Zhang Y, Gimmig S, Boucher G, Wilkinson P, Shi Y, Yassine-Diab B, Said EA, Trautmann L, El Far M, Balderas RS, Boulassel MR, Routy JP, Haddad EK, Sekaly RP.

Nat Med. 2008 Mar;14(3):266-74. doi: 10.1038/nm1728. Epub 2008 Mar 2.


Persistent human immunodeficiency virus-1 antigenaemia affects the expression of interleukin-7Ralpha on central and effector memory CD4+ and CD8+ T cell subsets.

Mercier F, Boulassel MR, Yassine-Diab B, Tremblay C, Bernard NF, Sekaly RP, Routy JP.

Clin Exp Immunol. 2008 Apr;152(1):72-80. doi: 10.1111/j.1365-2249.2008.03610.x. Epub 2008 Feb 14.


Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles.

Streeck H, Lichterfeld M, Alter G, Meier A, Teigen N, Yassine-Diab B, Sidhu HK, Little S, Kelleher A, Routy JP, Rosenberg ES, Sekaly RP, Walker BD, Altfeld M.

J Virol. 2007 Jul;81(14):7725-31. Epub 2007 May 9.


[mRNA-transfected dendritic cells: a promising strategy in immunotherapy].

Maisnier-Patin K, Crabé S, Breton G, Dupuy FP, Yassine-Diab B, Sékaly RP.

Med Sci (Paris). 2007 Mar;23(3):279-84. French.


The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells.

Younes SA, Trautmann L, Yassine-Diab B, Kalfayan LH, Kernaleguen AE, Cameron TO, Boulassel R, Stern LJ, Routy JP, Grossman Z, Dumont AR, Sekaly RP.

J Immunol. 2007 Jan 15;178(2):788-97.


Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells.

Riou C, Yassine-Diab B, Van grevenynghe J, Somogyi R, Greller LD, Gagnon D, Gimmig S, Wilkinson P, Shi Y, Cameron MJ, Campos-Gonzalez R, Balderas RS, Kelvin D, Sekaly RP, Haddad EK.

J Exp Med. 2007 Jan 22;204(1):79-91. Epub 2006 Dec 26.


Generation and maintenance of human memory cells during viral infection.

Halwani R, Doroudchi M, Yassine-Diab B, Janbazian L, Shi Y, Said EA, Haddad EK, Sékaly RP.

Springer Semin Immunopathol. 2006 Nov;28(3):197-208. Epub 2006 Sep 12. Review.


IL-4 influences the differentiation and the susceptibility to activation-induced cell death of human naive CD8+ T cells.

Riou C, Dumont AR, Yassine-Diab B, Haddad EK, Sekaly RP.

Int Immunol. 2006 Jun;18(6):827-35. Epub 2006 Apr 12.


HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity.

Younes SA, Yassine-Diab B, Dumont AR, Boulassel MR, Grossman Z, Routy JP, Sekaly RP.

J Exp Med. 2003 Dec 15;198(12):1909-22.


Diminished proliferation of human immunodeficiency virus-specific CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2.

Iyasere C, Tilton JC, Johnson AJ, Younes S, Yassine-Diab B, Sekaly RP, Kwok WW, Migueles SA, Laborico AC, Shupert WL, Hallahan CW, Davey RT Jr, Dybul M, Vogel S, Metcalf J, Connors M.

J Virol. 2003 Oct;77(20):10900-9.


Cutting edge: detection of antigen-specific CD4+ T cells by HLA-DR1 oligomers is dependent on the T cell activation state.

Cameron TO, Cochran JR, Yassine-Diab B, Sékaly RP, Stern LJ.

J Immunol. 2001 Jan 15;166(2):741-5. Erratum in: J Immunol 2001 Feb 15;166(4):2887.


Biased T-cell receptor usage is associated with allelic variation in the MHC class II peptide binding groove.

Yassine-Diab B, Carmichael P, L'Faqihi FE, Lombardi G, Deacock S, de Préval C, Coppin H, Lechler RI.

Immunogenetics. 1999 Jun;49(6):532-40.


Substance P enhances cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) expression on cultured rheumatoid fibroblast-like synoviocytes.

Lambert N, Lescoulié PL, Yassine-Diab B, Enault G, Mazières B, De Préval C, Cantagrel A.

Clin Exp Immunol. 1998 Aug;113(2):269-75.


Residue 67 in the DRbeta1*0101 and DRbeta1*0103 chains strongly influences antigen presentation and DR-peptide molecular complex conformation.

L'Faqihi FE, Praud C, Yassine-Diab B, Enault G, Lakhdar-Ghazal F, de Préval C, Coppin H.

Tissue Antigens. 1998 Jan;51(1):10-9.


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