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The Sodium Channel Voltage Sensor Slides to Rest.

Yarov-Yarovoy V, DeCaen P.

Trends Pharmacol Sci. 2019 Sep 5. pii: S0165-6147(19)30195-6. doi: 10.1016/ [Epub ahead of print]


Opening TRPP2 (PKD2L1) requires the transfer of gating charges.

Ng LCT, Vien TN, Yarov-Yarovoy V, DeCaen PG.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15540-15549. doi: 10.1073/pnas.1902917116. Epub 2019 Jul 17.


A distinct structural mechanism underlies TRPV1 activation by piperine.

Dong Y, Yin Y, Vu S, Yang F, Yarov-Yarovoy V, Tian Y, Zheng J.

Biochem Biophys Res Commun. 2019 Aug 20;516(2):365-372. doi: 10.1016/j.bbrc.2019.06.039. Epub 2019 Jun 15.


Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers.

Yin Y, Dong Y, Vu S, Yang F, Yarov-Yarovoy V, Tian Y, Zheng J.

Br J Pharmacol. 2019 Sep;176(17):3364-3377. doi: 10.1111/bph.14766. Epub 2019 Jul 22.


Pathogenic effects of agrin V1727F mutation are isoform specific and decrease its expression and affinity for HSPGs and LRP4.

Rudell JB, Maselli RA, Yarov-Yarovoy V, Ferns MJ.

Hum Mol Genet. 2019 Aug 15;28(16):2648-2658. doi: 10.1093/hmg/ddz081.


Sensitivity to the two peptide bacteriocin plantaricin EF is dependent on CorC, a membrane-bound, magnesium/cobalt efflux protein.

Heeney DD, Yarov-Yarovoy V, Marco ML.

Microbiologyopen. 2019 Mar 19:e827. doi: 10.1002/mbo3.827. [Epub ahead of print]



Noskov SY, Yarov-Yarovoy V.

Neurosci Lett. 2019 May 1;700:1-2. doi: 10.1016/j.neulet.2019.02.040. Epub 2019 Feb 26. No abstract available.


Antibodies and venom peptides: new modalities for ion channels.

Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V.

Nat Rev Drug Discov. 2019 May;18(5):339-357. doi: 10.1038/s41573-019-0013-8. Review.


Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel.

Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Yarov-Yarovoy V.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2945-2954. doi: 10.1073/pnas.1817446116. Epub 2019 Feb 6.


The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel.

Yang F, Xiao X, Lee BH, Vu S, Yang W, Yarov-Yarovoy V, Zheng J.

Nat Commun. 2018 Jul 23;9(1):2879. doi: 10.1038/s41467-018-05339-6.


Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121).

Brown BM, Shim H, Zhang M, Yarov-Yarovoy V, Wulff H.

Mol Pharmacol. 2017 Oct;92(4):469-480. doi: 10.1124/mol.117.109421. Epub 2017 Jul 31.


A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel.

Tang C, Zhou X, Nguyen PT, Zhang Y, Hu Z, Zhang C, Yarov-Yarovoy V, DeCaen PG, Liang S, Liu Z.

FASEB J. 2017 Jul;31(7):3167-3178. doi: 10.1096/fj.201600882R. Epub 2017 Apr 11.


Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development.

Tanaka BS, Nguyen PT, Zhou EY, Yang Y, Yarov-Yarovoy V, Dib-Hajj SD, Waxman SG.

J Biol Chem. 2017 Jun 2;292(22):9262-9272. doi: 10.1074/jbc.M117.778779. Epub 2017 Apr 5.


In vivo optophysiology reveals that G-protein activation triggers osmotic swelling and increased light scattering of rod photoreceptors.

Zhang P, Zawadzki RJ, Goswami M, Nguyen PT, Yarov-Yarovoy V, Burns ME, Pugh EN Jr.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2937-E2946. doi: 10.1073/pnas.1620572114. Epub 2017 Mar 20.


Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore.

Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V.

Mol Pharmacol. 2017 Apr;91(4):392-402. doi: 10.1124/mol.116.108068. Epub 2017 Jan 26.


Potassium channels in the heart: structure, function and regulation.

Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V.

J Physiol. 2017 Apr 1;595(7):2209-2228. doi: 10.1113/JP272864. Epub 2016 Nov 13. Review.


Activity-Dependent Palmitoylation Controls SynDIG1 Stability, Localization, and Function.

Kaur I, Yarov-Yarovoy V, Kirk LM, Plambeck KE, Barragan EV, Ontiveros ES, Díaz E.

J Neurosci. 2016 Jul 20;36(29):7562-8. doi: 10.1523/JNEUROSCI.4859-14.2016.


A Large and Phylogenetically Diverse Class of Type 1 Opsins Lacking a Canonical Retinal Binding Site.

Becker EA, Yao AI, Seitzer PM, Kind T, Wang T, Eigenheer R, Shao KS, Yarov-Yarovoy V, Facciotti MT.

PLoS One. 2016 Jun 21;11(6):e0156543. doi: 10.1371/journal.pone.0156543. eCollection 2016.


Rational design and validation of a vanilloid-sensitive TRPV2 ion channel.

Yang F, Vu S, Yarov-Yarovoy V, Zheng J.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3657-66. doi: 10.1073/pnas.1604180113. Epub 2016 Jun 13.


Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels.

Tuluc P, Yarov-Yarovoy V, Benedetti B, Flucher BE.

Structure. 2016 Feb 2;24(2):261-71. doi: 10.1016/j.str.2015.11.011. Epub 2015 Dec 31.


Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels.

Sihn CR, Kim HJ, Woltz RL, Yarov-Yarovoy V, Yang PC, Xu J, Clancy CE, Zhang XD, Chiamvimonvat N, Yamoah EN.

J Biol Chem. 2016 Jan 29;291(5):2499-509. doi: 10.1074/jbc.M115.668236. Epub 2015 Oct 29.


A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1.

Yang S, Yang F, Wei N, Hong J, Li B, Luo L, Rong M, Yarov-Yarovoy V, Zheng J, Wang K, Lai R.

Nat Commun. 2015 Sep 30;6:8297. doi: 10.1038/ncomms9297.


Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution.

Schmidt EM, Wiek C, Parkinson OT, Roellecke K, Freund M, Gombert M, Lottmann N, Steward CA, Kramm CM, Yarov-Yarovoy V, Rettie AE, Hanenberg H.

PLoS One. 2015 Sep 10;10(9):e0137110. doi: 10.1371/journal.pone.0137110. eCollection 2015.


A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function.

Kaur G, Pinggera A, Ortner NJ, Lieb A, Sinnegger-Brauns MJ, Yarov-Yarovoy V, Obermair GJ, Flucher BE, Striessnig J.

J Biol Chem. 2015 Aug 21;290(34):21086-100. doi: 10.1074/jbc.M115.645671. Epub 2015 Jun 22.


Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel.

Yang F, Xiao X, Cheng W, Yang W, Yu P, Song Z, Yarov-Yarovoy V, Zheng J.

Nat Chem Biol. 2015 Jul;11(7):518-524. doi: 10.1038/nchembio.1835. Epub 2015 Jun 8.


Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels.

Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ.

Elife. 2015 May 7;4:e06774. doi: 10.7554/eLife.06774.


Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review.


Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells.

Tilley DC, Eum KS, Fletcher-Taylor S, Austin DC, Dupré C, Patrón LA, Garcia RL, Lam K, Yarov-Yarovoy V, Cohen BE, Sack JT.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4789-96. doi: 10.1073/pnas.1406876111. Epub 2014 Oct 20.


Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.

Wiek C, Schmidt EM, Roellecke K, Freund M, Nakano M, Kelly EJ, Kaisers W, Yarov-Yarovoy V, Kramm CM, Rettie AE, Hanenberg H.

Biochem J. 2015 Jan 1;465(1):103-14. doi: 10.1042/BJ20140813.


Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel.

Boiteux C, Vorobyov I, French RJ, French C, Yarov-Yarovoy V, Allen TW.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13057-62. doi: 10.1073/pnas.1408710111. Epub 2014 Aug 18.


Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel.

Rafizadeh S, Zhang Z, Woltz RL, Kim HJ, Myers RE, Lu L, Tuteja D, Singapuri A, Bigdeli AA, Harchache SB, Knowlton AA, Yarov-Yarovoy V, Yamoah EN, Chiamvimonvat N.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9989-94. doi: 10.1073/pnas.1323541111. Epub 2014 Jun 20.


Computational Models for Predictive Cardiac Ion Channel Pharmacology.

Yarov-Yarovoy V, Allen TW, Clancy CE.

Drug Discov Today Dis Models. 2014 Winter;14:3-10. Epub 2014 Aug 5.


Channels: Sticking to nooks and crannies.

Wulff H, Yarov-Yarovoy V.

Nat Chem Biol. 2013 Aug;9(8):473-4. doi: 10.1038/nchembio.1292.


Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes.

Timofeyev V, Myers RE, Kim HJ, Woltz RL, Sirish P, Heiserman JP, Li N, Singapuri A, Tang T, Yarov-Yarovoy V, Yamoah EN, Hammond HK, Chiamvimonvat N.

Circ Res. 2013 Jun 7;112(12):1567-76. doi: 10.1161/CIRCRESAHA.112.300370. Epub 2013 Apr 22.


The bipolar assembly domain of the mitotic motor kinesin-5.

Acar S, Carlson DB, Budamagunta MS, Yarov-Yarovoy V, Correia JJ, Niñonuevo MR, Jia W, Tao L, Leary JA, Voss JC, Evans JE, Scholey JM.

Nat Commun. 2013;4:1343. doi: 10.1038/ncomms2348.


Na⁺/K⁺-ATPase E960 and phospholemman F28 are critical for their functional interaction.

Khafaga M, Bossuyt J, Mamikonian L, Li JC, Lee LL, Yarov-Yarovoy V, Despa S, Bers DM.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20756-61. doi: 10.1073/pnas.1207866109. Epub 2012 Nov 26.


An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations.

Vargas E, Yarov-Yarovoy V, Khalili-Araghi F, Catterall WA, Klein ML, Tarek M, Lindahl E, Schulten K, Perozo E, Bezanilla F, Roux B.

J Gen Physiol. 2012 Dec;140(6):587-94. doi: 10.1085/jgp.201210873.


Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels.

Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, Catterall WA.

J Biol Chem. 2012 Aug 31;287(36):30719-28. doi: 10.1074/jbc.M112.370742. Epub 2012 Jul 2.


Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations.

Cui Y, Yang F, Cao X, Yarov-Yarovoy V, Wang K, Zheng J.

J Gen Physiol. 2012 Apr;139(4):273-83. doi: 10.1085/jgp.201110724. Epub 2012 Mar 12.


Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase.

Watschinger K, Fuchs JE, Yarov-Yarovoy V, Keller MA, Golderer G, Hermetter A, Werner-Felmayer G, Hulo N, Werner ER.

Biochem J. 2012 Apr 1;443(1):279-86. doi: 10.1042/BJ20111509.


LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z-) agrin.

Maselli RA, Fernandez JM, Arredondo J, Navarro C, Ngo M, Beeson D, Cagney O, Williams DC, Wollmann RL, Yarov-Yarovoy V, Ferns MJ.

Hum Genet. 2012 Jul;131(7):1123-35. doi: 10.1007/s00439-011-1132-4. Epub 2011 Dec 29.


Structural basis for gating charge movement in the voltage sensor of a sodium channel.

Yarov-Yarovoy V, DeCaen PG, Westenbroek RE, Pan CY, Scheuer T, Baker D, Catterall WA.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):E93-102. doi: 10.1073/pnas.1118434109. Epub 2011 Dec 12.


Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway.

Oganesian A, Yarov-Yarovoy V, Parks WC, Schwinn DA.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19796-801. doi: 10.1073/pnas.1116271108. Epub 2011 Nov 16.


Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor.

DeCaen PG, Yarov-Yarovoy V, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18825-30. doi: 10.1073/pnas.1116449108. Epub 2011 Oct 31.


Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor.

Wang J, Yarov-Yarovoy V, Kahn R, Gordon D, Gurevitz M, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15426-31. doi: 10.1073/pnas.1112320108. Epub 2011 Aug 29. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3645.


Allosteric catch bond properties of the FimH adhesin from Salmonella enterica serovar Typhimurium.

Kisiela DI, Kramer JJ, Tchesnokova V, Aprikian P, Yarov-Yarovoy V, Clegg S, Sokurenko EV.

J Biol Chem. 2011 Nov 4;286(44):38136-47. doi: 10.1074/jbc.M111.237511. Epub 2011 Jul 27.


Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels.

Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, Catterall WA.

J Biol Chem. 2011 Sep 23;286(38):33641-51. doi: 10.1074/jbc.M111.282509. Epub 2011 Jul 27.


Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states.

Kelly EJ, Nakano M, Rohatgi P, Yarov-Yarovoy V, Rettie AE.

Mol Interv. 2011 Apr;11(2):124-32. doi: 10.1124/mi.11.2.10. Review.


Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations.

Subbotina J, Yarov-Yarovoy V, Lees-Miller J, Durdagi S, Guo J, Duff HJ, Noskov SY.

Proteins. 2010 Nov 1;78(14):2922-34. doi: 10.1002/prot.22815.


Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel.

Khalili-Araghi F, Jogini V, Yarov-Yarovoy V, Tajkhorshid E, Roux B, Schulten K.

Biophys J. 2010 May 19;98(10):2189-98. doi: 10.1016/j.bpj.2010.02.056.

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