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In Vitro Culture of Cryptosporidium parvum Using Hollow Fiber Bioreactor: Applications for Simultaneous Pharmacokinetic and Pharmacodynamic Evaluation of Test Compounds.

Yarlett N, Morada M, Gobin M, Van Voorhis W, Arnold S.

Methods Mol Biol. 2020;2052:335-350. doi: 10.1007/978-1-4939-9748-0_19.


P-Glycoprotein-Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium.

Arnold SLM, Choi R, Hulverson MA, Whitman GR, Mccloskey MC, Dorr CS, Vidadala RSR, Khatod M, Morada M, Barrett LK, Maly DJ, Yarlett N, Van Voorhis WC.

J Infect Dis. 2019 Aug 30;220(7):1188-1198. doi: 10.1093/infdis/jiz269.


Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations.

El Bissati K, Redel H, Ting LM, Lykins JD, McPhillie MJ, Upadhya R, Woster PM, Yarlett N, Kim K, Weiss LM.

Front Cell Infect Microbiol. 2019 Feb 14;9:9. doi: 10.3389/fcimb.2019.00009. eCollection 2019.


Mitochondrial Glycolysis in a Major Lineage of Eukaryotes.

Río Bártulos C, Rogers MB, Williams TA, Gentekaki E, Brinkmann H, Cerff R, Liaud MF, Hehl AB, Yarlett NR, Gruber A, Kroth PG, van der Giezen M.

Genome Biol Evol. 2018 Sep 1;10(9):2310-2325. doi: 10.1093/gbe/evy164.


Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.

Thompson AM, Marshall AJ, Maes L, Yarlett N, Bacchi CJ, Gaukel E, Wring SA, Launay D, Braillard S, Chatelain E, Mowbray CE, Denny WA.

Bioorg Med Chem Lett. 2018 Jan 15;28(2):207-213. doi: 10.1016/j.bmcl.2017.10.067. Epub 2017 Oct 27.


Potential of bisbenzimidazole-analogs toward metronidazole-resistant Trichomonas vaginalis isolates.

Korosh T, Bujans E, Morada M, Karaalioglu C, Vanden Eynde JJ, Mayence A, Huang TL, Yarlett N.

Chem Biol Drug Des. 2017 Oct;90(4):489-495. doi: 10.1111/cbdd.12972. Epub 2017 Apr 25.


Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents.

Vanden Eynde JJ, Mayence A, Mottamal M, Bacchi CJ, Yarlett N, Kaiser M, Brun R, Huang TL.

Pharmaceuticals (Basel). 2016 Apr 19;9(2). pii: E20. doi: 10.3390/ph9020020.


Continuous culture of Cryptosporidium parvum using hollow fiber technology.

Morada M, Lee S, Gunther-Cummins L, Weiss LM, Widmer G, Tzipori S, Yarlett N.

Int J Parasitol. 2016 Jan;46(1):21-9. doi: 10.1016/j.ijpara.2015.07.006. Epub 2015 Sep 2.


Eicosapentaenoic Acid Modulates Trichomonas vaginalis Activity.

Korosh T, Jordan KD, Wu JS, Yarlett N, Upmacis RK.

J Eukaryot Microbiol. 2016 Mar-Apr;63(2):153-61. doi: 10.1111/jeu.12263. Epub 2015 Sep 23.


Antioxidant defences of Spironucleus vortens: Glutathione is the major non-protein thiol.

Williams CF, Yarlett N, Aon MA, Lloyd D.

Mol Biochem Parasitol. 2014 Aug;196(1):45-52. doi: 10.1016/j.molbiopara.2014.07.010. Epub 2014 Aug 4.


Cryptosporidium parvum has an active hypusine biosynthesis pathway.

Mittal N, Morada M, Tripathi P, Gowri VS, Mandal S, Quirch A, Park MH, Yarlett N, Madhubala R.

Mol Biochem Parasitol. 2014 Jun;195(1):14-22. doi: 10.1016/j.molbiopara.2014.05.005. Epub 2014 Jun 2.


Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis.

Wring S, Gaukel E, Nare B, Jacobs R, Beaudet B, Bowling T, Mercer L, Bacchi C, Yarlett N, Randolph R, Parham R, Rewerts C, Platner J, Don R.

Parasitology. 2014 Jan;141(1):104-18. doi: 10.1017/S003118201300098X. Epub 2013 Sep 5. Review.


Cryptosporidium parvum induces an endoplasmic stress response in the intestinal adenocarcinoma HCT-8 cell line.

Morada M, Pendyala L, Wu G, Merali S, Yarlett N.

J Biol Chem. 2013 Oct 18;288(42):30356-64. doi: 10.1074/jbc.M113.459735. Epub 2013 Aug 28.


Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents.

Mayence A, Vanden Eynde JJ, Kaiser M, Brun R, Yarlett N, Huang TL.

Bioorg Med Chem. 2011 Dec 15;19(24):7493-500. doi: 10.1016/j.bmc.2011.10.039. Epub 2011 Oct 20.


Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis.

Jacobs RT, Plattner JJ, Nare B, Wring SA, Chen D, Freund Y, Gaukel EG, Orr MD, Perales JB, Jenks M, Noe RA, Sligar JM, Zhang YK, Bacchi CJ, Yarlett N, Don R.

Future Med Chem. 2011 Aug;3(10):1259-78. doi: 10.4155/fmc.11.80.


SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.

Jacobs RT, Nare B, Wring SA, Orr MD, Chen D, Sligar JM, Jenks MX, Noe RA, Bowling TS, Mercer LT, Rewerts C, Gaukel E, Owens J, Parham R, Randolph R, Beaudet B, Bacchi CJ, Yarlett N, Plattner JJ, Freund Y, Ding C, Akama T, Zhang YK, Brun R, Kaiser M, Scandale I, Don R.

PLoS Negl Trop Dis. 2011 Jun;5(6):e1151. doi: 10.1371/journal.pntd.0001151. Epub 2011 Jun 28.


SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei.

Perales JB, Freeman J, Bacchi CJ, Bowling T, Don R, Gaukel E, Mercer L, Moore JA 3rd, Nare B, Nguyen TM, Noe RA, Randolph R, Rewerts C, Wring SA, Yarlett N, Jacobs RT.

Bioorg Med Chem Lett. 2011 May 15;21(10):2816-9. doi: 10.1016/j.bmcl.2011.03.097. Epub 2011 Apr 1.


2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach.

Mercer L, Bowling T, Perales J, Freeman J, Nguyen T, Bacchi C, Yarlett N, Don R, Jacobs R, Nare B.

PLoS Negl Trop Dis. 2011 Feb 8;5(2):e956. doi: 10.1371/journal.pntd.0000956.


Hydrogenosome-localization of arginine deiminase in Trichomonas vaginalis.

Morada M, Smid O, Hampl V, Sutak R, Lam B, Rappelli P, Dessì D, Fiori PL, Tachezy J, Yarlett N.

Mol Biochem Parasitol. 2011 Mar;176(1):51-4. doi: 10.1016/j.molbiopara.2010.10.004. Epub 2010 Nov 11.


Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis.

Nare B, Wring S, Bacchi C, Beaudet B, Bowling T, Brun R, Chen D, Ding C, Freund Y, Gaukel E, Hussain A, Jarnagin K, Jenks M, Kaiser M, Mercer L, Mejia E, Noe A, Orr M, Parham R, Plattner J, Randolph R, Rattendi D, Rewerts C, Sligar J, Yarlett N, Don R, Jacobs R.

Antimicrob Agents Chemother. 2010 Oct;54(10):4379-88. doi: 10.1128/AAC.00498-10. Epub 2010 Jul 26.


Arginine metabolism in Trichomonas vaginalis infected with Mycoplasma hominis.

Morada M, Manzur M, Lam B, Tan C, Tachezy J, Rappelli P, Dessì D, Fiori PL, Yarlett N.

Microbiology. 2010 Dec;156(Pt 12):3734-43. doi: 10.1099/mic.0.042192-0. Epub 2010 Jul 23.


Discovery of novel benzoxaborole-based potent antitrypanosomal agents.

Ding D, Zhao Y, Meng Q, Xie D, Nare B, Chen D, Bacchi CJ, Yarlett N, Zhang YK, Hernandez V, Xia Y, Freund Y, Abdulla M, Ang KH, Ratnam J, McKerrow JH, Jacobs RT, Zhou H, Plattner JJ.

ACS Med Chem Lett. 2010 Apr 6;1(4):165-9. doi: 10.1021/ml100013s. eCollection 2010 Jul 8.


Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity.

Huang TL, Vanden Eynde JJ, Mayence A, Collins MS, Cushion MT, Rattendi D, Londono I, Mazumder L, Bacchi CJ, Yarlett N.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5884-6. doi: 10.1016/j.bmcl.2009.08.073. Epub 2009 Aug 23.


Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor.

Bacchi CJ, Barker RH Jr, Rodriguez A, Hirth B, Rattendi D, Yarlett N, Hendrick CL, Sybertz E.

Antimicrob Agents Chemother. 2009 Aug;53(8):3269-72. doi: 10.1128/AAC.00076-09. Epub 2009 May 18.


Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.

Barker RH Jr, Liu H, Hirth B, Celatka CA, Fitzpatrick R, Xiang Y, Willert EK, Phillips MA, Kaiser M, Bacchi CJ, Rodriguez A, Yarlett N, Klinger JD, Sybertz E.

Antimicrob Agents Chemother. 2009 May;53(5):2052-8. doi: 10.1128/AAC.01674-08. Epub 2009 Mar 16.


Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi.

Bacchi CJ, Yarlett N, Faciane E, Bi X, Rattendi D, Weiss LM, Woster PM.

Antimicrob Agents Chemother. 2009 Jun;53(6):2599-604. doi: 10.1128/AAC.00267-08. Epub 2009 Feb 17.


Biochemical characterization of a mitochondrial-like organelle from Blastocystis sp. subtype 7.

Lantsman Y, Tan KS, Morada M, Yarlett N.

Microbiology. 2008 Sep;154(Pt 9):2757-66. doi: 10.1099/mic.0.2008/017897-0.


Divergent polyamine metabolism in the Apicomplexa.

Cook T, Roos D, Morada M, Zhu G, Keithly JS, Feagin JE, Wu G, Yarlett N.

Microbiology. 2007 Apr;153(Pt 4):1123-30.


Cryptosporidium parvum spermidine/spermine N1-acetyltransferase exhibits different characteristics from the host enzyme.

Yarlett N, Wu G, Waters WR, Harp JA, Wannemuehler MJ, Morada M, Athanasopoulos D, Martinez MP, Upton SJ, Marton LJ, Frydman BJ.

Mol Biochem Parasitol. 2007 Apr;152(2):170-80. Epub 2007 Jan 9.


The arthritis severity quantitative trait loci Cia4 and Cia6 regulate neutrophil migration into inflammatory sites and levels of TNF-alpha and nitric oxide.

Laragione T, Yarlett NC, Brenner M, Mello A, Sherry B, Miller EJ, Metz CN, Gulko PS.

J Immunol. 2007 Feb 15;178(4):2344-51.


The arthritis severity quantitative trait locus Cia7 regulates neutrophil migration into inflammatory sites.

Laragione T, Brenner M, Yarlett NC, Mello A, Miller EJ, Metz CN, Sherry B, Gulko PS.

Genes Immun. 2007 Mar;8(2):147-53. Epub 2007 Feb 1.


Activities of DL-alpha-difluoromethylarginine and polyamine analogues against Cryptosporidium parvum infection in a T-cell receptor alpha-deficient mouse model.

Yarlett N, Waters WR, Harp JA, Wannemuehler MJ, Morada M, Bellcastro J, Upton SJ, Marton LJ, Frydman BJ.

Antimicrob Agents Chemother. 2007 Apr;51(4):1234-9. Epub 2007 Jan 22.


Cia27 is a novel non-MHC arthritis severity locus on rat chromosome 10 syntenic to the rheumatoid arthritis 17q22-q25 locus.

Brenner M, Laragione T, Yarlett NC, Li W, Mello A, Gulko PS.

Genes Immun. 2006 Jul;7(5):335-41. Epub 2006 May 4.


Hydrogenosomes and symbiosis.

Hackstein JH, Yarlett N.

Prog Mol Subcell Biol. 2006;41:117-42. Review. No abstract available.


The non-major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage.

Brenner M, Meng HC, Yarlett NC, Griffiths MM, Remmers EF, Wilder RL, Gulko PS.

Arthritis Rheum. 2005 Jan;52(1):322-32.


Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues.

Bacchi CJ, Rattendi D, Faciane E, Yarlett N, Weiss LM, Frydman B, Woster P, Wei B, Marton LJ, Wittner M.

Microbiology. 2004 May;150(Pt 5):1215-24.


Production of ammonia by Tritrichomonas foetus and Trichomonas vaginalis.

Kleydman Y, Yarlett N, Gorrell TE.

Microbiology. 2004 May;150(Pt 5):1139-45.


Anaerobic protists and hidden mitochondria.

Yarlett N.

Microbiology. 2004 May;150(Pt 5):1127-9. Review. No abstract available.


Bacterial-like energy metabolism in the amitochondriate protozoon Hexamita inflata.

Biagini GA, Yarlett N, Ball GE, Billetz AC, Lindmark DG, Martinez MP, Lloyd D, Edwards MR.

Mol Biochem Parasitol. 2003 Apr 25;128(1):11-9.


Polyamine metabolism in the Microsporidia.

Bacchi CJ, Yarlett N, Weiss LM.

Biochem Soc Trans. 2003 Apr;31(2):420-3.


Iron-dependent hydrogenases of Entamoeba histolytica and Giardia lamblia: activity of the recombinant entamoebic enzyme and evidence for lateral gene transfer.

Nixon JE, Field J, McArthur AG, Sogin ML, Yarlett N, Loftus BJ, Samuelson J.

Biol Bull. 2003 Feb;204(1):1-9.


Polyamine metabolism as chemotherapeutic target in protozoan parasites.

Bacchi CJ, Yarlett N.

Mini Rev Med Chem. 2002 Dec;2(6):553-63. Review.


SL-11158, a synthetic oligoamine, inhibits polyamine metabolism of Encephalitozoon cuniculi.

Bacchi CJ, Orozco D, Weiss LM, Frydman B, Valasinas A, Yarlett N, Marton LJ, Wittner M.

J Eukaryot Microbiol. 2001;Suppl:92S-94S. No abstract available.


Stage-specific polyamine metabolism in Trypanosoma cruzi.

Bacchi CJ, Braunstein VL, Rattendi D, Yarlett N, Wittner M, Tanowitz HB.

J Eukaryot Microbiol. 2001;Suppl:201S-202S. No abstract available.


Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection.

Bacchi CJ, Weiss LM, Lane S, Frydman B, Valasinas A, Reddy V, Sun JS, Marton LJ, Khan IA, Moretto M, Yarlett N, Wittner M.

Antimicrob Agents Chemother. 2002 Jan;46(1):55-61.


Polyamine synthesis and interconversion by the Microsporidian Encephalitozoon cuniculi.

Bacchi CJ, Lane S, Weiss LM, Yarlett N, Takvorian P, Cali A, Wittner M.

J Eukaryot Microbiol. 2001 May-Jun;48(3):374-81. Erratum in: J Eukaryot Microbiol 2002 Jan-Feb;49(1):92.


Dependence of Trichomonas vaginalis upon polyamine backconversion.

Yarlett N, Martinez MP, Goldberg B, Kramer DL, Porter CW.

Microbiology. 2000 Oct;146 ( Pt 10):2715-22.


[(1)N,(12)N]Bis(Ethyl)-cis-6,7-dehydrospermine: a new drug for treatment and prevention of Cryptosporidium parvum infection of mice deficient in T-cell receptor alpha.

Waters WR, Frydman B, Marton LJ, Valasinas A, Reddy VK, Harp JA, Wannemuehler MJ, Yarlett N.

Antimicrob Agents Chemother. 2000 Oct;44(10):2891-4.

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