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Items: 31


TMEM16A expression in cholinergic neurons of the medial habenula mediates anxiety-related behaviors.

Cho CH, Lee S, Kim A, Yarishkin O, Ryoo K, Lee YS, Jung HG, Yang E, Lee DY, Lee B, Kim H, Oh U, Im HI, Hwang EM, Park JY.

EMBO Rep. 2020 Feb 5;21(2):e48097. doi: 10.15252/embr.201948097. Epub 2019 Nov 29.


Volume sensing in the transient receptor potential vanilloid 4 ion channel is cell type-specific and mediated by an N-terminal volume-sensing domain.

Toft-Bertelsen TL, Yarishkin O, Redmon S, Phuong TTT, Križaj D, MacAulay N.

J Biol Chem. 2019 Nov 29;294(48):18421-18434. doi: 10.1074/jbc.RA119.011187. Epub 2019 Oct 16.


Mechano-electrical transduction in trabecular meshwork involves parallel activation of TRPV4 and TREK-1 channels.

Yarishkin O, Baumann JM, Križaj D.

Channels (Austin). 2019 Dec;13(1):168-171. doi: 10.1080/19336950.2019.1618149. No abstract available.


Trabecular Meshwork TREK-1 Channels Function as Polymodal Integrators of Pressure and pH.

Yarishkin O, Phuong TTT, Križaj D.

Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2294-2303. doi: 10.1167/iovs.19-26851.


Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease.

Park JH, Ju YH, Choi JW, Song HJ, Jang BK, Woo J, Chun H, Kim HJ, Shin SJ, Yarishkin O, Jo S, Park M, Yeon SK, Kim S, Kim J, Nam MH, Londhe AM, Kim J, Cho SJ, Cho S, Lee C, Hwang SY, Kim SW, Oh SJ, Cho J, Pae AN, Lee CJ, Park KD.

Sci Adv. 2019 Mar 20;5(3):eaav0316. doi: 10.1126/sciadv.aav0316. eCollection 2019 Mar.


trans-Anethole of Fennel Oil is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel.

Memon T, Yarishkin O, Reilly CA, Križaj D, Olivera BM, Teichert RW.

Mol Pharmacol. 2019 Apr;95(4):433-441. doi: 10.1124/mol.118.114561. Epub 2019 Jan 24.


TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells.

Yarishkin O, Phuong TTT, Bretz CA, Olsen KW, Baumann JM, Lakk M, Crandall A, Heurteaux C, Hartnett ME, Križaj D.

J Gen Physiol. 2018 Dec 3;150(12):1660-1675. doi: 10.1085/jgp.201812179. Epub 2018 Nov 16.


TWIK-1/TASK-3 heterodimeric channels contribute to the neurotensin-mediated excitation of hippocampal dentate gyrus granule cells.

Choi JH, Yarishkin O, Kim E, Bae Y, Kim A, Kim SC, Ryoo K, Cho CH, Hwang EM, Park JY.

Exp Mol Med. 2018 Nov 12;50(11):145. doi: 10.1038/s12276-018-0172-4.


TRPV4 Does Not Regulate the Distal Retinal Light Response.

Yarishkin O, Phuong TTT, Lakk M, Križaj D.

Adv Exp Med Biol. 2018;1074:553-560. doi: 10.1007/978-3-319-75402-4_67.


Dyslipidemia modulates Müller glial sensing and transduction of ambient information.

Lakk M, Vazquez-Chona F, Yarishkin O, Križaj D.

Neural Regen Res. 2018 Feb;13(2):207-210. doi: 10.4103/1673-5374.226383. Review.


Calcium influx through TRPV4 channels modulates the adherens contacts between retinal microvascular endothelial cells.

Phuong TTT, Redmon SN, Yarishkin O, Winter JM, Li DY, Križaj D.

J Physiol. 2017 Nov 15;595(22):6869-6885. doi: 10.1113/JP275052. Epub 2017 Oct 25.


Cholesterol regulates polymodal sensory transduction in Müller glia.

Lakk M, Yarishkin O, Baumann JM, Iuso A, Križaj D.

Glia. 2017 Dec;65(12):2038-2050. doi: 10.1002/glia.23213. Epub 2017 Aug 30.


Mouse retinal ganglion cell signalling is dynamically modulated through parallel anterograde activation of cannabinoid and vanilloid pathways.

Jo AO, Noel JM, Lakk M, Yarishkin O, Ryskamp DA, Shibasaki K, McCall MA, Križaj D.

J Physiol. 2017 Oct 15;595(20):6499-6516. doi: 10.1113/JP274562. Epub 2017 Sep 7.


TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye.

Ryskamp DA, Frye AM, Phuong TT, Yarishkin O, Jo AO, Xu Y, Lakk M, Iuso A, Redmon SN, Ambati B, Hageman G, Prestwich GD, Torrejon KY, Križaj D.

Sci Rep. 2016 Aug 11;6:30583. doi: 10.1038/srep30583.


Subcellular propagation of calcium waves in Müller glia does not require autocrine/paracrine purinergic signaling.

Phuong TT, Yarishkin O, Križaj D.

Channels (Austin). 2016 Sep 2;10(5):421-427. Epub 2016 May 24.


Differential volume regulation and calcium signaling in two ciliary body cell types is subserved by TRPV4 channels.

Jo AO, Lakk M, Frye AM, Phuong TT, Redmon SN, Roberts R, Berkowitz BA, Yarishkin O, Križaj D.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3885-90. doi: 10.1073/pnas.1515895113. Epub 2016 Mar 22.


Store-Operated Calcium Entry in Müller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels.

Molnár T, Yarishkin O, Iuso A, Barabas P, Jones B, Marc RE, Phuong TT, Križaj D.

J Neurosci. 2016 Mar 16;36(11):3184-98. doi: 10.1523/JNEUROSCI.4069-15.2016.


TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia.

Jo AO, Ryskamp DA, Phuong TT, Verkman AS, Yarishkin O, MacAulay N, Križaj D.

J Neurosci. 2015 Sep 30;35(39):13525-37. doi: 10.1523/JNEUROSCI.1987-15.2015.


Disinhibitory Action of Astrocytic GABA at the Perforant Path to Dentate Gyrus Granule Neuron Synapse Reverses to Inhibitory in Alzheimer's Disease Model.

Yarishkin O, Lee J, Jo S, Hwang EM, Lee CJ.

Exp Neurobiol. 2015 Sep;24(3):211-8. doi: 10.5607/en.2015.24.3.211. Epub 2015 Sep 2.


TWIK-1 contributes to the intrinsic excitability of dentate granule cells in mouse hippocampus.

Yarishkin O, Lee DY, Kim E, Cho CH, Choi JH, Lee CJ, Hwang EM, Park JY.

Mol Brain. 2014 Nov 19;7:80. doi: 10.1186/s13041-014-0080-z.


Depletion of 14-3-3γ reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death.

Cho CH, Kim E, Lee YS, Yarishkin O, Yoo JC, Park JY, Hong SG, Hwang EM.

Mol Brain. 2014 Jul 22;7:52. doi: 10.1186/s13041-014-0052-3.


A Novel Cytosolic Isoform of Mitochondrial Trans-2-Enoyl-CoA Reductase Enhances Peroxisome Proliferator-Activated Receptor α Activity.

Kim DG, Yoo JC, Kim E, Lee YS, Yarishkin OV, Lee DY, Lee KH, Hong SG, Hwang EM, Park JY.

Endocrinol Metab (Seoul). 2014 Jun;29(2):185-94. doi: 10.3803/EnM.2014.29.2.185. Epub 2014 Jun 26.


GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease.

Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee DY, Hong J, Kim HY, Oh SJ, Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D, Lee CJ.

Nat Med. 2014 Aug;20(8):886-96. doi: 10.1038/nm.3639. Epub 2014 Jun 29.


A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes.

Hwang EM, Kim E, Yarishkin O, Woo DH, Han KS, Park N, Bae Y, Woo J, Kim D, Park M, Lee CJ, Park JY.

Nat Commun. 2014;5:3227. doi: 10.1038/ncomms4227.


Enhancement of TREK1 channel surface expression by protein-protein interaction with beta-COP.

Kim E, Hwang EM, Yarishkin O, Yoo JC, Kim D, Park N, Cho M, Lee YS, Sun CH, Yi GS, Yoo J, Kang D, Han J, Hong SG, Park JY.

Biochem Biophys Res Commun. 2010 Apr 30;395(2):244-50. doi: 10.1016/j.bbrc.2010.03.171. Epub 2010 Apr 1.


Diclofenac, a Non-steroidal Anti-inflammatory Drug, Inhibits L-type Ca Channels in Neonatal Rat Ventricular Cardiomyocytes.

Yarishkin OV, Hwang EM, Kim D, Yoo JC, Kang SS, Kim DR, Shin JH, Chung HJ, Jeong HS, Kang D, Han J, Park JY, Hong SG.

Korean J Physiol Pharmacol. 2009 Dec;13(6):437-42. doi: 10.4196/kjpp.2009.13.6.437. Epub 2009 Dec 31.


Cloning and characterization of rat transient receptor potential-melastatin 4 (TRPM4).

Yoo JC, Yarishkin OV, Hwang EM, Kim E, Kim DG, Park N, Hong SG, Park JY.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):806-11. doi: 10.1016/j.bbrc.2009.11.142. Epub 2009 Nov 27.


Silencing of Kv4.1 potassium channels inhibits cell proliferation of tumorigenic human mammary epithelial cells.

Jang SH, Choi C, Hong SG, Yarishkin OV, Bae YM, Kim JG, O'Grady SM, Yoon KA, Kang KS, Ryu PD, Lee SY.

Biochem Biophys Res Commun. 2009 Jun 26;384(2):180-6. doi: 10.1016/j.bbrc.2009.04.108. Epub 2009 May 3.


Endogenous TRPM4-like channel in Chinese hamster ovary (CHO) cells.

Yarishkin OV, Hwang EM, Park JY, Kang D, Han J, Hong SG.

Biochem Biophys Res Commun. 2008 May 2;369(2):712-7. doi: 10.1016/j.bbrc.2008.02.081. Epub 2008 Feb 26.


TRPM4b channel suppresses store-operated Ca2+ entry by a novel protein-protein interaction with the TRPC3 channel.

Park JY, Hwang EM, Yarishkin O, Seo JH, Kim E, Yoo J, Yi GS, Kim DG, Park N, Ha CM, La JH, Kang D, Han J, Oh U, Hong SG.

Biochem Biophys Res Commun. 2008 Apr 11;368(3):677-83. doi: 10.1016/j.bbrc.2008.01.153. Epub 2008 Feb 8.


Sulfonate chalcone as new class voltage-dependent K+ channel blocker.

Yarishkin OV, Ryu HW, Park JY, Yang MS, Hong SG, Park KH.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):137-40. Epub 2007 Nov 4.


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