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Association of Diabetes Mellitus on Cardiac Remodeling, Quality of Life, and Clinical Outcomes in Heart Failure With Reduced and Preserved Ejection Fraction.

Yap J, Tay WT, Teng TK, Anand I, Richards AM, Ling LH, MacDonald MR, Chandramouli C, Tromp J, Siswanto BB; ASIAN‐HF (Asian Sudden Cardiac Death in Heart Failure) Registry Investigators, Zile M, McMurray J, Lam CSP.

J Am Heart Assoc. 2019 Sep 3;8(17):e013114. doi: 10.1161/JAHA.119.013114. Epub 2019 Aug 21.


Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods.

Yap J, Yuan J, Tee ZH, Huang X, Ng WH, Hu J.

J Vis Exp. 2019 Jul 17;(149). doi: 10.3791/59795.


En bloc resection of the external iliac vein along with broad ligament leiomyosarcoma: A case report.

Ahmed F, Pounds R, Teo HG, Nevin J, Singh K, Yap J.

Case Rep Womens Health. 2019 Jun 27;23:e00131. doi: 10.1016/j.crwh.2019.e00131. eCollection 2019 Jul.


'Spigelian-type' hernia: a rare laparoscopic trocar site hernia following total laparoscopic hysterectomy.

Leong E, Lloyd A, Pounds R, O'Neill D, Singh K, Yap J.

J Obstet Gynaecol. 2019 Jul 29:1-2. doi: 10.1080/01443615.2019.1626354. [Epub ahead of print] No abstract available.


Indications and Patterns of Use for Parenteral Nutrition in Pediatric Oncology.

McGrath KH, Evans V, Yap J.

JPEN J Parenter Enteral Nutr. 2019 Jul 22. doi: 10.1002/jpen.1685. [Epub ahead of print]


Design and evaluation of a 3D virtual environment for collaborative learning in interprofessional team care delivery.

Liaw SY, Soh SL, Tan KK, Wu LT, Yap J, Chow YL, Lau TC, Lim WS, Tan SC, Choo H, Wong LL, Lim SM, Ignacio J, Wong LF.

Nurse Educ Today. 2019 Jul 2;81:64-71. doi: 10.1016/j.nedt.2019.06.012. [Epub ahead of print]


SMART longitudinal analysis: A tutorial for using repeated outcome measures from SMART studies to compare adaptive interventions.

Nahum-Shani I, Almirall D, Yap JRT, McKay JR, Lynch KG, Freiheit EA, Dziak JJ.

Psychol Methods. 2019 Jul 18. doi: 10.1037/met0000219. [Epub ahead of print]


Microvascular Disease in Patients With Diabetes With Heart Failure and Reduced Ejection Versus Preserved Ejection Fraction.

Tromp J, Lim SL, Tay WT, Teng TK, Chandramouli C, Ouwerkerk W, Wander GS, Sawhney JPS, Yap J, MacDonald MR, Ling LH, Sattar N, McMurray JJV, Richards AM, Anand I, Lam CSP; ASIAN-HF Investigators.

Diabetes Care. 2019 Sep;42(9):1792-1799. doi: 10.2337/dc18-2515. Epub 2019 Jul 10.


Ultramorphological analysis of plaque advancement and cholesterol crystal formation in Ldlr knockout mouse atherosclerosis.

Baumer Y, McCurdy S, Jin X, Weatherby TM, Dey AK, Mehta NN, Yap JK, Kruth HS, Boisvert WA.

Atherosclerosis. 2019 Aug;287:100-111. doi: 10.1016/j.atherosclerosis.2019.05.029. Epub 2019 Jun 12.


Cornell product is an ECG marker of heart failure with preserved ejection fraction.

Tan ES, Chan SP, Xu CF, Yap J, Richards AM, Ling LH, Sim D, Jaufeerally F, Yeo D, Loh SY, Ong HY, Leong KTG, Ng TP, Nyunt SZ, Feng L, Okin P, Lam CS, Lim TW.

Heart Asia. 2019 May 28;11(1):e011108. doi: 10.1136/heartasia-2018-011108. eCollection 2019.


Increased mortality risk associated with serum sodium variations and borderline hypo- and hypernatremia in hospitalized adults.

Thongprayoon C, Cheungpasitporn W, Yap JQ, Qian Q.

Nephrol Dial Transplant. 2019 Jun 20. pii: gfz098. doi: 10.1093/ndt/gfz098. [Epub ahead of print]


Clinical impact of gastroesophageal reflux disease in patients with subacute/chronic cough.

Kanemitsu Y, Kurokawa R, Takeda N, Takemura M, Fukumitsu K, Asano T, Yap J, Suzuki M, Fukuda S, Ohkubo H, Maeno K, Ito Y, Oguri T, Niimi A.

Allergol Int. 2019 Jun 7. pii: S1323-8930(19)30063-2. doi: 10.1016/j.alit.2019.04.011. [Epub ahead of print]


Process Evaluation of the Community Pharmacist-Led Allergic Rhinitis Management (C-PhARM) Service in Singapore.

Yap JSY, Tang CWQ, Hor HML, Chong JBK, Yap KZ.

Pharmacy (Basel). 2019 Jun 7;7(2). pii: E56. doi: 10.3390/pharmacy7020056.


Small airway inflammation is associated with residual airway hyperresponsiveness in Th2-high asthma.

Asano T, Kanemitsu Y, Takemura M, Fukumitsu K, Kurokawa R, Inoue Y, Takeda N, Yap JMG, Ito K, Kitamura Y, Fukuda S, Ohkubo H, Maeno K, Ito Y, Oguri T, Niimi A.

J Asthma. 2019 Jun 19:1-9. doi: 10.1080/02770903.2019.1628251. [Epub ahead of print]


Finding the Right Blend of Technologically Enhanced Learning Environments: Randomized Controlled Study of the Effect of Instructional Sequences on Interprofessional Learning.

Liaw SY, Tan KK, Wu LT, Tan SC, Choo H, Yap J, Lim SM, Wong L, Ignacio J.

J Med Internet Res. 2019 May 28;21(5):e12537. doi: 10.2196/12537.


The Role of Neuronal NLRP1 Inflammasome in Alzheimer's Disease: Bringing Neurons into the Neuroinflammation Game.

Yap JKY, Pickard BS, Chan EWL, Gan SY.

Mol Neurobiol. 2019 May 20. doi: 10.1007/s12035-019-1638-7. [Epub ahead of print] Review.


Role of Macrophages in Cardioprotection.

Yap J, Cabrera-Fuentes HA, Irei J, Hausenloy DJ, Boisvert WA.

Int J Mol Sci. 2019 May 19;20(10). pii: E2474. doi: 10.3390/ijms20102474. Review.


Iatrogenic intralenticular broken steroid implant: a case report.

Yap JF, Wai YZ, Ng QX, Lim LT.

J Med Case Rep. 2019 May 6;13(1):131. doi: 10.1186/s13256-019-2064-1.


Prescription patterns of anti-diabetic medications and clinical outcomes in Asian patients with heart failure and diabetes mellitus.

Chia YMF, Teng TK, Tay WT, Anand I, MacDonald MR, Yap J, Chandramouli C, Richards AM, Tromp J, Ouwerkerk W, Ling LH, Lam CSP; ASIAN-HF Investigators.

Eur J Heart Fail. 2019 May;21(5):685-688. doi: 10.1002/ejhf.1467. Epub 2019 Apr 29. No abstract available.


Benign chondroid syringoma of the orbit: an atypical location.

Yap JF, Madatang A, Hanafi H.

Orbit. 2019 Apr 26:1-4. doi: 10.1080/01676830.2019.1604766. [Epub ahead of print]


Deletion of self-reactive CCR7- thymocytes in the absence of MHC expression on thymic epithelial cells.

Wirasinha RC, Chan A, Yap JY, Hu DY, Teh CE, Gray DHD, Goodnow CC, Daley SR.

Cell Death Differ. 2019 Apr 24. doi: 10.1038/s41418-019-0331-8. [Epub ahead of print]


Particulate air pollution on cardiovascular mortality in the tropics: impact on the elderly.

Yap J, Ng Y, Yeo KK, Sahlén A, Lam CSP, Lee V, Ma S.

Environ Health. 2019 Apr 18;18(1):34. doi: 10.1186/s12940-019-0476-4.


The Singapore Heart Failure Risk Score: Prediction of Survival in Southeast Asian Patients.

Yap J, Chia SY, Lim FY, Allen JC, Teo L, Sim D, Go YY, Jaufeerally FR, Seow M, Kwok B, Liew R, Lam CS, Ching CK.

Ann Acad Med Singapore. 2019 Mar;48(3):86-94.


Publisher Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.

Kinsey CG, Camolotto SA, Boespflug AM, Guillen KP, Foth M, Truong A, Schuman SS, Shea JE, Seipp MT, Yap JT, Burrell LD, Lum DH, Whisenant JR, Gilcrease GW 3rd, Cavalieri CC, Rehbein KM, Cutler SL, Affolter KE, Welm AL, Welm BE, Scaife CL, Snyder EL, McMahon M.

Nat Med. 2019 May;25(5):861. doi: 10.1038/s41591-019-0433-3.


Mixed Lipid, Fish Oil, and Soybean Oil Parenteral Lipids Impact Cholestasis, Hepatic Phytosterol, and Lipid Composition.

Isaac DM, Alzaben AS, Mazurak VC, Yap J, Wizzard PR, Nation PN, Zhao YY, Curtis JM, Sergi C, Wales PW, Mager DR, Turner JM.

J Pediatr Gastroenterol Nutr. 2019 Jun;68(6):861-867. doi: 10.1097/MPG.0000000000002313.


Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model.

Choo BKM, Kundap UP, Johan Arief MFB, Kumari Y, Yap JL, Wong CP, Othman I, Shaikh MF.

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8;92:483-493. doi: 10.1016/j.pnpbp.2019.02.014. Epub 2019 Mar 4.


Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.

Kinsey CG, Camolotto SA, Boespflug AM, Guillen KP, Foth M, Truong A, Schuman SS, Shea JE, Seipp MT, Yap JT, Burrell LD, Lum DH, Whisenant JR, Gilcrease GW 3rd, Cavalieri CC, Rehbein KM, Cutler SL, Affolter KE, Welm AL, Welm BE, Scaife CL, Snyder EL, McMahon M.

Nat Med. 2019 Apr;25(4):620-627. doi: 10.1038/s41591-019-0367-9. Epub 2019 Mar 4. Erratum in: Nat Med. 2019 Mar 27;:.


Prediction of Survival in Asian Patients Hospitalized With Heart Failure: Validation of the OPTIMIZE-HF Risk Score.

Yap J, Lim FY, Chia SY, Allen JC Jr, Jaufeerally FR, Macdonald MR, Chai P, Loh SY, Lim P, Zaw MWW, Teo L, Sim D, Lam CSP.

J Card Fail. 2019 Jul;25(7):571-575. doi: 10.1016/j.cardfail.2019.02.016. Epub 2019 Feb 26.


Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01.

Gu Y, Wong YH, Liew CW, Chan CEZ, Murali TM, Yap J, Too CT, Purushotorman K, Hamidinia M, El Sahili A, Goh ATH, Teo RZC, Wood KJ, Hanson BJ, Gascoigne NRJ, Lescar J, Vathsala A, MacAry PA.

Nat Commun. 2019 Feb 21;10(1):893. doi: 10.1038/s41467-019-08790-1.


Healthy Body Weights With Corticosteroid-free Immunosuppression Is the Best Predictor of Cardiovascular Health in Children After Liver Transplantation.

Mager DR, Hager A, Siminoski K, Yap JK, Gilmour SM.

J Pediatr Gastroenterol Nutr. 2019 May;68(5):713-719. doi: 10.1097/MPG.0000000000002271.


Bleeding Risk of Transesophageal Echocardiography in Patients With Esophageal Varices.

Nigatu A, Yap JE, Lee Chuy K, Go B, Doukky R.

J Am Soc Echocardiogr. 2019 May;32(5):674-676.e2. doi: 10.1016/j.echo.2018.11.017. Epub 2019 Jan 18. No abstract available.


A Data Analysis Method for Using Longitudinal Binary Outcome Data from a SMART to Compare Adaptive Interventions.

Dziak JJ, Yap JRT, Almirall D, McKay JR, Lynch KG, Nahum-Shani I.

Multivariate Behav Res. 2019 Jan 20:1-24. doi: 10.1080/00273171.2018.1558042. [Epub ahead of print]


Interprofessional bedside rounds: Nurse-physician collaboration and perceived barriers in an Asian hospital.

Chew BH, Tang CJ, Lim WS, Yap JKY, Zhou W, Liaw SY.

J Interprof Care. 2019 Jan 16:1-3. doi: 10.1080/13561820.2019.1566218. [Epub ahead of print]


Heart Failure With Preserved Ejection Fraction in the Young.

Tromp J, MacDonald MR, Tay WT, Teng TK, Hung CL, Narasimhan C, Shimizu W, Ling LH, Ng TP, Yap J, McMurray JJV, Zile MR, Richards AM, Anand IS, Lam CSP.

Circulation. 2018 Dec 11;138(24):2763-2773. doi: 10.1161/CIRCULATIONAHA.118.034720.


The Role of Platelets in Ischemic Conditioning.

Alpuche J, Quírino L, Sánchez-Vega JT, Yap J, Pérez-Campos E, Cabrera-Fuentes HA.

Cond Med. 2018 Oct;1(6):313-318.


Defining a 'frequent admitter' phenotype among patients with repeat heart failure admissions.

Go YY, Sellmair R, Allen JC Jr, Sahlén A, Bulluck H, Sim D, Jaufeerally FR, MacDonald MR, Lim ZY, Chai P, Loh SY, Yap J, Lam CSP.

Eur J Heart Fail. 2019 Mar;21(3):311-318. doi: 10.1002/ejhf.1348. Epub 2018 Dec 13.


Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry.

Chandramouli C, Teng TK, Tay WT, Yap J, MacDonald MR, Tromp J, Yan L, Siswanto B, Reyes EB, Ngarmukos T, Yu CM, Hung CL, Anand I, Richards AM, Ling LH, Regensteiner JG, Lam CSP; ASIAN-HF Investigators.

Eur J Heart Fail. 2019 Mar;21(3):297-307. doi: 10.1002/ejhf.1358. Epub 2018 Dec 10.


The diagnostic conundrum of chronic ectopic pregnancy: A case report.

O'Neill D, Pounds R, Vella J, Singh K, Yap J.

Case Rep Womens Health. 2018 Nov 9;20:e00086. doi: 10.1016/j.crwh.2018.e00086. eCollection 2018 Oct.


Air pollution in relation to very short-term risk of ST-segment elevation myocardial infarction: Case-crossover analysis of SWEDEHEART.

Sahlén A, Ljungman P, Erlinge D, Chan MY, Yap J, Hausenloy DJ, Yeo KK, Jernberg T.

Int J Cardiol. 2019 Jan 15;275:26-30. doi: 10.1016/j.ijcard.2018.10.069. Epub 2018 Oct 23.


Predictors of functional outcome in patients with stroke thrombolysis in a tertiary hospital in Malaysia.

Tai MLS, Goh KJ, Kadir KAA, Zakaria MI, Yap JF, Tan KS.

Singapore Med J. 2019 May;60(5):236-240. doi: 10.11622/smedj.2018150. Epub 2018 Nov 29.


Erratum: Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5.

Wang H, Chauhan J, Hu A, Pendleton K, Yap JL, Sabato PE, Jones JW, Perri M, Yu J, Cione E, Kane MA, Fletcher S, Prochownik EV.

Oncotarget. 2018 Oct 12;9(80):35196. doi: 10.18632/oncotarget.26241. eCollection 2018 Oct 12.


Themis-associated phosphatase activity controls signaling in T cell development.

Mehta M, Brzostek J, Chen EW, Tung DWH, Chen S, Sankaran S, Yap J, Rybakin V, Gascoigne NRJ.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11331-E11340. doi: 10.1073/pnas.1720209115. Epub 2018 Nov 9.


Gamma Glutamyltransferase Reduction Is Associated With Favorable Outcomes in Pediatric Primary Sclerosing Cholangitis.

Deneau MR, Mack C, Abdou R, Amin M, Amir A, Auth M, Bazerbachi F, Marie Broderick A, Chan A, DiGuglielmo M, El-Matary W, El-Youssef M, Ferrari F, Furuya KN, Gottrand F, Gupta N, Homan M, Jensen MK, Kamath BM, Mo Kim K, Kolho KL, Konidari A, Koot B, Iorio R, Martinez M, Mohan P, Palle S, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Valentino PL, Varier R, Venkat V, Vitola B, Vos MB, Woynarowski M, Yap J, Miloh T.

Hepatol Commun. 2018 Sep 25;2(11):1369-1378. doi: 10.1002/hep4.1251. eCollection 2018 Nov.


Effects of branched chain amino acid supplementation on patient care outcomes in adults and children with liver cirrhosis: A systematic review.

Ooi PH, Gilmour SM, Yap J, Mager DR.

Clin Nutr ESPEN. 2018 Dec;28:41-51. doi: 10.1016/j.clnesp.2018.07.012. Epub 2018 Aug 14. Review.


Under expression of the Sonic Hedgehog receptor, Patched1 (PTCH1), is associated with an increased risk of local recurrence in squamous cell carcinoma of the vulva arising on a background of Lichen Sclerosus.

Yap J, Fox R, Narsia N, Pinheiro-Maia S, Pounds R, Woodman C, Luesley D, Ganesan R, Kehoe S, Dawson C.

PLoS One. 2018 Oct 31;13(10):e0206553. doi: 10.1371/journal.pone.0206553. eCollection 2018.


Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis.

Yuan J, Ng WH, Tian Z, Yap J, Baccarini M, Chen Z, Hu J.

Sci Signal. 2018 Oct 30;11(554). pii: eaar6795. doi: 10.1126/scisignal.aar6795.


Diagnostic accuracy of content-based dermatoscopic image retrieval with deep classification features.

Tschandl P, Argenziano G, Razmara M, Yap J.

Br J Dermatol. 2019 Jul;181(1):155-165. doi: 10.1111/bjd.17189. Epub 2018 Oct 17.


Multimodal skin lesion classification using deep learning.

Yap J, Yolland W, Tschandl P.

Exp Dermatol. 2018 Nov;27(11):1261-1267. doi: 10.1111/exd.13777. Epub 2018 Sep 27.


Impact of Clinical Use of Parenteral Lipid Emulsions on Bile Acid Metabolism and Composition in Neonatal Piglets.

Lavallee CM, Lim DW, Wizzard PR, Mazurak VC, Mi S, Curtis JM, Willing BP, Yap JY, Wales PW, Turner JM.

JPEN J Parenter Enteral Nutr. 2019 Jul;43(5):668-676. doi: 10.1002/jpen.1437. Epub 2018 Aug 23.


Management of patients with diabetes and heart failure with reduced ejection fraction: An international comparison.

Arnold SV, Yap J, Lam CSP, Tang F, Tay WT, Teng THK, McGuire DK, Januzzi JL, Fonarow GC, Masoudi FA, Kosiborod M.

Diabetes Obes Metab. 2019 Feb;21(2):261-266. doi: 10.1111/dom.13511. Epub 2018 Sep 25.


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