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Helminth Infections Induce Tissue Tolerance Mitigating Immunopathology but Enhancing Microbial Pathogen Susceptibility.

Yap GS, Gause WC.

Front Immunol. 2018 Oct 16;9:2135. doi: 10.3389/fimmu.2018.02135. eCollection 2018. Review.


Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cells.

Lau CM, Tiniakou I, Perez OA, Kirkling ME, Yap GS, Hock H, Reizis B.

J Exp Med. 2018 Sep 3;215(9):2265-2278. doi: 10.1084/jem.20172323. Epub 2018 Aug 7.


Paneth Cell Multipotency Induced by Notch Activation following Injury.

Yu S, Tong K, Zhao Y, Balasubramanian I, Yap GS, Ferraris RP, Bonder EM, Verzi MP, Gao N.

Cell Stem Cell. 2018 Jul 5;23(1):46-59.e5. doi: 10.1016/j.stem.2018.05.002. Epub 2018 Jun 7.


Toxoplasma gondii Inactivates Human Plasmacytoid Dendritic Cells by Functional Mimicry of IL-10.

Pierog PL, Zhao Y, Singh S, Dai J, Yap GS, Fitzgerald-Bocarsly P.

J Immunol. 2018 Jan 1;200(1):186-195. doi: 10.4049/jimmunol.1701045. Epub 2017 Nov 27.


Correction: Cutting Edge: Helminth Coinfection Blocks Effector Differentiation of CD8 T Cells through Alternate Host Th2- and IL-10-Mediated Responses.

Marple A, Wu W, Shah S, Zhao Y, Du P, Gause WC, Yap GS.

J Immunol. 2017 Oct 15;199(8):3005. doi: 10.4049/jimmunol.1701193. No abstract available.


FISH-Flow, a protocol for the concurrent detection of mRNA and protein in single cells using fluorescence in situ hybridization and flow cytometry.

Arrigucci R, Bushkin Y, Radford F, Lakehal K, Vir P, Pine R, Martin D, Sugarman J, Zhao Y, Yap GS, Lardizabal AA, Tyagi S, Gennaro ML.

Nat Protoc. 2017 Jun;12(6):1245-1260. doi: 10.1038/nprot.2017.039. Epub 2017 May 18.


Cutting Edge: Helminth Coinfection Blocks Effector Differentiation of CD8 T Cells through Alternate Host Th2- and IL-10-Mediated Responses.

Marple A, Wu W, Shah S, Zhao Y, Du P, Gause WC, Yap GS.

J Immunol. 2017 Jan 15;198(2):634-639. doi: 10.4049/jimmunol.1601741. Epub 2016 Dec 12. Erratum in: J Immunol. 2017 Oct 15;199(8):3005.


Innate cell communication kick-starts pathogen-specific immunity.

Rivera A, Siracusa MC, Yap GS, Gause WC.

Nat Immunol. 2016 Apr;17(4):356-63. doi: 10.1038/ni.3375. Review.


An extrafollicular pathway for the generation of effector CD8(+) T cells driven by the proinflammatory cytokine, IL-12.

Shah S, Grotenbreg GM, Rivera A, Yap GS.

Elife. 2015 Aug 5;4. doi: 10.7554/eLife.09017.


Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells.

Cohen SB, Smith NL, McDougal C, Pepper M, Shah S, Yap GS, Acha-Orbea H, Jiang A, Clausen BE, Rudd BD, Denkers EY.

J Immunol. 2015 Jan 1;194(1):210-22.


Toxoplasma's arms race with the host interferon response: a ménage à trois of ROPs.

Zhao Y, Yap GS.

Cell Host Microbe. 2014 May 14;15(5):517-8. doi: 10.1016/j.chom.2014.05.002.


Avirulent strains of Toxoplasma gondii infect macrophages by active invasion from the phagosome.

Zhao Y, Marple AH, Ferguson DJ, Bzik DJ, Yap GS.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6437-42. doi: 10.1073/pnas.1316841111. Epub 2014 Apr 14.


Effect of helminth-induced immunity on infections with microbial pathogens.

Salgame P, Yap GS, Gause WC.

Nat Immunol. 2013 Nov;14(11):1118-1126. doi: 10.1038/ni.2736. Review.


Co-existence of classical and alternative activation programs in macrophages responding to Toxoplasma gondii.

Patil V, Zhao Y, Shah S, Fox BA, Rommereim LM, Bzik DJ, Yap GS.

Int J Parasitol. 2014 Feb;44(2):161-4. doi: 10.1016/j.ijpara.2013.08.003. Epub 2013 Sep 29.


IL-10 mediated regulation of liver inflammation during acute murine cytomegalovirus infection.

Gaddi PJ, Crane MJ, Kamanaka M, Flavell RA, Yap GS, Salazar-Mather TP.

PLoS One. 2012;7(8):e42850. doi: 10.1371/journal.pone.0042850. Epub 2012 Aug 3.


IFN-γ signals a changing of the guards.

Yap GS, Rivera A.

Immunity. 2012 Jun 29;36(6):904-6. doi: 10.1016/j.immuni.2012.06.007.


Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection.

Divanovic S, Sawtell NM, Trompette A, Warning JI, Dias A, Cooper AM, Yap GS, Arditi M, Shimada K, Duhadaway JB, Prendergast GC, Basaraba RJ, Mellor AL, Munn DH, Aliberti J, Karp CL.

J Infect Dis. 2012 Jan 1;205(1):152-61. doi: 10.1093/infdis/jir621. Epub 2011 Oct 11.


Epidemiological characteristics of the 2005 and 2007 dengue epidemics in Singapore - similarities and distinctions.

Ler TS, Ang LW, Yap GS, Ng LC, Tai JC, James L, Goh KT.

Western Pac Surveill Response J. 2011 May 20;2(2):24-9. doi: 10.5365/WPSAR.2010.1.1.011. Print 2011 Apr.


Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.

Wilson DC, Grotenbreg GM, Liu K, Zhao Y, Frickel EM, Gubbels MJ, Ploegh HL, Yap GS.

PLoS Pathog. 2010 Mar 19;6(3):e1000815. doi: 10.1371/journal.ppat.1000815.


Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function.

la Sala A, He J, Laricchia-Robbio L, Gorini S, Iwasaki A, Braun M, Yap GS, Sher A, Ozato K, Kelsall B.

J Exp Med. 2009 Jun 8;206(6):1227-35. doi: 10.1084/jem.20080912. Epub 2009 Jun 1. Erratum in: J Exp Med. 2009 Jul 6;206(7):1635.


Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages.

Zhao Y, Ferguson DJ, Wilson DC, Howard JC, Sibley LD, Yap GS.

J Immunol. 2009 Mar 15;182(6):3775-81. doi: 10.4049/jimmunol.0804190.


Securing mucosal borders--migrant monocytes to the rescue.

Yap GS, Iwasaki A.

Cell Host Microbe. 2008 Sep 11;4(3):192-4. doi: 10.1016/j.chom.2008.08.005.


Rapid elimination of Toxoplasma gondii by gamma interferon-primed mouse macrophages is independent of CD40 signaling.

Zhao Y, Wilson D, Matthews S, Yap GS.

Infect Immun. 2007 Oct;75(10):4799-803. Epub 2007 Aug 6.


A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.

Ivanov S, Dragoi AM, Wang X, Dallacosta C, Louten J, Musco G, Sitia G, Yap GS, Wan Y, Biron CA, Bianchi ME, Wang H, Chu WM.

Blood. 2007 Sep 15;110(6):1970-81. Epub 2007 Jun 4.


Cytokine regulation of immunopathology in toxoplasmosis.

Gaddi PJ, Yap GS.

Immunol Cell Biol. 2007 Feb-Mar;85(2):155-9. Epub 2007 Jan 16. Review.


Autophagic elimination of intracellular parasites: convergent induction by IFN-gamma and CD40 ligation?

Yap GS, Ling Y, Zhao Y.

Autophagy. 2007 Mar-Apr;3(2):163-5. Epub 2007 Mar 5.


Early Dengue infection and outcome study (EDEN) - study design and preliminary findings.

Low JG, Ooi EE, Tolfvenstam T, Leo YS, Hibberd ML, Ng LC, Lai YL, Yap GS, Li CS, Vasudevan SG, Ong A.

Ann Acad Med Singapore. 2006 Nov;35(11):783-9.


Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages.

Ling YM, Shaw MH, Ayala C, Coppens I, Taylor GA, Ferguson DJ, Yap GS.

J Exp Med. 2006 Sep 4;203(9):2063-71. Epub 2006 Aug 28.


Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation.

Shaw MH, Freeman GJ, Scott MF, Fox BA, Bzik DJ, Belkaid Y, Yap GS.

J Immunol. 2006 Jun 15;176(12):7263-71.


Genetic analysis of host resistance to intracellular pathogens: lessons from studies of Toxoplasma gondii infection.

Yap GS, Shaw MH, Ling Y, Sher A.

Microbes Infect. 2006 Apr;8(4):1174-8. Epub 2006 Jan 18. Review.


Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production.

Feng CG, Jankovic D, Kullberg M, Cheever A, Scanga CA, Hieny S, Caspar P, Yap GS, Sher A.

J Immunol. 2005 Apr 1;174(7):4185-92.


A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity.

Shaw MH, Boyartchuk V, Wong S, Karaghiosoff M, Ragimbeau J, Pellegrini S, Muller M, Dietrich WF, Yap GS.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11594-9. Epub 2003 Sep 18.


The use of germ line-mutated mice in understanding host-pathogen interactions.

Yap GS, Sher A.

Cell Microbiol. 2002 Oct;4(10):627-34. Review.


Mutation of Tec family kinases alters T helper cell differentiation.

Schaeffer EM, Yap GS, Lewis CM, Czar MJ, McVicar DW, Cheever AW, Sher A, Schwartzberg PL.

Nat Immunol. 2001 Dec;2(12):1183-8.


Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection.

Collazo CM, Yap GS, Sempowski GD, Lusby KC, Tessarollo L, Vande Woude GF, Sher A, Taylor GA.

J Exp Med. 2001 Jul 16;194(2):181-8.


Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.

Taylor GA, Collazo CM, Yap GS, Nguyen K, Gregorio TA, Taylor LS, Eagleson B, Secrest L, Southon EA, Reid SW, Tessarollo L, Bray M, McVicar DW, Komschlies KL, Young HA, Biron CA, Sher A, Vande Woude GF.

Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):751-5.


Cell-mediated immunity to Toxoplasma gondii: initiation, regulation and effector function.

Yap GS, Sher A.

Immunobiology. 1999 Dec;201(2):240-7. Review.


Role of cytokines in the formation and downregulation of hepatic circumoval granulomas and hepatic fibrosis in Schistosoma mansoni-infected mice.

Cheever AW, Jankovic D, Yap GS, Kullberg MC, Sher A, Wynn TA.

Mem Inst Oswaldo Cruz. 1998;93 Suppl 1:25-32.


Partially protective vaccination permits the development of latency in a normally virulent strain of Toxoplasma gondii.

Yap GS, Scharton-Kersten T, Ferguson DJ, Howe D, Suzuki Y, Sher A.

Infect Immun. 1998 Sep;66(9):4382-8.


A chicken embryo eye model for the analysis of alphaherpesvirus neuronal spread and virulence.

Banfield BW, Yap GS, Knapp AC, Enquist LW.

J Virol. 1998 Jun;72(6):4580-8.


Immunologic basis of disease and disease regulation in schistosomiasis.

Cheever AW, Yap GS.

Chem Immunol. 1997;66:159-76. Review. No abstract available.


Coding of visual space by premotor neurons.

Graziano MS, Yap GS, Gross CG.

Science. 1994 Nov 11;266(5187):1054-7.


Blood transfusion alters the course and outcome of Plasmodium chabaudi AS infection in mice.

Yap GS, Stevenson MM.

Infect Immun. 1994 Sep;62(9):3761-5. Erratum in: Infect Immun.2010 Feb;78(2):884.

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