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Items: 1 to 50 of 72

1.

Optimizing Vancomycin Dosing in Chronic Kidney Disease by Deriving and Implementing a Web-Based Tool Using a Population Pharmacokinetics Analysis.

Dorajoo SR, Winata CL, Goh JHF, Ooi ST, Somani J, Yeoh LY, Lee SY, Yap CW, Chan A, Chae JW.

Front Pharmacol. 2019 Jun 11;10:641. doi: 10.3389/fphar.2019.00641. eCollection 2019.

2.

Effects of chronic diseases on health-related quality of life and self-rated health among three adult age groups.

Ge L, Ong R, Yap CW, Heng BH.

Nurs Health Sci. 2019 Jun;21(2):214-222. doi: 10.1111/nhs.12585. Epub 2018 Dec 10.

PMID:
30537214
3.

Effectiveness of the eCARE Programme: A Short Message Service (SMS) for Asthma Monitoring.

Prabhakaran L, Yap CW, Neo LP, Gan CC, Tham LM, Wong WM, Abisheganaden J, Lim TK.

Ann Acad Med Singapore. 2018 Jun;47(6):233-236. No abstract available.

4.

Sex differences in associations between multimorbidity and physical function domains among community-dwelling adults in Singapore.

Ge L, Yap CW, Heng BH.

PLoS One. 2018 May 14;13(5):e0197443. doi: 10.1371/journal.pone.0197443. eCollection 2018.

5.

Prevalence of frailty and its association with depressive symptoms among older adults in Singapore.

Ge L, Yap CW, Heng BH.

Aging Ment Health. 2019 Mar;23(3):319-324. doi: 10.1080/13607863.2017.1416332. Epub 2018 Jan 16.

PMID:
29336608
6.

Effectiveness of Diabetes Foot Screening in Primary Care in Preventing Lower Extremity Amputations.

Ang GY, Yap CW, Saxena N.

Ann Acad Med Singapore. 2017 Nov;46(11):417-423.

7.

Incidence of thromboembolic and bleeding events in patients with newly diagnosed nonvalvular atrial fibrillation: An Asian multicenter retrospective cohort study in Singapore.

Wee XT, Ho LM, Ho HK, Lee JY, Yap CW, William H, Chan LCE, Tay HC, Goh CEM, Tan DS.

Clin Cardiol. 2017 Dec;40(12):1218-1226. doi: 10.1002/clc.22811. Epub 2017 Dec 18.

8.

Re-examining the sensitivity of HbA1c to screen for diabetes mellitus.

Yap CW, Ang YG, Quek TPL, Heng BH, Chew DEK.

J Diabetes. 2018 May;10(5):380-385. doi: 10.1111/1753-0407.12615. Epub 2017 Dec 11.

PMID:
29030996
9.

Lifetime cost for type 2 diabetes mellitus in Singapore.

Ang YG, Yap CW, You AX.

J Diabetes. 2018 Apr;10(4):296-301. doi: 10.1111/1753-0407.12604. Epub 2017 Sep 29.

PMID:
28834603
10.

Social isolation, loneliness and their relationships with depressive symptoms: A population-based study.

Ge L, Yap CW, Ong R, Heng BH.

PLoS One. 2017 Aug 23;12(8):e0182145. doi: 10.1371/journal.pone.0182145. eCollection 2017.

11.

HbA1c variability in type 2 diabetes is associated with the occurrence of new-onset albuminuria within three years.

Dorajoo SR, Ng JSL, Goh JHF, Lim SC, Yap CW, Chan A, Lee JYC.

Diabetes Res Clin Pract. 2017 Jun;128:32-39. doi: 10.1016/j.diabres.2017.02.007. Epub 2017 Feb 14.

PMID:
28432897
12.

Identifying Potentially Avoidable Readmissions: A Medication-Based 15-Day Readmission Risk Stratification Algorithm.

Dorajoo SR, See V, Chan CT, Tan JZ, Tan DS, Abdul Razak SM, Ong TT, Koomanan N, Yap CW, Chan A.

Pharmacotherapy. 2017 Mar;37(3):268-277. doi: 10.1002/phar.1896. Epub 2017 Feb 20.

PMID:
28052412
13.

A scoring model for predicting survival following primary tumour resection in stage IV colorectal cancer patients with unresectable metastasis.

Dorajoo SR, Tan WJ, Koo SX, Tan WS, Chew MH, Tang CL, Wee HL, Yap CW.

Int J Colorectal Dis. 2016 Feb;31(2):235-45. Epub 2015 Oct 21.

PMID:
26490055
14.

Predictors of anemia in a multi-ethnic chronic kidney disease population: a case-control study.

Lau BC, Ong KY, Yap CW, Vathsala A, How P.

Springerplus. 2015 May 20;4:233. doi: 10.1186/s40064-015-1001-z. eCollection 2015.

15.

Identification of novel peroxisome proliferator-activated receptor-gamma (PPARγ) agonists using molecular modeling method.

Gee VM, Wong FS, Ramachandran L, Sethi G, Kumar AP, Yap CW.

J Comput Aided Mol Des. 2014 Nov;28(11):1143-51. doi: 10.1007/s10822-014-9791-6. Epub 2014 Aug 29.

PMID:
25168706
16.

An automated Pearson's correlation change classification (APC3) approach for GC/MS metabonomic data using total ion chromatograms (TICs).

Prakash BD, Esuvaranathan K, Ho PC, Pasikanti KK, Chan EC, Yap CW.

Analyst. 2013 May 21;138(10):2883-9. doi: 10.1039/c3an00048f.

PMID:
23529371
17.

Determination of the Potential of Drug Candidates to Cause Severe Skin Disorders Using Computational Modeling.

He Y, Chong FH, Lim J, Lee RJ, Yap CW.

Mol Inform. 2013 Mar;32(3):303-12. doi: 10.1002/minf.201200086. Epub 2013 Mar 11.

PMID:
27481525
18.

QSAR and Predictors of Eye and Skin Effects.

Liew CY, Yap CW.

Mol Inform. 2013 Mar;32(3):281-90. doi: 10.1002/minf.201200119. Epub 2013 Mar 8.

PMID:
27481523
19.

Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity.

Gan FF, Kaminska KK, Yang H, Liew CY, Leow PC, So CL, Tu LN, Roy A, Yap CW, Kang TS, Chui WK, Chew EH.

Antioxid Redox Signal. 2013 Oct 10;19(11):1149-65. doi: 10.1089/ars.2012.4909. Epub 2013 Feb 28.

20.

QSAR Modeling is not "Push a Button and Find a Correlation": A Case Study of Toxicity of (Benzo-)triazoles on Algae.

Gramatica P, Cassani S, Roy PP, Kovarich S, Yap CW, Papa E.

Mol Inform. 2012 Dec;31(11-12):817-35. doi: 10.1002/minf.201200075. Epub 2012 Nov 19.

PMID:
27476736
21.

Rational design of selective organoruthenium inhibitors of protein tyrosine phosphatase 1B.

Ong JX, Yap CW, Ang WH.

Inorg Chem. 2012 Nov 19;51(22):12483-92. doi: 10.1021/ic301884j. Epub 2012 Nov 2.

PMID:
23121648
22.

PaDEL-DDPredictor: open-source software for PD-PK-T prediction.

He Y, Liew CY, Sharma N, Woo SK, Chau YT, Yap CW.

J Comput Chem. 2013 Mar 15;34(7):604-10. doi: 10.1002/jcc.23173. Epub 2012 Nov 1.

PMID:
23114987
23.
24.

Pyrrolidinediones reduce the toxicity of thiazolidinediones and modify their anti-diabetic and anti-cancer properties.

Saha S, Chan DS, Lee CY, Wong W, New LS, Chui WK, Yap CW, Chan EC, Ho HK.

Eur J Pharmacol. 2012 Dec 15;697(1-3):13-23. doi: 10.1016/j.ejphar.2012.09.021. Epub 2012 Oct 4.

PMID:
23041271
25.

Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.

Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT, Ashktorab H, Tan P, Ahn KS, Yap CW, Kumar AP, Sethi G.

J Biol Chem. 2012 Nov 2;287(45):38028-40. doi: 10.1074/jbc.M112.388702. Epub 2012 Sep 19. Erratum in: J Biol Chem. 2013 Jun 28;288(26):18777.

26.

Clinical and demographic predictors for vitamin D deficiency in multiethnic Asian patients with chronic kidney disease.

Loh ZY, Yap CW, Vathsala A, How P.

Clin Kidney J. 2012 Aug;5(4):303-8. doi: 10.1093/ckj/sfs074.

27.

Consensus QSAR model for identifying novel H5N1 inhibitors.

Sharma N, Yap CW.

Mol Divers. 2012 Aug;16(3):513-24. doi: 10.1007/s11030-012-9384-z. Epub 2012 Jul 21.

PMID:
22821301
28.

A clinical decision support tool to predict survival in cancer patients beyond 120 days after palliative chemotherapy.

Ng T, Chew L, Yap CW.

J Palliat Med. 2012 Aug;15(8):863-9. doi: 10.1089/jpm.2011.0417. Epub 2012 Jun 12.

29.

An investigation of the bioactivation potential and metabolism profile of Zebrafish versus human.

Chng HT, Ho HK, Yap CW, Lam SH, Chan EC.

J Biomol Screen. 2012 Aug;17(7):974-86. doi: 10.1177/1087057112447305. Epub 2012 May 29.

PMID:
22644267
30.

Interaction of lapatinib with cytochrome P450 3A5.

Chan EC, New LS, Chua TB, Yap CW, Ho HK, Nelson SD.

Drug Metab Dispos. 2012 Jul;40(7):1414-22. doi: 10.1124/dmd.112.044958. Epub 2012 Apr 17.

PMID:
22511346
31.

3D-QSAR Study on dihydro-1,3,5-triazines and their spiro derivatives as DHFR inhibitors by comparative molecular field analysis (CoMFA).

Ma X, Xiang G, Yap CW, Chui WK.

Bioorg Med Chem Lett. 2012 May 1;22(9):3194-7. doi: 10.1016/j.bmcl.2012.03.041. Epub 2012 Mar 16.

PMID:
22483391
32.

Selective agonism of human pregnane X receptor by individual ginkgolides.

Lau AJ, Yang G, Yap CW, Chang TK.

Drug Metab Dispos. 2012 Jun;40(6):1113-21. doi: 10.1124/dmd.112.045013. Epub 2012 Mar 5.

PMID:
22393123
33.

Automated systems to identify relevant documents in product risk management.

Wee XT, Koh Y, Yap CW.

BMC Med Inform Decis Mak. 2012 Mar 2;12:13. doi: 10.1186/1472-6947-12-13.

34.

QSAR classification of metabolic activation of chemicals into covalently reactive species.

Liew CY, Pan C, Tan A, Ang KX, Yap CW.

Mol Divers. 2012 May;16(2):389-400. doi: 10.1007/s11030-012-9364-3. Epub 2012 Feb 28.

PMID:
22370994
35.

Identification of active compounds from medicinal plant extracts using gas chromatography-mass spectrometry and multivariate data analysis.

Ching J, Soh WL, Tan CH, Lee JF, Tan JY, Yang J, Yap CW, Koh HL.

J Sep Sci. 2012 Jan;35(1):53-9. doi: 10.1002/jssc.201100705. Epub 2011 Nov 30.

PMID:
22127806
36.

Mixed learning algorithms and features ensemble in hepatotoxicity prediction.

Liew CY, Lim YC, Yap CW.

J Comput Aided Mol Des. 2011 Sep;25(9):855-71. doi: 10.1007/s10822-011-9468-3. Epub 2011 Sep 6.

PMID:
21898162
37.
38.

Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway.

Woo CC, Loo SY, Gee V, Yap CW, Sethi G, Kumar AP, Tan KH.

Biochem Pharmacol. 2011 Sep 1;82(5):464-75. doi: 10.1016/j.bcp.2011.05.030. Epub 2011 Jun 14.

PMID:
21679698
39.

Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists.

Cheong SL, Federico S, Venkatesan G, Paira P, Shao YM, Spalluto G, Yap CW, Pastorin G.

Bioorg Med Chem Lett. 2011 May 15;21(10):2898-905. doi: 10.1016/j.bmcl.2011.03.073. Epub 2011 Mar 26.

PMID:
21511471
40.

PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints.

Yap CW.

J Comput Chem. 2011 May;32(7):1466-74. doi: 10.1002/jcc.21707. Epub 2010 Dec 17.

PMID:
21425294
41.

Comparative evaluation of software for retention time alignment of gas chromatography/time-of-flight mass spectrometry-based metabonomic data.

Koh Y, Pasikanti KK, Yap CW, Chan EC.

J Chromatogr A. 2010 Dec 24;1217(52):8308-16. doi: 10.1016/j.chroma.2010.10.101. Epub 2010 Oct 31.

PMID:
21081237
42.
43.

Solubilization of vorinostat by cyclodextrins.

Cai YY, Yap CW, Wang Z, Ho PC, Chan SY, Ng KY, Ge ZG, Lin HS.

J Clin Pharm Ther. 2010 Oct;35(5):521-6. doi: 10.1111/j.1365-2710.2009.01095.x.

PMID:
20831676
44.

Surface tension and wettability in transdermal delivery: a study on the in-vitro permeation of haloperidol with cyclodextrin across human epidermis.

Azarbayjani AF, Lin H, Yap CW, Chan YW, Chan SY.

J Pharm Pharmacol. 2010 Jun;62(6):770-8. doi: 10.1211/jpp.62.06.0014.

PMID:
20636865
45.

Consensus model for identification of novel PI3K inhibitors in large chemical library.

Liew CY, Ma XH, Yap CW.

J Comput Aided Mol Des. 2010 Feb;24(2):131-41. doi: 10.1007/s10822-010-9321-0. Epub 2010 Feb 11.

PMID:
20148286
46.

SVM model for virtual screening of Lck inhibitors.

Liew CY, Ma XH, Liu X, Yap CW.

J Chem Inf Model. 2009 Apr;49(4):877-85. doi: 10.1021/ci800387z.

PMID:
19267483
47.

Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/time-of-flight mass spectrometry.

Chan EC, New LS, Yap CW, Goh LT.

Rapid Commun Mass Spectrom. 2009 Feb;23(3):384-94. doi: 10.1002/rcm.3887.

PMID:
19127546
48.
49.
50.

Machine learning approaches for predicting compounds that interact with therapeutic and ADMET related proteins.

Li H, Yap CW, Ung CY, Xue Y, Li ZR, Han LY, Lin HH, Chen YZ.

J Pharm Sci. 2007 Nov;96(11):2838-60. Review.

PMID:
17786989

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