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Items: 47

1.

Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.

Merchant M, Ma X, Maun HR, Zheng Z, Peng J, Romero M, Huang A, Yang NY, Nishimura M, Greve J, Santell L, Zhang YW, Su Y, Kaufman DW, Billeci KL, Mai E, Moffat B, Lim A, Duenas ET, Phillips HS, Xiang H, Young JC, Vande Woude GF, Dennis MS, Reilly DE, Schwall RH, Starovasnik MA, Lazarus RA, Yansura DG.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E2987-96. doi: 10.1073/pnas.1302725110. Epub 2013 Jul 23.

2.

Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies.

Spiess C, Merchant M, Huang A, Zheng Z, Yang NY, Peng J, Ellerman D, Shatz W, Reilly D, Yansura DG, Scheer JM.

Nat Biotechnol. 2013 Aug;31(8):753-8. doi: 10.1038/nbt.2621. Epub 2013 Jul 7.

PMID:
23831709
3.

Translation levels control multi-spanning membrane protein expression.

Kim HS, Ernst JA, Brown C, Bostrom J, Fuh G, Lee CV, Huang A, Vandlen RL, Yansura DG.

PLoS One. 2012;7(4):e35844. doi: 10.1371/journal.pone.0035844. Epub 2012 Apr 26.

4.

Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.

Wu AL, Kolumam G, Stawicki S, Chen Y, Li J, Zavala-Solorio J, Phamluong K, Feng B, Li L, Marsters S, Kates L, van Bruggen N, Leabman M, Wong A, West D, Stern H, Luis E, Kim HS, Yansura D, Peterson AS, Filvaroff E, Wu Y, Sonoda J.

Sci Transl Med. 2011 Dec 14;3(113):113ra126. doi: 10.1126/scitranslmed.3002669.

5.

Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling.

Jackman J, Chen Y, Huang A, Moffat B, Scheer JM, Leong SR, Lee WP, Zhang J, Sharma N, Lu Y, Iyer S, Shields RL, Chiang N, Bauer MC, Wadley D, Roose-Girma M, Vandlen R, Yansura DG, Wu Y, Wu LC.

J Biol Chem. 2010 Jul 2;285(27):20850-9. doi: 10.1074/jbc.M110.113910. Epub 2010 May 5.

6.

Isolation and characterization of the B-cell marker CD20.

Ernst JA, Li H, Kim HS, Nakamura GR, Yansura DG, Vandlen RL.

Biochemistry. 2005 Nov 22;44(46):15150-8.

PMID:
16285718
7.

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A.

Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. Erratum in: Genome Res. 2003 Dec;13(12):2759.

8.

Expression of full-length immunoglobulins in Escherichia coli: rapid and efficient production of aglycosylated antibodies.

Simmons LC, Reilly D, Klimowski L, Raju TS, Meng G, Sims P, Hong K, Shields RL, Damico LA, Rancatore P, Yansura DG.

J Immunol Methods. 2002 May 1;263(1-2):133-47.

PMID:
12009210
9.

Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid.

Szeto W, Jiang W, Tice DA, Rubinfeld B, Hollingshead PG, Fong SE, Dugger DL, Pham T, Yansura DG, Wong TA, Grimaldi JC, Corpuz RT, Singh JS, Frantz GD, Devaux B, Crowley CW, Schwall RH, Eberhard DA, Rastelli L, Polakis P, Pennica D.

Cancer Res. 2001 May 15;61(10):4197-205.

10.

Application of the E. coli trp promoter.

Bass SH, Yansura DG.

Mol Biotechnol. 2000 Nov;16(3):253-60.

PMID:
11252809
11.

IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp.

Pan G, Risser P, Mao W, Baldwin DT, Zhong AW, Filvaroff E, Yansura D, Lewis L, Eigenbrot C, Henzel WJ, Vandlen R.

Cytokine. 2001 Jan 7;13(1):1-7.

PMID:
11145836
12.

IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1.

Lee J, Ho WH, Maruoka M, Corpuz RT, Baldwin DT, Foster JS, Goddard AD, Yansura DG, Vandlen RL, Wood WI, Gurney AL.

J Biol Chem. 2001 Jan 12;276(2):1660-4.

13.

Genentech stands by original data.

Henner DJ, Goeddel DV, Heyneker H, Itakura K, Yansura D, Ross M, Miozzari G.

Nature. 1999 May 27;399(6734):297-8. No abstract available.

PMID:
10360564
14.

A His19 to Ala mutant of melanoma growth-stimulating activity is a partial antagonist of the CXCR2 receptor.

Baly DL, Horuk R, Yansura DG, Simmons LC, Fairbrother WJ, Kotts C, Wirth CM, Gillece-Castro BL, Toy K, Hesselgesser J, Allison DE.

J Immunol. 1998 Nov 1;161(9):4944-9.

15.

Expression, purification, and characterization of Escherichia coli-derived recombinant human melanoma growth stimulating activity.

Horuk R, Reilly D, Yansura D.

Methods Enzymol. 1997;287:3-12. No abstract available.

PMID:
9330311
16.

Application of the E. coli trp promoter.

Yansura DG, Bass SH.

Methods Mol Biol. 1997;62:55-62. No abstract available.

PMID:
9108512
17.
18.

High-level expression and characterization of a purified 142-residue polypeptide of the prion protein.

Mehlhorn I, Groth D, Stöckel J, Moffat B, Reilly D, Yansura D, Willett WS, Baldwin M, Fletterick R, Cohen FE, Vandlen R, Henner D, Prusiner SB.

Biochemistry. 1996 Apr 30;35(17):5528-37.

PMID:
8611544
19.

A mutant of melanoma growth stimulating activity does not activate neutrophils but blocks erythrocyte invasion by malaria.

Hesselgesser J, Chitnis CE, Miller LH, Yansura DG, Simmons LC, Fairbrother WJ, Kotts C, Wirth C, Gillece-Castro BL, Horuk R.

J Biol Chem. 1995 May 12;270(19):11472-6.

20.

Ecotin is a potent anticoagulant and reversible tight-binding inhibitor of factor Xa.

Seymour JL, Lindquist RN, Dennis MS, Moffat B, Yansura D, Reilly D, Wessinger ME, Lazarus RA.

Biochemistry. 1994 Apr 5;33(13):3949-58.

PMID:
8142399
21.

Purification, receptor binding analysis, and biological characterization of human melanoma growth stimulating activity (MGSA). Evidence for a novel MGSA receptor.

Horuk R, Yansura DG, Reilly D, Spencer S, Bourell J, Henzel W, Rice G, Unemori E.

J Biol Chem. 1993 Jan 5;268(1):541-6.

22.

Identification of heregulin, a specific activator of p185erbB2.

Holmes WE, Sliwkowski MX, Akita RW, Henzel WJ, Lee J, Park JW, Yansura D, Abadi N, Raab H, Lewis GD, et al.

Science. 1992 May 22;256(5060):1205-10.

PMID:
1350381
23.

Use of Escherichia coli trp promoter for direct expression of proteins.

Yansura DG, Henner DJ.

Methods Enzymol. 1990;185:54-60. No abstract available.

PMID:
2199794
24.

Expression as trpE fusion.

Yansura DG.

Methods Enzymol. 1990;185:161-6. No abstract available.

PMID:
2199778
25.

Purification of recombinant human tissue factor.

Paborsky LR, Tate KM, Harris RJ, Yansura DG, Band L, McCray G, Gorman CM, O'Brien DP, Chang JY, Swartz JR, et al.

Biochemistry. 1989 Oct 3;28(20):8072-7.

PMID:
2690932
26.

Nucleotide and amino acid sequence coding for polypeptides of foot-and-mouth disease virus type A12.

Robertson BH, Grubman MJ, Weddell GN, Moore DM, Welsh JD, Fischer T, Dowbenko DJ, Yansura DG, Small B, Kleid DG.

J Virol. 1985 Jun;54(3):651-60.

27.

Sequence variation in the gene for the immunogenic capsid protein VP1 of foot-and-mouth disease virus type A.

Weddell GN, Yansura DG, Dowbenko DJ, Hoatlin ME, Grubman MJ, Moore DM, Kleid DG.

Proc Natl Acad Sci U S A. 1985 May;82(9):2618-22.

28.

Dose-response evaluation of a genetically engineered foot-and-mouth disease virus polypeptide immunogen in cattle.

McKercher PD, Moore DM, Morgan DO, Robertson BH, Callis JJ, Kleid DG, Shire SJ, Yansura DG, Dowbenko D, Small B.

Am J Vet Res. 1985 Mar;46(3):587-90.

PMID:
2986495
29.
30.

Construction of a vector for cloning promoters in Bacillus subtilis.

Band L, Yansura DG, Henner DJ.

Gene. 1983 Dec;26(2-3):313-5.

PMID:
6323271
31.

Identification of amino acid and nucleotide sequence of the foot-and-mouth disease virus RNA polymerase.

Robertson BH, Morgan DO, Moore DM, Grubman MJ, Card J, Fischer T, Weddell G, Dowbenko D, Yansura D.

Virology. 1983 Apr 30;126(2):614-23.

PMID:
6305004
32.

Direct expression of hepatitis B surface antigen in monkey cells from an SV40 vector.

Liu CC, Yansura D, Levinson AD.

DNA. 1982;1(3):213-21.

PMID:
6301783
33.

Cloned viral protein vaccine for foot-and-mouth disease: responses in cattle and swine.

Kleid DG, Yansura D, Small B, Dowbenko D, Moore DM, Grubman MJ, McKercher PD, Morgan DO, Robertson BH, Bachrach HL.

Science. 1981 Dec 4;214(4525):1125-9.

PMID:
6272395
34.

Expression in Escherichia coli of a chemically synthesized gene for a "mini-C" analog of human proinsulin.

Wetzel R, Kleid DG, Crea R, Heyneker HL, Yansura DG, Hirose T, Kraszewski A, Riggs AD, Itakura K, Goeddel DV.

Gene. 1981 Dec;16(1-3):63-71.

PMID:
7044895
35.

Synthesis, cloning, and expression of hormone genes in Escherichia coli.

Riggs AD, Itakura K, Crea R, Hirose T, Kraszewski A, Goeddel D, Kleid D, Yansura DG, Bolivar F, Heyneker HL.

Recent Prog Horm Res. 1980;36:261-76. Review. No abstract available.

PMID:
6997943
36.

Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone.

Goeddel DV, Heyneker HL, Hozumi T, Arentzen R, Itakura K, Yansura DG, Ross MJ, Miozzari G, Crea R, Seeburg PH.

Nature. 1979 Oct 18;281(5732):544-8.

PMID:
386136
37.

Studied on gene control regions IX. The effect of hypoxanthine-substituted lac operators on the lac operator--lac repressor interaction.

Yansura DG, Goeddel DV, Kundu A, Caruthers MH.

J Mol Biol. 1979 Sep 5;133(1):117-35. No abstract available.

PMID:
393830
38.

Expression in Escherichia coli of chemically synthesized genes for human insulin.

Goeddel DV, Kleid DG, Bolivar F, Heyneker HL, Yansura DG, Crea R, Hirose T, Kraszewski A, Itakura K, Riggs AD.

Proc Natl Acad Sci U S A. 1979 Jan;76(1):106-10.

39.

Studies on gene control regions. VII. Effect of 5-bromuracil-substituted lac operators on the lac operator-lac repressor interaction.

Goeddel DV, Yansura DG, Winston C, Caruthers MH.

J Mol Biol. 1978 Aug 25;123(4):661-87. No abstract available.

PMID:
691058
40.

How lac repressor recognizes lac operator.

Goeddel DV, Yansura DG, Caruthers MH.

Proc Natl Acad Sci U S A. 1978 Aug;75(8):3578-82.

41.

Cloning of chemically synthesized lactose operators. II. EcoRI-linkered operators.

Sadler JR, Betz JL, Tecklenburg M, Goeddel DV, Yansura DG, Caruthers MH.

Gene. 1978 May;3(3):211-32.

PMID:
357249
42.

Studies on gene control regions. VI. The 5- methyl of thymine, a lac repressor recognition site.

Goeddel DV, Yansura DG, Caruthers MH.

Nucleic Acids Res. 1977 Sep;4(9):3039-54.

43.

Binding of synthetic lactose operator DNAs to lactose represessors.

Goeddel DV, Yansura DG, Caruthers MH.

Proc Natl Acad Sci U S A. 1977 Aug;74(8):3292-6.

44.

Cloning of chemically synthesized lactose operators.

Sadler JR, Tecklenburg M, Betz JL, Goeddel DV, Yansura DG, Caruthers MH.

Gene. 1977 Jul;1(5-6):305-21.

PMID:
338421
45.
46.

Studies on gene control regions. 1. Chemical synthesis of lactose operator deoxyribonucleic acid segments.

Goeddel DV, Yansura DG, Caruthers MH.

Biochemistry. 1977 May 3;16(9):1765-72.

PMID:
322706
47.

Studies of gene control regions. III. Binding of synthetic and modified synthetic lac operator DNAs to lactose repressor.

Yansura DG, Goeddel DV, Cribbs DL, Caruthers MH.

Nucleic Acids Res. 1977 Mar;4(3):723-37.

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