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A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.

Wu CC, Lin JLJ, Yang-Yen HF, Yuan HS.

Nucleic Acids Res. 2019 Jun 4;47(10):5405-5419. doi: 10.1093/nar/gkz241.


CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia.

Chiang YJ, Liao WT, Ho KC, Wang SH, Chen YG, Ho CL, Huang SF, Shih LY, Yang-Yen HF, Yen JJ.

Oncogene. 2019 Feb;38(9):1432-1447. doi: 10.1038/s41388-018-0507-6. Epub 2018 Sep 28.


Identification of UAP1L1 as a critical factor for protein O-GlcNAcylation and cell proliferation in human hepatoma cells.

Lai CY, Liu H, Tin KX, Huang Y, Yeh KH, Peng HW, Chen HD, He JY, Chiang YJ, Liu CS, Weng SY, Tao MH, Yen JJ, Yang-Yen HF.

Oncogene. 2019 Jan;38(3):317-331. doi: 10.1038/s41388-018-0442-6. Epub 2018 Aug 10.


SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCε-dependent Pathway.

Wei SC, Yang-Yen HF, Tsao PN, Weng MT, Tung CC, Yu LCH, Lai LC, Hsiao JH, Chuang EY, Shun CT, Ni YH, Xavier RJ, Podolsky DK, Yen JJY, Wong JM.

Inflamm Bowel Dis. 2017 Oct;23(10):1730-1740. doi: 10.1097/MIB.0000000000001250.


Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction.

Liu CS, Yang-Yen HF, Suen CS, Hwang MJ, Yen JJ.

Sci Rep. 2017 Jul 4;7(1):4613. doi: 10.1038/s41598-017-04078-w.


Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis.

Chen LY, Yang-Yen HF, Tsai CC, Thio CL, Chuang HL, Yang LT, Shen LF, Song IW, Liu KM, Huang YT, Liu FT, Chang YJ, Chen YT, Yen JJY.

J Invest Dermatol. 2017 Apr;137(4):894-904. doi: 10.1016/j.jid.2016.12.011. Epub 2016 Dec 23.


Murine tribbles homolog 2 deficiency affects erythroid progenitor development and confers macrocytic anemia on mice.

Lin KR, Yang-Yen HF, Lien HW, Liao WH, Huang CJ, Lin LI, Li CL, Yen JJ.

Sci Rep. 2016 Aug 23;6:31444. doi: 10.1038/srep31444.


CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling.

Ho KC, Chiang YJ, Lai AC, Liao NS, Chang YJ, Yang-Yen HF, Yen JJ.

Cell Death Dis. 2014 Nov 13;5:e1518. doi: 10.1038/cddis.2014.474.


Osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21.

Choi SW, Shin HK, Yang-Yen HF, Lee MS, Lee CH, Park SJ, Kim KJ, Lee K, Kim SH.

FEBS Lett. 2014 Nov 3;588(21):4026-31. doi: 10.1016/j.febslet.2014.09.022. Epub 2014 Sep 27.


Up-regulation of Rhoa/Rho kinase pathway by translationally controlled tumor protein in vascular smooth muscle cells.

Maeng J, Sheverdin V, Shin H, Ha I, Bae SS, Yang-Yen HF, Lee K.

Int J Mol Sci. 2014 Jun 10;15(6):10365-76. doi: 10.3390/ijms150610365.


TCTP is essential for β-cell proliferation and mass expansion during development and β-cell adaptation in response to insulin resistance.

Tsai MJ, Yang-Yen HF, Chiang MK, Wang MJ, Wu SS, Chen SH.

Endocrinology. 2014 Feb;155(2):392-404. doi: 10.1210/en.2013-1663. Epub 2013 Nov 18.


Thymic epithelial β-catenin is required for adult thymic homeostasis and function.

Liang CC, You LR, Yen JJ, Liao NS, Yang-Yen HF, Chen CM.

Immunol Cell Biol. 2013 Sep;91(8):511-23. doi: 10.1038/icb.2013.34. Epub 2013 Jul 16.


IL-15 modulates the balance between Bcl-2 and Bim via a Jak3/1-PI3K-Akt-ERK pathway to promote CD8αα+ intestinal intraepithelial lymphocyte survival.

Lai YG, Hou MS, Lo A, Huang ST, Huang YW, Yang-Yen HF, Liao NS.

Eur J Immunol. 2013 Sep;43(9):2305-16. doi: 10.1002/eji.201243026. Epub 2013 Jul 12.


Constitutive phosphorylation of GATA-1 at serine²⁶ attenuates the colony-forming activity of erythrocyte-committed progenitors.

Lin KR, Li CL, Yen JJ, Yang-Yen HF.

PLoS One. 2013 May 22;8(5):e64269. doi: 10.1371/journal.pone.0064269. Print 2013.


CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.

Chiang YJ, Ho KC, Sun CT, Chiu JJ, Lee FJ, Liao F, Yang-Yen HF, Yen JJ.

PLoS One. 2013 Apr 19;8(4):e61761. doi: 10.1371/journal.pone.0061761. Print 2013.


Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2.

Chen PH, Chien FC, Lee SP, Chan WE, Lin IH, Liu CS, Lee FJ, Lai JS, Chen P, Yang-Yen HF, Yen JJ.

Cell Cycle. 2012 Oct 1;11(19):3611-26. doi: 10.4161/cc.21920. Epub 2012 Aug 30.


Does N-terminal processing of Mcl-1 occur at mitochondrial outer membrane or matrix?

Yang-Yen HF.

J Biol Chem. 2011 Jul 29;286(30):le15; author reply le16. doi: 10.1074/jbc.L111.218321. No abstract available.


Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer.

Weng SY, Yang CY, Li CC, Sun TP, Tung SY, Yen JJ, Tsai TF, Chen CM, Chen SH, Hsiao M, Huang PH, Yang-Yen HF.

J Hepatol. 2011 Apr;54(4):685-94. doi: 10.1016/j.jhep.2010.07.035. Epub 2010 Sep 22.


The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity.

Huang CR, Yang-Yen HF.

FEBS Lett. 2010 Aug 4;584(15):3323-30. doi: 10.1016/j.febslet.2010.07.013. Epub 2010 Jul 11.


Critical roles of translationally controlled tumor protein in the homeostasis and TCR-mediated proliferation of peripheral T cells.

Wu PS, Yang CY, Yen JJ, Chou CH, Chen SH, Wang CK, Lai YG, Liao NS, Yang-Yen HF.

J Immunol. 2009 Aug 15;183(4):2373-81. doi: 10.4049/jimmunol.0900668. Epub 2009 Jul 15.


Promoter knock-in mutations reveal a role of Mcl-1 in thymocyte-positive selection and tissue or cell lineage-specific regulation of Mcl-1 expression.

Yang CY, Lin NH, Lee JM, Huang CY, Min HJ, Yen JJ, Liao NS, Yang-Yen HF.

J Immunol. 2009 Mar 1;182(5):2959-68. doi: 10.4049/jimmunol.0803550.


CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction.

Kao CJ, Chiang YJ, Chen PH, Lin KR, Hwang PI, Yang-Yen HF, Yen JJ.

Oncogene. 2008 Feb 28;27(10):1397-403. Epub 2007 Sep 10.


Survival factor withdrawal-induced apoptosis of TF-1 cells involves a TRB2-Mcl-1 axis-dependent pathway.

Lin KR, Lee SF, Hung CM, Li CL, Yang-Yen HF, Yen JJ.

J Biol Chem. 2007 Jul 27;282(30):21962-72. Epub 2007 Jun 1.


A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner.

Chen SH, Wu PS, Chou CH, Yan YT, Liu H, Weng SY, Yang-Yen HF.

Mol Biol Cell. 2007 Jul;18(7):2525-32. Epub 2007 May 2.


Transcription factors mediating interleukin-3 survival signals.

Yen JJ, Yang-Yen HF.

Vitam Horm. 2006;74:147-63. Review.


An internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway.

Chou CH, Lee RS, Yang-Yen HF.

Mol Biol Cell. 2006 Sep;17(9):3952-63. Epub 2006 Jul 5.


Mcl-1: a highly regulated cell death and survival controller.

Yang-Yen HF.

J Biomed Sci. 2006 Mar;13(2):201-4. Review.


Stabilization and enhancement of the antiapoptotic activity of mcl-1 by TCTP.

Liu H, Peng HW, Cheng YS, Yuan HS, Yang-Yen HF.

Mol Cell Biol. 2005 Apr;25(8):3117-26.


Lysophosphatidic acid promotes phorbol-ester-induced apoptosis in TF-1 cells by interfering with adhesion.

Lai JM, Lu CY, Yang-Yen HF, Chang ZF.

Biochem J. 2001 Oct 1;359(Pt 1):227-33.


CREB is one component of the binding complex of the Ces-2/E2A-HLF binding element and is an integral part of the interleukin-3 survival signal.

Chen W, Yu YL, Lee SF, Chiang YJ, Chao JR, Huang JH, Chiong JH, Huang CJ, Lai MZ, Yang-Yen HF, Yen JJ.

Mol Cell Biol. 2001 Jul;21(14):4636-46.


Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.

Epling-Burnette PK, Liu JH, Catlett-Falcone R, Turkson J, Oshiro M, Kothapalli R, Li Y, Wang JM, Yang-Yen HF, Karras J, Jove R, Loughran TP Jr.

J Clin Invest. 2001 Feb;107(3):351-62.


Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-macrophage colony-stimulating factor.

Lin YH, Huang CJ, Chao JR, Chen ST, Lee SF, Yen JJ, Yang-Yen HF.

Mol Cell Biol. 2000 Apr;20(8):2734-42. Erratum in: Mol Cell Biol 2001 Mar;21(6):2248.


Cytokine receptor common beta chain as a potential activator of cytokine withdrawal-induced apoptosis.

Lee SF, Huang HM, Chao JR, Lin S, Yang-Yen HF, Yen JJ.

Mol Cell Biol. 1999 Nov;19(11):7399-409.


Activation of Stat3 by v-Src is through a Ras-independent pathway.

Liu JJ, Nakajima K, Hirano T, Yang-Yen HF.

J Biomed Sci. 1998 Nov-Dec;5(6):446-50.


mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response.

Chao JR, Wang JM, Lee SF, Peng HW, Lin YH, Chou CH, Li JC, Huang HM, Chou CK, Kuo ML, Yen JJ, Yang-Yen HF.

Mol Cell Biol. 1998 Aug;18(8):4883-98.


Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines.

Jiang MC, Yang-Yen HF, Yen JJ, Lin JK.

Nutr Cancer. 1996;26(1):111-20.


Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells.

Liu JJ, Chao JR, Jiang MC, Ng SY, Yen JJ, Yang-Yen HF.

Mol Cell Biol. 1995 Jul;15(7):3654-63.


Restoring the apoptosis suppression response to IL-5 confers on erythroleukemic cells a phenotype of IL-5-dependent growth.

Yen JJ, Hsieh YC, Yen CL, Chang CC, Lin S, Yang-Yen HF.

J Immunol. 1995 Mar 1;154(5):2144-52.


Various modes of gene regulation by nuclear receptors for steroid and thyroid hormones.

Karin M, Yang-Yen HF, Chambard JC, Deng T, Saatcioglu F.

Eur J Clin Pharmacol. 1993;45 Suppl 1:S9-15; discussion S43-4. Review.


Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation.

Yang-Yen HF, Zhang XK, Graupner G, Tzukerman M, Sakamoto B, Karin M, Pfahl M.

New Biol. 1991 Dec;3(12):1206-19.


Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction.

Yang-Yen HF, Chambard JC, Sun YL, Smeal T, Schmidt TJ, Drouin J, Karin M.

Cell. 1990 Sep 21;62(6):1205-15.


Characterization of factors that direct transcription of rat ribosomal DNA.

Smith SD, Oriahi E, Lowe D, Yang-Yen HF, O'Mahony D, Rose K, Chen K, Rothblum LI.

Mol Cell Biol. 1990 Jun;10(6):3105-16.


Interaction of RNA polymerase I transcription factors with a promoter in the nontranscribed spacer of rat ribosomal DNA.

Smith SD, Oriahi E, Yang-Yen HF, Xie WQ, Chen C, Rothblum LI.

Nucleic Acids Res. 1990 Apr 11;18(7):1677-85.


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