Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 193


Krüppel-like Factor 5 Regulates Stemness, Lineage Specification, and Regeneration of Intestinal Epithelial Stem Cells.

Kim CK, Saxena M, Maharjan K, Song JJ, Shroyer KR, Bialkowska AB, Shivdasani RA, Yang VW.

Cell Mol Gastroenterol Hepatol. 2019 Nov 25;9(4):587-609. doi: 10.1016/j.jcmgh.2019.11.009. [Epub ahead of print]


The Novel Small-Molecule SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo.

Kim J, Wang C, de Sabando AR, Cole HL, Huang TJ, Yang J, Bannister TD, Yang VW, Bialkowska AB.

Mol Cancer Ther. 2019 Nov;18(11):1973-1984. doi: 10.1158/1535-7163.MCT-18-1366. Epub 2019 Jul 29.


Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet.

Luo Y, Yang Y, Liu M, Wang D, Wang F, Bi Y, Ji J, Li S, Liu Y, Chen R, Huang H, Wang X, Swidnicka-Siergiejko AK, Janowitz T, Beyaz S, Wang G, Xu S, Bialkowska AB, Luo CK, Pin CL, Liang G, Lu X, Wu M, Shroyer KR, Wolff RA, Plunkett W, Ji B, Li Z, Li E, Li X, Yang VW, Logsdon CD, Abbruzzese JL, Lu W.

Gastroenterology. 2019 Nov;157(5):1413-1428.e11. doi: 10.1053/j.gastro.2019.07.030. Epub 2019 Jul 25.


Enantioselective Synthesis of Yohimbine Analogues by an Organocatalytic and Pot-Economic Strategy.

Kao HK, Lin XJ, Hong BC, Yang VW, Lee GH.

J Org Chem. 2019 Sep 20;84(18):12138-12147. doi: 10.1021/acs.joc.9b01193. Epub 2019 Jul 24.


Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS.

Wang D, Bi Y, Hu L, Luo Y, Ji J, Mao AZ, Logsdon CD, Li E, Abbruzzese JL, Li Z, Yang VW, Lu W.

Cell Commun Signal. 2019 Feb 28;17(1):19. doi: 10.1186/s12964-019-0333-7.


Podocyte-Specific Induction of Krüppel-Like Factor 15 Restores Differentiation Markers and Attenuates Kidney Injury in Proteinuric Kidney Disease.

Guo Y, Pace J, Li Z, Ma'ayan A, Wang Z, Revelo MP, Chen E, Gu X, Attalah A, Yang Y, Estrada C, Yang VW, He JC, Mallipattu SK.

J Am Soc Nephrol. 2018 Oct;29(10):2529-2545. doi: 10.1681/ASN.2018030324. Epub 2018 Aug 24.


Podocyte-Specific Loss of Krüppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease.

Horne SJ, Vasquez JM, Guo Y, Ly V, Piret SE, Leonardo AR, Ling J, Revelo MP, Bogenhagen D, Yang VW, He JC, Mallipattu SK.

Diabetes. 2018 Nov;67(11):2420-2433. doi: 10.2337/db17-0958. Epub 2018 Aug 16.


Increased Genetic Instability and Accelerated Progression of Colitis-Associated Colorectal Cancer through Intestinal Epithelium-specific Deletion of Klf4.

Yang VW, Liu Y, Kim J, Shroyer KR, Bialkowska AB.

Mol Cancer Res. 2019 Jan;17(1):165-176. doi: 10.1158/1541-7786.MCR-18-0399. Epub 2018 Aug 14.


Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation.

Estrada CC, Paladugu P, Guo Y, Pace J, Revelo MP, Salant DJ, Shankland SJ, D'Agati VD, Mehrotra A, Cardona S, Bialkowska AB, Yang VW, He JC, Mallipattu SK.

JCI Insight. 2018 Jun 21;3(12). pii: 98214. doi: 10.1172/jci.insight.98214. eCollection 2018 Jun 21.


Correction to: The Role of Intestinal Stem Cells in Epithelial Regeneration Following Radiation-Induced Gut Injury.

Kim CK, Yang VW, Bialkowska AB.

Curr Stem Cell Rep. 2018;4(1):95. doi: 10.1007/s40778-018-0121-0. Epub 2018 Feb 19.


Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice.

He P, Yang JW, Yang VW, Bialkowska AB.

Gastroenterology. 2018 Apr;154(5):1494-1508.e13. doi: 10.1053/j.gastro.2017.12.005. Epub 2017 Dec 15.


Krüppel-like factor 5 is essential for maintenance of barrier function in mouse colon.

Liu Y, Chidgey M, Yang VW, Bialkowska AB.

Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G478-G491. doi: 10.1152/ajpgi.00172.2017. Epub 2017 Sep 1.


Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes.

Fujikawa J, Takeuchi Y, Kanazawa S, Nomir AG, Kito A, Elkhashab E, Ghaleb AM, Yang VW, Akiyama S, Morisaki I, Yamashiro T, Wakisaka S, Abe M.

Cell Tissue Res. 2017 Dec;370(3):441-449. doi: 10.1007/s00441-017-2674-0. Epub 2017 Aug 31.


The loss of Krüppel-like factor 15 in Foxd1+ stromal cells exacerbates kidney fibrosis.

Gu X, Mallipattu SK, Guo Y, Revelo MP, Pace J, Miller T, Gao X, Jain MK, Bialkowska AB, Yang VW, He JC, Mei C.

Kidney Int. 2017 Nov;92(5):1178-1193. doi: 10.1016/j.kint.2017.03.037. Epub 2017 Jun 24.


DNA Methyltransferases Modulate Hepatogenic Lineage Plasticity of Mesenchymal Stromal Cells.

Lee CW, Huang WC, Huang HD, Huang YH, Ho JH, Yang MH, Yang VW, Lee OK.

Stem Cell Reports. 2017 Jul 11;9(1):247-263. doi: 10.1016/j.stemcr.2017.05.008. Epub 2017 Jun 8.


SP and KLF Transcription Factors in Digestive Physiology and Diseases.

Kim CK, He P, Bialkowska AB, Yang VW.

Gastroenterology. 2017 Jun;152(8):1845-1875. doi: 10.1053/j.gastro.2017.03.035. Epub 2017 Mar 30. Review.


Krüppel-like factors in mammalian stem cells and development.

Bialkowska AB, Yang VW, Mallipattu SK.

Development. 2017 Mar 1;144(5):737-754. doi: 10.1242/dev.145441. Review.


Krüppel-like factor 4 (KLF4): What we currently know.

Ghaleb AM, Yang VW.

Gene. 2017 May 5;611:27-37. doi: 10.1016/j.gene.2017.02.025. Epub 2017 Feb 22. Review.


The Role of Intestinal Stem Cells in Epithelial Regeneration Following Radiation-Induced Gut Injury.

Kim CK, Yang VW, Bialkowska AB.

Curr Stem Cell Rep. 2017;3(4):320-332. doi: 10.1007/s40778-017-0103-7. Epub 2017 Oct 5. Review. Erratum in: Curr Stem Cell Rep. 2018;4(1):95.


Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis.

Walter L, Pujada A, Bhatnagar N, Bialkowska AB, Yang VW, Laroui H, Garg P.

Oncotarget. 2017 Jan 3;8(1):364-378. doi: 10.18632/oncotarget.13406.


Intestinal stem cell resurgence by enterocyte precursors.

Kim CK, Bialkowska AB, Yang VW.

Stem Cell Investig. 2016 Sep 23;3:49. eCollection 2016. No abstract available.


Role of neutral ceramidase in colon cancer.

García-Barros M, Coant N, Kawamori T, Wada M, Snider AJ, Truman JP, Wu BX, Furuya H, Clarke CJ, Bialkowska AB, Ghaleb A, Yang VW, Obeid LM, Hannun YA.

FASEB J. 2016 Dec;30(12):4159-4171. Epub 2016 Sep 8.


Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses.

Bialkowska AB, Ghaleb AM, Nandan MO, Yang VW.

J Vis Exp. 2016 Jul 13;(113). doi: 10.3791/54161.


Krüppel-Like Factor 15 Mediates Glucocorticoid-Induced Restoration of Podocyte Differentiation Markers.

Mallipattu SK, Guo Y, Revelo MP, Roa-Peña L, Miller T, Ling J, Shankland SJ, Bialkowska AB, Ly V, Estrada C, Jain MK, Lu Y, Ma'ayan A, Mehrotra A, Yacoub R, Nord EP, Woroniecki RP, Yang VW, He JC.

J Am Soc Nephrol. 2017 Jan;28(1):166-184. doi: 10.1681/ASN.2015060672. Epub 2016 Jun 10.


Krüppel-like Factor 4 Modulates Development of BMI1(+) Intestinal Stem Cell-Derived Lineage Following γ-Radiation-Induced Gut Injury in Mice.

Kuruvilla JG, Kim CK, Ghaleb AM, Bialkowska AB, Kuo CJ, Yang VW.

Stem Cell Reports. 2016 Jun 14;6(6):815-824. doi: 10.1016/j.stemcr.2016.04.014. Epub 2016 May 26.


Murine Model for Colitis-Associated Cancer of the Colon.

Snider AJ, Bialkowska AB, Ghaleb AM, Yang VW, Obeid LM, Hannun YA.

Methods Mol Biol. 2016;1438:245-54. doi: 10.1007/978-1-4939-3661-8_14. Review.


Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.

Wang K, Xu R, Snider AJ, Schrandt J, Li Y, Bialkowska AB, Li M, Zhou J, Hannun YA, Obeid LM, Yang VW, Mao C.

Cell Death Dis. 2016 Mar 3;7:e2124. doi: 10.1038/cddis.2016.36.


KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.

Ghaleb AM, Elkarim EA, Bialkowska AB, Yang VW.

Mol Cancer Res. 2016 Apr;14(4):385-96. doi: 10.1158/1541-7786.MCR-15-0410. Epub 2016 Feb 2.


ML264, A Novel Small-Molecule Compound That Potently Inhibits Growth of Colorectal Cancer.

Ruiz de Sabando A, Wang C, He Y, García-Barros M, Kim J, Shroyer KR, Bannister TD, Yang VW, Bialkowska AB.

Mol Cancer Ther. 2016 Jan;15(1):72-83. doi: 10.1158/1535-7163.MCT-15-0600. Epub 2015 Nov 30.


Mushtaq A. Khan, DVM, PhD: Unwavering Supporter for Digestive Diseases Research.

Yang VW.

Gastroenterology. 2016 Jan;150(1):4-6. doi: 10.1053/j.gastro.2015.11.009. Epub 2015 Nov 18. No abstract available.


One-Pot Dichotomous Construction of Inside-Azayohimban and Pro-Azayohimban Systems via an Enantioselective Organocatalytic Cascade; Their Use as a Model to Probe the (Aza-)Indole Local Solvent Environment.

Yang VW, Hong BC, Kao HK, Tu TH, Shen JY, Chen CL, Lee GH, Chou PT.

Org Lett. 2015 Dec 4;17(23):5816-9. doi: 10.1021/acs.orglett.5b02949. Epub 2015 Nov 20.


Role of Krüppel-like factor 5 in the maintenance of the stem cell niche in the intestinal crypt.

Kuruvilla JG, Ghaleb AM, Bialkowska AB, Nandan MO, Yang VW.

Stem Cell Transl Investig. 2015;2(2). pii: e839.


IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice.

Ghaleb AM, Bialkowska AB, Snider AJ, Gnatenko DV, Hannun YA, Yang VW, Schmidt VA.

PLoS One. 2015 Jun 5;10(6):e0129314. doi: 10.1371/journal.pone.0129314. eCollection 2015.


High-performance green flexible electronics based on biodegradable cellulose nanofibril paper.

Jung YH, Chang TH, Zhang H, Yao C, Zheng Q, Yang VW, Mi H, Kim M, Cho SJ, Park DW, Jiang H, Lee J, Qiu Y, Zhou W, Cai Z, Gong S, Ma Z.

Nat Commun. 2015 May 26;6:7170. doi: 10.1038/ncomms8170.


Krüppel-like factor 6 regulates mitochondrial function in the kidney.

Mallipattu SK, Horne SJ, D'Agati V, Narla G, Liu R, Frohman MA, Dickman K, Chen EY, Ma'ayan A, Bialkowska AB, Ghaleb AM, Nandan MO, Jain MK, Daehn I, Chuang PY, Yang VW, He JC.

J Clin Invest. 2015 Mar 2;125(3):1347-61. doi: 10.1172/JCI77084. Epub 2015 Feb 17.


Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells.

Nandan MO, Ghaleb AM, Bialkowska AB, Yang VW.

Stem Cell Res. 2015 Jan;14(1):10-9. doi: 10.1016/j.scr.2014.10.008. Epub 2014 Nov 6.


Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease.

Snider AJ, Ali WH, Sticca JA, Coant N, Ghaleb AM, Kawamori T, Yang VW, Hannun YA, Obeid LM.

PLoS One. 2014 Dec 2;9(12):e113998. doi: 10.1371/journal.pone.0113998. eCollection 2014.


Krüppel-like factor 4 is a radioprotective factor for the intestine following γ-radiation-induced gut injury in mice.

Talmasov D, Xinjun Z, Yu B, Nandan MO, Bialkowska AB, Elkarim E, Kuruvilla J, Yang VW, Ghaleb AM.

Am J Physiol Gastrointest Liver Physiol. 2015 Jan 15;308(2):G121-38. doi: 10.1152/ajpgi.00080.2014. Epub 2014 Nov 20.


Diabetic nephropathy in a nonobese mouse model of type 2 diabetes mellitus.

Mallipattu SK, Gallagher EJ, LeRoith D, Liu R, Mehrotra A, Horne SJ, Chuang PY, Yang VW, He JC.

Am J Physiol Renal Physiol. 2014 May 1;306(9):F1008-17. doi: 10.1152/ajprenal.00597.2013. Epub 2014 Mar 5.


Cryo-chemical decellularization of the whole liver for mesenchymal stem cells-based functional hepatic tissue engineering.

Jiang WC, Cheng YH, Yen MH, Chang Y, Yang VW, Lee OK.

Biomaterials. 2014 Apr;35(11):3607-17. doi: 10.1016/j.biomaterials.2014.01.024. Epub 2014 Jan 24.


Inducible intestine-specific deletion of Krüppel-like factor 5 is characterized by a regenerative response in adult mouse colon.

Nandan MO, Ghaleb AM, Liu Y, Bialkowska AB, McConnell BB, Shroyer KR, Robine S, Yang VW.

Dev Biol. 2014 Mar 15;387(2):191-202. doi: 10.1016/j.ydbio.2014.01.002. Epub 2014 Jan 15.


Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells.

Liu L, Souto J, Liao W, Jiang Y, Li Y, Nishinakamura R, Huang S, Rosengart T, Yang VW, Schuster M, Ma Y, Yang J.

J Biol Chem. 2013 Nov 29;288(48):34719-28. doi: 10.1074/jbc.M113.506568. Epub 2013 Oct 25.


What is the value of a food and drug administration investigational new drug application for fecal microbiota transplantation to treat Clostridium difficile Infection?

Hecht GA, Blaser MJ, Gordon J, Kaplan LM, Knight R, Laine L, Peek R, Sanders ME, Sartor B, Wu GD, Yang VW.

Clin Gastroenterol Hepatol. 2014 Feb;12(2):289-91. doi: 10.1016/j.cgh.2013.10.009. Epub 2013 Oct 20. No abstract available.


Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts.

El-Karim EA, Hagos EG, Ghaleb AM, Yu B, Yang VW.

Mol Cancer. 2013 Aug 6;12:89. doi: 10.1186/1476-4598-12-89.


Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5.

Lee SJ, No YR, Dang DT, Dang LH, Yang VW, Shim H, Yun CC.

J Biol Chem. 2013 Aug 30;288(35):25244-53. doi: 10.1074/jbc.M113.489708. Epub 2013 Jul 23.


ML264: An Antitumor Agent that Potently and Selectively Inhibits Krüppel-like Factor Five (KLF5) Expression: A Probe for Studying Colon Cancer Development and Progression.

Bialkowska A, Crisp M, Madoux F, Spicer T, Knapinska A, Mercer B, Bannister TD, He Y, Chowdhury S, Cameron M, Yang VW, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Oct 31 [updated 2013 Mar 7].


Our new president-Anil K. Rustgi, MD.

Wu GD, Yang VW, Omary MB.

Gastroenterology. 2013 May;144(5):1129-35. doi: 10.1053/j.gastro.2013.03.024. Epub 2013 Mar 23. No abstract available.


Supplemental Content

Support Center