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A Novel HIV-1 Nef Mutation in a Primary Pediatric Isolate Impairs MHC-Class I Downregulation and Cytopathicity.

Ali A, Furler RL, Pedroza-Martins L, Colantonio AD, Anisman-Posner D, Bryson Y, Yang OO, Uittenbogaart CH.

AIDS Res Hum Retroviruses. 2019 Oct 1. doi: 10.1089/AID.2019.0160. [Epub ahead of print]


Suboptimal stimulation by weak agonist epitope variants does not drive dysfunction of HIV-1-specific cytotoxic T lymphocyte clones.

Grossman MA, Hofmann C, Ng HL, Yang OO.

AIDS. 2019 Aug 1;33(10):1565-1574. doi: 10.1097/QAD.0000000000002259.


Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection.

Fulcher JA, Tamshen K, Wollenberg AL, Kickhoefer VA, Mrazek J, Elliott J, Ibarrondo FJ, Anton PA, Rome LH, Maynard HD, Deming T, Yang OO.

Bioconjug Chem. 2019 Aug 21;30(8):2216-2227. doi: 10.1021/acs.bioconjchem.9b00451. Epub 2019 Jul 16.


Nef-induced differential gene expression in primary CD4+ T cells following infection with HIV-1 isolates.

Furler RL, Ali A, Yang OO, Nixon DF.

Virus Genes. 2019 Aug;55(4):541-544. doi: 10.1007/s11262-019-01670-2. Epub 2019 May 15.


CD8+ Cytotoxic T Lymphocyte Responses and Viral Epitope Escape in Acute HIV-1 Infection.

Kim J, De La Cruz J, Lam K, Ng H, Daar ES, Balamurugan A, Yang OO.

Viral Immunol. 2018 Sep;31(7):525-536. doi: 10.1089/vim.2018.0040. Epub 2018 Jul 30.


Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones.

Balamurugan A, Ng HL, Yang OO.

J Virol. 2018 Jul 31;92(16). pii: e00617-18. doi: 10.1128/JVI.00617-18. Print 2018 Aug 15.


Highly Attenuated Infection With a Vpr-Deleted Molecular Clone of Human Immunodeficiency Virus-1.

Ali A, Ng HL, Blankson JN, Burton DR, Buckheit RW 3rd, Moldt B, Fulcher JA, Ibarrondo FJ, Anton PA, Yang OO.

J Infect Dis. 2018 Sep 22;218(9):1447-1452. doi: 10.1093/infdis/jiy346.


Solution Structures of Engineered Vault Particles.

Ding K, Zhang X, Mrazek J, Kickhoefer VA, Lai M, Ng HL, Yang OO, Rome LH, Zhou ZH.

Structure. 2018 Apr 3;26(4):619-626.e3. doi: 10.1016/j.str.2018.02.014. Epub 2018 Mar 15.


Brief Report: Changes in Plasma RANKL-Osteoprotegerin in a Prospective, Randomized Clinical Trial of Initial Antiviral Therapy: A5260s.

Kelesidis T, Moser CB, Johnston E, Stein JH, Dube MP, Yang OO, McComsey GA, Currier JS, Brown TT.

J Acquir Immune Defic Syndr. 2018 Jul 1;78(3):362-366. doi: 10.1097/QAI.0000000000001679.


Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes.

Du Y, Zhang TH, Dai L, Zheng X, Gorin AM, Oishi J, Wu TT, Yoshizawa JM, Li X, Yang OO, Martinez-Maza O, Detels R, Sun R.

MBio. 2017 Nov 28;8(6). pii: e01050-17. doi: 10.1128/mBio.01050-17.


HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection.

Leitman EM, Willberg CB, Tsai MH, Chen H, Buus S, Chen F, Riddell L, Haas D, Fellay J, Goedert JJ, Piechocka-Trocha A, Walker BD, Martin J, Deeks S, Wolinsky SM, Martinson J, Martin M, Qi Y, Sáez-Cirión A, Yang OO, Matthews PC, Carrington M, Goulder PJR.

J Virol. 2017 Oct 27;91(22). pii: e00544-17. doi: 10.1128/JVI.00544-17. Print 2017 Nov 15.


A novel rapid and reproducible flow cytometric method for optimization of transfection efficiency in cells.

Homann S, Hofmann C, Gorin AM, Nguyen HCX, Huynh D, Hamid P, Maithel N, Yacoubian V, Mu W, Kossyvakis A, Sen Roy S, Yang OO, Kelesidis T.

PLoS One. 2017 Sep 1;12(9):e0182941. doi: 10.1371/journal.pone.0182941. eCollection 2017.


Were we prepared for PrEP? Five years of implementation.

Weinstein M, Yang OO, Cohen AC.

AIDS. 2017 Oct 23;31(16):2303-2305. doi: 10.1097/QAD.0000000000001626. No abstract available.


Distinct aging profiles of CD8+ T cells in blood versus gastrointestinal mucosal compartments.

Dock J, Ramirez CM, Hultin L, Hausner MA, Hultin P, Elliott J, Yang OO, Anton PA, Jamieson BD, Effros RB.

PLoS One. 2017 Aug 23;12(8):e0182498. doi: 10.1371/journal.pone.0182498. eCollection 2017.


HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes.

Gorin AM, Du Y, Liu FY, Zhang TH, Ng HL, Hofmann C, Cumberland WG, Sun R, Yang OO.

PLoS Pathog. 2017 Aug 7;13(8):e1006541. doi: 10.1371/journal.ppat.1006541. eCollection 2017 Aug.


HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth.

Balamurugan A, Claiborne D, Ng HL, Yang OO.

J Virol. 2017 Jul 27;91(16). pii: e00771-17. doi: 10.1128/JVI.00771-17. Print 2017 Aug 15.


Highly Human Immunodeficiency Virus-Exposed Seronegative Men Have Lower Mucosal Innate Immune Reactivity.

Fulcher JA, Romas L, Hoffman JC, Elliott J, Saunders T, Burgener AD, Anton PA, Yang OO.

AIDS Res Hum Retroviruses. 2017 Aug;33(8):788-795. doi: 10.1089/AID.2017.0014. Epub 2017 Jun 19.


Detection of Donor-Derived Microparticles in the Peripheral Blood of a Hand Transplant Recipient During Rejection.

Kim JY, Kelesidis T, Yang OO.

Transplant Direct. 2017 Feb 7;3(3):e131. doi: 10.1097/TXD.0000000000000646. eCollection 2017 Mar.


Clinical efficacy of gene-modified stem cells in adenosine deaminase-deficient immunodeficiency.

Shaw KL, Garabedian E, Mishra S, Barman P, Davila A, Carbonaro D, Shupien S, Silvin C, Geiger S, Nowicki B, Smogorzewska EM, Brown B, Wang X, de Oliveira S, Choi Y, Ikeda A, Terrazas D, Fu PY, Yu A, Fernandez BC, Cooper AR, Engel B, Podsakoff G, Balamurugan A, Anderson S, Muul L, Jagadeesh GJ, Kapoor N, Tse J, Moore TB, Purdy K, Rishi R, Mohan K, Skoda-Smith S, Buchbinder D, Abraham RS, Scharenberg A, Yang OO, Cornetta K, Gjertson D, Hershfield M, Sokolic R, Candotti F, Kohn DB.

J Clin Invest. 2017 May 1;127(5):1689-1699. doi: 10.1172/JCI90367. Epub 2017 Mar 27.


Human immune compartment comparisons: Optimization of proliferative assays for blood and gut T lymphocytes.

Dock J, Hultin L, Hultin P, Elliot J, Yang OO, Anton PA, Jamieson BD, Effros RB.

J Immunol Methods. 2017 Jun;445:77-87. doi: 10.1016/j.jim.2017.03.014. Epub 2017 Mar 21.


Demographics and natural history of HIV-1-infected spontaneous controllers of viremia.

Yang OO, Cumberland WG, Escobar R, Liao D, Chew KW.

AIDS. 2017 May 15;31(8):1091-1098. doi: 10.1097/QAD.0000000000001443.


Risks Associated With Lentiviral Vector Exposures and Prevention Strategies.

Schlimgen R, Howard J, Wooley D, Thompson M, Baden LR, Yang OO, Christiani DC, Mostoslavsky G, Diamond DV, Duane EG, Byers K, Winters T, Gelfand JA, Fujimoto G, Hudson TW, Vyas JM.

J Occup Environ Med. 2016 Dec;58(12):1159-1166. Review.


Reimann's "Habitual Hyperthermia" Responding to Hormone Therapy.

Yang OO, Currier JS.

Open Forum Infect Dis. 2016 Jul 26;3(3):ofw127. eCollection 2016 Sep.


Oxidized lipoproteins are associated with markers of inflammation and immune activation in HIV-1 infection.

Kelesidis T, Jackson N, McComsey GA, Wang X, Elashoff D, Dube MP, Brown TT, Yang OO, Stein JH, Currier JS.

AIDS. 2016 Nov 13;30(17):2625-2633.


Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.

Zhang X, Lai M, Chang W, Yu I, Ding K, Mrazek J, Ng HL, Yang OO, Maslov DA, Zhou ZH.

Nat Commun. 2016 Oct 18;7:13223. doi: 10.1038/ncomms13223.


Changes in plasma levels of oxidized lipoproteins and lipoprotein subfractions with atazanavir-, raltegravir-, darunavir-based initial antiviral therapy and associations with common carotid artery intima-media thickness: ACTG 5260s.

Kelesidis T, Tran TTT, Brown TT, Moser C, Ribaudo HJ, Dube MP, Yang OO, McComsey GA, Stein JH, Currier JS.

Antivir Ther. 2017;22(2):113-126. doi: 10.3851/IMP3093. Epub 2016 Sep 23.


Telmisartan increases vascular reparative capacity in older HIV-infected adults: a pilot study.

Lake JE, Seang S, Kelesidis T, Currier JS, Yang OO.

HIV Clin Trials. 2016 Nov;17(6):225-232. Epub 2016 Sep 23.


Changes in Markers of T-Cell Senescence and Exhaustion With Atazanavir-, Raltegravir-, and Darunavir-Based Initial Antiviral Therapy: ACTG 5260s.

Kelesidis T, Moser C, Stein JH, Brown TT, Tran TT, Ribaudo HJ, Dube MP, Yang OO, Currier JS, McComsey GA.

J Infect Dis. 2016 Sep 1;214(5):748-52. doi: 10.1093/infdis/jiw253. Epub 2016 Jun 28.


Isoniazid therapy for Mycobacterium tuberculosis infection in HIV clinics, Los Angeles, California.

Shin SS, Chang AH, Ghosh JK, Dubé MP, Bolan R, Yang OO, Kerndt PR.

Int J Tuberc Lung Dis. 2016 Jul;20(7):961-6. doi: 10.5588/ijtld.15.0988.


HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies.

Ali A, Kitchen SG, Chen ISY, Ng HL, Zack JA, Yang OO.

J Virol. 2016 Jul 11;90(15):6999-7006. doi: 10.1128/JVI.00805-16. Print 2016 Aug 1.


Supranormal thymic output up to 2 decades after HIV-1 infection.

Aguilera-Sandoval CR, Yang OO, Jojic N, Lovato P, Chen DY, Boechat MI, Cooper P, Zuo J, Ramirez C, Belzer M, Church JA, Krogstad P.

AIDS. 2016 Mar 13;30(5):701-11. doi: 10.1097/QAD.0000000000001010.


Correction: Clonal CD8+ T Cell Persistence and Variable Gene Usage Bias in a Human Transplanted Hand.

Kim JY, Balamurugan A, Azari K, Hofmann C, Ng HL, Reed EF, McDiarmid S, Yang OO.

PLoS One. 2015 Dec 23;10(12):e0146008. doi: 10.1371/journal.pone.0146008. eCollection 2015. No abstract available.


Clonal CD8+ T Cell Persistence and Variable Gene Usage Bias in a Human Transplanted Hand.

Kim JY, Balamurugan A, Azari K, Hofmann C, Ng HL, Reed EF, McDiarmid S, Yang OO.

PLoS One. 2015 Aug 19;10(8):e0136235. doi: 10.1371/journal.pone.0136235. eCollection 2015. Erratum in: PLoS One. 2015;10(12):e0146008.


HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells.

Zhen A, Kamata M, Rezek V, Rick J, Levin B, Kasparian S, Chen IS, Yang OO, Zack JA, Kitchen SG.

Mol Ther. 2015 Aug;23(8):1358-1367. doi: 10.1038/mt.2015.102. Epub 2015 Jun 8.


Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates.

Shen X, Duffy R, Howington R, Cope A, Sadagopal S, Park H, Pal R, Kwa S, Ding S, Yang OO, Fouda GG, Le Grand R, Bolton D, Esteban M, Phogat S, Roederer M, Amara RR, Picker LJ, Seder RA, McElrath MJ, Barnett S, Permar SR, Shattock R, DeVico AL, Felber BK, Pavlakis GN, Pantaleo G, Korber BT, Montefiori DC, Tomaras GD.

J Virol. 2015 Aug;89(16):8643-50. doi: 10.1128/JVI.03635-14. Epub 2015 May 27.


Ectopic expression of anti-HIV-1 shRNAs protects CD8(+) T cells modified with CD4ζ CAR from HIV-1 infection and alleviates impairment of cell proliferation.

Kamata M, Kim PY, Ng HL, Ringpis GE, Kranz E, Chan J, O'Connor S, Yang OO, Chen IS.

Biochem Biophys Res Commun. 2015 Jul 31;463(3):216-21. doi: 10.1016/j.bbrc.2015.05.026. Epub 2015 May 19.


Changes in Inflammation and Immune Activation With Atazanavir-, Raltegravir-, Darunavir-Based Initial Antiviral Therapy: ACTG 5260s.

Kelesidis T, Tran TT, Stein JH, Brown TT, Moser C, Ribaudo HJ, Dube MP, Murphy R, Yang OO, Currier JS, McComsey GA.

Clin Infect Dis. 2015 Aug 15;61(4):651-60. doi: 10.1093/cid/civ327. Epub 2015 Apr 22.


T lymphocyte density and distribution in human colorectal mucosa, and inefficiency of current cell isolation protocols.

Preza GC, Yang OO, Elliott J, Anton PA, Ochoa MT.

PLoS One. 2015 Apr 9;10(4):e0122723. doi: 10.1371/journal.pone.0122723. eCollection 2015.


Adenovirus vectors as HIV-1 vaccines: where are we? What next?

DʼSouza MP, Yang OO.

AIDS. 2015 Feb 20;29(4):395-400. doi: 10.1097/QAD.0000000000000548. No abstract available.


Short conserved sequences of HIV-1 are highly immunogenic and shift immunodominance.

Yang OO, Ali A, Kasahara N, Faure-Kumar E, Bae JY, Picker LJ, Park H.

J Virol. 2015 Jan 15;89(2):1195-204. doi: 10.1128/JVI.02370-14. Epub 2014 Nov 5.


A high throughput biochemical fluorometric method for measuring lipid peroxidation in HDL.

Kelesidis T, Roberts CK, Huynh D, Martínez-Maza O, Currier JS, Reddy ST, Yang OO.

PLoS One. 2014 Nov 4;9(11):e111716. doi: 10.1371/journal.pone.0111716. eCollection 2014.


Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice.

Babad J, Mukherjee G, Follenzi A, Ali R, Roep BO, Shultz LD, Santamaria P, Yang OO, Goldstein H, Greiner DL, DiLorenzo TP.

Clin Exp Immunol. 2015 Mar;179(3):398-413. doi: 10.1111/cei.12465.


Seminal plasma HIV-1 RNA concentration is strongly associated with altered levels of seminal plasma interferon-γ, interleukin-17, and interleukin-5.

Hoffman JC, Anton PA, Baldwin GC, Elliott J, Anisman-Posner D, Tanner K, Grogan T, Elashoff D, Sugar C, Yang OO, Hoffman RM.

AIDS Res Hum Retroviruses. 2014 Nov;30(11):1082-8. doi: 10.1089/AID.2013.0217. Epub 2014 Oct 2.


Immunomodulation of antiretroviral drug-suppressed chronic HIV-1 infection in an oral probiotic double-blind placebo-controlled trial.

Yang OO, Kelesidis T, Cordova R, Khanlou H.

AIDS Res Hum Retroviruses. 2014 Oct;30(10):988-95. doi: 10.1089/AID.2014.0181. Epub 2014 Sep 11.


Role of RANKL-RANK/osteoprotegerin pathway in cardiovascular and bone disease associated with HIV infection.

Kelesidis T, Currier JS, Yang OO, Brown TT.

AIDS Rev. 2014 Jul-Sep;16(3):123-33. Review.


Short communication: HIV-1 gag genetic variation in a single acutely infected participant defined by high-resolution deep sequencing.

Al-Mawsawi LQ, Wu NC, De La Cruz J, Shi VC, Wu TT, Daar ES, Lewis MJ, Yang OO, Sun R.

AIDS Res Hum Retroviruses. 2014 Aug;30(8):806-11. doi: 10.1089/AID.2014.0097. Epub 2014 Jul 23.


HIV-1 quasispecies delineation by tag linkage deep sequencing.

Wu NC, De La Cruz J, Al-Mawsawi LQ, Olson CA, Qi H, Luan HH, Nguyen N, Du Y, Le S, Wu TT, Li X, Lewis MJ, Yang OO, Sun R.

PLoS One. 2014 May 19;9(5):e97505. doi: 10.1371/journal.pone.0097505. eCollection 2014.


Engineering the human thymic microenvironment to support thymopoiesis in vivo.

Chung B, Montel-Hagen A, Ge S, Blumberg G, Kim K, Klein S, Zhu Y, Parekh C, Balamurugan A, Yang OO, Crooks GM.

Stem Cells. 2014 Sep;32(9):2386-96. doi: 10.1002/stem.1731.


Ineffectual targeting of HIV-1 Nef by cytotoxic T lymphocytes in acute infection results in no functional impairment or viremia reduction.

De La Cruz J, Vollbrecht T, Frohnen P, Ng HL, Daar ES, Yang OO, Lewis MJ.

J Virol. 2014 Jul;88(14):7881-92. doi: 10.1128/JVI.00482-14. Epub 2014 Apr 30.


Differential blood and mucosal immune responses against an HIV-1 vaccine administered via inguinal or deltoid injection.

Yang OO, Ibarrondo FJ, Price C, Hultin LE, Elliott J, Hultin PM, Shih R, Hausner MA, Ng HL, Hoffman J, Jamieson BD, Anton PA.

PLoS One. 2014 Feb 18;9(2):e88621. doi: 10.1371/journal.pone.0088621. eCollection 2014.

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