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Integrin α1 promotes tumorigenicity and progressive capacity of colorectal cancer.

Li H, Wang Y, Rong SK, Li L, Chen T, Fan YY, Wang YF, Yang CR, Yang C, Cho WC, Yang J.

Int J Biol Sci. 2020 Jan 16;16(5):815-826. doi: 10.7150/ijbs.37275. eCollection 2020.


Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels.

Xin Y, Xu M, Wang YF, Zheng XH, Zhu HT, Wang D, Yang CR, Zhang YJ.

Nat Prod Res. 2020 Jan 24:1-8. doi: 10.1080/14786419.2020.1712387. [Epub ahead of print]


Genome-wide analysis reveals a switch in the translational program upon oocyte meiotic resumption.

Luong XG, Daldello EM, Rajkovic G, Yang CR, Conti M.

Nucleic Acids Res. 2020 Jan 23. pii: gkaa010. doi: 10.1093/nar/gkaa010. [Epub ahead of print]


4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1.

Jagtap AD, Kondekar NB, Hung PY, Hsieh CE, Yang CR, Chen GS, Chern JW.

Bioorg Chem. 2020 Jan;95:103135. doi: 10.1016/j.bioorg.2019.103135. Epub 2019 Jul 22.


CRISPR-Cas9/phosphoproteomics identifies multiple noncanonical targets of myosin light chain kinase.

Isobe K, Raghuram V, Krishnan L, Chou CL, Yang CR, Knepper MA.

Am J Physiol Renal Physiol. 2020 Mar 1;318(3):F600-F616. doi: 10.1152/ajprenal.00431.2019. Epub 2020 Jan 6.


The Genus Terminalia (Combretaceae): An Ethnopharmacological, Phytochemical and Pharmacological Review.

Zhang XR, Kaunda JS, Zhu HT, Wang D, Yang CR, Zhang YJ.

Nat Prod Bioprospect. 2019 Dec;9(6):357-392. doi: 10.1007/s13659-019-00222-3. Epub 2019 Nov 6. Review.


Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor.

Hao J, Beck JP, Schaus JM, Krushinski JH, Chen Q, Beadle CD, Vidal P, Reinhard MR, Dressman BA, Massey SM, Boulet SL, Cohen MP, Watson BM, Tupper D, Gardinier KM, Myers J, Johansson AM, Richardson J, Richards DS, Hembre EJ, Remick DM, Coates DA, Bhardwaj RM, Diseroad BA, Bender D, Stephenson G, Wolfangel CD, Diaz N, Getman BG, Wang XS, Heinz BA, Cramer JW, Zhou X, Maren DL, Falcone JF, Wright RA, Mitchell SN, Carter G, Yang CR, Bruns RF, Svensson KA.

J Med Chem. 2019 Oct 10;62(19):8711-8732. doi: 10.1021/acs.jmedchem.9b01234. Epub 2019 Sep 30.


Antidepressant Drugs Correct the Imbalance Between proBDNF/p75NTR/Sortilin and Mature BDNF/TrkB in the Brain of Mice with Chronic Stress.

Yang CR, Zhang XY, Liu Y, Du JY, Liang R, Yu M, Zhang FQ, Mu XF, Li F, Zhou L, Zhou FH, Meng FJ, Wang S, Ming D, Zhou XF.

Neurotox Res. 2020 Jan;37(1):171-182. doi: 10.1007/s12640-019-00101-2. Epub 2019 Sep 6.


Combining prostate health index and multiparametric magnetic resonance imaging in the diagnosis of clinically significant prostate cancer in an Asian population.

Hsieh PF, Li WJ, Lin WC, Chang H, Chang CH, Huang CP, Yang CR, Chen WC, Chang YH, Wu HC.

World J Urol. 2019 Aug 22. doi: 10.1007/s00345-019-02889-2. [Epub ahead of print]


The role of RENAL, PADUA, C-index, CSA nephrometry systems in predicting ipsilateral renal function after partial nephrectomy.

Wang YD, Huang CP, Chang CH, Wu HC, Yang CR, Wang YP, Hsieh PF.

BMC Urol. 2019 Aug 5;19(1):72. doi: 10.1186/s12894-019-0504-2.


PTM-Logo: a program for generation of sequence logos based on position-specific background amino-acid probabilities.

Saethang T, Hodge K, Yang CR, Zhao Y, Kimkong I, Knepper MA, Pisitkun T.

Bioinformatics. 2019 Dec 15;35(24):5313-5314. doi: 10.1093/bioinformatics/btz568.


Moscatilin Ameliorates Tau Phosphorylation and Cognitive Deficits in Alzheimer's Disease Models.

Huang JM, Huang FI, Yang CR.

J Nat Prod. 2019 Jul 26;82(7):1979-1988. doi: 10.1021/acs.jnatprod.9b00375. Epub 2019 Jul 10.


RNA-Seq and protein mass spectrometry in microdissected kidney tubules reveal signaling processes initiating lithium-induced nephrogenic diabetes insipidus.

Sung CC, Chen L, Limbutara K, Jung HJ, Gilmer GG, Yang CR, Lin SH, Khositseth S, Chou CL, Knepper MA.

Kidney Int. 2019 Aug;96(2):363-377. doi: 10.1016/j.kint.2019.02.015. Epub 2019 Mar 4.


Anti-inflammatory and Cytotoxic Triterpenes from the Rot Roots of Panax notoginseng.

Shang JH, Xu GW, Zhu HT, Wang D, Yang CR, Zhang YJ.

Nat Prod Bioprospect. 2019 Aug;9(4):287-295. doi: 10.1007/s13659-019-0211-4. Epub 2019 May 23.


MPT0G413, A Novel HDAC6-Selective Inhibitor, and Bortezomib Synergistically Exert Anti-tumor Activity in Multiple Myeloma Cells.

Huang FI, Wu YW, Sung TY, Liou JP, Lin MH, Pan SL, Yang CR.

Front Oncol. 2019 Apr 9;9:249. doi: 10.3389/fonc.2019.00249. eCollection 2019.


DNA methylation analysis and editing in single mammalian oocytes.

Wei Y, Lang J, Zhang Q, Yang CR, Zhao ZA, Zhang Y, Du Y, Sun Y.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):9883-9892. doi: 10.1073/pnas.1817703116. Epub 2019 Apr 22.


New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus.

Gu C, Yin AP, Yuan HY, Yang K, Luo J, Zhan YJ, Yang CR, Zuo DM, Li HZ, Xu M.

Fitoterapia. 2019 Sep;137:104151. doi: 10.1016/j.fitote.2019.04.006. Epub 2019 Apr 15.


The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders.

Troxler T, Feuerbach D, Zhang X, Yang CR, Lagu B, Perrone M, Wang TL, Briner K, Bock MG, Auberson YP.

ChemMedChem. 2019 Jul 3;14(13):1238-1247. doi: 10.1002/cmdc.201900176. Epub 2019 May 21.


Cyclin B2 is required for progression through meiosis in mouse oocytes.

Daldello EM, Luong XG, Yang CR, Kuhn J, Conti M.

Development. 2019 Apr 26;146(8). pii: dev172734. doi: 10.1242/dev.172734.


Alteration in gene expression profiles of thymoma: Genetic differences and potential novel targets.

Meng FJ, Wang S, Zhang J, Yan YJ, Wang CY, Yang CR, Guan ZY, Wang CL.

Thorac Cancer. 2019 May;10(5):1129-1135. doi: 10.1111/1759-7714.13053. Epub 2019 Apr 1.


Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo.

Hsieh YL, Tu HJ, Pan SL, Liou JP, Yang CR.

Biochim Biophys Acta Mol Cell Res. 2019 Jun;1866(6):992-1003. doi: 10.1016/j.bbamcr.2019.03.003. Epub 2019 Mar 10.


A Facile Method for Batch Preparation of Electrochemically Reduced Graphene Oxide.

Hung YF, Cheng C, Huang CK, Yang CR.

Nanomaterials (Basel). 2019 Mar 5;9(3). pii: E376. doi: 10.3390/nano9030376.


Phosphorylation Changes in Response to Kinase Inhibitor H89 in PKA-Null Cells.

Limbutara K, Kelleher A, Yang CR, Raghuram V, Knepper MA.

Sci Rep. 2019 Feb 26;9(1):2814. doi: 10.1038/s41598-019-39116-2.


[Clinicopathological features of follicular lymphoma in children].

Yang CR, Hu YC, Zhou XG, Zhang D.

Zhonghua Bing Li Xue Za Zhi. 2019 Feb 8;48(2):132-136. doi: 10.3760/cma.j.issn.0529-5807.2019.02.011. Chinese.


Improved Pharmacokinetics of Icariin (ICA) within Formulation of PEG-PLLA/PDLA-PNIPAM Polymeric Micelles.

Han LY, Wu YL, Zhu CY, Wu CS, Yang CR.

Pharmaceutics. 2019 Jan 25;11(2). pii: E51. doi: 10.3390/pharmaceutics11020051.


Outcomes of stage II-IV upper-tract urothelial carcinoma and adjuvant chemotherapy for locally advanced cancer.

Chang YH, Hsiao PJ, Chen GH, Lin CC, Chang CH, Wu HC, Huang CP, Yang CR, Yeh SP.

Oncol Lett. 2019 Jan;17(1):1341-1348. doi: 10.3892/ol.2018.9672. Epub 2018 Nov 7.


The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells.

Tu HJ, Lin YJ, Chao MW, Sung TY, Wu YW, Chen YY, Lin MH, Liou JP, Pan SL, Yang CR.

Clin Epigenetics. 2018 Dec 29;10(1):162. doi: 10.1186/s13148-018-0595-8.


Synthesis and evaluation of chalcone analogues containing a 4-oxoquinazolin-2-yl group as potential anti-tumor agents.

Han X, Peng B, Xiao BB, Sheng-Li Cao, Yang CR, Wang WZ, Wang FC, Li HY, Yuan XL, Shi R, Liao J, Wang H, Li J, Xu X.

Eur J Med Chem. 2019 Jan 15;162:586-601. doi: 10.1016/j.ejmech.2018.11.034. Epub 2018 Nov 16.


Plant Resources, Chemical Constituents, and Bioactivities of Tea Plants from the Genus Camellia Section Thea.

Meng XH, Li N, Zhu HT, Wang D, Yang CR, Zhang YJ.

J Agric Food Chem. 2019 May 15;67(19):5318-5349. doi: 10.1021/acs.jafc.8b05037. Epub 2018 Dec 3. Review.


Triterpenoid saponins with hepatoprotective effects from the fresh leaves of Metapanax delavayi.

Wei X, Gao DF, Abe Y, Tanaka Y, Zhu HT, Wang D, Yang CR, Zhang YJ.

Nat Prod Res. 2018 Nov 16:1-7. doi: 10.1080/14786419.2018.1512987. [Epub ahead of print]


Modulation of Cl- signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT.

Vachel L, Shcheynikov N, Yamazaki O, Fremder M, Ohana E, Son A, Shin DM, Yamazaki-Nakazawa A, Yang CR, Knepper MA, Muallem S.

Sci Signal. 2018 Oct 30;11(554). pii: eaat5018. doi: 10.1126/scisignal.aat5018.


Albocycline-type Macrolides with Antibacterial Activities from Streptomyces sp. 4205.

Gu CZ, Yuan SH, Lü J, Qiao YJ, Song YY, Abdalla Elzaki ME, Yang CR, Zhang YJ, Zeng RS.

Chem Biodivers. 2019 Jan;16(1):e1800344. doi: 10.1002/cbdv.201800344. Epub 2018 Dec 17.


Alteration in serum concentrations of FGF19, FGF21, and FGF23 in patients with urothelial carcinoma.

Li JR, Chiu KY, Ou YC, Wang SS, Chen CS, Yang CK, Ho HC, Cheng CL, Yang CR, Chen CC, Wang SC, Lin CY, Hung SC, Hsu CY, Chen CJ.

Biofactors. 2019 Jan;45(1):62-68. doi: 10.1002/biof.1460. Epub 2018 Oct 17.


Characteristics of Graphene Oxide Films Reduced by Using an Atmospheric Plasma System.

Yang CR, Tseng SF, Chen YT.

Nanomaterials (Basel). 2018 Oct 8;8(10). pii: E802. doi: 10.3390/nano8100802.


The Impact of Local Intervention Combined with Targeted Therapy on Metastatic Renal Cell Carcinoma.

Li JR, Ou YC, Yang CK, Wang SS, Chen CS, Ho HC, Cheng CL, Yang CR, Chen CC, Wang SC, Lin CY, Hung SC, Hsu CY, Chiu KY.

Anticancer Res. 2018 Sep;38(9):5339-5345. doi: 10.21873/anticanres.12861.


Intracellular Binding Site for a Positive Allosteric Modulator of the Dopamine D1 Receptor.

Wang X, Heinz BA, Qian YW, Carter JH, Gadski RA, Beavers LS, Little SP, Yang CR, Beck JP, Hao J, Schaus JM, Svensson KA, Bruns RF.

Mol Pharmacol. 2018 Oct;94(4):1232-1245. doi: 10.1124/mol.118.112649. Epub 2018 Aug 15.


Comparison of elective nodal irradiation and involved-field irradiation in esophageal squamous cell carcinoma: a meta-analysis.

Cheng YJ, Jing SW, Zhu LL, Wang J, Wang L, Liu Q, Yang CR, Wang Y, Cao F, Jiao WP, Wu YJ.

J Radiat Res. 2018 Sep 1;59(5):604-615. doi: 10.1093/jrr/rry055.


Progesterone maintains the status of granulosa cells and slows follicle development partly through PGRMC1.

Yuan XH, Yang CR, Wang XN, Zhang LL, Gao XR, Shi ZY.

J Cell Physiol. 2018 Jan;234(1):709-720. doi: 10.1002/jcp.26869. Epub 2018 Aug 1.


Prostate Health Index (PHI) improves prostate cancer detection at initial biopsy in Taiwanese men with PSA 4-10 ng/mL.

Hsieh PF, Chang CH, Yang CR, Huang CP, Chen WC, Yeh CC, Chou EC, Chen KL, Lien CS, Chen GH, Hsiao PJ, Chang YH, Wu HC.

Kaohsiung J Med Sci. 2018 Aug;34(8):461-466. doi: 10.1016/j.kjms.2018.02.007. Epub 2018 Apr 4.


5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes.

Lee HY, Fan SJ, Huang FI, Chao HY, Hsu KC, Lin TE, Yeh TK, Lai MJ, Li YH, Huang HL, Yang CR, Liou JP.

J Med Chem. 2018 Aug 23;61(16):7087-7102. doi: 10.1021/acs.jmedchem.8b00151. Epub 2018 Aug 9.


Research of Panax spp. in Kunming Institute of Botany, CAS.

Qiao YJ, Shang JH, Wang D, Zhu HT, Yang CR, Zhang YJ.

Nat Prod Bioprospect. 2018 Aug;8(4):245-263. doi: 10.1007/s13659-018-0176-8. Epub 2018 Jul 6. Review.


Proteomic determination of the lysine acetylome and phosphoproteome in the rat native inner medullary collecting duct.

Hyndman KA, Yang CR, Jung HJ, Umejiego EN, Chou CL, Knepper MA.

Physiol Genomics. 2018 Sep 1;50(9):669-679. doi: 10.1152/physiolgenomics.00029.2018. Epub 2018 Jun 22.


Two New Alkaloids from Fusarium tricinctum SYPF 7082, an Endophyte from the Root of Panax notoginseng.

Sun WJ, Zhu HT, Zhang TY, Zhang MY, Wang D, Yang CR, Zhang YX, Zhang YJ.

Nat Prod Bioprospect. 2018 Oct;8(5):391-396. doi: 10.1007/s13659-018-0171-0. Epub 2018 Jun 18.


C-8 N-Ethyl-2-pyrrolidinone-Substituted Flavan-3-ols from the Leaves of Camellia sinensis var. pubilimba.

Meng XH, Zhu HT, Yan H, Wang D, Yang CR, Zhang YJ.

J Agric Food Chem. 2018 Jul 11;66(27):7150-7155. doi: 10.1021/acs.jafc.8b02066. Epub 2018 Jun 26.


The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer's disease model.

Fan SJ, Huang FI, Liou JP, Yang CR.

Cell Death Dis. 2018 May 29;9(6):655. doi: 10.1038/s41419-018-0688-5.


Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position.

Yang CR, Peng B, Cao SL, Ren TT, Jiang W, Wang FC, Li YS, Wang G, Li Z, Xu S, Liao J, Wang H, Li J, Xu X.

Eur J Med Chem. 2018 Jun 25;154:324-340. doi: 10.1016/j.ejmech.2018.05.028. Epub 2018 May 21.


Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg.

Zhang H, Zhu HT, Wang D, Yang CR, Zhang YJ.

Nat Prod Res. 2019 May;33(9):1284-1291. doi: 10.1080/14786419.2018.1470627. Epub 2018 May 10.


Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.

Zhang H, Zhu HT, Wang D, Yang CR, Zhang YJ.

Nat Prod Bioprospect. 2018 Apr;8(2):107-111. doi: 10.1007/s13659-018-0156-z. Epub 2018 Mar 14.


(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo.

Lee HY, Nepali K, Huang FI, Chang CY, Lai MJ, Li YH, Huang HL, Yang CR, Liou JP.

J Med Chem. 2018 Feb 8;61(3):905-917. doi: 10.1021/acs.jmedchem.7b01404. Epub 2018 Jan 26.


Phyllaciduloids A-D: Four new cleistanthane diterpenoids from Phyllanthus acidus (L.) Skeels.

Zheng XH, Yang J, Lv JJ, Zhu HT, Wang D, Xu M, Yang CR, Zhang YJ.

Fitoterapia. 2018 Mar;125:89-93. doi: 10.1016/j.fitote.2017.12.005. Epub 2017 Dec 27.


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