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Investigating the structure-function relationship using Goldmann V standard automated perimetry where glaucomatous damage is advanced.

Yanagisawa M, Murata H, Matsuura M, Fujino Y, Hirasawa K, Asaoka R.

Ophthalmic Physiol Opt. 2019 Oct 8. doi: 10.1111/opo.12643. [Epub ahead of print]


Differential Roles of Each Orexin Receptor Signaling in Obesity.

Kakizaki M, Tsuneoka Y, Takase K, Kim SJ, Choi J, Ikkyu A, Abe M, Sakimura K, Yanagisawa M, Funato H.

iScience. 2019 Sep 9;20:1-13. doi: 10.1016/j.isci.2019.09.003. [Epub ahead of print]


Neuronal Myocyte-Specific Enhancer Factor 2D (MEF2D) Is Required for Normal Circadian and Sleep Behavior in Mice.

Mohawk JA, Cox KH, Sato M, Yoo SH, Yanagisawa M, Olson EN, Takahashi JS.

J Neurosci. 2019 Oct 2;39(40):7958-7967. doi: 10.1523/JNEUROSCI.0411-19.2019. Epub 2019 Aug 16.


DNA Origami Nanoplate-Based Emulsion with Nanopore Function.

Ishikawa D, Suzuki Y, Kurokawa C, Ohara M, Tsuchiya M, Morita M, Yanagisawa M, Endo M, Kawano R, Takinoue M.

Angew Chem Int Ed Engl. 2019 Aug 14. doi: 10.1002/anie.201908392. [Epub ahead of print]


A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain.

Furuse T, Mizuma H, Hirose Y, Kushida T, Yamada I, Miura I, Masuya H, Funato H, Yanagisawa M, Onoe H, Wakana S.

Dis Model Mech. 2019 Sep 12;12(9). pii: dmm038828. doi: 10.1242/dmm.038828.


Implementation of a Post-mastectomy Home Recovery Program in a Large, Integrated Health Care Delivery System.

Vuong B, Graff-Baker AN, Yanagisawa M, Chang SB, Mentakis M, Shim V, Knox M, Romero L, Kuehner G.

Ann Surg Oncol. 2019 Oct;26(10):3178-3184. doi: 10.1245/s10434-019-07551-0. Epub 2019 Aug 8.


Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.

Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.

Bioorg Med Chem Lett. 2019 Sep 15;29(18):2655-2658. doi: 10.1016/j.bmcl.2019.07.039. Epub 2019 Jul 24.


Relationship between novel intraocular pressure measurement from Corvis ST and central corneal thickness and corneal hysteresis.

Matsuura M, Murata H, Fujino Y, Yanagisawa M, Nakao Y, Tokumo K, Nakakura S, Kiuchi Y, Asaoka R.

Br J Ophthalmol. 2019 Jul 30. pii: bjophthalmol-2019-314370. doi: 10.1136/bjophthalmol-2019-314370. [Epub ahead of print]


Cell-sized confinement controls generation and stability of a protein wave for spatiotemporal regulation in cells.

Kohyama S, Yoshinaga N, Yanagisawa M, Fujiwara K, Doi N.

Elife. 2019 Jul 30;8. pii: e44591. doi: 10.7554/eLife.44591.


Morbidity, mortality and temporal trends in the surgical management of retroperitoneal sarcoma: An ACS-NSQIP follow up analysis.

Judge SJ, Lata-Arias K, Yanagisawa M, Darrow MA, Monjazeb AM, Kirane AR, Bold RJ, Canter RJ, Canter DJ.

J Surg Oncol. 2019 Sep;120(4):753-760. doi: 10.1002/jso.25649. Epub 2019 Jul 29.


Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice.

Miyoshi C, Kim SJ, Ezaki T, Ikkyu A, Hotta-Hirashima N, Kanno S, Kakizaki M, Yamada M, Wakana S, Yanagisawa M, Funato H.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16062-16067. doi: 10.1073/pnas.1906774116. Epub 2019 Jul 23.


Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model.

Ishikura N, Yorozu K, Kurasawa M, Yanagisawa M, Sugimoto M, Yamamoto K.

Oncol Rep. 2019 Sep;42(3):1057-1065. doi: 10.3892/or.2019.7211. Epub 2019 Jun 26.


Direct Observation of Long-Chain Branches in a Low-Density Polyethylene.

Shinohara KI, Yanagisawa M, Makida Y.

Sci Rep. 2019 Jul 5;9(1):9791. doi: 10.1038/s41598-019-46035-9.


Repeatability of the Novel Intraocular Pressure Measurement From Corvis ST.

Matsuura M, Murata H, Fujino Y, Yanagisawa M, Nakao Y, Nakakura S, Kiuchi Y, Asaoka R.

Transl Vis Sci Technol. 2019 Jun 24;8(3):48. doi: 10.1167/tvst.8.3.48. eCollection 2019 May.


Diagnosis and conservative treatment of a rare case of femoral intraosseous arteriovenous malformation in a patient with polyostotic fibrous dysplasia: A case report.

Ohshika S, Yanagisawa M, Tsushima F, Ishibashi Y.

Mol Clin Oncol. 2019 Jun;10(6):587-591. doi: 10.3892/mco.2019.1845. Epub 2019 Apr 16.


Investigating the Usefulness of Fundus Autofluorescence in Retinitis Pigmentosa.

Lee J, Asano S, Inoue T, Fujino Y, Matsuura M, Kitamoto K, Hashimoto Y, Ogawa A, Yanagisawa M, Azuma K, Murata H, Obata R, Asaoka R.

Ophthalmol Retina. 2018 Oct;2(10):1062-1070. doi: 10.1016/j.oret.2018.03.007. Epub 2018 May 18.


Toward the Mysteries of Sleep.

Yanagisawa M.

Keio J Med. 2019;68(1):27. doi: 10.2302/kjm.68-001-ABST. Review.


Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.

Yamamoto N, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H.

Bioorg Med Chem. 2019 Apr 15;27(8):1747-1758. doi: 10.1016/j.bmc.2019.03.010. Epub 2019 Mar 5.


Ventilator-associated events: prevalence and mortality in Japan.

Nakahashi S, Imai H, Imanaka H, Ohshimo S, Satou T, Shima M, Yanagisawa M, Yamashita C, Ogura T, Yamada T, Shime N.

J Thorac Dis. 2018 Dec;10(12):6942-6949. doi: 10.21037/jtd.2018.12.40.


Single Micrometer-Sized Gels: Unique Mechanics and Characters for Applications.

Yanagisawa M, Watanabe C, Fujiwara K.

Gels. 2018 Mar 28;4(2). pii: E29. doi: 10.3390/gels4020029. Review.


Dynamics of Spinodal Decomposition in a Ternary Gelling System.

Yamashita Y, Yanagisawa M, Tokita M.

Gels. 2018 Mar 22;4(2). pii: E26. doi: 10.3390/gels4020026.


Molecular targeting of HER2-overexpressing biliary tract cancer cells with trastuzumab emtansine, an antibody-cytotoxic drug conjugate.

Yamashita-Kashima Y, Yoshimura Y, Fujimura T, Shu S, Yanagisawa M, Yorozu K, Furugaki K, Higuchi R, Shoda J, Harada N.

Cancer Chemother Pharmacol. 2019 Apr;83(4):659-671. doi: 10.1007/s00280-019-03768-8. Epub 2019 Jan 18.


Sol-Gel Coexisting Phase of Polymer Microgels Triggers Spontaneous Buckling.

Koyanagi K, Kudo K, Yanagisawa M.

Langmuir. 2019 Feb 12;35(6):2283-2288. doi: 10.1021/acs.langmuir.8b03751. Epub 2019 Jan 28.


Logistic regression analysis of multiple interosseous hand-muscle activities using surface electromyography during finger-oriented tasks.

Yokoyama M, Yanagisawa M.

J Electromyogr Kinesiol. 2019 Feb;44:117-123. doi: 10.1016/j.jelekin.2018.12.006. Epub 2018 Dec 23.


[Development of a Therapeutic Drug for Narcolepsy].

Irukayama-Tomobe Y, Yanagisawa M.

Brain Nerve. 2018 Nov;70(11):1255-1263. doi: 10.11477/mf.1416201171. Japanese.


Heart Anatomy of Rhincodon typus: Three-Dimensional X-Ray Computed Tomography of Plastinated Specimens.

Hirasaki Y, Tomita T, Yanagisawa M, Ueda K, Sato K, Okabe M.

Anat Rec (Hoboken). 2018 Nov;301(11):1801-1808. doi: 10.1002/ar.23902. Epub 2018 Oct 5.


A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice.

Honda T, Fujiyama T, Miyoshi C, Ikkyu A, Hotta-Hirashima N, Kanno S, Mizuno S, Sugiyama F, Takahashi S, Funato H, Yanagisawa M.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10458-10463. doi: 10.1073/pnas.1810823115. Epub 2018 Sep 25.


Comparison of Esterman disability scores obtained using Goldmann perimetry and the Humphrey field analyzer in Japanese low-vision patients.

Yanagisawa M, Kato S, Ochiai M.

PLoS One. 2018 Sep 13;13(9):e0203258. doi: 10.1371/journal.pone.0203258. eCollection 2018.


Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response.

Iwasaki K, Komiya H, Kakizaki M, Miyoshi C, Abe M, Sakimura K, Funato H, Yanagisawa M.

Front Neurosci. 2018 Aug 7;12:535. doi: 10.3389/fnins.2018.00535. eCollection 2018.


Long-Term Effects of Ipragliflozin on Diabetic Nephropathy and Blood Pressure in Patients With Type 2 Diabetes: 104-Week Follow-up of an Open-Label Study.

Ito D, Inoue K, Sumita T, Hamaguchi K, Kaneko K, Yanagisawa M, Inukai K, Inoue I, Noda M, Shimada A.

J Clin Med Res. 2018 Sep;10(9):679-687. doi: 10.14740/jocmr3491w. Epub 2018 Jul 31.


Microtubule-Dependent Confinement of a Cell Signaling and Actin Polymerization Control Module Regulates Polarized Cell Growth.

Yanagisawa M, Alonso JM, Szymanski DB.

Curr Biol. 2018 Aug 6;28(15):2459-2466.e4. doi: 10.1016/j.cub.2018.05.076. Epub 2018 Jul 19.


Long-term monitoring of circulating progesterone and its relationship to peripheral white blood cells in female false killer whales Pseudorca crassidens.

Funasaka N, Yoshioka M, Ueda K, Koga H, Yanagisawa M, Koga S, Tokutake K.

J Vet Med Sci. 2018 Sep 13;80(9):1431-1437. doi: 10.1292/jvms.18-0075. Epub 2018 Jul 18.


Improving the structure-function relationship in glaucomatous and normative eyes by incorporating photoreceptor layer thickness.

Matsuura M, Fujino Y, Kanamoto T, Murata H, Yanagisawa M, Hirasawa K, Inoue T, Shoji N, Inoue K, Yamagami J, Asaoka R.

Sci Rep. 2018 Jul 11;8(1):10450. doi: 10.1038/s41598-018-28821-z.


Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain.

Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa T, Nagaoka M, Kawaguchi Y, Yanagawa Y, Magnuson MA, Muratani M, Shibuya A, Nabeshima YI, Yanagisawa M, Funato H, Hoshino M.

Cell Rep. 2018 Jul 3;24(1):79-94. doi: 10.1016/j.celrep.2018.06.010.


Quantitative phosphoproteomic analysis of the molecular substrates of sleep need.

Wang Z, Ma J, Miyoshi C, Li Y, Sato M, Ogawa Y, Lou T, Ma C, Gao X, Lee C, Fujiyama T, Yang X, Zhou S, Hotta-Hirashima N, Klewe-Nebenius D, Ikkyu A, Kakizaki M, Kanno S, Cao L, Takahashi S, Peng J, Yu Y, Funato H, Yanagisawa M, Liu Q.

Nature. 2018 Jun;558(7710):435-439. doi: 10.1038/s41586-018-0218-8. Epub 2018 Jun 13.


Imaging cell picker: A morphology-based automated cell separation system on a photodegradable hydrogel culture platform.

Shibuta M, Tamura M, Kanie K, Yanagisawa M, Matsui H, Satoh T, Takagi T, Kanamori T, Sugiura S, Kato R.

J Biosci Bioeng. 2018 Nov;126(5):653-660. doi: 10.1016/j.jbiosc.2018.05.004. Epub 2018 Jun 9.


Systemic Staphylococcus pseudintermedius infection in an arctic fox (Vulpes lagopus) with severe multifocal suppurative meningoencephalitis and nephritis.

Iwata K, Kasuya K, Takayama K, Nakahara Y, Kobayashi Y, Kato A, Senba H, Yanagisawa M, Shibahara T.

J Vet Med Sci. 2018 Aug 10;80(8):1219-1222. doi: 10.1292/jvms.18-0061. Epub 2018 Jun 11.


Mapping the Central 10° Visual Field to the Optic Nerve Head Using the Structure-Function Relationship.

Fujino Y, Murata H, Matsuura M, Yanagisawa M, Shoji N, Inoue K, Yamagami J, Asaoka R.

Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2801-2807. doi: 10.1167/iovs.17-23485.


Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors.

Wang Y, Cao L, Lee CY, Matsuo T, Wu K, Asher G, Tang L, Saitoh T, Russell J, Klewe-Nebenius D, Wang L, Soya S, Hasegawa E, Chérasse Y, Zhou J, Li Y, Wang T, Zhan X, Miyoshi C, Irukayama Y, Cao J, Meeks JP, Gautron L, Wang Z, Sakurai K, Funato H, Sakurai T, Yanagisawa M, Nagase H, Kobayakawa R, Kobayakawa K, Beutler B, Liu Q.

Nat Commun. 2018 May 23;9(1):2041. doi: 10.1038/s41467-018-04324-3.


Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy.

Kaushik MK, Aritake K, Imanishi A, Kanbayashi T, Ichikawa T, Shimizu T, Urade Y, Yanagisawa M.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):6046-6051. doi: 10.1073/pnas.1722686115. Epub 2018 May 21.


Increasing Elasticity through Changes in the Secondary Structure of Gelatin by Gelation in a Microsized Lipid Space.

Sakai A, Murayama Y, Fujiwara K, Fujisawa T, Sasaki S, Kidoaki S, Yanagisawa M.

ACS Cent Sci. 2018 Apr 25;4(4):477-483. doi: 10.1021/acscentsci.7b00625. Epub 2018 Mar 15.



Matsuura M, Murata H, Fujino Y, Hirasawa K, Yanagisawa M, Asaoka R.

Am J Ophthalmol. 2018 Jun;190:201-202. doi: 10.1016/j.ajo.2018.03.022. Epub 2018 Apr 5. No abstract available.


Cell-size confinement effect on protein diffusion in crowded poly(ethylene)glycol solution.

Watanabe C, Yanagisawa M.

Phys Chem Chem Phys. 2018 Mar 28;20(13):8842-8847. doi: 10.1039/c7cp08199e.


Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats.

Toyama S, Shimoyama N, Tagaito Y, Nagase H, Saitoh T, Yanagisawa M, Shimoyama M.

Anesthesiology. 2018 May;128(5):992-1003. doi: 10.1097/ALN.0000000000002161.


Changes in sex steroid hormone levels reflect the reproductive status of captive female zebra sharks (Stegostoma fasciatum).

Nozu R, Murakumo K, Yano N, Furuyama R, Matsumoto R, Yanagisawa M, Sato K.

Gen Comp Endocrinol. 2018 Sep 1;265:174-179. doi: 10.1016/j.ygcen.2018.03.006. Epub 2018 Mar 3.


Localization of orexin B and orexin-2 receptor in the rat epididymis.

Liguori G, Tafuri S, Miyoshi C, Yanagisawa M, Squillacioti C, De Pasquale V, Mirabella N, Vittoria A, Costagliola A.

Acta Histochem. 2018 Apr;120(3):292-297. doi: 10.1016/j.acthis.2018.02.011. Epub 2018 Feb 26.


Serum C-reactive Protein and Neutrophil/Lymphocyte Ratio After Neoadjuvant Radiotherapy in Soft Tissue Sarcoma.

Yanagisawa M, Gingrich AA, Judge S, Li CS, Wang N, Thorpe SW, Kirane AR, Bold RJ, Monjazeb AM, Canter RJ.

Anticancer Res. 2018 Mar;38(3):1491-1497.


Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice.

Saitoh A, Tominaga H, Ogawa Y, Irukayama-Tomobe Y, Yamada M, Yanagisawa M, Nagase H.

Pharmacol Rep. 2018 Apr;70(2):350-354. doi: 10.1016/j.pharep.2017.08.018. Epub 2017 Oct 28.


Hypocretin/orexin deficiency decreases cocaine abuse liability.

Steiner N, Rossetti C, Sakurai T, Yanagisawa M, de Lecea L, Magistretti PJ, Halfon O, Boutrel B.

Neuropharmacology. 2018 May 1;133:395-403. doi: 10.1016/j.neuropharm.2018.02.010. Epub 2018 Feb 15.


Acute Pressor Response to Psychosocial Stress Is Dependent on Endothelium-Derived Endothelin-1.

Fox BM, Becker BK, Loria AS, Hyndman KA, Jin C, Clark H, Johns R, Yanagisawa M, Pollock DM, Pollock JS.

J Am Heart Assoc. 2018 Feb 16;7(4). pii: e007863. doi: 10.1161/JAHA.117.007863.

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