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Effects of Empagliflozin on Left Ventricular Remodeling in Patients with Type 2 Diabetes and Coronary Artery Disease: Echocardiographic Substudy of the EMPA-HEART CardioLink-6 Randomized Clinical Trial.

Bami K, Gandhi S, Leong-Poi H, Yan AT, Ho E, Zahrani M, Garg V, Zuo F, Teoh H, Quan A, Leiter LA, Gilbert RE, Zinman B, Thorpe KE, Jüni P, Mazer CD, Verma S, Ong G, Connelly KA.

J Am Soc Echocardiogr. 2020 Mar 18. pii: S0894-7317(20)30076-6. doi: 10.1016/j.echo.2020.02.005. [Epub ahead of print] No abstract available.


The impact of empagliflozin on kidney injury molecule-1: a subanalysis of the Effects of Empagliflozin on Cardiac Structure, Function, and Circulating Biomarkers in Patients with Type 2 Diabetes CardioLink-6 trial.

Opingari E, Verma S, Connelly KA, Mazer CD, Teoh H, Quan A, Zuo F, Pan Y, Bhatt DL, Zinman B, Leiter LA, Yan AT, Cherney DZI, Gilbert RE.

Nephrol Dial Transplant. 2020 Mar 11. pii: gfz294. doi: 10.1093/ndt/gfz294. [Epub ahead of print] No abstract available.


Feature tracking for assessment of diastolic function by cardiovascular magnetic resonance imaging.

Ng MY, Tong X, He J, Lin Q, Luo L, Chen Y, Shen XP, Wan EYF, Yan AT, Yiu KH.

Clin Radiol. 2020 Apr;75(4):321.e1-321.e11. doi: 10.1016/j.crad.2019.11.013. Epub 2019 Dec 31.


Cardiac Remodeling in Middle-Aged Endurance Athletes and Recreationally Active Individuals: Challenges in Defining the "Athlete's Heart".

Banks L, Bentley RF, Currie KD, Vecchiarelli E, Aslam A, Connelly KA, Yan AT, Konieczny KM, Dorian P, Mak S, Sasson Z, Goodman JM.

J Am Soc Echocardiogr. 2020 Feb;33(2):247-249. doi: 10.1016/j.echo.2019.09.014. Epub 2019 Dec 4. No abstract available.


Sex-Specific Differences in New York Heart Association Classification and Outcomes of Decompensated Heart Failure.

Cai S, Gong IY, Gale CP, Yan AT.

Can J Cardiol. 2020 Jan;36(1):4-6. doi: 10.1016/j.cjca.2019.09.022. Epub 2019 Oct 10. No abstract available.


Peri-Infarct Quantification by Cardiac Magnetic Resonance to Predict Outcomes in Ischemic Cardiomyopathy: Prognostic Systematic Review and Meta-Analysis.

Haghbayan H, Lougheed N, Deva DP, Chan KKW, Lima JAC, Yan AT.

Circ Cardiovasc Imaging. 2019 Nov;12(11):e009156. doi: 10.1161/CIRCIMAGING.119.009156. Epub 2019 Nov 18.


Cardiac MRI measurements of pericardial adipose tissue volumes in patients on in-centre nocturnal hemodialysis.

Cai S, Wald R, Deva DP, Kiaii M, Ng MY, Karur GR, Bello O, Li ZJ, Leipsic J, Jimenez-Juan L, Kirpalani A, Connelly KA, Yan AT.

J Nephrol. 2019 Nov 14. doi: 10.1007/s40620-019-00665-4. [Epub ahead of print]


Effect of Empagliflozin on Erythropoietin Levels, Iron Stores, and Red Blood Cell Morphology in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease.

Mazer CD, Hare GMT, Connelly PW, Gilbert RE, Shehata N, Quan A, Teoh H, Leiter LA, Zinman B, Jüni P, Zuo F, Mistry N, Thorpe KE, Goldenberg RM, Yan AT, Connelly KA, Verma S.

Circulation. 2020 Feb 25;141(8):704-707. doi: 10.1161/CIRCULATIONAHA.119.044235. Epub 2019 Nov 11. No abstract available.


Looking beyond cancer for cabozantinib-induced cardiotoxicity: evidence of absence or absence of evidence?

Lee EY, Yan AT.

Ann Transl Med. 2019 Jul;7(Suppl 3):S121. doi: 10.21037/atm.2019.05.51. No abstract available.


Thiamin supplementation does not improve left ventricular ejection fraction in ambulatory heart failure patients: a randomized controlled trial.

Keith M, Quach S, Ahmed M, Azizi-Namini P, Al-Hesayen A, Azevedo E, James R, Leong-Poi H, Ong G, Desjardins S, Lee PJ, Ravamehr-Lake D, Yan AT.

Am J Clin Nutr. 2019 Dec 1;110(6):1287-1295. doi: 10.1093/ajcn/nqz192.


Evaluation of the impact of the GRACE risk score on the management and outcome of patients hospitalised with non-ST elevation acute coronary syndrome in the UK: protocol of the UKGRIS cluster-randomised registry-based trial.

Everett CC, Fox KA, Reynolds C, Fernandez C, Sharples L, Stocken DD, Carruthers K, Hemingway H, Yan AT, Goodman SG, Brieger D, Chew DP, Gale CP.

BMJ Open. 2019 Sep 5;9(9):e032165. doi: 10.1136/bmjopen-2019-032165.


SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus.

Hess DA, Terenzi DC, Trac JZ, Quan A, Mason T, Al-Omran M, Bhatt DL, Dhingra N, Rotstein OD, Leiter LA, Zinman B, Sabongui S, Yan AT, Teoh H, Mazer CD, Connelly KA, Verma S.

Cell Metab. 2019 Oct 1;30(4):609-613. doi: 10.1016/j.cmet.2019.08.015. Epub 2019 Aug 30.


Effect of Empagliflozin on Left Ventricular Mass in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease: The EMPA-HEART CardioLink-6 Randomized Clinical Trial.

Verma S, Mazer CD, Yan AT, Mason T, Garg V, Teoh H, Zuo F, Quan A, Farkouh ME, Fitchett DH, Goodman SG, Goldenberg RM, Al-Omran M, Gilbert RE, Bhatt DL, Leiter LA, Jüni P, Zinman B, Connelly KA.

Circulation. 2019 Nov 19;140(21):1693-1702. doi: 10.1161/CIRCULATIONAHA.119.042375. Epub 2019 Aug 22.


Prolonged P wave duration is associated with right atrial dimensions, but not atrial arrhythmias, in middle-aged endurance athletes.

Konieczny K, Banks L, Osman W, Glibbery M, Connelly KA, Yan AT, Goodman JM, Dorian P.

J Electrocardiol. 2019 Sep - Oct;56:115-120. doi: 10.1016/j.jelectrocard.2019.07.002. Epub 2019 Jul 9.


Growth differentiation factor 15 is decreased by kidney transplantation.

Connelly PW, Yan AT, Nash MM, Lok CE, Gunaratnam L, Prasad GVR.

Clin Biochem. 2019 Nov;73:57-61. doi: 10.1016/j.clinbiochem.2019.07.013. Epub 2019 Jul 27.


CMR and Tissue Characterization: Don't Forget the Strain!

Connelly KA, Yan AT, Amir E, Thavendiranathan P.

J Am Coll Cardiol. 2019 Jul 2;73(25):3359. doi: 10.1016/j.jacc.2019.03.521. No abstract available.


Assessment of left ventricular function by CMR versus MUGA scans in breast cancer patients receiving trastuzumab: a prospective observational study.

Dhir V, Yan AT, Nisenbaum R, Sloninko J, Connelly KA, Barfett J, Haq R, Kirpalani A, Chan KKW, Petrella TM, Brezden-Masley C.

Int J Cardiovasc Imaging. 2019 Nov;35(11):2085-2093. doi: 10.1007/s10554-019-01648-z. Epub 2019 Jun 13.


Underuse of ECG monitoring in oncology patients receiving QT-interval prolonging drugs.

Pezo RC, Yan AT, Earle C, Chan KK.

Heart. 2019 Nov;105(21):1649-1655. doi: 10.1136/heartjnl-2018-314674. Epub 2019 May 25.


Temporal Trends of Women Enrollment in Major Cardiovascular Randomized Clinical Trials.

Gong IY, Tan NS, Ali SH, Lebovic G, Mamdani M, Goodman SG, Ko DT, Laupacis A, Yan AT.

Can J Cardiol. 2019 May;35(5):653-660. doi: 10.1016/j.cjca.2019.01.010. Epub 2019 Jan 30. Review.


Prevalence of Thiamin Deficiency in Ambulatory Patients with Heart Failure.

Azizi-Namini P, Ahmed M, Yan AT, Desjardins S, Al-Hesayen A, Mangat I, Keith M.

J Acad Nutr Diet. 2019 Jul;119(7):1160-1167. doi: 10.1016/j.jand.2019.01.015. Epub 2019 Mar 28.


Association Between Patient and Physician Sex and Physician-Estimated Stroke and Bleeding Risks in Atrial Fibrillation.

Lee H, Tan MK, Yan AT, Angaran P, Dorian P, Bucci C, Gregoire JC, Bell AD, Green MS, Gross PL, Skanes A, Kerr CR, Mitchell LB, Cox JL, Essebag V, Heilbron B, Ramanathan K, Fournier C, Wheeler BH, Lin PJ, Berall M, Langer A, Goldin L, Goodman SG; FREEDOM AF and CONNECT AF Investigators.

Can J Cardiol. 2019 Feb;35(2):160-168. doi: 10.1016/j.cjca.2018.11.023. Epub 2018 Dec 3.


Global lessons for quality care: a tale of two countries.

Lee EY, Yan AT.

Heart. 2019 Jun;105(11):812-813. doi: 10.1136/heartjnl-2018-314624. Epub 2019 Feb 7. No abstract available.


Serial Measurements of Left Ventricular Systolic and Diastolic Function by Cardiac Magnetic Resonance Imaging in Patients with Early Stage Breast Cancer on Trastuzumab.

Song L, Brezden-Masley C, Ramanan V, Ghugre N, Barfett JJ, Chan KKW, Haq R, Petrella T, Dhir V, Jimenez-Juan L, Chacko BR, Kotha V, Connelly KA, Yan AT.

Am J Cardiol. 2019 Apr 1;123(7):1173-1179. doi: 10.1016/j.amjcard.2018.12.046. Epub 2019 Jan 8.


Empagliflozin and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Left Ventricular Hypertrophy: A Subanalysis of the EMPA-REG OUTCOME Trial.

Verma S, Mazer CD, Bhatt DL, Raj SR, Yan AT, Verma A, Ferrannini E, Simons G, Lee J, Zinman B, George JT, Fitchett D.

Diabetes Care. 2019 Mar;42(3):e42-e44. doi: 10.2337/dc18-1959. Epub 2019 Jan 23. No abstract available.


Clinical application of echocardiographic-derived myocardial strain imaging in subclinical disease: a primer for cardiologists.

Ong G, Yan AT, Connelly KA.

Curr Opin Cardiol. 2019 Mar;34(2):147-155. doi: 10.1097/HCO.0000000000000592. Review.


Cardiovascular magnetic resonance left ventricular strain in end-stage renal disease patients after kidney transplantation.

Gong IY, Al-Amro B, Prasad GVR, Connelly PW, Wald RM, Wald R, Deva DP, Leong-Poi H, Nash MM, Yuan W, Gunaratnam L, Kim SJ, Lok CE, Connelly KA, Yan AT.

J Cardiovasc Magn Reson. 2018 Dec 17;20(1):83. doi: 10.1186/s12968-018-0504-5.


Determinants of Left Ventricular Characteristics Assessed by Cardiac Magnetic Resonance Imaging and Cardiovascular Biomarkers Related to Kidney Transplantation.

Prasad GVR, Yan AT, Nash MM, Kim SJ, Wald R, Wald R, Lok C, Gunaratnam L, Karur GR, Kirpalani A, Connelly PW.

Can J Kidney Health Dis. 2018 Nov 9;5:2054358118809974. doi: 10.1177/2054358118809974. eCollection 2018.


Early diastolic strain rate measurements by cardiac MRI in breast cancer patients treated with trastuzumab: a longitudinal study.

Gong IY, Ong G, Brezden-Masley C, Dhir V, Deva DP, Chan KKW, Graham JJ, Chow CM, Thavendiranathan P, Dai D, Ng MY, Barfett JJ, Connelly KA, Yan AT.

Int J Cardiovasc Imaging. 2019 Apr;35(4):653-662. doi: 10.1007/s10554-018-1482-2. Epub 2018 Nov 2.


Frailty and Outcomes After Myocardial Infarction: Insights From the CONCORDANCE Registry.

Patel A, Goodman SG, Yan AT, Alexander KP, Wong CL, Cheema AN, Udell JA, Kaul P, D'Souza M, Hyun K, Adams M, Weaver J, Chew DP, Brieger D, Bagai A.

J Am Heart Assoc. 2018 Sep 18;7(18):e009859. doi: 10.1161/JAHA.118.009859.


Guideline-indicated treatments and diagnostics, GRACE risk score, and survival for non-ST elevation myocardial infarction.

Hall M, Bebb OJ, Dondo TB, Yan AT, Goodman SG, Bueno H, Chew DP, Brieger D, Batin PD, Farkouh ME, Hemingway H, Timmis A, Fox KAA, Gale CP.

Eur Heart J. 2018 Nov 7;39(42):3798-3806. doi: 10.1093/eurheartj/ehy517.


Left Atrial Remodeling Assessed by Cardiac MRI after Conversion from Conventional Hemodialysis to In-Centre Nocturnal Hemodialysis.

Law TK, Wald R, Goldstein M, Karur GR, Ng MY, Wang AYM, Deva DP, Kirpalani A, Wald RM, Kiaii M, Leipsic J, Connelly KA, Yan AT.

J Nephrol. 2019 Apr;32(2):273-281. doi: 10.1007/s40620-018-0522-2. Epub 2018 Aug 24.


Previous and New Onset Atrial Fibrillation and Associated Outcomes in Acute Coronary Syndromes (from the Global Registry of Acute Coronary Events).

Worme MD, Tan MK, Armstrong DWJ, Yan AT, Tan NS, Brieger D, Budaj A, Gore JM, López-Sendón J, Van de Werf F, Steg PG, Fox KAA, Goodman SG, Udell JA.

Am J Cardiol. 2018 Sep 15;122(6):944-951. doi: 10.1016/j.amjcard.2018.06.001. Epub 2018 Jun 21.


Mineralocorticoid receptor antagonists for heart failure: lost in translation?

Lee EY, Yan AT.

Eur Heart J Qual Care Clin Outcomes. 2018 Oct 1;4(4):237-238. doi: 10.1093/ehjqcco/qcy025. No abstract available.


Cardiac MRI and radionuclide ventriculography for measurement of left ventricular ejection fraction in ICD candidates.

Kotha VK, Deva DP, Connelly KA, Freeman MR, Yan RT, Mangat I, Kirpalani A, Barfett JJ, Sloninko J, Lin HM, Graham JJ, Crean AM, Jimenez-Juan L, Dorian P, Yan AT.

Magn Reson Imaging. 2018 Oct;52:69-74. doi: 10.1016/j.mri.2018.05.012. Epub 2018 May 31.


Excessive exercise in endurance athletes: Is atrial fibrillation a possible consequence?

Goodman JM, Banks L, Connelly KA, Yan AT, Backx PH, Dorian P.

Appl Physiol Nutr Metab. 2018 Sep;43(9):973-976. doi: 10.1139/apnm-2017-0764. Epub 2018 May 29.


Long-term Follow-up of the Trial of Routine Angioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI).

Arbel Y, Ko DT, Yan AT, Cantor WJ, Bagai A, Koh M, Eberg M, Tan M, Fitchett D, Borgundvaag B, Ducas J, Heffernan M, Morrison LJ, Langer A, Dzavik V, Mehta SR, Goodman SG; TRANSFER-AMI Trial Investigators.

Can J Cardiol. 2018 Jun;34(6):736-743. doi: 10.1016/j.cjca.2018.02.005. Epub 2018 Feb 10.


Left ventricular strain analysis using cardiac magnetic resonance imaging in patients undergoing in-centre nocturnal haemodialysis.

Ong JP, Wald R, Goldstein MB, Leipsic J, Kiaii M, Deva DP, Kirpalani A, Jimenez-Juan L, Bello O, Azizi PM, Wald RM, Wright GA, Harel Z, Connelly KA, Yan AT.

Nephrology (Carlton). 2019 May;24(5):557-563. doi: 10.1111/nep.13404.


Trends in the incidence and outcomes of patients with aortic stenosis hospitalization.

Czarnecki A, Qiu F, Koh M, Alter DA, Austin PC, Fremes SE, Tu JV, Wijeysundera HC, Yan AT, Ko DT.

Am Heart J. 2018 May;199:144-149. doi: 10.1016/j.ahj.2018.02.010. Epub 2018 Feb 13.


Early discontinuation of prasugrel or clopidogrel in acute coronary syndromes: insights from the TRILOGY ACS trial.

Yan AT, Roe MT, Neely M, Cyr DD, White H, Fox KAA, Prabhakaran D, Armstrong PW, Ohman EM, Goodman SG.

Coron Artery Dis. 2018 Sep;29(6):469-476. doi: 10.1097/MCA.0000000000000623.


Immediate non-culprit vessel percutaneous coronary intervention (PCI) in patients with acute myocardial infarction and cardiogenic shock: a swinging pendulum.

Russo JJ, Bagai A, Le May MR, Yan AT.

J Thorac Dis. 2018 Feb;10(2):661-666. doi: 10.21037/jtd.2018.01.106. No abstract available.


A new risk stratification tool for women with acute coronary syndrome.

Gong IY, Yan AT.

Int J Cardiol. 2018 May 15;259:53-54. doi: 10.1016/j.ijcard.2018.02.070. No abstract available.


Marital status and outcomes after myocardial infarction: Observations from the Canadian Observational Antiplatelet Study (COAPT).

Ghosh-Swaby OR, Tan M, Bagai A, Yan AT, Goodman SG, Mehta SR, Fisher HN, Cohen EA, Huynh T, Cantor WJ, Le May MR, Déry JP, Welsh RC, Udell JA.

Clin Cardiol. 2018 Mar;41(3):285-292. doi: 10.1002/clc.22901. Epub 2018 Mar 25.


Myocardial strain imaging by cardiac magnetic resonance for detection of subclinical myocardial dysfunction in breast cancer patients receiving trastuzumab and chemotherapy.

Ong G, Brezden-Masley C, Dhir V, Deva DP, Chan KKW, Chow CM, Thavendiranathan D, Haq R, Barfett JJ, Petrella TM, Connelly KA, Yan AT.

Int J Cardiol. 2018 Jun 15;261:228-233. doi: 10.1016/j.ijcard.2018.03.041. Epub 2018 Mar 11.


Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort.

Hall M, Dondo TB, Yan AT, Mamas MA, Timmis AD, Deanfield JE, Jernberg T, Hemingway H, Fox KAA, Gale CP.

PLoS Med. 2018 Mar 6;15(3):e1002501. doi: 10.1371/journal.pmed.1002501. eCollection 2018 Mar.


Left ventricular structure and diastolic function by cardiac magnetic resonance imaging in hypertrophic cardiomyopathy.

Chacko BR, Karur GR, Connelly KA, Yan RT, Kirpalani A, Wald R, Jimenez-Juan L, Jacob JR, Deva DP, Yan AT.

Indian Heart J. 2018 Jan - Feb;70(1):75-81. doi: 10.1016/j.ihj.2016.12.021. Epub 2017 Jan 6.


Extended Duration Nocturnal Hemodialysis and Changes in Plasma Metabolite Profiles.

Kalim S, Wald R, Yan AT, Goldstein MB, Kiaii M, Xu D, Berg AH, Clish C, Thadhani R, Rhee EP, Perl J.

Clin J Am Soc Nephrol. 2018 Mar 7;13(3):436-444. doi: 10.2215/CJN.08790817. Epub 2018 Feb 14.


Use of clinical risk stratification in non-ST elevation acute coronary syndromes: an analysis from the CONCORDANCE registry.

Bing R, Goodman SG, Yan AT, Fox K, Gale CP, Hyun K, D'Souza M, Shetty P, Atherton J, Hammett C, Chew D, Brieger D.

Eur Heart J Qual Care Clin Outcomes. 2018 Oct 1;4(4):309-317. doi: 10.1093/ehjqcco/qcy002.


Temporal changes in treatments and outcomes after acute myocardial infarction among cancer survivors and patients without cancer, 1995 to 2013.

Gong IY, Yan AT, Ko DT, Earle CC, Cheung WY, Peacock S, Hall M, Gale CP, Chan KKW.

Cancer. 2018 Mar 15;124(6):1269-1278. doi: 10.1002/cncr.31174. Epub 2017 Dec 6.


Electrocardiographic Findings in Patients With Acute Coronary Syndrome Presenting With Out-of-Hospital Cardiac Arrest.

Sarak B, Goodman SG, Brieger D, Gale CP, Tan NS, Budaj A, Wong GC, Huynh T, Tan MK, Udell JA, Bagai A, Fox KAA, Yan AT; Global Registry of Acute Coronary Events (GRACE) Investigators and the Canadian Acute Coronary Syndromes I Investigators.

Am J Cardiol. 2018 Feb 1;121(3):294-300. doi: 10.1016/j.amjcard.2017.10.030. Epub 2017 Nov 3.


Does renal function affect the efficacy or safety of a pharmacoinvasive strategy in patients with ST-elevation myocardial infarction? A meta-analysis.

Russo JJ, Goodman SG, Cantor WJ, Ko DT, Bagai A, Tan MK, Di Mario C, Halvorsen S, Le May M, Fernandez-Avilés F, Scheller B, Armstrong PW, Borgia F, Piscione F, Sanchez PL, Yan AT.

Am Heart J. 2017 Nov;193:46-54. doi: 10.1016/j.ahj.2017.07.015. Epub 2017 Aug 2. Review.


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