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Items: 21

1.

A Stable and Cleavable O-Linked Spacer for Drug Delivery Systems.

Ito K, Tatsumi T, Takahashi K, Shimizu Y, Yamatsugu K, Kanai M.

Chem Pharm Bull (Tokyo). 2019 Jun 12. doi: 10.1248/cpb.c19-00376. [Epub ahead of print]

2.

Site-Selective Synthetic Acylation of a Target Protein in Living Cells Promoted by a Chemical Catalyst/Donor System.

Hamajima W, Fujimura A, Fujiwara Y, Yamatsugu K, Kawashima SA, Kanai M.

ACS Chem Biol. 2019 Jun 21;14(6):1102-1109. doi: 10.1021/acschembio.9b00102. Epub 2019 May 24.

PMID:
31117394
3.
4.

Kinetic analyses and structure-activity relationship studies of synthetic lysine acetylation catalysts.

Yamatsugu K, Furuta M, Xi S, Amamoto Y, Liu J, Kawashima SA, Kanai M.

Bioorg Med Chem. 2018 Oct 15;26(19):5359-5367. doi: 10.1016/j.bmc.2018.07.009. Epub 2018 Jul 7.

PMID:
30006145
5.

Leading approaches in synthetic epigenetics for novel therapeutic strategies.

Yamatsugu K, Kawashima SA, Kanai M.

Curr Opin Chem Biol. 2018 Oct;46:10-17. doi: 10.1016/j.cbpa.2018.03.011. Epub 2018 Apr 6. Review.

PMID:
29631088
6.

LC-MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes.

Tanabe K, Liu J, Kato D, Kurumizaka H, Yamatsugu K, Kanai M, Kawashima SA.

Sci Rep. 2018 Feb 8;8(1):2656. doi: 10.1038/s41598-018-21060-2.

7.

Synthetic Posttranslational Modifications: Chemical Catalyst-Driven Regioselective Histone Acylation of Native Chromatin.

Amamoto Y, Aoi Y, Nagashima N, Suto H, Yoshidome D, Arimura Y, Osakabe A, Kato D, Kurumizaka H, Kawashima SA, Yamatsugu K, Kanai M.

J Am Chem Soc. 2017 Jun 7;139(22):7568-7576. doi: 10.1021/jacs.7b02138. Epub 2017 May 23.

PMID:
28534629
8.

Fidelity and Promiscuity of a Mycobacterial Glycosyltransferase.

Yamatsugu K, Splain RA, Kiessling LL.

J Am Chem Soc. 2016 Jul 27;138(29):9205-11. doi: 10.1021/jacs.6b04481. Epub 2016 Jul 13.

9.

Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis.

Takemoto A, Kawashima SA, Li JJ, Jeffery L, Yamatsugu K, Elemento O, Nurse P.

J Cell Sci. 2016 Mar 15;129(6):1250-9. doi: 10.1242/jcs.181560. Epub 2016 Feb 11.

10.

Supramolecular Ligands for Histone Tails by Employing a Multivalent Display of Trisulfonated Calix[4]arenes.

Kimura Y, Saito N, Hanada K, Liu J, Okabe T, Kawashima SA, Yamatsugu K, Kanai M.

Chembiochem. 2015 Dec;16(18):2599-604. doi: 10.1002/cbic.201500448. Epub 2015 Nov 18.

PMID:
26503405
11.

Two approaches toward the formal total synthesis of oseltamivir phosphate (Tamiflu): catalytic enantioselective three-component reaction strategy and L-glutamic acid strategy.

Alagiri K, Furutachi M, Yamatsugu K, Kumagai N, Watanabe T, Shibasaki M.

J Org Chem. 2013 Apr 19;78(8):4019-26. doi: 10.1021/jo400360j. Epub 2013 Mar 21.

PMID:
23517385
12.

Intracellular activation of acetyl-CoA by an artificial reaction promoter and its fluorescent detection.

Komatsu H, Shindo Y, Kawashima SA, Yamatsugu K, Oka K, Kanai M.

Chem Commun (Camb). 2013 Apr 11;49(28):2876-8. doi: 10.1039/c3cc40616d.

PMID:
23443073
13.

Enantioselective synthesis of SM-130686 based on the development of asymmetric Cu(I)F catalysis to access 2-oxindoles containing a tetrasubstituted carbon.

Tomita D, Yamatsugu K, Kanai M, Shibasaki M.

J Am Chem Soc. 2009 May 27;131(20):6946-8. doi: 10.1021/ja901995a.

PMID:
19453193
15.

A synthesis of Tamiflu by using a barium-catalyzed asymmetric Diels-Alder-type reaction.

Yamatsugu K, Yin L, Kamijo S, Kimura Y, Kanai M, Shibasaki M.

Angew Chem Int Ed Engl. 2009;48(6):1070-6. doi: 10.1002/anie.200804777. No abstract available.

PMID:
19016287
16.

Oseltamivir enhances hippocampal network synchronization.

Usami A, Sasaki T, Satoh N, Akiba T, Yokoshima S, Fukuyama T, Yamatsugu K, Kanai M, Shibasaki M, Matsuki N, Ikegaya Y.

J Pharmacol Sci. 2008 Apr;106(4):659-62. Epub 2008 Apr 9.

17.

Pharmacologic action of oseltamivir on the nervous system.

Ishii K, Hamamoto H, Sasaki T, Ikegaya Y, Yamatsugu K, Kanai M, Shibasaki M, Sekimizu K.

Drug Discov Ther. 2008 Feb;2(1):24-34.

18.

A method for the synthesis of an oseltamivir PET tracer.

Morita M, Sone T, Yamatsugu K, Sohtome Y, Matsunaga S, Kanai M, Watanabe Y, Shibasaki M.

Bioorg Med Chem Lett. 2008 Jan 15;18(2):600-2. Epub 2007 Nov 28.

PMID:
18055200
19.

P-glycoprotein restricts the penetration of oseltamivir across the blood-brain barrier.

Ose A, Kusuhara H, Yamatsugu K, Kanai M, Shibasaki M, Fujita T, Yamamoto A, Sugiyama Y.

Drug Metab Dispos. 2008 Feb;36(2):427-34. Epub 2007 Nov 26.

PMID:
18039806
20.

Identification of potent, selective protein kinase C inhibitors based on a phorbol skeleton.

Yamatsugu K, Motoki R, Kanai M, Shibasaki M.

Chem Asian J. 2006 Sep 18;1(3):314-21.

PMID:
17441066
21.

Total synthesis of (+/-)-garsubellin A.

Kuramochi A, Usuda H, Yamatsugu K, Kanai M, Shibasaki M.

J Am Chem Soc. 2005 Oct 19;127(41):14200-1.

PMID:
16218611

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