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Sunny walking counts more.

Zhang R, Chen H, Liu YX, Zhang WH, Lu Q, Yamanishi H, Yamanishi C, Yamanishi K, Qiu YL, Ye XF, Huang ZR, Zhang BY, Chen YF, Zheng YQ, Zhang YF, Guo ZZ, Dong D, Liu TX, Dai YQ, Xu MH, Hao Y, Li SZ, Cai FY, Wang RQ, Guo XY, Zhu DH, Zhang HY, Zeng ZT, Higashino H.

Acta Pharmacol Sin. 2019 Jun 27. doi: 10.1038/s41401-019-0241-9. [Epub ahead of print] No abstract available.


Fulminant type 1 diabetes mellitus associated with Coxsackievirus type B1 infection during pregnancy: a case report.

Hayakawa T, Nakano Y, Hayakawa K, Yoshimatu H, Hori Y, Yamanishi K, Yamanishi H, Ota T, Fujimoto T.

J Med Case Rep. 2019 Jun 19;13(1):186. doi: 10.1186/s13256-019-2130-8.


Report of the Japan Health Physics Society ad hoc working group for the Plutonium Intake Accident.

Iwai S, Sasaki M, Higaki S, Yamanishi H, Kai M.

J Radiol Prot. 2019 Jun 4. doi: 10.1088/1361-6498/ab26e1. [Epub ahead of print]


Interleukin-18-deficient mice develop hippocampal abnormalities related to possible depressive-like behaviors.

Yamanishi K, Doe N, Mukai K, Ikubo K, Hashimoto T, Uwa N, Sumida M, El-Darawish Y, Gamachi N, Li W, Kuwahara-Otani S, Maeda S, Watanabe Y, Hayakawa T, Yamanishi H, Matsuyama T, Yagi H, Okamura H, Matsunaga H.

Neuroscience. 2019 Jun 1;408:147-160. doi: 10.1016/j.neuroscience.2019.04.003. Epub 2019 Apr 11.


A new approach to identifying hypertension-associated genes in the mesenteric artery of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats.

Ikawa T, Watanabe Y, Okuzaki D, Goto N, Okamura N, Yamanishi K, Higashino T, Yamanishi H, Okamura H, Higashino H.

J Hypertens. 2019 Aug;37(8):1644-1656. doi: 10.1097/HJH.0000000000002083.


Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects: how far shall we wander?

Lu Q, Wang SM, Liu YX, Chen H, Zhang R, Zhang WH, Zou YY, Zhou JW, Guo XY, Zhang Y, Huang TL, Liu YH, Zhang SQ, Yamanishi K, Yamanishi H, Higashino H, Okamura H.

Acta Pharmacol Sin. 2019 Feb 13. doi: 10.1038/s41401-018-0202-8. [Epub ahead of print]


1-(2-Hydroxyethyl)-2-imidazolidinone, a heparanase and matrix metalloproteinase inhibitor, improves epidermal basement membrane structure and epidermal barrier function.

Iriyama S, Yamanishi H, Kunizawa N, Hirao T, Amano S.

Exp Dermatol. 2019 Mar;28(3):247-253. doi: 10.1111/exd.13876.


Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia.

Yamanishi K, Maeda S, Kuwahara-Otani S, Hashimoto T, Ikubo K, Mukai K, Nakasho K, Gamachi N, El-Darawish Y, Li W, Okuzaki D, Watanabe Y, Yamanishi H, Okamura H, Matsunaga H.

J Transl Med. 2018 Nov 19;16(1):314. doi: 10.1186/s12967-018-1684-3.


Marked Changes in Lamellar Granule and Trans-Golgi Network Structure Occur during Epidermal Keratinocyte Differentiation.

Yamanishi H, Soma T, Kishimoto J, Hibino T, Ishida-Yamamoto A.

J Invest Dermatol. 2019 Feb;139(2):352-359. doi: 10.1016/j.jid.2018.07.043. Epub 2018 Sep 18.


Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: Evidence for a neuroimmune crosstalk.

Sekiguchi F, Domoto R, Nakashima K, Yamasoba D, Yamanishi H, Tsubota M, Wake H, Nishibori M, Kawabata A.

Neuropharmacology. 2018 Oct;141:201-213. doi: 10.1016/j.neuropharm.2018.08.040. Epub 2018 Sep 1.


Dosimetric Comparison of Irregular Surface Compensator and Field-in-Field for Whole Breast Radiotherapy.

Kuwahata N, Fujita H, Yamanishi H, Okazaki E, Fukuda H.

J Med Phys. 2018 Apr-Jun;43(2):79-84. doi: 10.4103/jmp.JMP_73_17.


Frontline Science: IL-18 primes murine NK cells for proliferation by promoting protein synthesis, survival, and autophagy.

El-Darawish Y, Li W, Yamanishi K, Pencheva M, Oka N, Yamanishi H, Matsuyama T, Tanaka Y, Minato N, Okamura H.

J Leukoc Biol. 2018 Aug;104(2):253-264. doi: 10.1002/JLB.1HI1017-396RR. Epub 2018 Mar 30.


Physiological and molecular effects of interleukin-18 administration on the mouse kidney.

Yamanishi K, Mukai K, Hashimoto T, Ikubo K, Nakasho K, El-Darawish Y, Li W, Okuzaki D, Watanabe Y, Hayakawa T, Nojima H, Yamanishi H, Okamura H, Matsunaga H.

J Transl Med. 2018 Mar 7;16(1):51. doi: 10.1186/s12967-018-1426-6.


Diagnostic Challenge in Pancreatic Sarcoidosis Using Endoscopic Ultrasonography.

Azemoto N, Kumagi T, Koizumi M, Kuroda T, Yamanishi H, Ohno Y, Imamura Y, Takeshita E, Soga Y, Ikeda Y, Onji M, Hiasa Y.

Intern Med. 2018 Jan 15;57(2):231-235. doi: 10.2169/internalmedicine.9084-17. Epub 2017 Oct 16.


Efficacy of chemotherapy in elderly patients with unresectable pancreatic cancer: a multicenter review of 895 patients.

Kuroda T, Kumagi T, Yokota T, Azemoto N, Hasebe A, Seike H, Nishiyama M, Inada N, Shibata N, Miyata H, Kawamura T, Imai Y, Ueno-Toshimori A, Tanaka Y, Terao T, Imamura Y, Koizumi M, Yamanishi H, Ohno Y, Hiasa Y; Ehime Pancreato-Cholangiology (EPOCH) Study Group.

BMC Gastroenterol. 2017 May 22;17(1):66. doi: 10.1186/s12876-017-0623-8. Review.


Molecular analysis of the mouse brain exposed to chronic mild stress: The influence of hepatocyte nuclear factor 4α on physiological homeostasis.

Ikubo K, Yamanishi K, Doe N, Hashimoto T, Sumida M, Watanabe Y, El-Darawish Y, Li W, Okamura H, Yamanishi H, Matsunaga H.

Mol Med Rep. 2017 Jul;16(1):301-309. doi: 10.3892/mmr.2017.6577. Epub 2017 May 11.


Involvement of high mobility group box 1 in the development and maintenance of chemotherapy-induced peripheral neuropathy in rats.

Nishida T, Tsubota M, Kawaishi Y, Yamanishi H, Kamitani N, Sekiguchi F, Ishikura H, Liu K, Nishibori M, Kawabata A.

Toxicology. 2016 Jul 15;365:48-58. doi: 10.1016/j.tox.2016.07.016. Epub 2016 Jul 27.


Dysfunction of mitochondria and deformed gap junctions in the heart of IL-18-deficient mice.

Li W, Jin D, Hata M, Takai S, Yamanishi K, Shen W, El-Darawish Y, Yamanishi H, Okamura H.

Am J Physiol Heart Circ Physiol. 2016 Aug 1;311(2):H313-25. doi: 10.1152/ajpheart.00927.2015. Epub 2016 Jun 10.


Carbonic Anhydrate I Epitope Peptide Improves Inflammation in a Murine Model of Inflammatory Bowel Disease.

Yagi S, Abe M, Yamashita M, Mori K, Yamanishi H, Arimitsu E, Yamamoto Y, Takeshita E, Ikeda Y, Hiasa Y.

Inflamm Bowel Dis. 2016 Aug;22(8):1835-46. doi: 10.1097/MIB.0000000000000781.


Difficulty in management of intraductal papillary mucinous neoplasm-associated pancreatobiliary fistulas and the role of "pig-nose" appearance and intraductal ultrasonography in diagnosis.

Koizumi M, Kumagi T, Kuroda T, Azemoto N, Yamanishi H, Ohno Y, Yokota T, Ochi H, Tange K, Ikeda Y, Hiasa Y.

Endosc Int Open. 2016 Apr;4(4):E446-50. doi: 10.1055/s-0042-102956. Epub 2016 Mar 30.


Interleukin-18-deficient mice develop dyslipidemia resulting in nonalcoholic fatty liver disease and steatohepatitis.

Yamanishi K, Maeda S, Kuwahara-Otani S, Watanabe Y, Yoshida M, Ikubo K, Okuzaki D, El-Darawish Y, Li W, Nakasho K, Nojima H, Yamanishi H, Hayakawa T, Okamura H, Matsunaga H.

Transl Res. 2016 Jul;173:101-114.e7. doi: 10.1016/j.trsl.2016.03.010. Epub 2016 Mar 19.


The topical penta-peptide Gly-Pro-Ile-Gly-Ser increases the proportion of thick hair in Japanese men with androgenetic alopecia.

Iwabuchi T, Takeda S, Yamanishi H, Ideta R, Ehama R, Tsuruda A, Shibata H, Ito T, Komatsu N, Terai K, Oka S.

J Cosmet Dermatol. 2016 Jun;15(2):176-84. doi: 10.1111/jocd.12216. Epub 2016 Mar 31.


Augmentation of Immune Checkpoint Cancer Immunotherapy with IL18.

Ma Z, Li W, Yoshiya S, Xu Y, Hata M, El-Darawish Y, Markova T, Yamanishi K, Yamanishi H, Tahara H, Tanaka Y, Okamura H.

Clin Cancer Res. 2016 Jun 15;22(12):2969-80. doi: 10.1158/1078-0432.CCR-15-1655. Epub 2016 Jan 11.


Parallel Post-Polyketide Synthase Modification Mechanism Involved in FD-891 Biosynthesis in Streptomyces graminofaciens A-8890.

Kudo F, Kawamura K, Furuya T, Yamanishi H, Motegi A, Komatsubara A, Numakura M, Miyanaga A, Eguchi T.

Chembiochem. 2016 Feb 2;17(3):233-8. doi: 10.1002/cbic.201500533. Epub 2016 Jan 8.


Evaluation of menstrual cycle-related changes in 85 clinical laboratory analytes.

Masuda S, Ichihara K, Yamanishi H, Hirano Y, Tanaka Y, Kamisako T; Scientific Committee for Asia-Pasific Federation of Clinical Biochemistry.

Ann Clin Biochem. 2016 May;53(Pt 3):365-76. doi: 10.1177/0004563215617212. Epub 2015 Nov 3.


Topical adenosine increases the proportion of thick hair in Caucasian men with androgenetic alopecia.

Iwabuchi T, Ideta R, Ehama R, Yamanishi H, Iino M, Nakazawa Y, Kobayashi T, Ohyama M, Kishimoto J.

J Dermatol. 2016 May;43(5):567-70. doi: 10.1111/1346-8138.13159. Epub 2015 Oct 28.


Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the kidneys.

Watanabe Y, Yoshida M, Yamanishi K, Yamamoto H, Okuzaki D, Nojima H, Yasunaga T, Okamura H, Matsunaga H, Yamanishi H.

Int J Mol Med. 2015 Sep;36(3):712-24. doi: 10.3892/ijmm.2015.2281. Epub 2015 Jul 10.


Utility of Contrast-Enhanced Transabdominal Ultrasonography to Diagnose Early Chronic Pancreatitis.

Azemoto N, Kumagi T, Yokota T, Hirooka M, Kuroda T, Koizumi M, Ohno Y, Yamanishi H, Abe M, Onji M, Hiasa Y.

Biomed Res Int. 2015;2015:393124. doi: 10.1155/2015/393124. Epub 2015 May 19.


Tocilizumab for intestinal amyloidosis complicated by multi-centric Castleman's disease.

Tamura T, Tamura S, Tanaka H, Ohagi Y, Taniguchi F, Yamanishi H, Kohara T, Kimura R, Kurihara T, Ozaki T, Nakano Y, Fujimoto T.

Clin Res Hepatol Gastroenterol. 2015 Dec;39(6):e79-81. doi: 10.1016/j.clinre.2015.05.003. Epub 2015 Jun 10. No abstract available.


Hepatocyte nuclear factor 4 alpha is a key factor related to depression and physiological homeostasis in the mouse brain.

Yamanishi K, Doe N, Sumida M, Watanabe Y, Yoshida M, Yamamoto H, Xu Y, Li W, Yamanishi H, Okamura H, Matsunaga H.

PLoS One. 2015 Mar 16;10(3):e0119021. doi: 10.1371/journal.pone.0119021. eCollection 2015.


[Relationship between spot urine pH and number of metabolic syndrome features].

Yamanishi H.

Rinsho Byori. 2014 Jul;62(7):692-8. Review. Japanese.


Phlegmonous gastritis associated with group A streptococcal toxic shock syndrome.

Morimoto M, Tamura S, Hayakawa T, Yamanishi H, Nakamoto C, Nakamoto H, Ikebe T, Nakano Y, Fujimoto T.

Intern Med. 2014;53(22):2639-42. Epub 2014 Nov 15.


Methodology using a portable X-ray fluorescence device for on-site and rapid evaluation of heavy-atom contamination in wounds: a model study for application to plutonium contamination.

Yoshii H, Yanagihara K, Imaseki H, Hamano T, Yamanishi H, Inagaki M, Sakai Y, Sugiura N, Kurihara O, Sakai K.

PLoS One. 2014 Jul 10;9(7):e101966. doi: 10.1371/journal.pone.0101966. eCollection 2014.


Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats.

Takai S, Jin D, Chen H, Li W, Yamamoto H, Yamanishi K, Miyazaki M, Higashino H, Yamanishi H, Okamura H.

J Hypertens. 2014 Aug;32(8):1637-48; discussion 1649. doi: 10.1097/HJH.0000000000000231.


Signet-ring cell carcinoma of the gallbladder complicated by pulmonary tumor thrombotic microangiopathy.

Ohno Y, Kumagi T, Kuroda T, Koizumi M, Azemoto N, Yamanishi H, Oda M, Hirooka M, Abe M, Ikeda Y, Matsuura B, Onji M, Soga Y, Mizuno Y, Sugita A, Hiasa Y.

Intern Med. 2014;53(11):1125-9. Epub 2014 Jun 1.


Analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: gene expression profiles in the brain.

Yoshida M, Watanabe Y, Yamanishi K, Yamashita A, Yamamoto H, Okuzaki D, Shimada K, Nojima H, Yasunaga T, Okamura H, Matsunaga H, Yamanishi H.

Int J Mol Med. 2014 Apr;33(4):887-96. doi: 10.3892/ijmm.2014.1631. Epub 2014 Jan 22.


Keratinocyte-specific mesotrypsin contributes to the desquamation process via kallikrein activation and LEKTI degradation.

Miyai M, Matsumoto Y, Yamanishi H, Yamamoto-Tanaka M, Tsuboi R, Hibino T.

J Invest Dermatol. 2014 Jun;134(6):1665-1674. doi: 10.1038/jid.2014.3. Epub 2014 Jan 3.


Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18.

Li W, Okuda A, Yamamoto H, Yamanishi K, Terada N, Yamanishi H, Tanaka Y, Okamura H.

PLoS One. 2013 Dec 20;8(12):e82586. doi: 10.1371/journal.pone.0082586. eCollection 2013.


A missense mutation in Rev7 disrupts formation of Polζ, impairing mouse development and repair of genotoxic agent-induced DNA lesions.

Khalaj M, Abbasi A, Yamanishi H, Akiyama K, Wakitani S, Kikuchi S, Hirose M, Yuzuriha M, Magari M, Degheidy HA, Abe K, Ogura A, Hashimoto H, Kunieda T.

J Biol Chem. 2014 Feb 7;289(6):3811-24. doi: 10.1074/jbc.M113.514752. Epub 2013 Dec 19.


Improvement of long-term outcomes in pancreatic cancer and its associated factors within the gemcitabine era: a collaborative retrospective multicenter clinical review of 1,082 patients.

Kuroda T, Kumagi T, Yokota T, Seike H, Nishiyama M, Imai Y, Inada N, Shibata N, Imamine S, Okada S, Koizumi M, Yamanishi H, Azemoto N, Miyaike J, Tanaka Y, Tatsukawa H, Utsunomiya H, Ohno Y, Miyake T, Hirooka M, Furukawa S, Abe M, Ikeda Y, Matsuura B, Hiasa Y, Onji M; EPOCH Study Group.

BMC Gastroenterol. 2013 Aug 31;13:134. doi: 10.1186/1471-230X-13-134.


Increased B cell-activating factor promotes tumor invasion and metastasis in human pancreatic cancer.

Koizumi M, Hiasa Y, Kumagi T, Yamanishi H, Azemoto N, Kobata T, Matsuura B, Abe M, Onji M.

PLoS One. 2013 Aug 6;8(8):e71367. doi: 10.1371/journal.pone.0071367. Print 2013.


Phenolics profile of mume, Japanese apricot (Prunus mume Sieb. et Zucc.) fruit.

Mitani T, Horinishi A, Kishida K, Kawabata T, Yano F, Mimura H, Inaba N, Yamanishi H, Oe T, Negoro K, Mori H, Miyake Y, Hosoda A, Tanaka Y, Mori M, Ozaki Y.

Biosci Biotechnol Biochem. 2013;77(8):1623-7. Epub 2013 Aug 7.


[Cerebral small vessel disease: the pathological features of cerebral amyloid angiopathy].

Ogata J, Yamanishi H, Ishibashi-Ueda H.

Brain Nerve. 2013 Jul;65(7):879-85. Review. Japanese.


Present status of the standardization of HDL-C, LDL-C, and TG measurement values available in Japan.

Nakajima Y, Yamanishi H, Matsuura N.

J Clin Lab Anal. 2013 May;27(3):195-203. doi: 10.1002/jcla.21583.


Oral administration of carbonic anhydrase I ameliorates murine experimental colitis induced by Foxp3-CD4+CD25- T cells.

Mori K, Yamanishi H, Ikeda Y, Kumagi T, Hiasa Y, Matsuura B, Abe M, Onji M.

J Leukoc Biol. 2013 Jun;93(6):963-72. doi: 10.1189/jlb.1212612. Epub 2013 Apr 1.


Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats.

Yamamoto H, Okuzaki D, Yamanishi K, Xu Y, Watanabe Y, Yoshida M, Yamashita A, Goto N, Nishiguchi S, Shimada K, Nojima H, Yasunaga T, Okamura H, Matsunaga H, Yamanishi H.

Int J Mol Med. 2013 May;31(5):1057-65. doi: 10.3892/ijmm.2013.1304. Epub 2013 Mar 15.


Effect of a free radical scavenger on nitric oxide release in microvessels.

Yamashita T, Sakamoto K, Yamanishi H, Totani N, Yamamoto J.

Vascul Pharmacol. 2013 Jan;58(1-2):134-9. doi: 10.1016/j.vph.2012.10.006. Epub 2012 Oct 26.


Rapid alternative absorption of dietary long-chain fatty acids with upregulation of intestinal glycosylated CD36 in liver cirrhosis.

Yamamoto Y, Hiasa Y, Murakami H, Ikeda Y, Yamanishi H, Abe M, Matsuura B, Onji M.

Am J Clin Nutr. 2012 Jul;96(1):90-101. doi: 10.3945/ajcn.111.033084. Epub 2012 May 30.


Regulatory dendritic cells pulsed with carbonic anhydrase I protect mice from colitis induced by CD4+CD25- T cells.

Yamanishi H, Murakami H, Ikeda Y, Abe M, Kumagi T, Hiasa Y, Matsuura B, Onji M.

J Immunol. 2012 Mar 1;188(5):2164-72. doi: 10.4049/jimmunol.1100559. Epub 2012 Jan 30.


An unusual case of subclinical diffuse glucagonoma coexisting with two nodules in the pancreas: characteristic features on computed tomography.

Azemoto N, Kumagi T, Yokota T, Kuroda T, Koizumi M, Yamanishi H, Soga Y, Furukawa S, Abe M, Ikeda Y, Hiasa Y, Matsuura B, Watanabe J, Kushihata F, Onji M.

Clin Res Hepatol Gastroenterol. 2012 Jun;36(3):e43-7. doi: 10.1016/j.clinre.2011.12.003. Epub 2012 Jan 11.


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