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Items: 1 to 50 of 100

1.

A novel mechanism of depression: role for connexins.

Xia CY, Wang ZZ, Yamakuni T, Chen NH.

Eur Neuropsychopharmacol. 2018 Apr;28(4):483-498. doi: 10.1016/j.euroneuro.2018.01.009. Epub 2018 Mar 5. Review.

PMID:
29519610
3.

Ginsenoside Rg1 alleviates corticosterone-induced dysfunction of gap junctions in astrocytes.

Xia CY, Chu SF, Zhang S, Gao Y, Ren Q, Lou YX, Luo P, Tian MT, Wang ZQ, Du GH, Tomioka Y, Yamakuni T, Zhang Y, Wang ZZ, Chen NH.

J Ethnopharmacol. 2017 Aug 17;208:207-213. doi: 10.1016/j.jep.2017.06.031. Epub 2017 Jun 20.

PMID:
28642095
4.

Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4'-demethylnobiletin prevents MK801-induced memory impairment.

Kawahata I, Suzuki T, Rico EG, Kusano S, Tamura H, Mimaki Y, Yamakuni T.

J Nat Med. 2017 Oct;71(4):617-631. doi: 10.1007/s11418-017-1091-8. Epub 2017 May 9.

PMID:
28488113
5.

Tyrosine hydroxylase gene expression is facilitated by alcohol followed by the degradation of the protein by ubiquitin proteasome system.

Kawahata I, Evelyn GR, Huinan X, Ohtaku S, Tomioka Y, Yamakuni T.

Neuro Endocrinol Lett. 2017 Feb;38(1):43-49.

PMID:
28456147
6.

Ginsenoside Rg1-induced antidepressant effects involve the protection of astrocyte gap junctions within the prefrontal cortex.

Jin C, Wang ZZ, Zhou H, Lou YX, Chen J, Zuo W, Tian MT, Wang ZQ, Du GH, Kawahata I, Yamakuni T, Zhang Y, Chen NH, Zhang DS.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75:183-191. doi: 10.1016/j.pnpbp.2016.09.006. Epub 2016 Nov 20.

PMID:
27876669
7.

Dopamine or biopterin deficiency potentiates phosphorylation at (40)Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system.

Kawahata I, Ohtaku S, Tomioka Y, Ichinose H, Yamakuni T.

Biochem Biophys Res Commun. 2015 Sep 11;465(1):53-8. doi: 10.1016/j.bbrc.2015.07.125. Epub 2015 Jul 27.

PMID:
26225746
8.

[Pharmacological superiority of nobiletin-rich Citrus reticulata peel, a multicomponent drug, over nobiletin alone regarding anti-dementia action].

Yamakuni T, Kawahata I.

Nihon Yakurigaku Zasshi. 2015 May;145(5):229-33. doi: 10.1254/fpj.145.229. Japanese. No abstract available.

PMID:
25958909
9.

SLC10A4 is a protease-activated transporter that transports bile acids.

Abe T, Kanemitu Y, Nakasone M, Kawahata I, Yamakuni T, Nakajima A, Suzuki N, Nishikawa M, Hishinuma T, Tomioka Y.

J Biochem. 2013 Jul;154(1):93-101. doi: 10.1093/jb/mvt031. Epub 2013 Apr 14.

PMID:
23589386
10.

Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action.

Kawahata I, Yoshida M, Sun W, Nakajima A, Lai Y, Osaka N, Matsuzaki K, Yokosuka A, Mimaki Y, Naganuma A, Tomioka Y, Yamakuni T.

J Neural Transm (Vienna). 2013 Oct;120(10):1397-409. doi: 10.1007/s00702-013-1025-x. Epub 2013 Apr 16.

PMID:
23588349
12.

Nobiletin-rich Citrus reticulata peels, a kampo medicine for Alzheimer's disease: a case series.

Seki T, Kamiya T, Furukawa K, Azumi M, Ishizuka S, Takayama S, Nagase S, Arai H, Yamakuni T, Yaegashi N.

Geriatr Gerontol Int. 2013 Jan;13(1):236-8. doi: 10.1111/j.1447-0594.2012.00892.x. No abstract available.

PMID:
23286569
13.

Four new myrsinol diterpenes from Euphorbia prolifera.

Xu J, Yang B, Fang L, Wang S, Guo Y, Yamakuni T, Ohizumi Y.

J Nat Med. 2013 Apr;67(2):333-8. doi: 10.1007/s11418-012-0688-1. Epub 2012 Jul 31.

PMID:
22847378
14.

Repeated treatment with nicotine induces phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization.

Nakajima A, Kinugasa Y, Torii J, Hishinuma T, Tomioka Y, Yamada K, Yamakuni T.

Neurosci Lett. 2012 Aug 30;524(2):133-8. doi: 10.1016/j.neulet.2012.07.022. Epub 2012 Jul 20.

PMID:
22819974
15.

[Olfaction- and olfactory nerve-destroyed animal models of dementia].

Yamakuni T.

Nihon Rinsho. 2011 Oct;69 Suppl 8:247-51. Japanese. No abstract available.

PMID:
22787790
16.

Isolation, structural elucidation, and neuroprotective effects of iridoids from Valeriana jatamansi.

Xu J, Li Y, Guo Y, Guo P, Yamakuni T, Ohizumi Y.

Biosci Biotechnol Biochem. 2012;76(7):1401-3. Epub 2012 Jul 7.

17.

New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production.

Xu J, Jin DQ, Guo Y, Xie C, Ma Y, Yamakuni T, Ohizumi Y.

Bioorg Med Chem Lett. 2012 Jun 1;22(11):3612-8. doi: 10.1016/j.bmcl.2012.04.052. Epub 2012 Apr 18.

PMID:
22560584
18.

Three new iridoids from the roots of Valeriana jatamansi.

Xu J, Guo Y, Jin DQ, Zhao P, Guo P, Yamakuni T, Ohizumi Y.

J Nat Med. 2012 Oct;66(4):653-7. doi: 10.1007/s11418-012-0631-5. Epub 2012 Feb 14.

PMID:
22331424
19.

Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells.

Fujiwara H, Kogure A, Sakamoto M, Yamakuni T, Mimaki Y, Murata K, Hitomi N, Yamaguchi K, Ohizumi Y.

J Pharmacol Sci. 2011;116(4):384-7. Epub 2011 Jul 9.

20.

Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis.

Xu J, Guo P, Liu C, Sun Z, Gui L, Guo Y, Yamakuni T, Ohizumi Y.

Biosci Biotechnol Biochem. 2011;75(7):1386-8. Epub 2011 Jul 7.

21.

High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound.

Saigusa D, Shibuya M, Jinno D, Yamakoshi H, Iwabuchi Y, Yokosuka A, Mimaki Y, Naganuma A, Ohizumi Y, Tomioka Y, Yamakuni T.

Anal Bioanal Chem. 2011 Jul;400(10):3635-41. doi: 10.1007/s00216-011-5031-2. Epub 2011 May 11.

PMID:
21559759
22.

Two distinct mechanisms for actin capping protein regulation--steric and allosteric inhibition.

Takeda S, Minakata S, Koike R, Kawahata I, Narita A, Kitazawa M, Ota M, Yamakuni T, MaƩda Y, Nitanai Y.

PLoS Biol. 2010 Jul 6;8(7):e1000416. doi: 10.1371/journal.pbio.1000416.

23.

Dual effects of nobiletin, a citrus polymethoxy flavone, on catecholamine secretion in cultured bovine adrenal medullary cells.

Zhang H, Toyohira Y, Ueno S, Shinohara Y, Itoh H, Furuno Y, Yamakuni T, Tsutsui M, Takahashi K, Yanagihara N.

J Neurochem. 2010 Aug;114(4):1030-8. doi: 10.1111/j.1471-4159.2010.06840.x. Epub 2010 Jun 1.

26.

Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.

Yamamoto Y, Shioda N, Han F, Moriguchi S, Nakajima A, Yokosuka A, Mimaki Y, Sashida Y, Yamakuni T, Ohizumi Y, Fukunaga K.

Brain Res. 2009 Oct 27;1295:218-29. doi: 10.1016/j.brainres.2009.07.081. Epub 2009 Jul 30.

PMID:
19646972
27.

4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.

Al Rahim M, Nakajima A, Saigusa D, Tetsu N, Maruyama Y, Shibuya M, Yamakoshi H, Tomioka Y, Iwabuchi Y, Ohizumi Y, Yamakuni T.

Biochemistry. 2009 Aug 18;48(32):7713-21. doi: 10.1021/bi901088w.

PMID:
19601643
28.

Neurobehavioral effects of tetrabromobisphenol A, a brominated flame retardant, in mice.

Nakajima A, Saigusa D, Tetsu N, Yamakuni T, Tomioka Y, Hishinuma T.

Toxicol Lett. 2009 Aug 25;189(1):78-83. doi: 10.1016/j.toxlet.2009.05.003. Epub 2009 May 20.

PMID:
19463927
29.

A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Abeta-inhibition of the cascade in cultured rat CNS neurons.

Al Rahim M, Nakajima A, Misawa N, Shindo K, Adachi K, Shizuri Y, Ohizumi Y, Yamakuni T.

Eur J Pharmacol. 2008 Dec 14;600(1-3):10-7. doi: 10.1016/j.ejphar.2008.09.046. Epub 2008 Oct 9.

PMID:
18948095
30.

Pharmacological action of nobiletin, a component of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, and its application for development of functional foods.

Yamakuni T, Nakajima A, Ohizumi Y.

Nihon Yakurigaku Zasshi. 2008 Sep;132(3):155-9. doi: 10.1254/fpj.132.155. Review. Japanese. No abstract available.

PMID:
18787297
31.

Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease.

Onozuka H, Nakajima A, Matsuzaki K, Shin RW, Ogino K, Saigusa D, Tetsu N, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y.

J Pharmacol Exp Ther. 2008 Sep;326(3):739-44. doi: 10.1124/jpet.108.140293. Epub 2008 Jun 10.

PMID:
18544674
32.

Beneficial effects of Ajuga decumbens on osteoporosis and arthritis.

Ono Y, Fukaya Y, Imai S, Yamakuni T.

Biol Pharm Bull. 2008 Jun;31(6):1199-204.

33.

Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus.

Matsuzaki K, Miyazaki K, Sakai S, Yawo H, Nakata N, Moriguchi S, Fukunaga K, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y.

Eur J Pharmacol. 2008 Jan 14;578(2-3):194-200. Epub 2007 Oct 2.

PMID:
17976577
34.

Clerodane diterpenoids and flavonoids with NGF-potentiating activity from the aerial parts of Baccharis gaudichaudiana.

Guo Y, Li Y, Xu J, Li N, Yamakuni T, Ohizumi Y.

Chem Pharm Bull (Tokyo). 2007 Oct;55(10):1532-4.

35.

Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.

Nakajima A, Yamakuni T, Haraguchi M, Omae N, Song SY, Kato C, Nakagawasai O, Tadano T, Yokosuka A, Mimaki Y, Sashida Y, Ohizumi Y.

J Pharmacol Sci. 2007 Sep;105(1):122-6.

36.

Nobiletin, a citrus flavonoid, reverses learning impairment associated with N-methyl-D-aspartate receptor antagonism by activation of extracellular signal-regulated kinase signaling.

Nakajima A, Yamakuni T, Matsuzaki K, Nakata N, Onozuka H, Yokosuka A, Sashida Y, Mimaki Y, Ohizumi Y.

J Pharmacol Exp Ther. 2007 May;321(2):784-90. Epub 2007 Feb 8.

PMID:
17289833
37.

Metronomic scheduling of a cyclic hexapeptide Ra-VII for anti-angiogenesis, tumor vessel maturation and anti-tumor activity.

Koizumi T, Abe M, Yamakuni T, Ohizumi Y, Hitotsuyanagi Y, Takeya K, Sato Y.

Cancer Sci. 2006 Jul;97(7):665-74.

38.

Proinsulin C-peptide stimulates a PKC/IkappaB/NF-kappaB signaling pathway to activate COX-2 gene transcription in Swiss 3T3 fibroblasts.

Kitazawa M, Shibata Y, Hashimoto S, Ohizumi Y, Yamakuni T.

J Biochem. 2006 Jun;139(6):1083-8.

PMID:
16788059
39.

Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats.

Matsuzaki K, Yamakuni T, Hashimoto M, Haque AM, Shido O, Mimaki Y, Sashida Y, Ohizumi Y.

Neurosci Lett. 2006 Jun 12;400(3):230-4. Epub 2006 Apr 3.

PMID:
16581185
40.

Ca2+ channel activating action of maitotoxin in cultured brainstem neurons.

Kakizaki A, Takahashi M, Akagi H, Tachikawa E, Yamamoto T, Taira E, Yamakuni T, Ohizumi Y.

Eur J Pharmacol. 2006 May 1;536(3):223-31. Epub 2006 Mar 10.

PMID:
16581067
41.

Three-membered ring sesquiterpenoids with NGF-potentiating activity from the roots of Valeriana fauriei.

Guo Y, Xu J, Li Y, Yamakuni T, Ohizumi Y.

Planta Med. 2006 Mar;72(4):373-5. Erratum in: Planta Med. 2008 Nov;74(14):1767.

PMID:
16557481
42.

Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana.

Guo Y, Li Y, Xu J, Watanabe R, Oshima Y, Yamakuni T, Ohizumi Y.

J Nat Prod. 2006 Feb;69(2):274-6.

PMID:
16499330
43.

Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei.

Guo Y, Xu J, Li Y, Watanabe R, Oshima Y, Yamakuni T, Ohizumi Y.

Chem Pharm Bull (Tokyo). 2006 Jan;54(1):123-5.

44.

Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells.

Yamakuni T, Aoki K, Nakatani K, Kondo N, Oku H, Ishiguro K, Ohizumi Y.

Neurosci Lett. 2006 Feb 20;394(3):206-10. Epub 2005 Nov 2.

PMID:
16260090
45.

Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities.

Nagase H, Omae N, Omori A, Nakagawasai O, Tadano T, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y.

Biochem Biophys Res Commun. 2005 Dec 2;337(4):1330-6. Epub 2005 Oct 10.

PMID:
16253614
46.

Mechanism of neurotrophic action of nobiletin in PC12D cells.

Nagase H, Yamakuni T, Matsuzaki K, Maruyama Y, Kasahara J, Hinohara Y, Kondo S, Mimaki Y, Sashida Y, Tank AW, Fukunaga K, Ohizumi Y.

Biochemistry. 2005 Oct 25;44(42):13683-91.

PMID:
16229458
47.
48.

Intracellular cAMP controls a physical association of V-1 with CapZ in cultured mammalian endocrine cells.

Kitazawa M, Yamakuni T, Song SY, Kato C, Tsuchiya R, Ishida M, Suzuki N, Adachi E, Iwashita S, Ueno S, Yanagihara N, Taoka M, Isobe T, Ohizumi Y.

Biochem Biophys Res Commun. 2005 May 27;331(1):181-6.

PMID:
15845376
49.

Acidosis-induced protein tyrosine phosphorylation depends on Ca2+ influx via voltage-dependent Ca2+ channels in SHR aorta.

Rohra DK, Yamakuni T, Ohizumi Y.

Eur J Pharmacol. 2004 Nov 3;504(1-2):105-11.

PMID:
15507226
50.

gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells.

Nakatani K, Yamakuni T, Kondo N, Arakawa T, Oosawa K, Shimura S, Inoue H, Ohizumi Y.

Mol Pharmacol. 2004 Sep;66(3):667-74.

PMID:
15322259

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