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Items: 1 to 50 of 152


The efficacy of vacuum-ultraviolet light disinfection of some common environmental pathogens.

Szeto W, Yam WC, Huang H, Leung DYC.

BMC Infect Dis. 2020 Feb 11;20(1):127. doi: 10.1186/s12879-020-4847-9.


Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region.

Luo Y, Cheong E, Bian Q, Collins DA, Ye J, Shin JH, Yam WC, Takata T, Song X, Wang X, Kamboj M, Gottlieb T, Jiang J, Riley TV, Tang YW, Jin D.

Emerg Microbes Infect. 2019;8(1):1553-1562. doi: 10.1080/22221751.2019.1682472.


Direct Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis by Use of pncA PCR Sequencing.

Tam KK, Leung KS, Siu GK, Chang KC, Wong SS, Ho PL, Leung EK, Yam WC.

J Clin Microbiol. 2019 Jul 26;57(8). pii: e00145-19. doi: 10.1128/JCM.00145-19. Print 2019 Aug.


Molecular Characterization of HIV-1 Minority Subtypes in Hong Kong: A Recent Epidemic of CRF07_BC among the Men who have Sex with Men Population.

Leung KS, To SW, Chen JH, Siu GK, Chan KC, Yam WC.

Curr HIV Res. 2019;17(1):53-64. doi: 10.2174/1570162X17666190530081355.


Genomic investigation of a sequence type 67 Clostridium difficile causing community-acquired fulminant colitis in Hong Kong.

Cao H, Wong SC, Yam WC, Liu MC, Chow KH, Wu AK, Ho PL.

Int J Med Microbiol. 2019 Jul;309(5):270-273. doi: 10.1016/j.ijmm.2019.05.003. Epub 2019 May 11.


In vivo electroporation of a codon-optimized BERopt DNA vaccine protects mice from pathogenic Mycobacterium tuberculosis aerosol challenge.

Tang J, Cai Y, Liang J, Tan Z, Tang X, Zhang C, Cheng L, Zhou J, Wang H, Yam WC, Chen X, Wang H, Chen Z.

Tuberculosis (Edinb). 2018 Dec;113:65-75. doi: 10.1016/ Epub 2018 Jul 10.


Diagnostic evaluation of an in-house developed single-tube, duplex, nested IS6110 real-time PCR assay for rapid pulmonary tuberculosis diagnosis.

Leung KS, Siu GK, Tam KK, Ho PL, Wong SS, Leung EK, Yu SH, Ma OC, Yam WC.

Tuberculosis (Edinb). 2018 Sep;112:120-125. doi: 10.1016/ Epub 2018 Aug 22.


Drug resistance mechanisms and drug susceptibility testing for tuberculosis.

Miotto P, Zhang Y, Cirillo DM, Yam WC.

Respirology. 2018 Dec;23(12):1098-1113. doi: 10.1111/resp.13393. Epub 2018 Sep 6. Review.


Pre-exposure prophylaxis (PrEP) for MSM in low HIV incidence places: should high risk individuals be targeted?

Wong NS, Kwan TH, Tsang OTY, Lee MP, Yam WC, Lam W, Leung WS, Chan JMC, Ho KM, Lee SS.

Sci Rep. 2018 Aug 3;8(1):11641. doi: 10.1038/s41598-018-30101-9.


Whole genome sequencing data of 1110 Mycobacterium tuberculosis isolates identifies insertions and deletions associated with drug resistance.

Zeng X, Kwok JS, Yang KY, Leung KS, Shi M, Yang Z, Yam WC, Tsui SK.

BMC Genomics. 2018 May 16;19(1):365. doi: 10.1186/s12864-018-4734-6.


Comparative Whole-Genomic Analysis of an Ancient L2 Lineage Mycobacterium tuberculosis Reveals a Novel Phylogenetic Clade and Common Genetic Determinants of Hypervirulent Strains.

Rajwani R, Yam WC, Zhang Y, Kang Y, Wong BKC, Leung KSS, Tam KKG, Tulu KT, Zhu L, Siu GKH.

Front Cell Infect Microbiol. 2018 Jan 12;7:539. doi: 10.3389/fcimb.2017.00539. eCollection 2017.


Comparative Genomic Analysis of Two Clonally Related Multidrug Resistant Mycobacterium tuberculosis by Single Molecule Real Time Sequencing.

Leung KS, Siu GK, Tam KK, To SW, Rajwani R, Ho PL, Wong SS, Zhao WW, Ma OC, Yam WC.

Front Cell Infect Microbiol. 2017 Nov 15;7:478. doi: 10.3389/fcimb.2017.00478. eCollection 2017.


Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realtime MTB detection and RIF/INH resistance assay.

Tam KK, Leung KS, To SW, Siu GK, Lau TC, Shek VC, Tse CW, Wong SS, Ho PL, Yam WC.

Diagn Microbiol Infect Dis. 2017 Oct;89(2):118-124. doi: 10.1016/j.diagmicrobio.2017.06.018. Epub 2017 Jul 1.


Rapid Differentiation of Haemophilus influenzae and Haemophilus haemolyticus by Use of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry with ClinProTools Mass Spectrum Analysis.

Chen JHK, Cheng VCC, Wong CP, Wong SCY, Yam WC, Yuen KY.

J Clin Microbiol. 2017 Sep;55(9):2679-2685. doi: 10.1128/JCM.00267-17. Epub 2017 Jun 21.


Application of a dual target PCR-high resolution melting (HRM) method for rapid nontuberculous mycobacteria identification.

Chen JH, Cheng VC, She KK, Yam WC, Yuen KY.

J Microbiol Methods. 2017 Jan;132:1-3. doi: 10.1016/j.mimet.2016.11.004. Epub 2016 Nov 9.


Development and in-use evaluation of a novel Luminex MicroPlex microsphere-based (TRIOL) assay for simultaneous identification of Mycobacterium tuberculosis and detection of first-line and second-line anti-tuberculous drug resistance in China.

Yin F, Chan JF, Zhu Q, Fu R, Chen JH, Choi GK, Tee KM, Li L, Qian S, Yam WC, Lu G, Yuen KY.

J Clin Pathol. 2017 Apr;70(4):342-349. doi: 10.1136/jclinpath-2016-203952. Epub 2016 Sep 19.


Mycobacterium tuberculosis infection and vaccine development.

Tang J, Yam WC, Chen Z.

Tuberculosis (Edinb). 2016 May;98:30-41. doi: 10.1016/ Epub 2016 Feb 27. Review.


Poor agreement between diagnostic tests for latent tuberculosis infection among HIV-infected persons in Hong Kong.

Leung CC, Chan K, Yam WC, Lee MP, Chan CK, Wong KH, Ho PL, Mak I, Tam CM.

Respirology. 2016 Oct;21(7):1322-9. doi: 10.1111/resp.12805. Epub 2016 Apr 28.


Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System.

Cheung KW, Peng Q, He L, Cai K, Jiang Q, Zhou B, To SW, Yam WC, Liu L, Chen Z, Wang H.

PLoS One. 2016 Apr 19;11(4):e0153641. doi: 10.1371/journal.pone.0153641. eCollection 2016.


Use of interferon gamma release assay to assess latent tuberculosis infection among healthcare workers in Hong Kong.

Tsang DN, Lai CK, Yam WC, Chan JW, Mok YW, Seto WH, Fung SC, Chu CM, Lam BH, Ng TK.

Hong Kong Med J. 2015 Dec;21 Suppl 7:S22-5. No abstract available.


The importance of matrix-assisted laser desorption ionization-time of flight mass spectrometry for correct identification of Clostridium difficile isolated from chromID C. difficile chromogenic agar.

Chen JHK, Cheng VCC, Wong OY, Wong SCY, So SYC, Yam WC, Yuen KY.

J Microbiol Immunol Infect. 2017 Oct;50(5):723-726. doi: 10.1016/j.jmii.2015.12.002. Epub 2016 Jan 11.


Performance Evaluation of the Verigene Gram-Positive and Gram-Negative Blood Culture Test for Direct Identification of Bacteria and Their Resistance Determinants from Positive Blood Cultures in Hong Kong.

Siu GK, Chen JH, Ng TK, Lee RA, Fung KS, To SW, Wong BK, Cheung S, Wong IW, Tam MM, Lee SS, Yam WC.

PLoS One. 2015 Oct 2;10(10):e0139728. doi: 10.1371/journal.pone.0139728. eCollection 2015.


Risk group characteristics and viral transmission clusters in South-East Asian patients infected with human immunodeficiency virus-1 (HIV-1) circulating recombinant form (CRF) 01_AE and subtype B.

Oyomopito RA, Chen YJ, Sungkanuparph S, Kantor R, Merati T, Yam WC, Sirisanthana T, Li PC, Kantipong P, Phanuphak P, Lee CK, Kamarulzaman A, Ditangco R, Huang SW, Sohn AH, Law M, Chen YM.

Kaohsiung J Med Sci. 2015 Sep;31(9):445-53. doi: 10.1016/j.kjms.2015.07.002. Epub 2015 Aug 21.


Emergence of Macrolide-Resistant Mycoplasma pneumoniae in Hong Kong Is Linked to Increasing Macrolide Resistance in Multilocus Variable-Number Tandem-Repeat Analysis Type 4-5-7-2.

Ho PL, Law PY, Chan BW, Wong CW, To KK, Chiu SS, Cheng VC, Yam WC.

J Clin Microbiol. 2015 Nov;53(11):3560-4. doi: 10.1128/JCM.01983-15. Epub 2015 Sep 2.


Molecular tests for rapid detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis.

Ho PL, Yam WC, Leung CC, Yew WW, Mok TY, Chan KS, Tam CM.

Hong Kong Med J. 2015 Jun;21 Suppl 4:4-7. No abstract available.


Performance of the new automated Abbott RealTime MTB assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens.

Chen JH, She KK, Kwong TC, Wong OY, Siu GK, Leung CC, Chang KC, Tam CM, Ho PL, Cheng VC, Yuen KY, Yam WC.

Eur J Clin Microbiol Infect Dis. 2015 Sep;34(9):1827-32. doi: 10.1007/s10096-015-2419-5. Epub 2015 Jun 13.


Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers.

Lau SK, Lam CW, Curreem SO, Lee KC, Lau CC, Chow WN, Ngan AH, To KK, Chan JF, Hung IF, Yam WC, Yuen KY, Woo PC.

Emerg Microbes Infect. 2015 Jan;4(1):e6. doi: 10.1038/emi.2015.6. Epub 2015 Jan 28.


Use of MALDI Biotyper plus ClinProTools mass spectra analysis for correct identification of Streptococcus pneumoniae and Streptococcus mitis/oralis.

Chen JH, She KK, Wong OY, Teng JL, Yam WC, Lau SK, Woo PC, Cheng VC, Yuen KY.

J Clin Pathol. 2015 Aug;68(8):652-6. doi: 10.1136/jclinpath-2014-202818. Epub 2015 May 13.


Community-Based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong.

Liang J, Liu L, Cheung M, Lee MP, Wang H, Li CH, Chan CC, Nishiura K, Tang X, Tan Z, Peng J, Cheung KW, Yam WC, Chen Z.

PLoS One. 2015 Apr 27;10(4):e0125715. doi: 10.1371/journal.pone.0125715. eCollection 2015.


Containment of Clostridium difficile infection without reduction in antimicrobial use in Hong Kong.

Cheng VC, Chau PH, So SY, Chen JH, Poon RW, Wong SC, Hung IF, Lee WM, Tai JW, Ho PL, Yam WC, Yuen KY.

Eur J Clin Microbiol Infect Dis. 2015 Jul;34(7):1381-6. doi: 10.1007/s10096-015-2362-5. Epub 2015 Mar 24.


T-Spot.TB outperforms tuberculin skin test in predicting development of active tuberculosis among household contacts.

Leung CC, Yam WC, Ho PL, Yew WW, Chan CK, Law WS, Lee SN, Chang KC, Tai LB, Tam CM.

Respirology. 2015 Apr;20(3):496-503. doi: 10.1111/resp.12483. Epub 2015 Feb 17.


Transmitted drug resistance in recently infected HIV-positive Individuals from four urban locations across Asia (2007-2010) - TASER-S.

Jiamsakul A, Sirivichayakul S, Ditangco R, Wong KH, Li PC, Praparattanapan J, Phanuphak P, Segubre-Mercado E, Yam WC, Sirisanthana T, Singtoroj T, Law M; TREAT Asia Studies to Evaluate Resistance – Surveillance Study (TASER-S).

AIDS Res Ther. 2015 Feb 13;12:3. doi: 10.1186/s12981-015-0043-1. eCollection 2015.


Performance of the VITEK MS matrix-assisted laser desorption ionization-time of flight mass spectrometry system for rapid bacterial identification in two diagnostic centres in China.

Luo Y, Siu GK, Yeung AS, Chen JH, Ho PL, Leung KW, Tsang JL, Cheng VC, Guo L, Yang J, Ye L, Yam WC.

J Med Microbiol. 2015 Jan;64(Pt 1):18-24. doi: 10.1099/jmm.0.080317-0. Epub 2014 Nov 23.


Recombinant ESAT-6-like proteins provoke protective immune responses against invasive Staphylococcus aureus disease in a murine model.

Zhang BZ, Hua YH, Yu B, Lau CC, Cai JP, Zheng SY, Yam WC, Kao RY, Sze KH, Zheng BJ, Yuen KY, Huang JD.

Infect Immun. 2015 Jan;83(1):339-45. doi: 10.1128/IAI.02498-14. Epub 2014 Nov 3.


Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis.

Lan Y, Lam JT, Siu GK, Yam WC, Mason AJ, Lam JK.

Tuberculosis (Edinb). 2014 Dec;94(6):678-89. doi: 10.1016/ Epub 2014 Aug 12.


Clonality of bacterial consortia in root canals and subjacent gingival crevices.

Parahitiyawa NB, Chu FC, Leung WK, Yam WC, Jin LJ, Samaranayake LP.

J Investig Clin Dent. 2015 Feb;6(1):32-9. doi: 10.1111/jicd.12070. Epub 2014 Aug 23.


An upstream truncation of the furA-katG operon confers high-level isoniazid resistance in a Mycobacterium tuberculosis clinical isolate with no known resistance-associated mutations.

Siu GK, Yam WC, Zhang Y, Kao RY.

Antimicrob Agents Chemother. 2014 Oct;58(10):6093-100. doi: 10.1128/AAC.03277-14. Epub 2014 Aug 4.


Evaluation of real-time PCR for quantitative detection of Escherichia coli in beach water.

Lam JT, Lui E, Chau S, Kueh CS, Yung YK, Yam WC.

J Water Health. 2014 Mar;12(1):51-6. doi: 10.2166/wh.2013.038.


pIMP-PH114 carrying bla IMP-4 in a Klebsiella pneumoniae strain is closely related to other multidrug-resistant IncA/C2 plasmids.

Ho PL, Lo WU, Chan J, Cheung YY, Chow KH, Yam WC, Lin CH, Que TL.

Curr Microbiol. 2014 Feb;68(2):227-32.


Advantages of using matrix-assisted laser desorption ionization-time of flight mass spectrometry as a rapid diagnostic tool for identification of yeasts and mycobacteria in the clinical microbiological laboratory.

Chen JH, Yam WC, Ngan AH, Fung AM, Woo WL, Yan MK, Choi GK, Ho PL, Cheng VC, Yuen KY.

J Clin Microbiol. 2013 Dec;51(12):3981-7. doi: 10.1128/JCM.01437-13. Epub 2013 Sep 18.


Performance comparison of an in-house integrase genotyping assay versus the ViroSeq™ Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong.

To SW, Chen JH, Wong KH, Chan KC, Ng HM, Wu H, Lam JT, Yam WC.

J Clin Virol. 2013 Sep;58(1):299-302. doi: 10.1016/j.jcv.2013.06.040. Epub 2013 Jul 22.


Evaluation of the LightCycler methicillin-resistant Staphylococcus aureus (MRSA) advanced test for detection of MRSA nasal colonization.

Yam WC, Siu GK, Ho PL, Ng TK, Que TL, Yip KT, Fok CP, Chen JH, Cheng VC, Yuen KY.

J Clin Microbiol. 2013 Sep;51(9):2869-74. doi: 10.1128/JCM.00488-13. Epub 2013 Jun 19.


Determination of the high prevalence of Dual/Mixed- or X4-tropism among HIV type 1 CRF01_AE in Hong Kong by genotyping and phenotyping methods.

To SW, Chen JH, Wong KH, Chan KC, Chen Z, Yam WC.

AIDS Res Hum Retroviruses. 2013 Aug;29(8):1123-8. doi: 10.1089/AID.2013.0067. Epub 2013 May 31.


Direct bacterial identification in positive blood cultures by use of two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems.

Chen JH, Ho PL, Kwan GS, She KK, Siu GK, Cheng VC, Yuen KY, Yam WC.

J Clin Microbiol. 2013 Jun;51(6):1733-9. doi: 10.1128/JCM.03259-12. Epub 2013 Mar 20.


HLA-B*5701 genetic screening among HIV-1 infected patients in Hong Kong: is this a practical approach in Han-Chinese?

To SW, Chen JH, Wong KH, Chan KC, Tsang OT, Yam WC.

Int J STD AIDS. 2013 Jan;24(1):50-2. doi: 10.1258/ijsa.2012.012102. Epub 2013 May 6.


Clinical significance of Pneumocystis jiroveci in patients with active tuberculosis.

To KK, Hung IF, Xu T, Poon RW, Ip WC, Li PT, Li CP, Lau SK, Yam WC, Chan KH, Yuen KY.

Diagn Microbiol Infect Dis. 2013 Mar;75(3):260-5. doi: 10.1016/j.diagmicrobio.2012.11.016. Epub 2013 Jan 16.


Point-of-care diagnosis of tuberculosis: past, present and future.

Dheda K, Ruhwald M, Theron G, Peter J, Yam WC.

Respirology. 2013 Feb;18(2):217-32. doi: 10.1111/resp.12022. Review.


The use of high-resolution melting analysis for rapid spa typing on methicillin-resistant Staphylococcus aureus clinical isolates.

Chen JH, Cheng VC, Chan JF, She KK, Yan MK, Yau MC, Kwan GS, Yam WC, Yuen KY.

J Microbiol Methods. 2013 Feb 15;92(2):99-102. doi: 10.1016/j.mimet.2012.11.006. Epub 2012 Nov 13.


Clonality and antimicrobial susceptibility of Staphylococcus aureus and methicillin-resistant S. aureus isolates from food animals and other animals.

Ho PL, Chow KH, Lai EL, Law PY, Chan PY, Ho AY, Ng TK, Yam WC.

J Clin Microbiol. 2012 Nov;50(11):3735-7. doi: 10.1128/JCM.02053-12. Epub 2012 Aug 15.

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