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Lipid rafts in glial cells: Role in neuroinflammation and pain processing.

Miller YI, Navia-Pelaez JM, Corr M, Yaksh TL.

J Lipid Res. 2019 Dec 20. pii: jlr.TR119000468. doi: 10.1194/jlr.TR119000468. [Epub ahead of print]


Role of Toll-like receptor 4 signaling in mast cell-mediated migraine pain pathway.

Ramachandran R, Wang Z, Saavedra C, DiNardo A, Corr M, Powell SB, Yaksh TL.

Mol Pain. 2019 Jan-Dec;15:1744806919867842. doi: 10.1177/1744806919867842. No abstract available.


Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling.

Yaksh TL, Eddinger KA, Kokubu S, Wang Z, DiNardo A, Ramachandran R, Zhu Y, He Y, Weren F, Quang D, Malkmus SA, Lansu K, Kroeze WK, Eliceiri B, Steinauer JJ, Schiller PW, Gmeiner P, Page LM, Hildebrand KR.

Anesthesiology. 2019 Jul;131(1):132-147. doi: 10.1097/ALN.0000000000002730.


Rapid continuous 3D printing of customizable peripheral nerve guidance conduits.

Zhu W, Tringale KR, Woller SA, You S, Johnson S, Shen H, Schimelman J, Whitney M, Steinauer J, Xu W, Yaksh TL, Nguyen QT, Chen S.

Mater Today (Kidlington). 2018 Nov;21(9):951-959. doi: 10.1016/j.mattod.2018.04.001. Epub 2018 Apr 27.


Characterization of Effect of Repeated Bolus or Continuous Intrathecal Infusion of Morphine on Spinal Mass Formation in the Dog.

Hildebrand KR, Page LM, Billstrom TM, Steinauer JJ, Eddinger KA, Arjomand S, Yaksh TL.

Neuromodulation. 2019 Oct;22(7):790-798. doi: 10.1111/ner.12963. Epub 2019 May 23.


Characterization of Analgesic Actions of the Chronic Intrathecal Infusion of H-Dmt-D-Arg-Phe-Lys-NH2 in Rat.

Kokubu S, Eddinger KA, Yamaguchi S, Huerta-Esquivel LL, Schiller PW, Yaksh TL.

Neuromodulation. 2019 Oct;22(7):781-789. doi: 10.1111/ner.12925. Epub 2019 Feb 22.


Spinal Exparel®-an extended duration of preclinical study needed.

Eisenach JC, Yaksh TL.

Br J Anaesth. 2019 Mar;122(3):298-300. doi: 10.1016/j.bja.2018.11.021. Epub 2018 Dec 24. No abstract available.


Botulinum toxin blocks mast cells and prevents rosacea like inflammation.

Choi JE, Werbel T, Wang Z, Wu CC, Yaksh TL, Di Nardo A.

J Dermatol Sci. 2019 Jan;93(1):58-64. doi: 10.1016/j.jdermsci.2018.12.004. Epub 2018 Dec 28.


Letter to Editor re: "Unique Intradural Inflammatory Mass Containing Precipitated Morphine" by Kim et al.

Yaksh TL.

Pain Pract. 2019 Apr;19(4):456. doi: 10.1111/papr.12761. Epub 2019 Feb 4. No abstract available.


Unilateral Epidural Targeting of Resiniferatoxin Induces Bilateral Neurolysis of Spinal Nociceptive Afferents.

Unger MD, Pleticha J, Steinauer J, Kanwar R, Diehn F, LaVallee KT, Banck MS, Jones B, Yaksh TL, Maus TP, Beutler AS.

Pain Med. 2019 May 1;20(5):897-906. doi: 10.1093/pm/pny276.


Neuraxial TNF and IFN-beta co-modulate persistent allodynia in arthritic mice.

Woller SA, Ocheltree C, Wong SY, Bui A, Fujita Y, Gonçalves Dos Santos G, Yaksh TL, Corr M.

Brain Behav Immun. 2019 Feb;76:151-158. doi: 10.1016/j.bbi.2018.11.014. Epub 2018 Nov 19.


Development of New Analgesics: An Answer to Opioid Epidemic.

Yaksh TL, Hunt MA, Dos Santos GG.

Trends Pharmacol Sci. 2018 Dec;39(12):1000-1002. doi: 10.1016/


Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome.

Shubayev VI, Strongin AY, Yaksh TL.

Mol Pain. 2018 Jan-Dec;14:1744806918815005. doi: 10.1177/1744806918815005. Epub 2018 Nov 5. Review.


Characterization of the antinociceptive effects of intrathecal DALDA peptides following bolus intrathecal delivery.

Kokubu S, Eddinger KA, Nguyen TM, Huerta-Esquivel LL, Yamaguchi S, Schiller PW, Yaksh TL.

Scand J Pain. 2019 Jan 28;19(1):193-206. doi: 10.1515/sjpain-2018-0120.


Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.

Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL.

Pain. 2018 Dec;159(12):2620-2629. doi: 10.1097/j.pain.0000000000001373.


Targeting toll-like receptor-4 (TLR4)-an emerging therapeutic target for persistent pain states.

Bruno K, Woller SA, Miller YI, Yaksh TL, Wallace M, Beaton G, Chakravarthy K.

Pain. 2018 Oct;159(10):1908-1915. doi: 10.1097/j.pain.0000000000001306. Review.


Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States.

Woller SA, Choi SH, An EJ, Low H, Schneider DA, Ramachandran R, Kim J, Bae YS, Sviridov D, Corr M, Yaksh TL, Miller YI.

Cell Rep. 2018 May 29;23(9):2667-2677. doi: 10.1016/j.celrep.2018.04.110.


Complexity of systems and actions underlying neurogenic inflammation.

Yaksh TL, Di Nardo A.

Semin Immunopathol. 2018 May;40(3):225-228. doi: 10.1007/s00281-018-0683-z. No abstract available.


Transition to chronic pain: opportunities for novel therapeutics.

Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH.

Nat Rev Neurosci. 2018 Jul;19(7):383-384. doi: 10.1038/s41583-018-0012-5. No abstract available.


A Study and Review of Effects of Botulinum Toxins on Mast Cell Dependent and Independent Pruritus.

Ramachandran R, Marino MJ, Paul S, Wang Z, Mascarenhas NL, Pellett S, Johnson EA, DiNardo A, Yaksh TL.

Toxins (Basel). 2018 Mar 23;10(4). pii: E134. doi: 10.3390/toxins10040134.


An overview of pathways encoding nociception.

Woller SA, Eddinger KA, Corr M, Yaksh TL.

Clin Exp Rheumatol. 2018 Jan-Feb;36(1):172. Epub 2018 Feb 6. No abstract available.


Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation.

Sorkin LS, Eddinger KA, Woller SA, Yaksh TL.

Semin Immunopathol. 2018 May;40(3):237-247. doi: 10.1007/s00281-017-0669-2. Epub 2018 Feb 8. Review.


Target engagement and histopathology of neuraxial resiniferatoxin in dog.

Hockman TM, Cisternas AF, Jones B, Butt MT, Osborn KG, Steinauer JJ, Malkmus SA, Yaksh TL.

Vet Anaesth Analg. 2018 Mar;45(2):212-226. doi: 10.1016/j.vaa.2017.10.005. Epub 2017 Dec 5.


Corrigendum to "Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state" [Brain Behav. Immun. 56 (2016) 271-280].

Woller SA, Ravula SB, Tucci FC, Beaton G, Corr M, Isseroff RR, Soulika AM, Chigbrow M, Eddinger KA, Yaksh TL.

Brain Behav Immun. 2018 Mar;69:632. doi: 10.1016/j.bbi.2017.12.008. Epub 2017 Dec 29. No abstract available.


Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular.

Emami A, Tepper J, Short B, Yaksh TL, Bendele AM, Ramani T, Cisternas AF, Chang JH, Mellon RD.

Int J Toxicol. 2018 Jan/Feb;37(1):4-27. doi: 10.1177/1091581817741840. Epub 2017 Dec 21.


Effects of opioid and nonopioid analgesics on canine wheal formation and cultured human mast cell degranulation.

Schmidt-Rondon E, Wang Z, Malkmus SA, Di Nardo A, Hildebrand K, Page L, Yaksh TL.

Toxicol Appl Pharmacol. 2018 Jan 1;338:54-64. doi: 10.1016/j.taap.2017.10.017. Epub 2017 Oct 27.


Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics.

Knezevic NN, Yekkirala A, Yaksh TL.

Anesth Analg. 2017 Nov;125(5):1714-1732. doi: 10.1213/ANE.0000000000002442. Review.


An overview of pathways encoding nociception.

Woller SA, Eddinger KA, Corr M, Yaksh TL.

Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 107(5):40-46. Epub 2017 Sep 29. Review.


Editor's Highlight: Formulation and Toxicology Evaluation of the Intrathecal AYX1 DNA-Decoy in Sprague Dawley Rats.

Mamet J, Yeomans DC, Yaksh TL, Manning DC, Harris S.

Toxicol Sci. 2017 Sep 1;159(1):76-85. doi: 10.1093/toxsci/kfx118.


Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model.

Rijsdijk M, Agalave NM, van Wijck AJM, Kalkman CJ, Ramachandran R, Baharpoor A, Svensson CI, Yaksh TL.

Scand J Pain. 2017 Jul;16:1-9. doi: 10.1016/j.sjpain.2016.12.008. Epub 2017 Feb 3.


Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.

Yaksh TL, Schwarcz R, Snodgrass HR.

J Pain. 2017 Oct;18(10):1184-1196. doi: 10.1016/j.jpain.2017.03.014. Epub 2017 Apr 18.


Modeling Spinal Intrathecal Drug Distribution: The Challenge of Defining and Predicting Cerebrospinal Fluid Dynamics.

Bert RJ, Hayek SM, Yaksh TL.

Anesth Analg. 2017 May;124(5):1403-1406. doi: 10.1213/ANE.0000000000002071. No abstract available.


Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.

Flinspach M, Xu Q, Piekarz AD, Fellows R, Hagan R, Gibbs A, Liu Y, Neff RA, Freedman J, Eckert WA, Zhou M, Bonesteel R, Pennington MW, Eddinger KA, Yaksh TL, Hunter M, Swanson RV, Wickenden AD.

Sci Rep. 2017 Jan 3;7:39662. doi: 10.1038/srep39662.


The Polyanalgesic Consensus Conference (PACC): Recommendations for Intrathecal Drug Delivery: Guidance for Improving Safety and Mitigating Risks.

Deer TR, Pope JE, Hayek SM, Lamer TJ, Veizi IE, Erdek M, Wallace MS, Grider JS, Levy RM, Prager J, Rosen SM, Saulino M, Yaksh TL, De Andrés JA, Abejon Gonzalez D, Vesper J, Schu S, Simpson B, Mekhail N.

Neuromodulation. 2017 Feb;20(2):155-176. doi: 10.1111/ner.12579. Epub 2017 Jan 2. Review.


The Polyanalgesic Consensus Conference (PACC): Recommendations on Intrathecal Drug Infusion Systems Best Practices and Guidelines.

Deer TR, Pope JE, Hayek SM, Bux A, Buchser E, Eldabe S, De Andrés JA, Erdek M, Patin D, Grider JS, Doleys DM, Jacobs MS, Yaksh TL, Poree L, Wallace MS, Prager J, Rauck R, DeLeon O, Diwan S, Falowski SM, Gazelka HM, Kim P, Leong M, Levy RM, McDowell G II, McRoberts P, Naidu R, Narouze S, Perruchoud C, Rosen SM, Rosenberg WS, Saulino M, Staats P, Stearns LJ, Willis D, Krames E, Huntoon M, Mekhail N.

Neuromodulation. 2017 Feb;20(2):96-132. doi: 10.1111/ner.12538. Epub 2017 Jan 2. Review. Erratum in: Neuromodulation. 2017 Jun;20(4):405-406.


Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain.

Hong S, Remacle AG, Shiryaev SA, Choi W, Hullugundi SK, Dolkas J, Angert M, Nishihara T, Yaksh TL, Strongin AY, Shubayev VI.

Brain Behav Immun. 2017 Feb;60:282-292. doi: 10.1016/j.bbi.2016.11.003. Epub 2016 Nov 7.


Ethical Concerns Regarding Human Study.

Eisenach JC, Yaksh TL.

CNS Neurosci Ther. 2016 Oct;22(10):866. doi: 10.1111/cns.12604. Epub 2016 Aug 31. No abstract available.


Role of myelin auto-antigens in pain: a female connection.

Shubayev VI, Strongin AY, Yaksh TL.

Neural Regen Res. 2016 Jun;11(6):890-1. doi: 10.4103/1673-5374.184452. No abstract available.


Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation.

Eddinger KA, Rondon ES, Shubayev VI, Grafe MR, Scadeng M, Hildebrand KR, Page LM, Malkmus SA, Steinauer JJ, Yaksh TL.

Anesthesiology. 2016 Aug;125(2):378-94. doi: 10.1097/ALN.0000000000001166.


Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt.

Sikandar S, Gustavsson Y, Marino MJ, Dickenson AH, Yaksh TL, Sorkin LS, Ramachandran R.

Eur J Neurosci. 2016 Jul;44(1):1714-22. doi: 10.1111/ejn.13261. Epub 2016 May 19.


Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state.

Woller SA, Ravula SB, Tucci FC, Beaton G, Corr M, Isseroff RR, Soulika AM, Chigbrow M, Eddinger KA, Yaksh TL.

Brain Behav Immun. 2016 Aug;56:271-80. doi: 10.1016/j.bbi.2016.03.026. Epub 2016 Apr 1. Erratum in: Brain Behav Immun. 2017 Dec 29;:.


Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia.

Ko JS, Eddinger KA, Angert M, Chernov AV, Dolkas J, Strongin AY, Yaksh TL, Shubayev VI.

Brain Behav Immun. 2016 Aug;56:378-89. doi: 10.1016/j.bbi.2016.03.003. Epub 2016 Mar 9.


Current and Future Issues in the Development of Spinal Agents for the Management of Pain.

Yaksh TL, Fisher CJ, Hockman TM, Wiese AJ.

Curr Neuropharmacol. 2017;15(2):232-259. Review.


Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models.

Rijsdijk M, Svensson CI, Wijck AJ, Kalkman CJ, Yaksh TL.

Scand J Pain. 2016 Jan;10:90-102. doi: 10.1016/j.sjpain.2015.10.006. Epub 2015 Nov 20.


Current status and future directions of botulinum neurotoxins for targeting pain processing.

Pellett S, Yaksh TL, Ramachandran R.

Toxins (Basel). 2015 Nov 4;7(11):4519-63. doi: 10.3390/toxins7114519. Review.


The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation.

Park HJ, Sandor K, McQueen J, Woller SA, Svensson CI, Corr M, Yaksh TL.

Eur J Pain. 2016 Jul;20(6):917-25. doi: 10.1002/ejp.816. Epub 2015 Oct 30.


The search for novel analgesics: targets and mechanisms.

Yaksh TL, Woller SA, Ramachandran R, Sorkin LS.

F1000Prime Rep. 2015 May 26;7:56. doi: 10.12703/P7-56. eCollection 2015. Review.


The effects of intraplantar and intrathecal botulinum toxin type B on tactile allodynia in mono and polyneuropathy in the mouse.

Park HJ, Marino MJ, Rondon ES, Xu Q, Yaksh TL.

Anesth Analg. 2015 Jul;121(1):229-38. doi: 10.1213/ANE.0000000000000777.


Botulinum toxin in migraine: Role of transport in trigemino-somatic and trigemino-vascular afferents.

Ramachandran R, Lam C, Yaksh TL.

Neurobiol Dis. 2015 Jul;79:111-22. doi: 10.1016/j.nbd.2015.04.011. Epub 2015 May 6.


Differences in cisplatin-induced mechanical allodynia in male and female mice.

Woller SA, Corr M, Yaksh TL.

Eur J Pain. 2015 Nov;19(10):1476-85. doi: 10.1002/ejp.679. Epub 2015 Feb 25.

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