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Targeting toll-like receptor-4 (TLR4)-an emerging therapeutic target for persistent pain states.

Bruno K, Woller SA, Miller YI, Yaksh TL, Wallace M, Beaton G, Chakravarthy K.

Pain. 2018 Jun 7. doi: 10.1097/j.pain.0000000000001306. [Epub ahead of print]


Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States.

Woller SA, Choi SH, An EJ, Low H, Schneider DA, Ramachandran R, Kim J, Bae YS, Sviridov D, Corr M, Yaksh TL, Miller YI.

Cell Rep. 2018 May 29;23(9):2667-2677. doi: 10.1016/j.celrep.2018.04.110.


Complexity of systems and actions underlying neurogenic inflammation.

Yaksh TL, Di Nardo A.

Semin Immunopathol. 2018 May;40(3):225-228. doi: 10.1007/s00281-018-0683-z. No abstract available.


Transition to chronic pain: opportunities for novel therapeutics.

Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH.

Nat Rev Neurosci. 2018 May 15. doi: 10.1038/s41583-018-0012-5. [Epub ahead of print] No abstract available.


A Study and Review of Effects of Botulinum Toxins on Mast Cell Dependent and Independent Pruritus.

Ramachandran R, Marino MJ, Paul S, Wang Z, Mascarenhas NL, Pellett S, Johnson EA, DiNardo A, Yaksh TL.

Toxins (Basel). 2018 Mar 23;10(4). pii: E134. doi: 10.3390/toxins10040134.


An overview of pathways encoding nociception.

Woller SA, Eddinger KA, Corr M, Yaksh TL.

Clin Exp Rheumatol. 2018 Jan-Feb;36(1):172. Epub 2018 Feb 6. No abstract available.


Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation.

Sorkin LS, Eddinger KA, Woller SA, Yaksh TL.

Semin Immunopathol. 2018 May;40(3):237-247. doi: 10.1007/s00281-017-0669-2. Epub 2018 Feb 8. Review.


Target engagement and histopathology of neuraxial resiniferatoxin in dog.

Hockman TM, Cisternas AF, Jones B, Butt MT, Osborn KG, Steinauer JJ, Malkmus SA, Yaksh TL.

Vet Anaesth Analg. 2018 Mar;45(2):212-226. doi: 10.1016/j.vaa.2017.10.005. Epub 2017 Dec 5.


Corrigendum to "Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state" [Brain Behav. Immun. 56 (2016) 271-280].

Woller SA, Ravula SB, Tucci FC, Beaton G, Corr M, Isseroff RR, Soulika AM, Chigbrow M, Eddinger KA, Yaksh TL.

Brain Behav Immun. 2018 Mar;69:632. doi: 10.1016/j.bbi.2017.12.008. Epub 2017 Dec 29. No abstract available.


Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular.

Emami A, Tepper J, Short B, Yaksh TL, Bendele AM, Ramani T, Cisternas AF, Chang JH, Mellon RD.

Int J Toxicol. 2018 Jan/Feb;37(1):4-27. doi: 10.1177/1091581817741840. Epub 2017 Dec 21.


Effects of opioid and nonopioid analgesics on canine wheal formation and cultured human mast cell degranulation.

Schmidt-Rondon E, Wang Z, Malkmus SA, Di Nardo A, Hildebrand K, Page L, Yaksh TL.

Toxicol Appl Pharmacol. 2018 Jan 1;338:54-64. doi: 10.1016/j.taap.2017.10.017. Epub 2017 Oct 27.


Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics.

Knezevic NN, Yekkirala A, Yaksh TL.

Anesth Analg. 2017 Nov;125(5):1714-1732. doi: 10.1213/ANE.0000000000002442. Review.


An overview of pathways encoding nociception.

Woller SA, Eddinger KA, Corr M, Yaksh TL.

Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 107(5):40-46. Epub 2017 Sep 29. Review.


Editor's Highlight: Formulation and Toxicology Evaluation of the Intrathecal AYX1 DNA-Decoy in Sprague Dawley Rats.

Mamet J, Yeomans DC, Yaksh TL, Manning DC, Harris S.

Toxicol Sci. 2017 Sep 1;159(1):76-85. doi: 10.1093/toxsci/kfx118.


Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model.

Rijsdijk M, Agalave NM, van Wijck AJM, Kalkman CJ, Ramachandran R, Baharpoor A, Svensson CI, Yaksh TL.

Scand J Pain. 2017 Jul;16:1-9. doi: 10.1016/j.sjpain.2016.12.008. Epub 2017 Feb 3.


Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.

Yaksh TL, Schwarcz R, Snodgrass HR.

J Pain. 2017 Oct;18(10):1184-1196. doi: 10.1016/j.jpain.2017.03.014. Epub 2017 Apr 18.


Modeling Spinal Intrathecal Drug Distribution: The Challenge of Defining and Predicting Cerebrospinal Fluid Dynamics.

Bert RJ, Hayek SM, Yaksh TL.

Anesth Analg. 2017 May;124(5):1403-1406. doi: 10.1213/ANE.0000000000002071. No abstract available.


Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.

Flinspach M, Xu Q, Piekarz AD, Fellows R, Hagan R, Gibbs A, Liu Y, Neff RA, Freedman J, Eckert WA, Zhou M, Bonesteel R, Pennington MW, Eddinger KA, Yaksh TL, Hunter M, Swanson RV, Wickenden AD.

Sci Rep. 2017 Jan 3;7:39662. doi: 10.1038/srep39662.


The Polyanalgesic Consensus Conference (PACC): Recommendations for Intrathecal Drug Delivery: Guidance for Improving Safety and Mitigating Risks.

Deer TR, Pope JE, Hayek SM, Lamer TJ, Veizi IE, Erdek M, Wallace MS, Grider JS, Levy RM, Prager J, Rosen SM, Saulino M, Yaksh TL, De Andrés JA, Abejon Gonzalez D, Vesper J, Schu S, Simpson B, Mekhail N.

Neuromodulation. 2017 Feb;20(2):155-176. doi: 10.1111/ner.12579. Epub 2017 Jan 2. Review.


The Polyanalgesic Consensus Conference (PACC): Recommendations on Intrathecal Drug Infusion Systems Best Practices and Guidelines.

Deer TR, Pope JE, Hayek SM, Bux A, Buchser E, Eldabe S, De Andrés JA, Erdek M, Patin D, Grider JS, Doleys DM, Jacobs MS, Yaksh TL, Poree L, Wallace MS, Prager J, Rauck R, DeLeon O, Diwan S, Falowski SM, Gazelka HM, Kim P, Leong M, Levy RM, McDowell G II, McRoberts P, Naidu R, Narouze S, Perruchoud C, Rosen SM, Rosenberg WS, Saulino M, Staats P, Stearns LJ, Willis D, Krames E, Huntoon M, Mekhail N.

Neuromodulation. 2017 Feb;20(2):96-132. doi: 10.1111/ner.12538. Epub 2017 Jan 2. Review. Erratum in: Neuromodulation. 2017 Jun;20(4):405-406.


Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain.

Hong S, Remacle AG, Shiryaev SA, Choi W, Hullugundi SK, Dolkas J, Angert M, Nishihara T, Yaksh TL, Strongin AY, Shubayev VI.

Brain Behav Immun. 2017 Feb;60:282-292. doi: 10.1016/j.bbi.2016.11.003. Epub 2016 Nov 7.


Ethical Concerns Regarding Human Study.

Eisenach JC, Yaksh TL.

CNS Neurosci Ther. 2016 Oct;22(10):866. doi: 10.1111/cns.12604. Epub 2016 Aug 31. No abstract available.


Role of myelin auto-antigens in pain: a female connection.

Shubayev VI, Strongin AY, Yaksh TL.

Neural Regen Res. 2016 Jun;11(6):890-1. doi: 10.4103/1673-5374.184452. No abstract available.


Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation.

Eddinger KA, Rondon ES, Shubayev VI, Grafe MR, Scadeng M, Hildebrand KR, Page LM, Malkmus SA, Steinauer JJ, Yaksh TL.

Anesthesiology. 2016 Aug;125(2):378-94. doi: 10.1097/ALN.0000000000001166.


Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt.

Sikandar S, Gustavsson Y, Marino MJ, Dickenson AH, Yaksh TL, Sorkin LS, Ramachandran R.

Eur J Neurosci. 2016 Jul;44(1):1714-22. doi: 10.1111/ejn.13261. Epub 2016 May 19.


Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state.

Woller SA, Ravula SB, Tucci FC, Beaton G, Corr M, Isseroff RR, Soulika AM, Chigbrow M, Eddinger KA, Yaksh TL.

Brain Behav Immun. 2016 Aug;56:271-80. doi: 10.1016/j.bbi.2016.03.026. Epub 2016 Apr 1. Erratum in: Brain Behav Immun. 2017 Dec 29;:.


Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia.

Ko JS, Eddinger KA, Angert M, Chernov AV, Dolkas J, Strongin AY, Yaksh TL, Shubayev VI.

Brain Behav Immun. 2016 Aug;56:378-89. doi: 10.1016/j.bbi.2016.03.003. Epub 2016 Mar 9.


Current and Future Issues in the Development of Spinal Agents for the Management of Pain.

Yaksh TL, Fisher CJ, Hockman TM, Wiese AJ.

Curr Neuropharmacol. 2017;15(2):232-259. Review.


Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models.

Rijsdijk M, Svensson CI, Wijck AJ, Kalkman CJ, Yaksh TL.

Scand J Pain. 2016 Jan;10:90-102. doi: 10.1016/j.sjpain.2015.10.006. Epub 2015 Nov 20.


Current status and future directions of botulinum neurotoxins for targeting pain processing.

Pellett S, Yaksh TL, Ramachandran R.

Toxins (Basel). 2015 Nov 4;7(11):4519-63. doi: 10.3390/toxins7114519. Review.


The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation.

Park HJ, Sandor K, McQueen J, Woller SA, Svensson CI, Corr M, Yaksh TL.

Eur J Pain. 2016 Jul;20(6):917-25. doi: 10.1002/ejp.816. Epub 2015 Oct 30.


The search for novel analgesics: targets and mechanisms.

Yaksh TL, Woller SA, Ramachandran R, Sorkin LS.

F1000Prime Rep. 2015 May 26;7:56. doi: 10.12703/P7-56. eCollection 2015. Review.


The effects of intraplantar and intrathecal botulinum toxin type B on tactile allodynia in mono and polyneuropathy in the mouse.

Park HJ, Marino MJ, Rondon ES, Xu Q, Yaksh TL.

Anesth Analg. 2015 Jul;121(1):229-38. doi: 10.1213/ANE.0000000000000777.


Botulinum toxin in migraine: Role of transport in trigemino-somatic and trigemino-vascular afferents.

Ramachandran R, Lam C, Yaksh TL.

Neurobiol Dis. 2015 Jul;79:111-22. doi: 10.1016/j.nbd.2015.04.011. Epub 2015 May 6.


Differences in cisplatin-induced mechanical allodynia in male and female mice.

Woller SA, Corr M, Yaksh TL.

Eur J Pain. 2015 Nov;19(10):1476-85. doi: 10.1002/ejp.679. Epub 2015 Feb 25.


High cerebrospinal fluid levels of interleukin-10 attained by AAV in dogs.

Pleticha J, Malkmus SA, Heilmann LF, Veesart SL, Rezek R, Xu Q, Yaksh TL, Beutler AS.

Gene Ther. 2015 Feb;22(2):202-8. doi: 10.1038/gt.2014.96. Epub 2014 Oct 30.


Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity.

Bas DB, Abdelmoaty S, Sandor K, Codeluppi S, Fitzsimmons B, Steinauer J, Hua XY, Yaksh TL, Svensson CI.

Eur J Pain. 2015 Feb;19(2):260-70. doi: 10.1002/ejp.544. Epub 2014 Jun 18.


Therapeutic use of botulinum toxin in migraine: mechanisms of action.

Ramachandran R, Yaksh TL.

Br J Pharmacol. 2014 Sep;171(18):4177-92. doi: 10.1111/bph.12763. Review.


The effects of glucocorticoids on neuropathic pain: a review with emphasis on intrathecal methylprednisolone acetate delivery.

Rijsdijk M, van Wijck AJ, Kalkman CJ, Yaksh TL.

Anesth Analg. 2014 May;118(5):1097-112. doi: 10.1213/ANE.0000000000000161. Review.


Spinal cord ischemia/injury.

Ishikawa T, Suzuki H, Ishikawa K, Yasuda S, Matsui T, Yamamoto M, Kakeda T, Yamamoto S, Owada Y, Yaksh TL.

Curr Pharm Des. 2014;20(36):5738-43. Review.


Preclinical toxicity screening of intrathecal oxytocin in rats and dogs.

Yaksh TL, Hobo S, Peters C, Osborn KG, Richter PJ Jr, Rossi SS, Grafe MR, Eisenach JC.

Anesthesiology. 2014 Apr;120(4):951-61. doi: 10.1097/ALN.0000000000000148. Erratum in: Anesthesiology. 2017 Jun;126(6):1209.


Botulinum toxin B in the sensory afferent: transmitter release, spinal activation, and pain behavior.

Marino MJ, Terashima T, Steinauer JJ, Eddinger KA, Yaksh TL, Xu Q.

Pain. 2014 Apr;155(4):674-84. doi: 10.1016/j.pain.2013.12.009. Epub 2013 Dec 11.


Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice.

Stokes JA, Cheung J, Eddinger K, Corr M, Yaksh TL.

J Neuroinflammation. 2013 Dec 9;10:148. doi: 10.1186/1742-2094-10-148.


Toll-like receptor signaling regulates cisplatin-induced mechanical allodynia in mice.

Park HJ, Stokes JA, Corr M, Yaksh TL.

Cancer Chemother Pharmacol. 2014 Jan;73(1):25-34. doi: 10.1007/s00280-013-2304-9. Epub 2013 Oct 27.


Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury.

Mamet J, Klukinov M, Yaksh TL, Malkmus SA, Williams S, Harris S, Manning DC, Taylor BK, Donahue RR, Porreca F, Xie JY, Oyarzo J, Brennan TJ, Subieta A, Schmidt WK, Yeomans DC.

Pain. 2014 Feb;155(2):322-33. doi: 10.1016/j.pain.2013.10.015. Epub 2013 Oct 18.


Intrathecal substance P-saporin in the dog: distribution, safety, and spinal neurokinin-1 receptor ablation.

Wiese AJ, Rathbun M, Butt MT, Malkmus SA, Richter PJ, Osborn KG, Xu Q, Veesart SL, Steinauer JJ, Higgins D, Lappi DA, Russell B, Yaksh TL.

Anesthesiology. 2013 Nov;119(5):1163-77. doi: 10.1097/ALN.0b013e3182a95164.


Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release.

Kouchek M, Takasusuki T, Terashima T, Yaksh TL, Xu Q.

J Pharmacol Exp Ther. 2013 Nov;347(2):258-64. doi: 10.1124/jpet.113.206573. Epub 2013 Aug 26.


Intrathecal P/Q- and R-type calcium channel blockade of spinal substance P release and c-Fos expression.

Terashima T, Xu Q, Yamaguchi S, Yaksh TL.

Neuropharmacology. 2013 Dec;75:1-8. doi: 10.1016/j.neuropharm.2013.06.018. Epub 2013 Jun 26.


Effects of general anesthetics on substance P release and c-Fos expression in the spinal dorsal horn.

Takasusuki T, Yamaguchi S, Hamaguchi S, Yaksh TL.

Anesthesiology. 2013 Aug;119(2):433-42. doi: 10.1097/ALN.0b013e31829996b6.

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