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Items: 1 to 50 of 138

1.

Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer.

Achlaug L, Sarfstein R, Nagaraj K, Lapkina-Gendler L, Bruchim I, Dixit M, Laron Z, Yakar S, Werner H.

Oncotarget. 2019 Jul 8;10(43):4437-4448. doi: 10.18632/oncotarget.27055. eCollection 2019 Jul 8.

2.

Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways.

Werner H, Lapkina-Gendler L, Achlaug L, Nagaraj K, Somri L, Yaron-Saminsky D, Pasmanik-Chor M, Sarfstein R, Laron Z, Yakar S.

Cells. 2019 Jun 15;8(6). pii: E596. doi: 10.3390/cells8060596. Review.

3.

Low IGF-I Bioavailability Impairs Growth and Glucose Metabolism in a Mouse Model of Human PAPPA2 p.Ala1033Val Mutation.

Fujimoto M, Andrew M, Liao L, Zhang D, Yildirim G, Sluss P, Kalra B, Kumar A, Yakar S, Hwa V, Dauber A.

Endocrinology. 2019 Jun 1;160(6):1363-1376. doi: 10.1210/en.2018-00755.

PMID:
30977789
4.

An Analysis of Patients who Underwent Tube Thoracostomy in the Emergency Department: A Single Center Study.

Kantar Y, Durukan P, Hasdıraz L, Baykan N, Yakar Ş, Kaymaz ND.

Turk Thorac J. 2019 Jan 1;20(1):25-29. doi: 10.5152/TurkThoracJ.2018.18056.

5.

Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice.

Liu Z, Solesio ME, Schaffler MB, Frikha-Benayed D, Rosen CJ, Werner H, Kopchick JJ, Pavlov EV, Abramov AY, Yakar S.

J Bone Miner Res. 2019 Jan;34(1):106-122. doi: 10.1002/jbmr.3573. Epub 2018 Sep 14.

6.

Loss of neutrophil polarization in colon carcinoma liver metastases of mice with an inducible, liver-specific IGF-I deficiency.

Rayes RF, Milette S, Fernandez MC, Ham B, Wang N, Bourdeau F, Perrino S, Yakar S, Brodt P.

Oncotarget. 2018 Feb 28;9(21):15691-15704. doi: 10.18632/oncotarget.24593. eCollection 2018 Mar 20.

7.

Insulin-like growth factors: actions on the skeleton.

Yakar S, Werner H, Rosen CJ.

J Mol Endocrinol. 2018 Jul;61(1):T115-T137. doi: 10.1530/JME-17-0298. Epub 2018 Apr 6. Review.

8.

Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action.

Nagaraj K, Lapkina-Gendler L, Sarfstein R, Gurwitz D, Pasmanik-Chor M, Laron Z, Yakar S, Werner H.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1045-1050. doi: 10.1073/pnas.1715930115. Epub 2018 Jan 16.

9.

Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass.

Liu Z, Han T, Werner H, Rosen CJ, Schaffler MB, Yakar S.

J Bone Miner Res. 2018 Jan;33(1):123-136. doi: 10.1002/jbmr.3290. Epub 2017 Nov 6.

10.

A novel heterozygous IGF-1 receptor mutation associated with hypoglycemia.

Solomon-Zemler R, Basel-Vanagaite L, Steier D, Yakar S, Mel E, Phillip M, Bazak L, Bercovich D, Werner H, de Vries L.

Endocr Connect. 2017 Aug;6(6):395-403. doi: 10.1530/EC-17-0038. Epub 2017 Jun 25.

11.

IGF-1 Mediates EphrinB1 Activation in Regulating Tertiary Dentin Formation.

Matsumura S, Quispe-Salcedo A, Schiller CM, Shin JS, Locke BM, Yakar S, Shimizu E.

J Dent Res. 2017 Sep;96(10):1153-1161. doi: 10.1177/0022034517708572. Epub 2017 May 10.

12.

Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis.

Raisingani M, Preneet B, Kohn B, Yakar S.

Growth Horm IGF Res. 2017 Jun;34:13-21. doi: 10.1016/j.ghir.2017.04.003. Epub 2017 Apr 28. Review.

13.

Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth.

Liu Z, Han T, Fishman S, Butler J, Zimmermann T, Tremblay F, Harbison C, Agrawal N, Kopchick JJ, Schaffler MB, Yakar S.

Endocrinology. 2017 Aug 1;158(8):2556-2571. doi: 10.1210/en.2016-1952.

14.

Hepatic lipid metabolism and non-alcoholic fatty liver disease in aging.

Gong Z, Tas E, Yakar S, Muzumdar R.

Mol Cell Endocrinol. 2017 Nov 5;455:115-130. doi: 10.1016/j.mce.2016.12.022. Epub 2016 Dec 23. Review.

PMID:
28017785
15.

Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue.

Kaya S, Basta-Pljakic J, Seref-Ferlengez Z, Majeska RJ, Cardoso L, Bromage TG, Zhang Q, Flach CR, Mendelsohn R, Yakar S, Fritton SP, Schaffler MB.

J Bone Miner Res. 2017 Apr;32(4):688-697. doi: 10.1002/jbmr.3044. Epub 2016 Dec 12.

16.

Treatment With Recombinant Human Insulin-Like Growth Factor-1 Improves Growth in Patients With PAPP-A2 Deficiency.

Muñoz-Calvo MT, Barrios V, Pozo J, Chowen JA, Martos-Moreno GÁ, Hawkins F, Dauber A, Domené HM, Yakar S, Rosenfeld RG, Pérez-Jurado LA, Oxvig C, Frystyk J, Argente J.

J Clin Endocrinol Metab. 2016 Nov;101(11):3879-3883. Epub 2016 Sep 20.

17.

Prostatic Acid Phosphatase Alters the RANKL/OPG System and Induces Osteoblastic Prostate Cancer Bone Metastases.

Kirschenbaum A, Izadmehr S, Yao S, O'Connor-Chapman KL, Huang A, Gregoriades EM, Yakar S, Levine AC.

Endocrinology. 2016 Dec;157(12):4526-4533. Epub 2016 Oct 26.

18.

Growth Hormone Control of Hepatic Lipid Metabolism.

Liu Z, Cordoba-Chacon J, Kineman RD, Cronstein BN, Muzumdar R, Gong Z, Werner H, Yakar S.

Diabetes. 2016 Dec;65(12):3598-3609. Epub 2016 Sep 27.

19.

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability.

Dauber A, Muñoz-Calvo MT, Barrios V, Domené HM, Kloverpris S, Serra-Juhé C, Desikan V, Pozo J, Muzumdar R, Martos-Moreno GÁ, Hawkins F, Jasper HG, Conover CA, Frystyk J, Yakar S, Hwa V, Chowen JA, Oxvig C, Rosenfeld RG, Pérez-Jurado LA, Argente J.

EMBO Mol Med. 2016 Apr 1;8(4):363-74. doi: 10.15252/emmm.201506106.

20.

Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs.

Cabahug-Zuckerman P, Frikha-Benayed D, Majeska RJ, Tuthill A, Yakar S, Judex S, Schaffler MB.

J Bone Miner Res. 2016 Jul;31(7):1356-65. doi: 10.1002/jbmr.2807. Epub 2016 Mar 22.

21.

Does the GH/IGF-1 axis contribute to skeletal sexual dimorphism? Evidence from mouse studies.

Liu Z, Mohan S, Yakar S.

Growth Horm IGF Res. 2016 Apr;27:7-17. doi: 10.1016/j.ghir.2015.12.004. Epub 2015 Dec 31. Review.

22.

DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH.

Liu Z, Kennedy OD, Cardoso L, Basta-Pljakic J, Partridge NC, Schaffler MB, Rosen CJ, Yakar S.

FASEB J. 2016 Feb;30(2):635-52. doi: 10.1096/fj.15-275859. Epub 2015 Oct 19.

23.

Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models.

Yakar S, Isaksson O.

Growth Horm IGF Res. 2016 Jun;28:26-42. doi: 10.1016/j.ghir.2015.09.004. Epub 2015 Sep 28. Review.

24.

Central effects of humanin on hepatic triglyceride secretion.

Gong Z, Su K, Cui L, Tas E, Zhang T, Dong HH, Yakar S, Muzumdar RH.

Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E283-92. doi: 10.1152/ajpendo.00043.2015. Epub 2015 Jun 9.

25.

Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene.

Kennedy OD, Sun H, Wu Y, Courtland HW, Williams GA, Cardoso L, Basta-Pljakic J, Schaffler MB, Yakar S.

Endocrinology. 2014 Mar;155(3):987-99. doi: 10.1210/en.2013-1819. Epub 2014 Jan 1.

26.

Acute coronary syndrome presenting with earache and sore throat.

Ocak U, Avşaroğulları L, Kaya MG, Özmen Y, Taşlıdere B, Güldeste EA, Yakar Ş.

Am J Emerg Med. 2014 May;32(5):487.e5-6. doi: 10.1016/j.ajem.2013.10.059. Epub 2013 Nov 8.

PMID:
24342866
27.

Reductions in serum IGF-1 during aging impair health span.

Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW Jr, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S.

Aging Cell. 2014 Jun;13(3):408-18. doi: 10.1111/acel.12188. Epub 2013 Dec 30.

28.

The effect of dipeptidyl peptidase-IV inhibition on bone in a mouse model of type 2 diabetes.

Gallagher EJ, Sun H, Kornhauser C, Tobin-Hess A, Epstein S, Yakar S, LeRoith D.

Diabetes Metab Res Rev. 2014 Mar;30(3):191-200. doi: 10.1002/dmrr.2466.

29.

Deletion of growth hormone receptors in postnatal skeletal muscle of male mice does not alter muscle mass and response to pathological injury.

Vijayakumar A, Buffin NJ, Gallagher EJ, Blank J, Wu Y, Yakar S, LeRoith D.

Endocrinology. 2013 Oct;154(10):3776-83. doi: 10.1210/en.2013-1209. Epub 2013 Jul 16.

30.

Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer.

Ferguson RD, Gallagher EJ, Cohen D, Tobin-Hess A, Alikhani N, Novosyadlyy R, Haddad N, Yakar S, LeRoith D.

Endocr Relat Cancer. 2013 May 21;20(3):391-401. doi: 10.1530/ERC-12-0333. Print 2013 Jun.

31.

Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor.

Wu Y, Sun H, Basta-Pljakic J, Cardoso L, Kennedy OD, Jasper H, Domené H, Karabatas L, Guida C, Schaffler MB, Rosen CJ, Yakar S.

J Bone Miner Res. 2013 Jul;28(7):1575-86. doi: 10.1002/jbmr.1920.

32.

Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis.

Bechmann LP, Vetter D, Ishida J, Hannivoort RA, Lang UE, Kocabayoglu P, Fiel MI, Muñoz U, Patman GL, Ge F, Yakar S, Li X, Agius L, Lee YM, Zhang W, Hui KY, Televantou D, Schwartz GJ, LeRoith D, Berk PD, Nagai R, Suzuki T, Reeves HL, Friedman SL.

J Hepatol. 2013 May;58(5):1000-6. doi: 10.1016/j.jhep.2013.01.020. Epub 2013 Jan 23.

33.

Skeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidation.

Vijayakumar A, Wu Y, Buffin NJ, Li X, Sun H, Gordon RE, Yakar S, LeRoith D.

PLoS One. 2012;7(9):e44777. Epub 2012 Sep 14.

34.

Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging.

Courtland HW, Kennedy OD, Wu Y, Gao Y, Sun H, Schaffler MB, Yakar S.

Age (Dordr). 2013 Oct;35(5):1691-703. doi: 10.1007/s11357-012-9469-8. Epub 2012 Sep 14.

35.

Insulin-like growth factor 1 physiology: lessons from mouse models.

Yakar S, Adamo ML.

Endocrinol Metab Clin North Am. 2012 Jun;41(2):231-47, v. doi: 10.1016/j.ecl.2012.04.008. Epub 2012 May 15. Review.

36.

Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model.

Alikhani N, Ferguson RD, Novosyadlyy R, Gallagher EJ, Scheinman EJ, Yakar S, LeRoith D.

Oncogene. 2013 Feb 21;32(8):961-7. doi: 10.1038/onc.2012.113. Epub 2012 Apr 2.

37.

Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes.

Ferguson RD, Novosyadlyy R, Fierz Y, Alikhani N, Sun H, Yakar S, Leroith D.

Breast Cancer Res. 2012 Jan 7;14(1):R8.

38.

Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration.

Vijayakumar A, Wu Y, Sun H, Li X, Jeddy Z, Liu C, Schwartz GJ, Yakar S, LeRoith D.

Diabetes. 2012 Jan;61(1):94-103. doi: 10.2337/db11-0814.

39.

Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy.

Troncoso R, Vicencio JM, Parra V, Nemchenko A, Kawashima Y, Del Campo A, Toro B, Battiprolu PK, Aranguiz P, Chiong M, Yakar S, Gillette TG, Hill JA, Abel ED, Leroith D, Lavandero S.

Cardiovasc Res. 2012 Feb 1;93(2):320-9. doi: 10.1093/cvr/cvr321. Epub 2011 Dec 1.

40.

Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia.

Gallagher EJ, Fierz Y, Vijayakumar A, Haddad N, Yakar S, LeRoith D.

Oncogene. 2012 Jul 5;31(27):3213-22. doi: 10.1038/onc.2011.495. Epub 2011 Oct 31.

41.

A marked deficiency in circulating and renal IGF-I peptide does not inhibit compensatory renal enlargement in uninephrectomized mice.

Landau D, Biada J, Chen Y, Sood S, Yakar S, Leroith D, Segev Y, Rabkin R.

Growth Horm IGF Res. 2011 Oct;21(5):279-84. doi: 10.1016/j.ghir.2011.07.008. Epub 2011 Aug 23.

42.

Unbound (bioavailable) IGF1 enhances somatic growth.

Elis S, Wu Y, Courtland HW, Cannata D, Sun H, Beth-On M, Liu C, Jasper H, Domené H, Karabatas L, Guida C, Basta-Pljakic J, Cardoso L, Rosen CJ, Frystyk J, Yakar S.

Dis Model Mech. 2011 Sep;4(5):649-58. doi: 10.1242/dmm.006775. Epub 2011 May 31.

43.

Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice.

Wu Y, Liu C, Sun H, Vijayakumar A, Giglou PR, Qiao R, Oppenheimer J, Yakar S, LeRoith D.

J Clin Invest. 2011 Jun;121(6):2422-6. doi: 10.1172/JCI45027. Epub 2011 May 9.

44.

Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner.

Courtland HW, Elis S, Wu Y, Sun H, Rosen CJ, Jepsen KJ, Yakar S.

PLoS One. 2011 Mar 18;6(3):e14762. doi: 10.1371/journal.pone.0014762.

45.

Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression.

Elis S, Wu Y, Courtland HW, Sun H, Rosen CJ, Adamo ML, Yakar S.

Aging Cell. 2011 Jun;10(3):547-50. doi: 10.1111/j.1474-9726.2011.00683.x. Epub 2011 Mar 22.

46.

The intricate role of growth hormone in metabolism.

Vijayakumar A, Yakar S, Leroith D.

Front Endocrinol (Lausanne). 2011 Sep 27;2:32. doi: 10.3389/fendo.2011.00032. eCollection 2011.

47.

Growth hormone mediates pubertal skeletal development independent of hepatic IGF-1 production.

Courtland HW, Sun H, Beth-On M, Wu Y, Elis S, Rosen CJ, Yakar S.

J Bone Miner Res. 2011 Apr;26(4):761-8. doi: 10.1002/jbmr.265.

48.

Elevated circulating IGF-I promotes mammary gland development and proliferation.

Cannata D, Lann D, Wu Y, Elis S, Sun H, Yakar S, Lazzarino DA, Wood TL, Leroith D.

Endocrinology. 2010 Dec;151(12):5751-61. doi: 10.1210/en.2010-0792. Epub 2010 Oct 6.

49.

IGF-1 and bone: New discoveries from mouse models.

Yakar S, Courtland HW, Clemmons D.

J Bone Miner Res. 2010 Dec;25(12):2543-52. doi: 10.1002/jbmr.234. Review. Erratum in: J Bone Miner Res. 2011 Feb;26(2):439.

50.

Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes.

Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, LeRoith D.

Endocr Relat Cancer. 2010 Oct 5;17(4):941-51. doi: 10.1677/ERC-10-0091. Print 2010 Dec.

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