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Items: 1 to 50 of 241

1.

Clot activators do not expedite the time to predict massive transfusion in trauma patients analyzed with tissue plasminogen activator thrombelastography.

Walker CB, Moore EE, Kam A, Dexter-Meldrum J, Nydam TL, Chapman MP, Chandler J, Sauaia A, Barrett CD, Yaffe MB, Moore HB.

Surgery. 2019 Jun 20. pii: S0039-6060(19)30251-X. doi: 10.1016/j.surg.2019.05.011. [Epub ahead of print]

PMID:
31230841
2.

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.

Bandopadhayay P, Piccioni F, O'Rourke R, Ho P, Gonzalez EM, Buchan G, Qian K, Gionet G, Girard E, Coxon M, Rees MG, Brenan L, Dubois F, Shapira O, Greenwald NF, Pages M, Balboni Iniguez A, Paolella BR, Meng A, Sinai C, Roti G, Dharia NV, Creech A, Tanenbaum B, Khadka P, Tracy A, Tiv HL, Hong AL, Coy S, Rashid R, Lin JR, Cowley GS, Lam FC, Goodale A, Lee Y, Schoolcraft K, Vazquez F, Hahn WC, Tsherniak A, Bradner JE, Yaffe MB, Milde T, Pfister SM, Qi J, Schenone M, Carr SA, Ligon KL, Kieran MW, Santagata S, Olson JM, Gokhale PC, Jaffe JD, Root DE, Stegmaier K, Johannessen CM, Beroukhim R.

Nat Commun. 2019 Jun 3;10(1):2400. doi: 10.1038/s41467-019-10307-9.

3.

Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs.

van de Kooij B, Creixell P, van Vlimmeren A, Joughin BA, Miller CJ, Haider N, Simpson CD, Linding R, Stambolic V, Turk BE, Yaffe MB.

Elife. 2019 May 24;8. pii: e44635. doi: 10.7554/eLife.44635.

4.

Atlas Drugged.

Chen JK, Yaffe MB.

Cell. 2019 May 2;177(4):803-805. doi: 10.1016/j.cell.2019.04.023.

PMID:
31051104
5.

Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.

Miller CJ, Lou HJ, Simpson C, van de Kooij B, Ha BH, Fisher OS, Pirman NL, Boggon TJ, Rinehart J, Yaffe MB, Linding R, Turk BE.

PLoS Biol. 2019 Mar 21;17(3):e2006540. doi: 10.1371/journal.pbio.2006540. eCollection 2019 Mar.

6.

Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer.

Kasikara C, Davra V, Calianese D, Geng K, Spires TE, Quigley M, Wichroski M, Sriram G, Suarez-Lopez L, Yaffe MB, Kotenko SV, De Lorenzo MS, Birge RB.

Cancer Res. 2019 May 15;79(10):2669-2683. doi: 10.1158/0008-5472.CAN-18-2614. Epub 2019 Mar 15.

PMID:
30877108
7.

ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest.

Patterson JC, Joughin BA, van de Kooij B, Lim DC, Lauffenburger DA, Yaffe MB.

Cell Syst. 2019 Feb 27;8(2):163-167.e2. doi: 10.1016/j.cels.2019.01.005. Epub 2019 Feb 20.

PMID:
30797774
8.

Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes.

Rohani N, Hao L, Alexis MS, Joughin BA, Krismer K, Moufarrej MN, Soltis AR, Lauffenburger DA, Yaffe MB, Burge CB, Bhatia SN, Gertler FB.

Cancer Res. 2019 Apr 15;79(8):1952-1966. doi: 10.1158/0008-5472.CAN-18-1604. Epub 2019 Feb 12.

PMID:
30755444
9.

TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression.

Hwang JH, Kim AR, Kim KM, Il Park J, Oh HT, Moon SA, Byun MR, Jeong H, Kim HK, Yaffe MB, Hwang ES, Hong JH.

Nat Commun. 2019 Jan 24;10(1):421. doi: 10.1038/s41467-019-08287-x.

10.

Why geneticists stole cancer research even though cancer is primarily a signaling disease.

Yaffe MB.

Sci Signal. 2019 Jan 22;12(565). pii: eaaw3483. doi: 10.1126/scisignal.aaw3483. Review.

PMID:
30670634
11.

Tranexamic acid mediates proinflammatory and anti-inflammatory signaling via complement C5a regulation in a plasminogen activator-dependent manner.

Barrett CD, Moore HB, Kong YW, Chapman MP, Sriram G, Lim D, Moore EE, Yaffe MB.

J Trauma Acute Care Surg. 2019 Jan;86(1):101-107. doi: 10.1097/TA.0000000000002092.

PMID:
30575685
12.

Correction: Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system.

Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Parada-Kusz M, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ.

Mucosal Immunol. 2019 Mar;12(2):580. doi: 10.1038/s41385-018-0074-8.

PMID:
30514887
13.

Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy.

Barrett CD, Hsu AT, Ellson CD, Y Miyazawa B, Kong YW, Greenwood JD, Dhara S, Neal MD, Sperry JL, Park MS, Cohen MJ, Zuckerbraun BS, Yaffe MB.

Clin Exp Immunol. 2018 Oct;194(1):103-117. doi: 10.1111/cei.13166. Epub 2018 Sep 9.

PMID:
30260475
14.

Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.

Creixell P, Pandey JP, Palmeri A, Bhattacharyya M, Creixell M, Ranganathan R, Pincus D, Yaffe MB.

Cell Syst. 2018 Oct 24;7(4):371-383.e4. doi: 10.1016/j.cels.2018.08.008. Epub 2018 Sep 19.

15.

Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.

Hymel D, Grant RA, Tsuji K, Yaffe MB, Burke TR Jr.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3202-3205. doi: 10.1016/j.bmcl.2018.08.018. Epub 2018 Aug 19.

PMID:
30174151
16.

Modeling chemotherapy-induced stress to identify rational combination therapies in the DNA damage response pathway.

Alkan O, Schoeberl B, Shah M, Koshkaryev A, Heinemann T, Drummond DC, Yaffe MB, Raue A.

Sci Signal. 2018 Jul 24;11(540). pii: eaat0229. doi: 10.1126/scisignal.aat0229.

PMID:
30042127
17.

A subset of five human mitochondrial formyl peptides mimics bacterial peptides and functionally deactivates human neutrophils.

Kaczmarek E, Hauser CJ, Kwon WY, Riça I, Chen L, Sandler N, Otterbein LE, Campbell Y, Cook CH, Yaffe MB, Marusich MF, Itagaki K.

J Trauma Acute Care Surg. 2018 Nov;85(5):936-943. doi: 10.1097/TA.0000000000001971.

PMID:
29787548
18.

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.

Lam FC, Morton SW, Wyckoff J, Vu Han TL, Hwang MK, Maffa A, Balkanska-Sinclair E, Yaffe MB, Floyd SR, Hammond PT.

Nat Commun. 2018 May 18;9(1):1991. doi: 10.1038/s41467-018-04315-4.

19.

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.

Suarez-Lopez L, Sriram G, Kong YW, Morandell S, Merrick KA, Hernandez Y, Haigis KM, Yaffe MB.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4236-E4244. doi: 10.1073/pnas.1722020115. Epub 2018 Apr 16.

20.

RNA-Peptide nanoplexes drug DNA damage pathways in high-grade serous ovarian tumors.

Dreaden EC, Kong YW, Quadir MA, Correa S, Suárez-López L, Barberio AE, Hwang MK, Shi AC, Oberlton B, Gallagher PN, Shopsowitz KE, Elias KM, Yaffe MB, Hammond PT.

Bioeng Transl Med. 2018 Jan 19;3(1):26-36. doi: 10.1002/btm2.10086. eCollection 2018 Jan.

21.

Predicting the future of signaling for 2018.

Yaffe MB.

Sci Signal. 2018 Jan 2;11(511). pii: eaar7429. doi: 10.1126/scisignal.aar7429.

PMID:
29295956
22.

TAZ/WWTR1 Mediates the Pulmonary Effects of NKX2-1 Mutations in Brain-Lung-Thyroid Syndrome.

Moya CM, Zaballos MA, Garzón L, Luna C, Simón R, Yaffe MB, Gallego E, Santisteban P, Moreno JC.

J Clin Endocrinol Metab. 2018 Mar 1;103(3):839-852. doi: 10.1210/jc.2017-01241.

PMID:
29294041
23.

Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system.

Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Parada-kusz M, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ.

Mucosal Immunol. 2018 May;11(3):703-715. doi: 10.1038/mi.2017.91. Epub 2017 Nov 15. Erratum in: Mucosal Immunol. 2019 Mar;12(2):580. Parada-kusz, M [added].

24.

Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.

Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA.

Cancer Cell. 2017 Oct 9;32(4):411-426.e11. doi: 10.1016/j.ccell.2017.08.018. Epub 2017 Sep 28.

25.

Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin.

Barrett CD, Moore HB, Banerjee A, Silliman CC, Moore EE, Yaffe MB.

J Trauma Acute Care Surg. 2017 Dec;83(6):1053-1061. doi: 10.1097/TA.0000000000001685.

26.

Highlight: Understanding radiation sialadenitis.

Yaffe MB.

Sci Signal. 2017 Jun 6;10(482). pii: eaan8666. doi: 10.1126/scisignal.aan8666.

PMID:
28588084
27.

Science Signaling Podcast for 14 March 2017: The Cancer Moonshot.

Yaffe MB, VanHook AM.

Sci Signal. 2017 Mar 14;10(470). pii: eaan1418. doi: 10.1126/scisignal.aan1418.

PMID:
28292953
28.

Maximizing Synergistic Activity When Combining RNAi and Platinum-Based Anticancer Agents.

Xiao H, Qi R, Li T, Awuah SG, Zheng Y, Wei W, Kang X, Song H, Wang Y, Yu Y, Bird MA, Jing X, Yaffe MB, Birrer MJ, Ghoroghchian PP.

J Am Chem Soc. 2017 Mar 1;139(8):3033-3044. doi: 10.1021/jacs.6b12108. Epub 2017 Feb 16.

PMID:
28166401
29.

Protein Regulation in Signal Transduction.

Lee MJ, Yaffe MB.

Cold Spring Harb Perspect Biol. 2016 Jun 1;8(6). pii: a005918. doi: 10.1101/cshperspect.a005918. Review.

30.

Kicking Genomic Profiling to the Curb: How Re-wiring the Phosphoproteome Can Explain Treatment Resistance in Glioma.

Lam FC, Yaffe MB.

Cancer Cell. 2016 Apr 11;29(4):435-436. doi: 10.1016/j.ccell.2016.03.022.

31.

Leveraging signaling research to understand and treat disease.

Yaffe MB, Gough NR.

Sci Signal. 2016 Mar 29;9(421):eg4. doi: 10.1126/scisignal.aaf6275.

PMID:
27025875
32.

A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.

Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB.

Cancer Cell. 2015 Dec 14;28(6):831. doi: 10.1016/j.ccell.2015.11.003. Epub 2015 Dec 14. No abstract available.

33.

A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.

Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB.

Cancer Cell. 2015 Nov 9;28(5):623-637. doi: 10.1016/j.ccell.2015.09.009. Erratum in: Cancer Cell. 2015 Dec 14;28(6):831.

34.

Neighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.

Qian WJ, Park JE, Grant R, Lai CC, Kelley JA, Yaffe MB, Lee KS, Burke TR Jr.

Biopolymers. 2015 Nov;104(6):663-73. doi: 10.1002/bip.22698.

35.

Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle.

Dreaden EC, Kong YW, Morton SW, Correa S, Choi KY, Shopsowitz KE, Renggli K, Drapkin R, Yaffe MB, Hammond PT.

Clin Cancer Res. 2015 Oct 1;21(19):4410-9. doi: 10.1158/1078-0432.CCR-15-0013. Epub 2015 Jun 1.

36.

Kinetics and Role of Plasma Matrix Metalloproteinase-9 Expression in Acute Lung Injury and the Acute Respiratory Distress Syndrome.

Hsu AT, Barrett CD, DeBusk GM, Ellson CD, Gautam S, Talmor DS, Gallagher DC, Yaffe MB.

Shock. 2015 Aug;44(2):128-36. doi: 10.1097/SHK.0000000000000386.

37.

A Multivariate Computational Method to Analyze High-Content RNAi Screening Data.

Rameseder J, Krismer K, Dayma Y, Ehrenberger T, Hwang MK, Airoldi EM, Floyd SR, Yaffe MB.

J Biomol Screen. 2015 Sep;20(8):985-97. doi: 10.1177/1087057115583037. Epub 2015 Apr 27.

38.

Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.

Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, Stephan MT, Kim JS, Yaffe MB, Irvine DJ, Weiner LM, Dranoff G, Wittrup KD.

Cancer Cell. 2015 Apr 13;27(4):489-501. doi: 10.1016/j.ccell.2015.03.004.

39.

Computational prediction of protein-protein interactions.

Ehrenberger T, Cantley LC, Yaffe MB.

Methods Mol Biol. 2015;1278:57-75. doi: 10.1007/978-1-4939-2425-7_4.

40.

Criteria for biological reproducibility: what does "n" mean?

Naegle K, Gough NR, Yaffe MB.

Sci Signal. 2015 Apr 7;8(371):fs7. doi: 10.1126/scisignal.aab1125. Review.

PMID:
25852186
41.

Reproducibility in science.

Yaffe MB.

Sci Signal. 2015 Apr 7;8(371):eg5. doi: 10.1126/scisignal.aaa5764.

PMID:
25852185
42.

Engineered bromodomains to explore the acetylproteome.

Bryson BD, Del Rosario AM, Gootenberg JS, Yaffe MB, White FM.

Proteomics. 2015 May;15(9):1470-5. doi: 10.1002/pmic.201400401. Epub 2015 Mar 5.

43.

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.

Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt SM, Vander Heiden MG.

Mol Cell. 2015 Jan 8;57(1):95-107. doi: 10.1016/j.molcel.2014.10.027. Epub 2014 Dec 4.

44.

The initial response to the Boston marathon bombing: lessons learned to prepare for the next disaster.

Gates JD, Arabian S, Biddinger P, Blansfield J, Burke P, Chung S, Fischer J, Friedman F, Gervasini A, Goralnick E, Gupta A, Larentzakis A, McMahon M, Mella J, Michaud Y, Mooney D, Rabinovici R, Sweet D, Ulrich A, Velmahos G, Weber C, Yaffe MB.

Ann Surg. 2014 Dec;260(6):960-6. doi: 10.1097/SLA.0000000000000914.

45.

Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells.

Qian WJ, Park JE, Lim D, Lai CC, Kelley JA, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR Jr.

Biopolymers. 2014 Nov;102(6):444-55. doi: 10.1002/bip.22569.

46.

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM.

Cell. 2014 Aug 28;158(5):1094-1109. doi: 10.1016/j.cell.2014.07.032.

47.

Selective mitogen activated protein kinase activity sensors through the application of directionally programmable D domain motifs.

Peterson LB, Yaffe MB, Imperiali B.

Biochemistry. 2014 Sep 16;53(36):5771-8. doi: 10.1021/bi500862c. Epub 2014 Sep 3.

48.

Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.

Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, Lim E, Liu W, Bronson RT, Bowden M, Brock J, Krop IE, Dillon DA, Gygi SP, Mills GB, Richardson AL, Signoretti S, Yaffe MB, Kaelin WG Jr.

Cancer Cell. 2014 Aug 11;26(2):222-34. doi: 10.1016/j.ccr.2014.06.026.

49.

A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways.

Morton SW, Lee MJ, Deng ZJ, Dreaden EC, Siouve E, Shopsowitz KE, Shah NJ, Yaffe MB, Hammond PT.

Sci Signal. 2014 May 13;7(325):ra44. doi: 10.1126/scisignal.2005261.

50.

Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation.

Byun MR, Hwang JH, Kim AR, Kim KM, Hwang ES, Yaffe MB, Hong JH.

Cell Death Differ. 2014 Jun;21(6):854-63. doi: 10.1038/cdd.2014.8. Epub 2014 Feb 7.

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