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Correction: Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system.

Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Parada-Kusz M, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ.

Mucosal Immunol. 2018 Nov 30. doi: 10.1038/s41385-018-0074-8. [Epub ahead of print]


Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy.

Barrett CD, Hsu AT, Ellson CD, Y Miyazawa B, Kong YW, Greenwood JD, Dhara S, Neal MD, Sperry JL, Park MS, Cohen MJ, Zuckerbraun BS, Yaffe MB.

Clin Exp Immunol. 2018 Oct;194(1):103-117. doi: 10.1111/cei.13166. Epub 2018 Sep 9.


Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.

Creixell P, Pandey JP, Palmeri A, Bhattacharyya M, Creixell M, Ranganathan R, Pincus D, Yaffe MB.

Cell Syst. 2018 Oct 24;7(4):371-383.e4. doi: 10.1016/j.cels.2018.08.008. Epub 2018 Sep 19.


Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.

Hymel D, Grant RA, Tsuji K, Yaffe MB, Burke TR Jr.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3202-3205. doi: 10.1016/j.bmcl.2018.08.018. Epub 2018 Aug 19.


Modeling chemotherapy-induced stress to identify rational combination therapies in the DNA damage response pathway.

Alkan O, Schoeberl B, Shah M, Koshkaryev A, Heinemann T, Drummond DC, Yaffe MB, Raue A.

Sci Signal. 2018 Jul 24;11(540). pii: eaat0229. doi: 10.1126/scisignal.aat0229.


A subset of five human mitochondrial formyl peptides mimics bacterial peptides and functionally deactivates human neutrophils.

Kaczmarek E, Hauser CJ, Kwon WY, Riça I, Chen L, Sandler N, Otterbein LE, Campbell Y, Cook CH, Yaffe MB, Marusich MF, Itagaki K.

J Trauma Acute Care Surg. 2018 Nov;85(5):936-943. doi: 10.1097/TA.0000000000001971.


Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.

Lam FC, Morton SW, Wyckoff J, Vu Han TL, Hwang MK, Maffa A, Balkanska-Sinclair E, Yaffe MB, Floyd SR, Hammond PT.

Nat Commun. 2018 May 18;9(1):1991. doi: 10.1038/s41467-018-04315-4.


MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.

Suarez-Lopez L, Sriram G, Kong YW, Morandell S, Merrick KA, Hernandez Y, Haigis KM, Yaffe MB.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4236-E4244. doi: 10.1073/pnas.1722020115. Epub 2018 Apr 16.


RNA-Peptide nanoplexes drug DNA damage pathways in high-grade serous ovarian tumors.

Dreaden EC, Kong YW, Quadir MA, Correa S, Suárez-López L, Barberio AE, Hwang MK, Shi AC, Oberlton B, Gallagher PN, Shopsowitz KE, Elias KM, Yaffe MB, Hammond PT.

Bioeng Transl Med. 2018 Jan 19;3(1):26-36. doi: 10.1002/btm2.10086. eCollection 2018 Jan.


Predicting the future of signaling for 2018.

Yaffe MB.

Sci Signal. 2018 Jan 2;11(511). pii: eaar7429. doi: 10.1126/scisignal.aar7429.


TAZ/WWTR1 Mediates the Pulmonary Effects of NKX2-1 Mutations in Brain-Lung-Thyroid Syndrome.

Moya CM, Zaballos MA, Garzón L, Luna C, Simón R, Yaffe MB, Gallego E, Santisteban P, Moreno JC.

J Clin Endocrinol Metab. 2018 Mar 1;103(3):839-852. doi: 10.1210/jc.2017-01241.


Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system.

Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ.

Mucosal Immunol. 2018 May;11(3):703-715. doi: 10.1038/mi.2017.91. Epub 2017 Nov 15. Erratum in: Mucosal Immunol. 2018 Nov 30;:.


Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.

Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA.

Cancer Cell. 2017 Oct 9;32(4):411-426.e11. doi: 10.1016/j.ccell.2017.08.018. Epub 2017 Sep 28.


Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin.

Barrett CD, Moore HB, Banerjee A, Silliman CC, Moore EE, Yaffe MB.

J Trauma Acute Care Surg. 2017 Dec;83(6):1053-1061. doi: 10.1097/TA.0000000000001685.


Highlight: Understanding radiation sialadenitis.

Yaffe MB.

Sci Signal. 2017 Jun 6;10(482). pii: eaan8666. doi: 10.1126/scisignal.aan8666.


Science Signaling Podcast for 14 March 2017: The Cancer Moonshot.

Yaffe MB, VanHook AM.

Sci Signal. 2017 Mar 14;10(470). pii: eaan1418. doi: 10.1126/scisignal.aan1418.


Maximizing Synergistic Activity When Combining RNAi and Platinum-Based Anticancer Agents.

Xiao H, Qi R, Li T, Awuah SG, Zheng Y, Wei W, Kang X, Song H, Wang Y, Yu Y, Bird MA, Jing X, Yaffe MB, Birrer MJ, Ghoroghchian PP.

J Am Chem Soc. 2017 Mar 1;139(8):3033-3044. doi: 10.1021/jacs.6b12108. Epub 2017 Feb 16.


Protein Regulation in Signal Transduction.

Lee MJ, Yaffe MB.

Cold Spring Harb Perspect Biol. 2016 Jun 1;8(6). pii: a005918. doi: 10.1101/cshperspect.a005918. Review.


Kicking Genomic Profiling to the Curb: How Re-wiring the Phosphoproteome Can Explain Treatment Resistance in Glioma.

Lam FC, Yaffe MB.

Cancer Cell. 2016 Apr 11;29(4):435-436. doi: 10.1016/j.ccell.2016.03.022.


Leveraging signaling research to understand and treat disease.

Yaffe MB, Gough NR.

Sci Signal. 2016 Mar 29;9(421):eg4. doi: 10.1126/scisignal.aaf6275.


A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.

Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB.

Cancer Cell. 2015 Dec 14;28(6):831. doi: 10.1016/j.ccell.2015.11.003. Epub 2015 Dec 14. No abstract available.


A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.

Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB.

Cancer Cell. 2015 Nov 9;28(5):623-637. doi: 10.1016/j.ccell.2015.09.009. Erratum in: Cancer Cell. 2015 Dec 14;28(6):831.


Neighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.

Qian WJ, Park JE, Grant R, Lai CC, Kelley JA, Yaffe MB, Lee KS, Burke TR Jr.

Biopolymers. 2015 Nov;104(6):663-73. doi: 10.1002/bip.22698.


Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle.

Dreaden EC, Kong YW, Morton SW, Correa S, Choi KY, Shopsowitz KE, Renggli K, Drapkin R, Yaffe MB, Hammond PT.

Clin Cancer Res. 2015 Oct 1;21(19):4410-9. doi: 10.1158/1078-0432.CCR-15-0013. Epub 2015 Jun 1.


Kinetics and Role of Plasma Matrix Metalloproteinase-9 Expression in Acute Lung Injury and the Acute Respiratory Distress Syndrome.

Hsu AT, Barrett CD, DeBusk GM, Ellson CD, Gautam S, Talmor DS, Gallagher DC, Yaffe MB.

Shock. 2015 Aug;44(2):128-36. doi: 10.1097/SHK.0000000000000386.


A Multivariate Computational Method to Analyze High-Content RNAi Screening Data.

Rameseder J, Krismer K, Dayma Y, Ehrenberger T, Hwang MK, Airoldi EM, Floyd SR, Yaffe MB.

J Biomol Screen. 2015 Sep;20(8):985-97. doi: 10.1177/1087057115583037. Epub 2015 Apr 27.


Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.

Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, Stephan MT, Kim JS, Yaffe MB, Irvine DJ, Weiner LM, Dranoff G, Wittrup KD.

Cancer Cell. 2015 Apr 13;27(4):489-501. doi: 10.1016/j.ccell.2015.03.004.


Computational prediction of protein-protein interactions.

Ehrenberger T, Cantley LC, Yaffe MB.

Methods Mol Biol. 2015;1278:57-75. doi: 10.1007/978-1-4939-2425-7_4.


Criteria for biological reproducibility: what does "n" mean?

Naegle K, Gough NR, Yaffe MB.

Sci Signal. 2015 Apr 7;8(371):fs7. doi: 10.1126/scisignal.aab1125. Review.


Reproducibility in science.

Yaffe MB.

Sci Signal. 2015 Apr 7;8(371):eg5. doi: 10.1126/scisignal.aaa5764.


Engineered bromodomains to explore the acetylproteome.

Bryson BD, Del Rosario AM, Gootenberg JS, Yaffe MB, White FM.

Proteomics. 2015 May;15(9):1470-5. doi: 10.1002/pmic.201400401. Epub 2015 Mar 5.


Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.

Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt SM, Vander Heiden MG.

Mol Cell. 2015 Jan 8;57(1):95-107. doi: 10.1016/j.molcel.2014.10.027. Epub 2014 Dec 4.


The initial response to the Boston marathon bombing: lessons learned to prepare for the next disaster.

Gates JD, Arabian S, Biddinger P, Blansfield J, Burke P, Chung S, Fischer J, Friedman F, Gervasini A, Goralnick E, Gupta A, Larentzakis A, McMahon M, Mella J, Michaud Y, Mooney D, Rabinovici R, Sweet D, Ulrich A, Velmahos G, Weber C, Yaffe MB.

Ann Surg. 2014 Dec;260(6):960-6. doi: 10.1097/SLA.0000000000000914.


Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells.

Qian WJ, Park JE, Lim D, Lai CC, Kelley JA, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR Jr.

Biopolymers. 2014 Nov;102(6):444-55. doi: 10.1002/bip.22569.


Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM.

Cell. 2014 Aug 28;158(5):1094-1109. doi: 10.1016/j.cell.2014.07.032.


Selective mitogen activated protein kinase activity sensors through the application of directionally programmable D domain motifs.

Peterson LB, Yaffe MB, Imperiali B.

Biochemistry. 2014 Sep 16;53(36):5771-8. doi: 10.1021/bi500862c. Epub 2014 Sep 3.


Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.

Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, Lim E, Liu W, Bronson RT, Bowden M, Brock J, Krop IE, Dillon DA, Gygi SP, Mills GB, Richardson AL, Signoretti S, Yaffe MB, Kaelin WG Jr.

Cancer Cell. 2014 Aug 11;26(2):222-34. doi: 10.1016/j.ccr.2014.06.026.


A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways.

Morton SW, Lee MJ, Deng ZJ, Dreaden EC, Siouve E, Shopsowitz KE, Shah NJ, Yaffe MB, Hammond PT.

Sci Signal. 2014 May 13;7(325):ra44. doi: 10.1126/scisignal.2005261.


Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation.

Byun MR, Hwang JH, Kim AR, Kim KM, Hwang ES, Yaffe MB, Hong JH.

Cell Death Differ. 2014 Jun;21(6):854-63. doi: 10.1038/cdd.2014.8. Epub 2014 Feb 7.


Death of a Titan.

Sudol M, Yaffe MB.

Sci Signal. 2013 Dec 17;6(306):eg6. doi: 10.1126/scisignal.2004914.


A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo.

Morandell S, Reinhardt HC, Cannell IG, Kim JS, Ruf DM, Mitra T, Couvillon AD, Jacks T, Yaffe MB.

Cell Rep. 2013 Nov 27;5(4):868-77. doi: 10.1016/j.celrep.2013.10.025. Epub 2013 Nov 14.


Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence.

Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JP.

J Biol Chem. 2013 Nov 29;288(48):34968-80. doi: 10.1074/jbc.M113.523266. Epub 2013 Oct 15.


Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs.

Qian WJ, Park JE, Lim D, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR Jr.

Chem Biol. 2013 Oct 24;20(10):1255-64. doi: 10.1016/j.chembiol.2013.09.005. Epub 2013 Oct 10. Retraction in: Chem Biol. 2014 Sep 18;21(9):1254.


Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response.

Reinhardt HC, Yaffe MB.

Nat Rev Mol Cell Biol. 2013 Sep;14(9):563-80. doi: 10.1038/nrm3640. Review.


mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.

Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM.

Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566.


The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.

Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB.

Nature. 2013 Jun 13;498(7453):246-50. doi: 10.1038/nature12147. Epub 2013 Jun 2.


Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.

Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM.

Integr Biol (Camb). 2013 Jul 24;5(7):940-63. doi: 10.1039/c3ib40013a. Epub 2013 May 20.


Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.

Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR 3rd, Winey M, Smerdon SJ, Yaffe MB, Amon A.

Science. 2013 May 17;340(6134):871-5. doi: 10.1126/science.1235822. Epub 2013 Apr 11.


The scientific drunk and the lamppost: massive sequencing efforts in cancer discovery and treatment.

Yaffe MB.

Sci Signal. 2013 Apr 2;6(269):pe13. doi: 10.1126/scisignal.2003684.


Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.

Murugan RN, Park JE, Lim D, Ahn M, Cheong C, Kwon T, Nam KY, Choi SH, Kim BY, Yoon DY, Yaffe MB, Yu DY, Lee KS, Bang JK.

Bioorg Med Chem. 2013 May 1;21(9):2623-34. doi: 10.1016/j.bmc.2013.02.020. Epub 2013 Feb 27.


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