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Formyl Peptide Receptor-1 Blockade Prevents Receptor Regulation by Mitochondrial Danger-Associated Molecular Patterns and Preserves Neutrophil Function After Trauma.

Itagaki K, Kaczmarek E, Kwon WY, Chen L, Vlková B, Zhang Q, Riça I, Yaffe MB, Campbell Y, Marusich MF, Wang JM, Gong WH, Gao JL, Jung F, Douglas G, Otterbein LE, Hauser CJ.

Crit Care Med. 2019 Nov 15. doi: 10.1097/CCM.0000000000004094. [Epub ahead of print]


Substrate-based kinase activity inference identifies MK2 as driver of colitis.

Strasser SD, Ghazi PC, Starchenko A, Boukhali M, Edwards A, Suarez-Lopez L, Lyons J, Changelian PS, Monahan JB, Jacobsen J, Brubaker DK, Joughin BA, Yaffe MB, Haas W, Lauffenburger DA, Haigis KM.

Integr Biol (Camb). 2019 Nov 26;11(7):301-314. doi: 10.1093/intbio/zyz025.


Self-management across chronic diseases: Targeting education and support needs.

Bartlett SJ, Lambert SD, McCusker J, Yaffe M, de Raad M, Belzile E, Ciampi A, Di Carlo M, Lyddiatt A.

Patient Educ Couns. 2019 Sep 6. pii: S0738-3991(19)30380-5. doi: 10.1016/j.pec.2019.08.038. [Epub ahead of print]


Long-term Outcomes and Cost-effectiveness of Breast Cancer Screening with Digital Breast Tomosynthesis in the United States.

Lowry KP, Trentham-Dietz A, Schechter CB, Alagoz O, Barlow WE, Burnside ES, Conant EF, Hampton JM, Huang H, Kerlikowske K, Lee SJ, Miglioretti DL, Sprague BL, Tosteson ANA, Yaffe M, Stout NK.

J Natl Cancer Inst. 2019 Sep 10. pii: djz184. doi: 10.1093/jnci/djz184. [Epub ahead of print]


A Case-Control Study to Add Volumetric or Clinical Mammographic Density into the Tyrer-Cuzick Breast Cancer Risk Model.

Brentnall AR, Cohn WF, Knaus WA, Yaffe MJ, Cuzick J, Harvey JA.

J Breast Imaging. 2019 Jun;1(2):99-106. doi: 10.1093/jbi/wbz006. Epub 2019 May 11.


Investigating the feasibility of stratified breast cancer screening using a masking risk predictor.

Alonzo-Proulx O, Mainprize JG, Harvey JA, Yaffe MJ.

Breast Cancer Res. 2019 Aug 9;21(1):91. doi: 10.1186/s13058-019-1179-z.


VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.

Patterson JC, Joughin BA, Prota AE, Mühlethaler T, Jonas OH, Whitman MA, Varmeh S, Chen S, Balk SP, Steinmetz MO, Lauffenburger DA, Yaffe MB.

Cell Syst. 2019 Jul 24;9(1):74-92.e8. doi: 10.1016/j.cels.2019.05.009. Epub 2019 Jul 10.


Predictors of mammographic density among women with a strong family history of breast cancer.

Moran O, Eisen A, Demsky R, Blackmore K, Knight JA, Panchal S, Ginsburg O, Zbuk K, Yaffe M, Metcalfe KA, Narod SA, Kotsopoulos J.

BMC Cancer. 2019 Jun 26;19(1):631. doi: 10.1186/s12885-019-5855-2.


Clot activators do not expedite the time to predict massive transfusion in trauma patients analyzed with tissue plasminogen activator thrombelastography.

Walker CB, Moore EE, Kam A, Dexter-Meldrum J, Nydam TL, Chapman MP, Chandler J, Sauaia A, Barrett CD, Yaffe MB, Moore HB.

Surgery. 2019 Sep;166(3):408-415. doi: 10.1016/j.surg.2019.05.011. Epub 2019 Jun 21.


Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.

Bandopadhayay P, Piccioni F, O'Rourke R, Ho P, Gonzalez EM, Buchan G, Qian K, Gionet G, Girard E, Coxon M, Rees MG, Brenan L, Dubois F, Shapira O, Greenwald NF, Pages M, Balboni Iniguez A, Paolella BR, Meng A, Sinai C, Roti G, Dharia NV, Creech A, Tanenbaum B, Khadka P, Tracy A, Tiv HL, Hong AL, Coy S, Rashid R, Lin JR, Cowley GS, Lam FC, Goodale A, Lee Y, Schoolcraft K, Vazquez F, Hahn WC, Tsherniak A, Bradner JE, Yaffe MB, Milde T, Pfister SM, Qi J, Schenone M, Carr SA, Ligon KL, Kieran MW, Santagata S, Olson JM, Gokhale PC, Jaffe JD, Root DE, Stegmaier K, Johannessen CM, Beroukhim R.

Nat Commun. 2019 Jun 3;10(1):2400. doi: 10.1038/s41467-019-10307-9.


Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs.

van de Kooij B, Creixell P, van Vlimmeren A, Joughin BA, Miller CJ, Haider N, Simpson CD, Linding R, Stambolic V, Turk BE, Yaffe MB.

Elife. 2019 May 24;8. pii: e44635. doi: 10.7554/eLife.44635.


Atlas Drugged.

Chen JK, Yaffe MB.

Cell. 2019 May 2;177(4):803-805. doi: 10.1016/j.cell.2019.04.023.


A Report from a Workshop of the International Stem Cell Banking Initiative, Held in Collaboration of Global Alliance for iPSC Therapies and the Harvard Stem Cell Institute, Boston, 2017.

Kim JH, Alderton A, Crook JM, Benvenisty N, Brandsten C, Firpo M, Harrison PW, Kawamata S, Kawase E, Kurtz A, Loring JF, Ludwig T, Man J, Mountford JC, Turner ML, Oh S, da Veiga Pereira L, Pranke P, Sheldon M, Steeg R, Sullivan S, Yaffe M, Zhou Q, Stacey GN.

Stem Cells. 2019 Sep;37(9):1130-1135. doi: 10.1002/stem.3003. Epub 2019 Aug 6.


Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.

Miller CJ, Lou HJ, Simpson C, van de Kooij B, Ha BH, Fisher OS, Pirman NL, Boggon TJ, Rinehart J, Yaffe MB, Linding R, Turk BE.

PLoS Biol. 2019 Mar 21;17(3):e2006540. doi: 10.1371/journal.pbio.2006540. eCollection 2019 Mar.


Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer.

Kasikara C, Davra V, Calianese D, Geng K, Spires TE, Quigley M, Wichroski M, Sriram G, Suarez-Lopez L, Yaffe MB, Kotenko SV, De Lorenzo MS, Birge RB.

Cancer Res. 2019 May 15;79(10):2669-2683. doi: 10.1158/0008-5472.CAN-18-2614. Epub 2019 Mar 15.


Reproductive Factors and Mammographic Density: Associations Among 24,840 Women and Comparison of Studies Using Digitized Film-Screen Mammography and Full-Field Digital Mammography.

Alexeeff SE, Odo NU, McBride R, McGuire V, Achacoso N, Rothstein JH, Lipson JA, Liang RY, Acton L, Yaffe MJ, Whittemore AS, Rubin DL, Sieh W, Habel LA.

Am J Epidemiol. 2019 Jun 1;188(6):1144-1154. doi: 10.1093/aje/kwz033.


Emergence of "Big Data" and Its Potential and Current Limitations in Medical Imaging.

Yaffe MJ.

Semin Nucl Med. 2019 Mar;49(2):94-104. doi: 10.1053/j.semnuclmed.2018.11.010. Epub 2018 Dec 6. Review.


ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest.

Patterson JC, Joughin BA, van de Kooij B, Lim DC, Lauffenburger DA, Yaffe MB.

Cell Syst. 2019 Feb 27;8(2):163-167.e2. doi: 10.1016/j.cels.2019.01.005. Epub 2019 Feb 20.


Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes.

Rohani N, Hao L, Alexis MS, Joughin BA, Krismer K, Moufarrej MN, Soltis AR, Lauffenburger DA, Yaffe MB, Burge CB, Bhatia SN, Gertler FB.

Cancer Res. 2019 Apr 15;79(8):1952-1966. doi: 10.1158/0008-5472.CAN-18-1604. Epub 2019 Feb 12.


RE: A Methodological Issue in Prediction of Cancer Masking in Screening Mammography Using Density and Textural Features - Authors' Response.

Mainprize JG, Alonzo-Proulx O, Alshafeiy T, Patrie JT, Harvey JA, Yaffe MJ.

Acad Radiol. 2019 May;26(5):e78. doi: 10.1016/j.acra.2018.11.022. Epub 2019 Jan 31. No abstract available.


TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression.

Hwang JH, Kim AR, Kim KM, Il Park J, Oh HT, Moon SA, Byun MR, Jeong H, Kim HK, Yaffe MB, Hwang ES, Hong JH.

Nat Commun. 2019 Jan 24;10(1):421. doi: 10.1038/s41467-019-08287-x.


Why geneticists stole cancer research even though cancer is primarily a signaling disease.

Yaffe MB.

Sci Signal. 2019 Jan 22;12(565). pii: eaaw3483. doi: 10.1126/scisignal.aaw3483. Review.


Three-dimensional tumor visualization of invasive breast carcinomas using whole-mount serial section histopathology: implications for tumor size assessment.

Clarke GM, Holloway CMB, Zubovits JT, Nofech-Mozes S, Murray M, Liu K, Wang D, Kiss A, Yaffe MJ.

Breast Cancer Res Treat. 2019 Apr;174(3):669-677. doi: 10.1007/s10549-018-05122-7. Epub 2019 Jan 5.


Pilot Study of a Transitional Intervention for Family Caregivers of Older Adults.

McCusker J, Lambert SD, Yaffe MJ, Cole MG, Hidalgo M, Amir E, de Raad M, Belzile E.

Can J Aging. 2018 Dec 27:1-12. doi: 10.1017/S071498081800051X. [Epub ahead of print]


Tranexamic acid mediates proinflammatory and anti-inflammatory signaling via complement C5a regulation in a plasminogen activator-dependent manner.

Barrett CD, Moore HB, Kong YW, Chapman MP, Sriram G, Lim D, Moore EE, Yaffe MB.

J Trauma Acute Care Surg. 2019 Jan;86(1):101-107. doi: 10.1097/TA.0000000000002092.


Correction: Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system.

Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Parada-Kusz M, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ.

Mucosal Immunol. 2019 Mar;12(2):580. doi: 10.1038/s41385-018-0074-8.


Self-management support in primary care is associated with improvement in patient activation.

McCusker J, Lambert SD, Haggerty J, Yaffe MJ, Belzile E, Ciampi A.

Patient Educ Couns. 2019 Mar;102(3):571-577. doi: 10.1016/j.pec.2018.10.026. Epub 2018 Nov 3.


Towards improving accuracy, effectiveness, and efficiency in breast cancer screening.

Yaffe MJ.

Lancet Oncol. 2018 Nov;19(11):1426-1427. doi: 10.1016/S1470-2045(18)30589-8. Epub 2018 Oct 12. No abstract available.


Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy.

Barrett CD, Hsu AT, Ellson CD, Y Miyazawa B, Kong YW, Greenwood JD, Dhara S, Neal MD, Sperry JL, Park MS, Cohen MJ, Zuckerbraun BS, Yaffe MB.

Clin Exp Immunol. 2018 Oct;194(1):103-117. doi: 10.1111/cei.13166. Epub 2018 Sep 9.


Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.

Creixell P, Pandey JP, Palmeri A, Bhattacharyya M, Creixell M, Ranganathan R, Pincus D, Yaffe MB.

Cell Syst. 2018 Oct 24;7(4):371-383.e4. doi: 10.1016/j.cels.2018.08.008. Epub 2018 Sep 19.


The Doctor Shortage.

Yaffe MJ.

J Am Geriatr Soc. 2018 Nov;66(11):2222. doi: 10.1111/jgs.15535. Epub 2018 Sep 17. No abstract available.


Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.

Hymel D, Grant RA, Tsuji K, Yaffe MB, Burke TR Jr.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3202-3205. doi: 10.1016/j.bmcl.2018.08.018. Epub 2018 Aug 19.


Prediction of Cancer Masking in Screening Mammography Using Density and Textural Features.

Mainprize JG, Alonzo-Proulx O, Alshafeiy TI, Patrie JT, Harvey JA, Yaffe MJ.

Acad Radiol. 2019 May;26(5):608-619. doi: 10.1016/j.acra.2018.06.011. Epub 2018 Aug 10.


Unmet needs of family caregivers of hospitalized older adults preparing for discharge home.

McCusker J, Yaffe M, Lambert SD, Cole M, de Raad M, Belzile E, Ciampi A, Amir E, Hidalgo M.

Chronic Illn. 2018 Aug 4:1742395318789467. doi: 10.1177/1742395318789467. [Epub ahead of print]


Priorities for caregiver research in cancer care: an international Delphi survey of caregivers, clinicians, managers, and researchers.

Lambert SD, Ould Brahim L, Morrison M, Girgis A, Yaffe M, Belzile E, Clayberg K, Robinson J, Thorne S, Bottorff JL, Duggleby W, Campbell-Enns H, Kim Y, Loiselle CG.

Support Care Cancer. 2019 Mar;27(3):805-817. doi: 10.1007/s00520-018-4314-y. Epub 2018 Jul 31.


The effect of mammography screening regimen on incidence-based breast cancer mortality.

Yaffe MJ, Mittmann N, Alagoz O, Trentham-Dietz A, Tosteson AN, Stout NK.

J Med Screen. 2018 Dec;25(4):197-204. doi: 10.1177/0969141318780152. Epub 2018 Jul 26.


Modeling chemotherapy-induced stress to identify rational combination therapies in the DNA damage response pathway.

Alkan O, Schoeberl B, Shah M, Koshkaryev A, Heinemann T, Drummond DC, Yaffe MB, Raue A.

Sci Signal. 2018 Jul 24;11(540). pii: eaat0229. doi: 10.1126/scisignal.aat0229.


[18F]-Fluorodeoxyglucose PET/CT imaging as a marker of carotid plaque inflammation: Comparison to immunohistology and relationship to acuity of events.

Cocker MS, Spence JD, Hammond R, deKemp RA, Lum C, Wells G, Bernick J, Hill A, Nagpal S, Stotts G, Alturkustani M, Adeeko A, Yerofeyeva Y, Rayner K, Peterson J, Khan AR, Naidas AC, Garrard L, Yaffe MJ, Leung E, Prato FS, Tardif JC, Beanlands RSB; Canadian Atherosclerosis Imaging Network (CAIN) - Project II.

Int J Cardiol. 2018 Nov 15;271:378-386. doi: 10.1016/j.ijcard.2018.05.057. Epub 2018 Jun 2.


A subset of five human mitochondrial formyl peptides mimics bacterial peptides and functionally deactivates human neutrophils.

Kaczmarek E, Hauser CJ, Kwon WY, Riça I, Chen L, Sandler N, Otterbein LE, Campbell Y, Cook CH, Yaffe MB, Marusich MF, Itagaki K.

J Trauma Acute Care Surg. 2018 Nov;85(5):936-943. doi: 10.1097/TA.0000000000001971.


Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.

Lam FC, Morton SW, Wyckoff J, Vu Han TL, Hwang MK, Maffa A, Balkanska-Sinclair E, Yaffe MB, Floyd SR, Hammond PT.

Nat Commun. 2018 May 18;9(1):1991. doi: 10.1038/s41467-018-04315-4.


Serum osteoprotegerin levels and mammographic density among high-risk women.

Moran O, Zaman T, Eisen A, Demsky R, Blackmore K, Knight JA, Elser C, Ginsburg O, Zbuk K, Yaffe M, Narod SA, Salmena L, Kotsopoulos J.

Cancer Causes Control. 2018 Jun;29(6):507-517. doi: 10.1007/s10552-018-1035-y. Epub 2018 Apr 20.


MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.

Suarez-Lopez L, Sriram G, Kong YW, Morandell S, Merrick KA, Hernandez Y, Haigis KM, Yaffe MB.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4236-E4244. doi: 10.1073/pnas.1722020115. Epub 2018 Apr 16.


Factors influencing survival among patients with HER2-positive metastatic breast cancer treated with trastuzumab.

Blanchette PS, Desautels DN, Pond GR, Bartlett JMS, Nofech-Mozes S, Yaffe MJ, Pritchard KI.

Breast Cancer Res Treat. 2018 Jul;170(1):169-177. doi: 10.1007/s10549-018-4734-x. Epub 2018 Mar 8.


The origins of breast cancer associated with mammographic density: a testable biological hypothesis.

Boyd N, Berman H, Zhu J, Martin LJ, Yaffe MJ, Chavez S, Stanisz G, Hislop G, Chiarelli AM, Minkin S, Paterson AD.

Breast Cancer Res. 2018 Mar 7;20(1):17. doi: 10.1186/s13058-018-0941-y.


Cost-effectiveness of mammography from a publicly funded health care system perspective.

Mittmann N, Stout NK, Tosteson ANA, Trentham-Dietz A, Alagoz O, Yaffe MJ.

CMAJ Open. 2018 Feb 8;6(1):E77-E86. doi: 10.9778/cmajo.20170106.


RNA-Peptide nanoplexes drug DNA damage pathways in high-grade serous ovarian tumors.

Dreaden EC, Kong YW, Quadir MA, Correa S, Suárez-López L, Barberio AE, Hwang MK, Shi AC, Oberlton B, Gallagher PN, Shopsowitz KE, Elias KM, Yaffe MB, Hammond PT.

Bioeng Transl Med. 2018 Jan 19;3(1):26-36. doi: 10.1002/btm2.10086. eCollection 2018 Jan.


Predicting the future of signaling for 2018.

Yaffe MB.

Sci Signal. 2018 Jan 2;11(511). pii: eaar7429. doi: 10.1126/scisignal.aar7429.


TAZ/WWTR1 Mediates the Pulmonary Effects of NKX2-1 Mutations in Brain-Lung-Thyroid Syndrome.

Moya CM, Zaballos MA, Garzón L, Luna C, Simón R, Yaffe MB, Gallego E, Santisteban P, Moreno JC.

J Clin Endocrinol Metab. 2018 Mar 1;103(3):839-852. doi: 10.1210/jc.2017-01241.


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