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Enhanced A1 adenosine receptor-induced vascular contractions in mesenteric artery and aorta of in L-NAME mouse model of hypertension.

Yadav VR, Teng B, Mustafa SJ.

Eur J Pharmacol. 2019 Jan 5;842:111-117. doi: 10.1016/j.ejphar.2018.10.024. Epub 2018 Oct 19.


PLCγ1-PKCε-IP3R1 signaling plays an important role in hypoxia-induced calcium response in pulmonary artery smooth muscle cells.

Yadav VR, Song T, Mei L, Joseph L, Zheng YM, Wang YX.

Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L724-L735. doi: 10.1152/ajplung.00243.2017. Epub 2018 Feb 1.


Impaired Aortic Contractility to Uridine Adenosine Tetraphosphate in Angiotensin II-Induced Hypertensive Mice: Receptor Desensitization?

Zhou Z, Yadav VR, Sun C, Teng B, Mustafa JS.

Am J Hypertens. 2017 Mar 1;30(3):304-312. doi: 10.1093/ajh/hpw163.


Nanovesicular liposome-encapsulated hemoglobin (LEH) prevents multi-organ injuries in a rat model of hemorrhagic shock.

Yadav VR, Rao G, Houson H, Hedrick A, Awasthi S, Roberts PR, Awasthi V.

Eur J Pharm Sci. 2016 Oct 10;93:97-106. doi: 10.1016/j.ejps.2016.08.010. Epub 2016 Aug 5.


3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.

Yadav VR, Prasad S, Gupta SC, Sung B, Phatak SS, Zhang S, Aggarwal BB.

J Biol Chem. 2016 Aug 5;291(32):16926. doi: 10.1074/jbc.A111.274613. No abstract available.


Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors. EVIDENCE FOR THE ROLE OF REACTIVE OXYGEN SPECIES AND JNK.

Prasad S, Yadav VR, Kannappan R, Aggarwal BB.

J Biol Chem. 2016 Aug 5;291(32):16924. doi: 10.1074/jbc.A110.183699. No abstract available.


Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway.

Prasad S, Yadav VR, Sundaram C, Reuter S, Hema PS, Nair MS, Chaturvedi MM, Aggarwal BB.

J Biol Chem. 2016 Aug 5;291(32):16921. doi: 10.1074/jbc.A110.121061. No abstract available.


Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.

Sung B, Park B, Yadav VR, Aggarwal BB.

J Biol Chem. 2016 Aug 5;291(32):16920. doi: 10.1074/jbc.A109.090209. No abstract available.


Effect of liposome-encapsulated hemoglobin resuscitation on proteostasis in small intestinal epithelium after hemorrhagic shock.

Rao G, Yadav VR, Awasthi S, Roberts PR, Awasthi V.

Am J Physiol Gastrointest Liver Physiol. 2016 Jul 1;311(1):G180-91. doi: 10.1152/ajpgi.00157.2016. Epub 2016 Jun 10.


Angiotensin II stimulation alters vasomotor response to adenosine in mouse mesenteric artery: role for A1 and A2B adenosine receptors.

Yadav VR, Nayeem MA, Tilley SL, Mustafa SJ.

Br J Pharmacol. 2015 Oct;172(20):4959-69. doi: 10.1111/bph.13265. Epub 2015 Oct 14.


The brain metabolic activity after resuscitation with liposome-encapsulated hemoglobin in a rat model of hypovolemic shock.

Rao G, Hedrick AF, Yadav VR, Xie J, Hussain A, Awasthi V.

J Cereb Blood Flow Metab. 2015 Sep;35(9):1528-36. doi: 10.1038/jcbfm.2015.82. Epub 2015 May 6.


The salutary effects of diphenyldifluoroketone EF24 in liver of a rat hemorrhagic shock model.

Yadav VR, Hussain A, Xie J, Kosanke S, Awasthi V.

Scand J Trauma Resusc Emerg Med. 2015 Feb 3;23:8. doi: 10.1186/s13049-015-0098-y.


Suppression of tumor growth in mice by rationally designed pseudopeptide inhibitors of fibroblast activation protein and prolyl oligopeptidase.

Jackson KW, Christiansen VJ, Yadav VR, Silasi-Mansat R, Lupu F, Awasthi V, Zhang RR, McKee PA.

Neoplasia. 2015 Jan;17(1):43-54. doi: 10.1016/j.neo.2014.11.002.


Liposomes modified with superhydrophilic polymer linked to a nonphospholipid anchor exhibit reduced complement activation and enhanced circulation.

Nag OK, Yadav VR, Croft B, Hedrick A, Awasthi V.

J Pharm Sci. 2015 Jan;104(1):114-23. doi: 10.1002/jps.24254. Epub 2014 Nov 12.


Remediation of hemorrhagic shock-induced intestinal barrier dysfunction by treatment with diphenyldihaloketones EF24 and CLEFMA.

Yadav VR, Hussain A, Sahoo K, Awasthi V.

J Pharmacol Exp Ther. 2014 Nov;351(2):413-22. doi: 10.1124/jpet.114.217331. Epub 2014 Sep 9.


Hemorrhage-induced interleukin-1 receptor pathway in lung is suppressed by 3,5-bis(2-fluorobenzylidene)-4-piperidone in a rat model of hypovolemic shock.

Yadav VR, Vilekar P, Awasthi S, Awasthi V.

Artif Organs. 2014 Aug;38(8):675-83. doi: 10.1111/aor.12305. Epub 2014 Apr 22.


Biological evaluation of liposome-encapsulated hemoglobin surface-modified with a novel PEGylated nonphospholipid amphiphile.

Yadav VR, Nag O, Awasthi V.

Artif Organs. 2014 Aug;38(8):625-33. doi: 10.1111/aor.12304. Epub 2014 Apr 22.


Pharmacologic suppression of inflammation by a diphenyldifluoroketone, EF24, in a rat model of fixed-volume hemorrhage improves survival.

Yadav VR, Sahoo K, Roberts PR, Awasthi V.

J Pharmacol Exp Ther. 2013 Nov;347(2):346-56. doi: 10.1124/jpet.113.208009. Epub 2013 Aug 30.


RANKL signaling and osteoclastogenesis is negatively regulated by cardamonin.

Sung B, Prasad S, Yadav VR, Gupta SC, Reuter S, Yamamoto N, Murakami A, Aggarwal BB.

PLoS One. 2013 May 17;8(5):e64118. doi: 10.1371/journal.pone.0064118. Print 2013.


Post-modification of preformed liposomes with novel non-phospholipid poly(ethylene glycol)-conjugated hexadecylcarbamoylmethyl hexadecanoic acid for enhanced circulation persistence in vivo.

Nag OK, Yadav VR, Hedrick A, Awasthi V.

Int J Pharm. 2013 Mar 25;446(1-2):119-29. doi: 10.1016/j.ijpharm.2013.02.026. Epub 2013 Feb 16.


Modulation of oxidative stability of haemoglobin inside liposome-encapsulated haemoglobin.

Awasthi V, Yadav VR, Goins B, Phillips WT.

J Microencapsul. 2013;30(5):471-8. doi: 10.3109/02652048.2012.752535. Epub 2012 Dec 11.


Important role of PLC-γ1 in hypoxic increase in intracellular calcium in pulmonary arterial smooth muscle cells.

Yadav VR, Song T, Joseph L, Mei L, Zheng YM, Wang YX.

Am J Physiol Lung Cell Mol Physiol. 2013 Feb 1;304(3):L143-51. doi: 10.1152/ajplung.00310.2012. Epub 2012 Nov 30.


Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors.

Sung B, Prasad S, Ravindran J, Yadav VR, Aggarwal BB.

Free Radic Biol Med. 2012 Nov 15;53(10):1977-87. doi: 10.1016/j.freeradbiomed.2012.08.012. Epub 2012 Aug 15.


Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.

Prasad S, Yadav VR, Sung B, Reuter S, Kannappan R, Deorukhkar A, Diagaradjane P, Wei C, Baladandayuthapani V, Krishnan S, Guha S, Aggarwal BB.

Clin Cancer Res. 2012 Sep 15;18(18):4942-53. doi: 10.1158/1078-0432.CCR-11-2805. Epub 2012 Jul 25.


WITHDRAWN: Cardamonin Inhibits Osteoclastogenesis Induced by Tumor Cells Through Interruption of the Signaling Pathway Activated by Receptor Activator of NF-κB Ligand.

Yadav VR, Prasad S, Reuter S, Sung B, Yamamoto N, Murakami A, Aggarwal BB.

Cancer Lett. 2011 Dec 17. [Epub ahead of print]


Cancer cell signaling pathways targeted by spice-derived nutraceuticals.

Sung B, Prasad S, Yadav VR, Aggarwal BB.

Nutr Cancer. 2012;64(2):173-97. doi: 10.1080/01635581.2012.630551. Epub 2011 Dec 9. Review.


Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.

Yadav VR, Prasad S, Sung B, Kannappan R, Aggarwal BB.

Toxins (Basel). 2010 Oct;2(10):2428-66. doi: 10.3390/toxins2102428. Epub 2010 Oct 22. Review.


Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.

Park B, Sung B, Yadav VR, Chaturvedi MM, Aggarwal BB.

Biochem Pharmacol. 2011 Nov 1;82(9):1134-44. doi: 10.1016/j.bcp.2011.07.062. Epub 2011 Jul 27. Retraction in: Biochem Pharmacol. 2016 Feb 15;102:141.


Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins.

Yadav VR, Prasad S, Aggarwal BB.

Br J Pharmacol. 2012 Feb;165(3):741-53. doi: 10.1111/j.1476-5381.2011.01603.x. Erratum in: Br J Pharmacol. 2013 Jan;168(1):276-8.


Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers.

Yadav VR, Prasad S, Sung B, Gelovani JG, Guha S, Krishnan S, Aggarwal BB.

Int J Cancer. 2012 May 1;130(9):2176-84. doi: 10.1002/ijc.26251. Epub 2011 Sep 12.


Cancer and diet: How are they related?

Sung B, Prasad S, Yadav VR, Lavasanifar A, Aggarwal BB.

Free Radic Res. 2011 Aug;45(8):864-79. doi: 10.3109/10715762.2011.582869. Epub 2011 Jun 9. Review.


Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis.

Prasad S, Pandey MK, Yadav VR, Aggarwal BB.

Cancer Prev Res (Phila). 2011 Jul;4(7):1084-94. doi: 10.1158/1940-6207.CAPR-10-0340. Epub 2011 Apr 13. Retraction in: Cancer Prev Res (Phila). 2018 Sep;11(9):593.


Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression.

Park B, Sung B, Yadav VR, Cho SG, Liu M, Aggarwal BB.

Int J Cancer. 2011 Jul 1;129(1):23-33. doi: 10.1002/ijc.25966. Epub 2011 Mar 29.


Primary role of mitochondrial Rieske iron-sulfur protein in hypoxic ROS production in pulmonary artery myocytes.

Korde AS, Yadav VR, Zheng YM, Wang YX.

Free Radic Biol Med. 2011 Apr 15;50(8):945-52. doi: 10.1016/j.freeradbiomed.2011.01.010. Epub 2011 Jan 14.


Curcumin: a component of the golden spice, targets multiple angiogenic pathways.

Yadav VR, Aggarwal BB.

Cancer Biol Ther. 2011 Jan 15;11(2):236-41. Epub 2011 Jan 15. No abstract available.


The role of chalcones in suppression of NF-κB-mediated inflammation and cancer.

Yadav VR, Prasad S, Sung B, Aggarwal BB.

Int Immunopharmacol. 2011 Mar;11(3):295-309. doi: 10.1016/j.intimp.2010.12.006. Epub 2010 Dec 22. Review.


NF-κB addiction and its role in cancer: 'one size does not fit all'.

Chaturvedi MM, Sung B, Yadav VR, Kannappan R, Aggarwal BB.

Oncogene. 2011 Apr 7;30(14):1615-30. doi: 10.1038/onc.2010.566. Epub 2010 Dec 20. Review.


ROS and CHOP are critical for dibenzylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins.

Prasad S, Yadav VR, Ravindran J, Aggarwal BB.

Cancer Res. 2011 Jan 15;71(2):538-49. doi: 10.1158/0008-5472.CAN-10-3121. Epub 2010 Dec 2. Retraction in: Cancer Res. 2018 Sep 1;78(17):5185.


Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer.

Reuter S, Prasad S, Phromnoi K, Ravindran J, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB.

Cancer Prev Res (Phila). 2010 Nov;3(11):1462-72. doi: 10.1158/1940-6207.CAPR-10-0037. Epub 2010 Oct 26.


A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.

Phromnoi K, Reuter S, Sung B, Prasad S, Kannappan R, Yadav VR, Chanmahasathien W, Limtrakul P, Aggarwal BB.

Mol Pharmacol. 2011 Feb;79(2):279-89. doi: 10.1124/mol.110.067512. Epub 2010 Oct 7. Retraction in: Mol Pharmacol. 2016 Jul;90(1):64.


{Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment.

Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Yadav VR, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB.

Cancer Res. 2010 Nov 1;70(21):8695-705. doi: 10.1158/0008-5472.CAN-10-2318. Epub 2010 Sep 23. Erratum in: Cancer Res. 2018 Sep 1;78(17):5181.


Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.

Gupta SC, Prasad S, Reuter S, Kannappan R, Yadav VR, Ravindran J, Hema PS, Chaturvedi MM, Nair M, Aggarwal BB.

J Biol Chem. 2010 Nov 12;285(46):35406-17. doi: 10.1074/jbc.M110.161984. Epub 2010 Sep 9. Erratum in: J Biol Chem. 2012 Apr 6;287(15):12152.


Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway.

Reuter S, Prasad S, Phromnoi K, Kannappan R, Yadav VR, Aggarwal BB.

Mol Cancer Res. 2010 Oct;8(10):1425-36. doi: 10.1158/1541-7786.MCR-10-0141. Epub 2010 Sep 8. Retraction in: Mol Cancer Res. 2018 Sep;16(9):1443.

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