Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 63

1.

Thiosemicarbazones as a Potent Anticancer Agents and Their Modes of Action.

Shakya B, Yadav PN.

Mini Rev Med Chem. 2019 Oct 29. doi: 10.2174/1389557519666191029130310. [Epub ahead of print]

PMID:
31660812
2.

2-Pyridineformamide N(4)-ring incorporated thiosemicarbazones inhibit MCF-7 cells by inhibiting JNK pathway.

Shakya B, Shahi N, Ahmad F, Yadav PN, Pokharel YR.

Bioorg Med Chem Lett. 2019 Jul 1;29(13):1677-1681. doi: 10.1016/j.bmcl.2019.04.031. Epub 2019 Apr 24.

PMID:
31053506
3.

Novel Tetrahydroquinazolinamines as Selective Histamine 3 Receptor Antagonists for the Treatment of Obesity.

Kumar A, Pasam VR, Thakur RK, Singh M, Singh K, Shukla M, Yadav A, Dogra S, Sona C, Umrao D, Jaiswal S, Ahmad H, Rashid M, Singh SK, Wahajuddin M, Dwivedi AK, Siddiqi MI, Lal J, Tripathi RP, Yadav PN.

J Med Chem. 2019 May 9;62(9):4638-4655. doi: 10.1021/acs.jmedchem.9b00241. Epub 2019 Apr 29.

PMID:
30998358
4.

Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action.

Adhikari HS, Yadav PN.

Int J Biomater. 2018 Dec 30;2018:2952085. doi: 10.1155/2018/2952085. eCollection 2018. Review.

5.

Identification of dual role of piperazine-linked phenyl cyclopropyl methanone as positive allosteric modulator of 5-HT2C and negative allosteric modulator of 5-HT2B receptors.

Singh K, Sona C, Ojha V, Singh M, Mishra A, Kumar A, Siddiqi MI, Tripathi RP, Yadav PN.

Eur J Med Chem. 2019 Feb 15;164:499-516. doi: 10.1016/j.ejmech.2018.12.070. Epub 2018 Dec 29.

PMID:
30622024
6.

Discovery of an isocoumarin analogue that modulates neuronal functions via neurotrophin receptor TrkB.

Sudarshan K, Boda AK, Dogra S, Bose I, Yadav PN, Aidhen IS.

Bioorg Med Chem Lett. 2019 Feb 15;29(4):585-590. doi: 10.1016/j.bmcl.2018.12.057. Epub 2018 Dec 26.

PMID:
30600206
7.

Chronic histamine 3 receptor antagonism alleviates depression like conditions in mice via modulation of brain-derived neurotrophic factor and hypothalamus-pituitary adrenal axis.

Kumar A, Dogra S, Sona C, Umrao D, Rashid M, Singh SK, Wahajuddin M, Yadav PN.

Psychoneuroendocrinology. 2019 Mar;101:128-137. doi: 10.1016/j.psyneuen.2018.11.007. Epub 2018 Nov 11.

PMID:
30458370
8.

Corrigendum to "Identification of novel β-lactams and pyrrolidinone derivatives as selective Histamine-3 receptor (H3R) modulators as possible anti-obesity agents" [Eur. J. Med. Chem. 152 (2018) 148-159].

Ghoshal A, Kumar A, Yugandhar D, Sona C, Kuriakose S, Nagesh K, Rashid M, Singh SK, Wahajuddin M, Yadav PN, Srivastava AK.

Eur J Med Chem. 2018 Aug 5;156:628-630. doi: 10.1016/j.ejmech.2018.07.034. Epub 2018 Jul 19. No abstract available.

PMID:
30031973
9.

Dye-Labeled Polyacryloyl Hydrazide-Ag Nanoparticle Fluorescent Probe for Ultrasensitive and Selective Detection of Au Ion.

Ujjwal RR, Sona C, Debnath S, Yadav PN, Ojha U.

ACS Omega. 2017 Aug 31;2(8):4278-4286. doi: 10.1021/acsomega.7b00857. Epub 2017 Aug 7.

10.

Docosahexaenoic acid modulates brain-derived neurotrophic factor via GPR40 in the brain and alleviates diabesity-associated learning and memory deficits in mice.

Sona C, Kumar A, Dogra S, Kumar BA, Umrao D, Yadav PN.

Neurobiol Dis. 2018 Oct;118:94-107. doi: 10.1016/j.nbd.2018.07.002. Epub 2018 Jul 6.

PMID:
29981843
11.

Discovery of coumarin-dihydroquinazolinone analogs as niacin receptor 1 agonist with in-vivo anti-obesity efficacy.

Singh LR, Kumar A, Upadhyay A, Gupta S, Palanati GR, Sikka K, Siddiqi MI, Yadav PN, Sashidhara KV.

Eur J Med Chem. 2018 May 25;152:208-222. doi: 10.1016/j.ejmech.2018.04.037. Epub 2018 Apr 21.

PMID:
29709786
12.

Identification of novel β-lactams and pyrrolidinone derivatives as selective Histamine-3 receptor (H3R) modulators as possible anti-obesity agents.

Ghoshal A, Kumar A, Yugandhar D, Sona C, Kuriakose S, Nagesh K, Rashid M, Singh SK, Wahajuddin M, Yadav PN, Srivastava AK.

Eur J Med Chem. 2018 May 25;152:148-159. doi: 10.1016/j.ejmech.2018.04.020. Epub 2018 Apr 26. Erratum in: Eur J Med Chem. 2018 Aug 5;156:628-630.

PMID:
29704723
13.

Discovery of Novel Muscarinic Receptor Modulators by Integrating a Natural Product Framework and a Bioactive Molecule.

Varkhedkar R, Dogra S, Tiwari D, Hussain Y, Yadav PN, Pandey G.

ChemMedChem. 2018 Feb 20;13(4):384-395. doi: 10.1002/cmdc.201800001. Epub 2018 Feb 9.

PMID:
29319226
14.

A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis.

Ghosh E, Srivastava A, Baidya M, Kumari P, Dwivedi H, Nidhi K, Ranjan R, Dogra S, Koide A, Yadav PN, Sidhu SS, Koide S, Shukla AK.

Nat Nanotechnol. 2017 Dec;12(12):1190-1198. doi: 10.1038/nnano.2017.188. Epub 2017 Oct 2.

15.

GloSensor assay for discovery of GPCR-selective ligands.

Kumar BA, Kumari P, Sona C, Yadav PN.

Methods Cell Biol. 2017;142:27-50. doi: 10.1016/bs.mcb.2017.07.012. Epub 2017 Sep 11.

PMID:
28964338
16.

Opioid Receptor Modulators with a Cinnamyl Group.

Ravilla L, Venkata Subba Naidu N, Dogra S, Umrao D, Yadav PN, Biswas A, Michael D, Sekar K, Nagarajan K.

J Med Chem. 2017 Aug 10;60(15):6733-6750. doi: 10.1021/acs.jmedchem.7b00643. Epub 2017 Aug 1.

PMID:
28726402
17.

Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation.

Kumari P, Srivastava A, Ghosh E, Ranjan R, Dogra S, Yadav PN, Shukla AK.

Mol Biol Cell. 2017 Apr 15;28(8):1003-1010. doi: 10.1091/mbc.E16-12-0818. Epub 2017 Feb 22.

18.

Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning.

Muthusamy N, Zhang X, Johnson CA, Yadav PN, Ghashghaei HT.

Nat Neurosci. 2017 Jan;20(1):20-23. doi: 10.1038/nn.4452. Epub 2016 Dec 5.

19.

Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression.

Dogra S, Kumar A, Umrao D, Sahasrabuddhe AA, Yadav PN.

Sci Rep. 2016 Sep 16;6:33401. doi: 10.1038/srep33401.

20.

Intranasal Eutectic Powder of Zolmitriptan with Enhanced Bioavailability in the Rat Brain.

Khan T, Ranjan R, Dogra Y, Pandya SM, Shafi H, Singh SK, Yadav PN, Misra A.

Mol Pharm. 2016 Sep 6;13(9):3234-40. doi: 10.1021/acs.molpharmaceut.6b00453. Epub 2016 Aug 19.

PMID:
27518323
21.

Epidermal growth factor receptor inhibitor cancer drug gefitinib modulates cell growth and differentiation of acute myeloid leukemia cells via histamine receptors.

Yadav M, Singh AK, Kumar H, Rao G, Chakravarti B, Gurjar A, Dogra S, Kushwaha S, Vishwakarma AL, Yadav PN, Datta D, Tripathi AK, Chattopadhyay N, Trivedi AK, Sanyal S.

Biochim Biophys Acta. 2016 Oct;1860(10):2178-90. doi: 10.1016/j.bbagen.2016.05.011. Epub 2016 May 11.

PMID:
27180173
22.

Epigenetic regulation of G protein coupled receptor signaling and its implications in psychiatric disorders.

Dogra S, Sona C, Kumar A, Yadav PN.

Int J Biochem Cell Biol. 2016 Aug;77(Pt B):226-39. doi: 10.1016/j.biocel.2016.03.012. Epub 2016 Mar 29. Review.

PMID:
27046448
23.

Tango assay for ligand-induced GPCR-β-arrestin2 interaction: Application in drug discovery.

Dogra S, Sona C, Kumar A, Yadav PN.

Methods Cell Biol. 2016;132:233-54. doi: 10.1016/bs.mcb.2015.11.001. Epub 2015 Dec 24.

PMID:
26928547
24.

Biased agonism at kappa opioid receptors: Implication in pain and mood disorders.

Dogra S, Yadav PN.

Eur J Pharmacol. 2015 Sep 15;763(Pt B):184-90. doi: 10.1016/j.ejphar.2015.07.018. Epub 2015 Jul 8. Review.

PMID:
26164787
25.

Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors.

Singh N, Yadav M, Singh AK, Kumar H, Dwivedi SK, Mishra JS, Gurjar A, Manhas A, Chandra S, Yadav PN, Jagavelu K, Siddiqi MI, Trivedi AK, Chattopadhyay N, Sanyal S.

Mol Endocrinol. 2014 May;28(5):659-73. doi: 10.1210/me.2013-1353. Epub 2014 Mar 5.

26.

Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents.

Shakya B, Yadav PN, Ueda JY, Awale S.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):458-61. doi: 10.1016/j.bmcl.2013.12.044. Epub 2013 Dec 18.

PMID:
24380769
27.

A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.

Farrell MS, Pei Y, Wan Y, Yadav PN, Daigle TL, Urban DJ, Lee HM, Sciaky N, Simmons A, Nonneman RJ, Huang XP, Hufeisen SJ, Guettier JM, Moy SS, Wess J, Caron MG, Calakos N, Roth BL.

Neuropsychopharmacology. 2013 Apr;38(5):854-62. doi: 10.1038/npp.2012.251. Epub 2012 Dec 5.

28.

Intestinal epithelial cell-derived μ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling.

Goldsmith JR, Perez-Chanona E, Yadav PN, Whistler J, Roth B, Jobin C.

Am J Pathol. 2013 Mar;182(3):776-85. doi: 10.1016/j.ajpath.2012.11.021. Epub 2013 Jan 2.

29.

Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.

Allen JA, Yost JM, Setola V, Chen X, Sassano MF, Chen M, Peterson S, Yadav PN, Huang XP, Feng B, Jensen NH, Che X, Bai X, Frye SV, Wetsel WC, Caron MG, Javitch JA, Roth BL, Jin J.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18488-93. doi: 10.1073/pnas.1104807108. Epub 2011 Oct 24.

30.

Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo.

Yadav PN, Kroeze WK, Farrell MS, Roth BL.

J Pharmacol Exp Ther. 2011 Oct;339(1):99-105. doi: 10.1124/jpet.111.183780. Epub 2011 Jul 7.

31.

Synthesis and biological activities of 4-N-(anilinyl-n-[oxazolyl])-7-chloroquinolines (n=3' or 4') against Plasmodium falciparum in in vitro models.

Gordey EE, Yadav PN, Merrin MP, Davies J, Ward SA, Woodman GM, Sadowy AL, Smith TG, Gossage RA.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4512-5. doi: 10.1016/j.bmcl.2011.05.131. Epub 2011 Jun 15.

PMID:
21723121
32.

Schizophrenia risk gene CAV1 is both pro-psychotic and required for atypical antipsychotic drug actions in vivo.

Allen JA, Yadav PN, Setola V, Farrell M, Roth BL.

Transl Psychiatry. 2011 Aug 16;1:e33. doi: 10.1038/tp.2011.35.

33.

The presynaptic component of the serotonergic system is required for clozapine's efficacy.

Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, Roth BL.

Neuropsychopharmacology. 2011 Feb;36(3):638-51. doi: 10.1038/npp.2010.195. Epub 2010 Nov 3.

34.

CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling.

Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, Drysdale L, Poulter MO, Roth BL, Pin JP, Anisman H, Ferguson SS.

Nat Neurosci. 2010 May;13(5):622-9. doi: 10.1038/nn.2529. Epub 2010 Apr 11.

35.

Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment.

Huang XP, Setola V, Yadav PN, Allen JA, Rogan SC, Hanson BJ, Revankar C, Robers M, Doucette C, Roth BL.

Mol Pharmacol. 2009 Oct;76(4):710-22. doi: 10.1124/mol.109.058057. Epub 2009 Jul 1.

36.

PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.

Abbas AI, Yadav PN, Yao WD, Arbuckle MI, Grant SG, Caron MG, Roth BL.

J Neurosci. 2009 Jun 3;29(22):7124-36. doi: 10.1523/JNEUROSCI.1090-09.2009.

37.

Purification and mass spectrometric analysis of the kappa opioid receptor.

Wannemacher KM, Terskiy A, Bian S, Yadav PN, Li H, Howells RD.

Brain Res. 2008 Sep 16;1230:13-26. doi: 10.1016/j.brainres.2008.06.121. Epub 2008 Jul 12.

38.

Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases.

Allen JA, Yadav PN, Roth BL.

Neuropharmacology. 2008 Nov;55(6):961-8. doi: 10.1016/j.neuropharm.2008.06.048. Epub 2008 Jul 2. Review.

39.
40.

Search of the human proteome for endomorphin-1 and endomorphin-2 precursor proteins.

Terskiy A, Wannemacher KM, Yadav PN, Tsai M, Tian B, Howells RD.

Life Sci. 2007 Nov 30;81(23-24):1593-601. Epub 2007 Oct 5.

41.
43.
44.

Zinc(II) complexes derived from pyridine-2-carbaldehyde thiosemicarbazone and (1E)-1-pyridin-2-ylethan-1-one thiosemicarbazone. Synthesis, crystal structures and antiproliferative activity of zinc(II) complexes.

Kovala-Demertzi D, Yadav PN, Wiecek J, Skoulika S, Varadinova T, Demertzis MA.

J Inorg Biochem. 2006 Sep;100(9):1558-67. Epub 2006 May 27.

PMID:
16828164
45.

Platinum(II) and palladium(II) complexes with 2-acetyl pyridine 4N-ethyl thiosemicarbazone able to overcome the cis-platin resistance. Structure, antibacterial activity and DNA strand breakage.

Kovala-Demertzi D, Demertzis MA, Filiou E, Pantazaki AA, Yadav PN, Miller JR, Zheng Y, Kyriakidis DA.

Biometals. 2003 Sep;16(3):411-8.

PMID:
12680703
47.
49.

Platinum(II) and palladium(II) complexes with 2-acetylpyridine thiosemicarbazone: cytogenetic and antineoplastic effects.

Lakovidou Z, Papageorgiou A, Demertzis MA, Mioglou E, Mourelatos D, Kotsis A, Yadav PN, Kovala-Demertzi D.

Anticancer Drugs. 2001 Jan;12(1):65-70.

PMID:
11272288
50.

Supplemental Content

Loading ...
Support Center