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Items: 1 to 50 of 68

1.

Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders.

Rao X, Thapa KS, Chen AB, Lin H, Gao H, Reiter JL, Hargreaves KA, Ipe J, Lai D, Xuei X, Wang Y, Gu H, Kapoor M, Farris SP, Tischfield J, Foroud T, Goate AM, Skaar TC, Mayfield RD, Edenberg HJ, Liu Y.

Mol Psychiatry. 2019 Sep 2. doi: 10.1038/s41380-019-0508-z. [Epub ahead of print]

PMID:
31477794
2.

Ethanol activates immune response in lymphoblastoid cells.

McClintick JN, Tischfield JA, Deng L, Kapoor M, Xuei X, Edenberg HJ.

Alcohol. 2019 Sep;79:81-91. doi: 10.1016/j.alcohol.2019.01.001. Epub 2019 Jan 9.

PMID:
30639126
3.

High glucose alters fetal rat islet transcriptome and induces progeny islet dysfunction.

Casasnovas J, Jo Y, Rao X, Xuei X, Brown ME, Kua KL.

J Endocrinol. 2019 Feb 1;240(2):309-323. doi: 10.1530/JOE-18-0493.

PMID:
30508415
4.

Angiotensin-related genetic determinants of cardiovascular disease in patients undergoing hemodialysis.

Moe SM, Long J, Schwantes-An TL, Decker BS, Wetherill L, Edenberg HJ, Xuei X, Vatta M, Foroud TM, Chertow GM.

Nephrol Dial Transplant. 2019 Nov 1;34(11):1924-1931. doi: 10.1093/ndt/gfy191.

5.

Gene expression changes in the ventral hippocampus and medial prefrontal cortex of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking.

McClintick JN, McBride WJ, Bell RL, Ding ZM, Liu Y, Xuei X, Edenberg HJ.

Alcohol. 2018 May;68:37-47. doi: 10.1016/j.alcohol.2017.09.002. Epub 2017 Sep 14.

6.

RareVar: A Framework for Detecting Low-Frequency Single-Nucleotide Variants.

Hao Y, Xuei X, Li L, Nakshatri H, Edenberg HJ, Liu Y.

J Comput Biol. 2017 Jul;24(7):637-646. doi: 10.1089/cmb.2017.0057. Epub 2017 May 25.

7.

Statistical modeling for sensitive detection of low-frequency single nucleotide variants.

Hao Y, Zhang P, Xuei X, Nakshatri H, Edenberg HJ, Li L, Liu Y.

BMC Genomics. 2016 Aug 22;17 Suppl 7:514. doi: 10.1186/s12864-016-2905-x.

8.

High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model.

Lo CL, Lossie AC, Liang T, Liu Y, Xuei X, Lumeng L, Zhou FC, Muir WM.

PLoS Genet. 2016 Aug 4;12(8):e1006178. doi: 10.1371/journal.pgen.1006178. eCollection 2016 Aug.

9.

Gene Expression Changes in Glutamate and GABA-A Receptors, Neuropeptides, Ion Channels, and Cholesterol Synthesis in the Periaqueductal Gray Following Binge-Like Alcohol Drinking by Adolescent Alcohol-Preferring (P) Rats.

McClintick JN, McBride WJ, Bell RL, Ding ZM, Liu Y, Xuei X, Edenberg HJ.

Alcohol Clin Exp Res. 2016 May;40(5):955-68. doi: 10.1111/acer.13056. Epub 2016 Apr 8.

10.

Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking.

Kosobud AE, Wetherill L, Plawecki MH, Kareken DA, Liang T, Nurnberger JL, Windisch K, Xuei X, Edenberg HJ, Foroud TM, O'Connor SJ.

Alcohol Clin Exp Res. 2015 Jul;39(7):1148-57. doi: 10.1111/acer.12749. Epub 2015 Jun 19.

11.

Genome-wide association data suggest ABCB1 and immune-related gene sets may be involved in adult antisocial behavior.

Salvatore JE, Edwards AC, McClintick JN, Bigdeli TB, Adkins A, Aliev F, Edenberg HJ, Foroud T, Hesselbrock V, Kramer J, Nurnberger JI, Schuckit M, Tischfield JA, Xuei X, Dick DM.

Transl Psychiatry. 2015 Apr 28;5:e558. doi: 10.1038/tp.2015.36.

12.

Characteristics of Bipolar I patients grouped by externalizing disorders.

Swaminathan S, Koller DL, Foroud T, Edenberg HJ, Xuei X, Niculescu AB 3rd; Bipolar Genome Study (BiGS) Consortium,, Nurnberger JI Jr.

J Affect Disord. 2015 Jun 1;178:206-14. doi: 10.1016/j.jad.2015.03.011. Epub 2015 Mar 14.

13.

Gene expression changes in serotonin, GABA-A receptors, neuropeptides and ion channels in the dorsal raphe nucleus of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking.

McClintick JN, McBride WJ, Bell RL, Ding ZM, Liu Y, Xuei X, Edenberg HJ.

Pharmacol Biochem Behav. 2015 Feb;129:87-96. doi: 10.1016/j.pbb.2014.12.007. Epub 2014 Dec 24.

14.

Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression.

McClintick JN, Brooks AI, Deng L, Liang L, Wang JC, Kapoor M, Xuei X, Foroud T, Tischfield JA, Edenberg HJ.

Alcohol. 2014 Sep;48(6):603-10. doi: 10.1016/j.alcohol.2014.07.004. Epub 2014 Jul 22.

15.

Association of substance dependence phenotypes in the COGA sample.

Wetherill L, Agrawal A, Kapoor M, Bertelsen S, Bierut LJ, Brooks A, Dick D, Hesselbrock M, Hesselbrock V, Koller DL, Le N, Nurnberger JI Jr, Salvatore JE, Schuckit M, Tischfield JA, Wang JC, Xuei X, Edenberg HJ, Porjesz B, Bucholz K, Goate AM, Foroud T.

Addict Biol. 2015 May;20(3):617-27. doi: 10.1111/adb.12153. Epub 2014 May 16.

16.

SIBLING family genes and bone mineral density: association and allele-specific expression in humans.

Alam I, Padgett LR, Ichikawa S, Alkhouli M, Koller DL, Lai D, Peacock M, Xuei X, Foroud T, Edenberg HJ, Econs MJ.

Bone. 2014 Jul;64:166-72. doi: 10.1016/j.bone.2014.04.013. Epub 2014 Apr 18.

17.

Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence.

Haller G, Kapoor M, Budde J, Xuei X, Edenberg H, Nurnberger J, Kramer J, Brooks A, Tischfield J, Almasy L, Agrawal A, Bucholz K, Rice J, Saccone N, Bierut L, Goate A.

Hum Mol Genet. 2014 Feb 1;23(3):810-9. doi: 10.1093/hmg/ddt463. Epub 2013 Sep 20.

18.

Family-based association analysis of alcohol dependence criteria and severity.

Wetherill L, Kapoor M, Agrawal A, Bucholz K, Koller D, Bertelsen SE, Le N, Wang JC, Almasy L, Hesselbrock V, Kramer J, Nurnberger JI Jr, Schuckit M, Tischfield JA, Xuei X, Porjesz B, Edenberg HJ, Goate AM, Foroud T.

Alcohol Clin Exp Res. 2014 Feb;38(2):354-66. doi: 10.1111/acer.12251. Epub 2013 Sep 9.

19.

Stress-response pathways are altered in the hippocampus of chronic alcoholics.

McClintick JN, Xuei X, Tischfield JA, Goate A, Foroud T, Wetherill L, Ehringer MA, Edenberg HJ.

Alcohol. 2013 Nov;47(7):505-15. doi: 10.1016/j.alcohol.2013.07.002. Epub 2013 Aug 24.

20.

A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.

Wang JC, Foroud T, Hinrichs AL, Le NX, Bertelsen S, Budde JP, Harari O, Koller DL, Wetherill L, Agrawal A, Almasy L, Brooks AI, Bucholz K, Dick D, Hesselbrock V, Johnson EO, Kang S, Kapoor M, Kramer J, Kuperman S, Madden PA, Manz N, Martin NG, McClintick JN, Montgomery GW, Nurnberger JI Jr, Rangaswamy M, Rice J, Schuckit M, Tischfield JA, Whitfield JB, Xuei X, Porjesz B, Heath AC, Edenberg HJ, Bierut LJ, Goate AM.

Mol Psychiatry. 2013 Nov;18(11):1218-24. doi: 10.1038/mp.2012.143. Epub 2012 Oct 23.

21.

Variations in the potassium channel genes KCNK3 and KCNK9 in relation to blood pressure and aldosterone production: an exploratory study.

Jung J, Barrett PQ, Eckert GJ, Edenberg HJ, Xuei X, Tu W, Pratt JH.

J Clin Endocrinol Metab. 2012 Nov;97(11):E2160-7. doi: 10.1210/jc.2012-2196. Epub 2012 Aug 14.

22.

Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking.

Kapoor M, Wang JC, Bertelsen S, Bucholz K, Budde JP, Hinrichs A, Agrawal A, Brooks A, Chorlian D, Dick D, Hesselbrock V, Foroud T, Kramer J, Kuperman S, Manz N, Nurnberger J Jr, Porjesz B, Rice J, Tischfield J, Xuei X, Schuckit M, Edenberg HJ, Bierut LJ, Goate AM.

PLoS One. 2012;7(3):e33513. doi: 10.1371/journal.pone.0033513. Epub 2012 Mar 16.

23.

Genetic variation of GPLD1 associates with serum GPI-PLD levels: a preliminary study.

Deeg MA, Xuei X, Eckert G, Considine RV, Li YG, Pratt JH.

Biochim Biophys Acta. 2012 Mar;1821(3):381-5. doi: 10.1016/j.bbalip.2011.12.009. Epub 2012 Jan 8.

PMID:
22260953
24.

Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene.

Hartz SM, Lin P, Edenberg HJ, Xuei X, Rochberg N, Saccone S, Berrettini W, Nelson E, Nurnberger J, Bierut LJ, Rice JP; NIMH Genetics Initiative Bipolar Disorder Consortium.

Psychiatr Genet. 2011 Apr;21(2):77-84. doi: 10.1097/YPG.0b013e32834135eb.

25.

Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence.

Zlojutro M, Manz N, Rangaswamy M, Xuei X, Flury-Wetherill L, Koller D, Bierut LJ, Goate A, Hesselbrock V, Kuperman S, Nurnberger J Jr, Rice JP, Schuckit MA, Foroud T, Edenberg HJ, Porjesz B, Almasy L.

Am J Med Genet B Neuropsychiatr Genet. 2011 Jan;156B(1):44-58. doi: 10.1002/ajmg.b.31136. Epub 2010 Nov 2.

26.

Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages.

Cheng BH, Liu Y, Xuei X, Liao CP, Lu D, Lasbury ME, Durant PJ, Lee CH.

BMC Microbiol. 2010 Apr 8;10:103. doi: 10.1186/1471-2180-10-103.

27.

Genome-wide association study of alcohol dependence implicates a region on chromosome 11.

Edenberg HJ, Koller DL, Xuei X, Wetherill L, McClintick JN, Almasy L, Bierut LJ, Bucholz KK, Goate A, Aliev F, Dick D, Hesselbrock V, Hinrichs A, Kramer J, Kuperman S, Nurnberger JI Jr, Rice JP, Schuckit MA, Taylor R, Todd Webb B, Tischfield JA, Porjesz B, Foroud T.

Alcohol Clin Exp Res. 2010 May;34(5):840-52. doi: 10.1111/j.1530-0277.2010.01156.x. Epub 2010 Mar 1.

28.

Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women.

Koller DL, Ichikawa S, Lai D, Padgett LR, Doheny KF, Pugh E, Paschall J, Hui SL, Edenberg HJ, Xuei X, Peacock M, Econs MJ, Foroud T.

J Clin Endocrinol Metab. 2010 Apr;95(4):1802-9. doi: 10.1210/jc.2009-1903. Epub 2010 Feb 17.

29.

GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence.

Xuei X, Flury-Wetherill L, Dick D, Goate A, Tischfield J, Nurnberger J Jr, Schuckit M, Kramer J, Kuperman S, Hesselbrock V, Porjesz B, Foroud T, Edenberg HJ.

Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):418-427. doi: 10.1002/ajmg.b.30995.

30.

Association of adenylate cyclase 10 (ADCY10) polymorphisms and bone mineral density in healthy adults.

Ichikawa S, Koller DL, Curry LR, Lai D, Xuei X, Edenberg HJ, Hui SL, Peacock M, Foroud T, Econs MJ.

Calcif Tissue Int. 2009 Feb;84(2):97-102. doi: 10.1007/s00223-008-9200-z. Epub 2008 Dec 18.

31.

Association of the calcium-sensing receptor gene with blood pressure and urinary calcium in African-Americans.

Jung J, Foroud TM, Eckert GJ, Flury-Wetherill L, Edenberg HJ, Xuei X, Zaidi SA, Pratt JH.

J Clin Endocrinol Metab. 2009 Mar;94(3):1042-8. doi: 10.1210/jc.2008-1861. Epub 2008 Dec 9.

32.

Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder.

Liu L, Foroud T, Xuei X, Berrettini W, Byerley W, Coryell W, El-Mallakh R, Gershon ES, Kelsoe JR, Lawson WB, MacKinnon DF, McInnis M, McMahon FJ, Murphy DL, Rice J, Scheftner W, Zandi PP, Lohoff FW, Niculescu AB, Meyer ET, Edenberg HJ, Nurnberger JI Jr.

Psychiatr Genet. 2008 Dec;18(6):267-74. doi: 10.1097/YPG.0b013e3283060f59.

33.

Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.

Agrawal A, Wetherill L, Dick DM, Xuei X, Hinrichs A, Hesselbrock V, Kramer J, Nurnberger JI Jr, Schuckit M, Bierut LJ, Edenberg HJ, Foroud T.

Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 5;150B(5):736-40. doi: 10.1002/ajmg.b.30881.

34.

Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence.

Wetherill L, Schuckit MA, Hesselbrock V, Xuei X, Liang T, Dick DM, Kramer J, Nurnberger JI Jr, Tischfield JA, Porjesz B, Edenberg HJ, Foroud T.

Alcohol Clin Exp Res. 2008 Dec;32(12):2031-40. doi: 10.1111/j.1530-0277.2008.00790.x. Epub 2008 Sep 25.

35.

CLCN7 polymorphisms and bone mineral density in healthy premenopausal white women and in white men.

Chu K, Koller DL, Ichikawa S, Snyder R, Curry L, Lai D, Austin A, Xuei X, Edenberg HJ, Hui SL, Foroud TM, Peacock M, Econs MJ.

Bone. 2008 Dec;43(6):995-8. doi: 10.1016/j.bone.2008.07.249. Epub 2008 Aug 8.

36.

Variants in nicotinic receptors and risk for nicotine dependence.

Bierut LJ, Stitzel JA, Wang JC, Hinrichs AL, Grucza RA, Xuei X, Saccone NL, Saccone SF, Bertelsen S, Fox L, Horton WJ, Breslau N, Budde J, Cloninger CR, Dick DM, Foroud T, Hatsukami D, Hesselbrock V, Johnson EO, Kramer J, Kuperman S, Madden PA, Mayo K, Nurnberger J Jr, Pomerleau O, Porjesz B, Reyes O, Schuckit M, Swan G, Tischfield JA, Edenberg HJ, Rice JP, Goate AM.

Am J Psychiatry. 2008 Sep;165(9):1163-71. doi: 10.1176/appi.ajp.2008.07111711. Epub 2008 Jun 2.

37.

Identification of a linkage disequilibrium block in chromosome 1q associated with BMD in premenopausal white women.

Ichikawa S, Koller DL, Curry LR, Lai D, Xuei X, Pugh EW, Tsai YY, Doheny KF, Edenberg HJ, Hui SL, Foroud T, Peacock M, Econs MJ.

J Bone Miner Res. 2008 Oct;23(10):1680-8. doi: 10.1359/jbmr.080509.

38.

The tachykinin receptor 3 is associated with alcohol and cocaine dependence.

Foroud T, Wetherill LF, Kramer J, Tischfield JA, Nurnberger JI Jr, Schuckit MA, Xuei X, Edenberg HJ.

Alcohol Clin Exp Res. 2008 Jun;32(6):1023-30. doi: 10.1111/j.1530-0277.2008.00663.x. Epub 2008 Apr 15.

39.

Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence.

Wang JC, Grucza R, Cruchaga C, Hinrichs AL, Bertelsen S, Budde JP, Fox L, Goldstein E, Reyes O, Saccone N, Saccone S, Xuei X, Bucholz K, Kuperman S, Nurnberger J Jr, Rice JP, Schuckit M, Tischfield J, Hesselbrock V, Porjesz B, Edenberg HJ, Bierut LJ, Goate AM.

Mol Psychiatry. 2009 May;14(5):501-10. doi: 10.1038/mp.2008.42. Epub 2008 Apr 15.

40.

A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence.

Edenberg HJ, Wang J, Tian H, Pochareddy S, Xuei X, Wetherill L, Goate A, Hinrichs T, Kuperman S, Nurnberger JI Jr, Schuckit M, Tischfield JA, Foroud T.

Hum Mol Genet. 2008 Jun 15;17(12):1783-9. doi: 10.1093/hmg/ddn068. Epub 2008 Mar 4.

41.

A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9.

Dick DM, Aliev F, Wang JC, Saccone S, Hinrichs A, Bertelsen S, Budde J, Saccone N, Foroud T, Nurnberger J Jr, Xuei X, Conneally PM, Schuckit M, Almasy L, Crowe R, Kuperman S, Kramer J, Tischfield JA, Hesselbrock V, Edenberg HJ, Porjesz B, Rice JP, Bierut L, Goate A.

Biol Psychiatry. 2008 Jun 1;63(11):1047-53. doi: 10.1016/j.biopsych.2007.11.005. Epub 2007 Dec 27.

42.

Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence.

Edenberg HJ, Xuei X, Wetherill LF, Bierut L, Bucholz K, Dick DM, Hesselbrock V, Kuperman S, Porjesz B, Schuckit MA, Tischfield JA, Almasy LA, Nurnberger JI Jr, Foroud T.

Hum Mol Genet. 2008 Apr 1;17(7):963-70. Epub 2007 Dec 12.

PMID:
18079108
43.

Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence.

Xuei X, Flury-Wetherill L, Almasy L, Bierut L, Tischfield J, Schuckit M, Nurnberger JI Jr, Foroud T, Edenberg HJ.

Addict Biol. 2008 Mar;13(1):80-7. Epub 2007 Oct 2.

PMID:
17910740
44.

Association studies of ALOX5 and bone mineral density in healthy adults.

Foroud T, Ichikawa S, Koller D, Lai D, Curry L, Xuei X, Edenberg HJ, Hui S, Peacock M, Econs MJ.

Osteoporos Int. 2008 May;19(5):637-43. Epub 2007 Oct 2.

45.

Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase.

Foroud T, Wetherill LF, Dick DM, Hesselbrock V, Nurnberger JI Jr, Kramer J, Tischfield J, Schuckit M, Bierut LJ, Xuei X, Edenberg HJ.

Alcohol Clin Exp Res. 2007 Nov;31(11):1773-9. Epub 2007 Sep 11.

PMID:
17850222
46.

The opioid system in alcohol and drug dependence: family-based association study.

Xuei X, Flury-Wetherill L, Bierut L, Dick D, Nurnberger J Jr, Foroud T, Edenberg HJ.

Am J Med Genet B Neuropsychiatr Genet. 2007 Oct 5;144B(7):877-84.

PMID:
17503481
47.

Association of alcohol craving with alpha-synuclein (SNCA).

Foroud T, Wetherill LF, Liang T, Dick DM, Hesselbrock V, Kramer J, Nurnberger J, Schuckit M, Carr L, Porjesz B, Xuei X, Edenberg HJ.

Alcohol Clin Exp Res. 2007 Apr;31(4):537-45.

PMID:
17374032
48.

Association of the kappa-opioid system with alcohol dependence.

Xuei X, Dick D, Flury-Wetherill L, Tian HJ, Agrawal A, Bierut L, Goate A, Bucholz K, Schuckit M, Nurnberger J Jr, Tischfield J, Kuperman S, Porjesz B, Begleiter H, Foroud T, Edenberg HJ.

Mol Psychiatry. 2006 Nov;11(11):1016-24. Epub 2006 Aug 22.

PMID:
16924269
49.

Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample.

Dick DM, Plunkett J, Wetherill LF, Xuei X, Goate A, Hesselbrock V, Schuckit M, Crowe R, Edenberg HJ, Foroud T.

Alcohol Clin Exp Res. 2006 Jul;30(7):1101-10.

PMID:
16792556
50.

Human ALOX12, but not ALOX15, is associated with BMD in white men and women.

Ichikawa S, Koller DL, Johnson ML, Lai D, Xuei X, Edenberg HJ, Klein RF, Orwoll ES, Hui SL, Foroud TM, Peacock M, Econs MJ.

J Bone Miner Res. 2006 Apr;21(4):556-64. Epub 2006 Apr 5.

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