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Items: 12

1.

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.

Wang X, Barbosa J, Blomgren P, Bremer MC, Chen J, Crawford JJ, Deng W, Dong L, Eigenbrot C, Gallion S, Hau J, Hu H, Johnson AR, Katewa A, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Mitchell SA, Ortwine DF, DiPaolo J, Reif K, Scheerens H, Schmitt A, Wong H, Xiong JM, Xu J, Zhao Z, Zhou F, Currie KS, Young WB.

ACS Med Chem Lett. 2017 May 3;8(6):608-613. doi: 10.1021/acsmedchemlett.7b00103. eCollection 2017 Jun 8.

2.

The CD25-binding antibody Daclizumab High-Yield Process has a distinct glycosylation pattern and reduced antibody-dependent cell-mediated cytotoxicity in comparison to Zenapax®.

Ganguly B, Balasa B, Efros L, Hinton PR, Hartman S, Thakur A, Xiong JM, Schmidt B, Robinson RR, Sornasse T, Vexler V, Sheridan JP.

MAbs. 2016 Oct;8(7):1417-1424. Epub 2016 Jul 1.

3.

Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.

Young WB, Barbosa J, Blomgren P, Bremer MC, Crawford JJ, Dambach D, Eigenbrot C, Gallion S, Johnson AR, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Mitchell SA, Ortwine DF, Di Paolo J, Reif K, Scheerens H, Schmitt A, Wang X, Wong H, Xiong JM, Xu J, Yu C, Zhao Z, Currie KS.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):575-579. doi: 10.1016/j.bmcl.2015.11.076. Epub 2015 Nov 24.

PMID:
26675441
4.

A Split-Face Study of Dual-Wavelength Laser on Neck and Facial Port-Wine Stains in Chinese Patients.

Tu HD, Li YH, Xie HF, Xiong JM, Wang B, Xu XG, Tong LG, Gold MH, Chen HD.

J Drugs Dermatol. 2015 Nov;14(11):1336-40.

PMID:
26580884
5.

Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.

Young WB, Barbosa J, Blomgren P, Bremer MC, Crawford JJ, Dambach D, Gallion S, Hymowitz SG, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Maurer B, Mitchell SA, Ortwine DF, Di Paolo J, Reif K, Scheerens H, Schmitt A, Sowell CG, Wang X, Wong H, Xiong JM, Xu J, Zhao Z, Currie KS.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1333-7. doi: 10.1016/j.bmcl.2015.01.032. Epub 2015 Feb 7.

PMID:
25701252
6.

The human G1m1 allotype associates with CD4+ T-cell responsiveness to a highly conserved IgG1 constant region peptide and confers an asparaginyl endopeptidase cleavage site.

Stickler MM, Reddy A, Xiong JM, Hinton PR, DuBridge R, Harding FA.

Genes Immun. 2011 Apr;12(3):213-21. doi: 10.1038/gene.2010.68. Epub 2011 Feb 17.

7.

Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4.

Mitchell SA, Danca MD, Blomgren PA, Darrow JW, Currie KS, Kropf JE, Lee SH, Gallion SL, Xiong JM, Pippin DA, DeSimone RW, Brittelli DR, Eustice DC, Bourret A, Hill-Drzewi M, Maciejewski PM, Elkin LL.

Bioorg Med Chem Lett. 2009 Dec 15;19(24):6991-5. doi: 10.1016/j.bmcl.2009.10.037. Epub 2009 Oct 15.

PMID:
19879134
8.

An engineered human IgG1 antibody with longer serum half-life.

Hinton PR, Xiong JM, Johlfs MG, Tang MT, Keller S, Tsurushita N.

J Immunol. 2006 Jan 1;176(1):346-56.

9.

Engineered human IgG antibodies with longer serum half-lives in primates.

Hinton PR, Johlfs MG, Xiong JM, Hanestad K, Ong KC, Bullock C, Keller S, Tang MT, Tso JY, Vásquez M, Tsurushita N.

J Biol Chem. 2004 Feb 20;279(8):6213-6. Epub 2003 Dec 29.

10.

[Teratologic studies of methyl 5-aminosalicylate and salicylazopyridine].

Xiong JM, Liang B, Mo YQ, Chen ZH.

Zhongguo Yao Li Xue Bao. 1992 May;13(3):265-7. Chinese.

11.

[Effects of acetylgastrodin on vertebral and internal carotid artery blood flow in anesthetized dogs and rabbits].

Chen ZH, Zhang ZX, Wang XH, Xiang JM, Xiong JM, Mo YQ.

Zhongguo Yao Li Xue Bao. 1987 Jul;8(4):321-5. Chinese. No abstract available.

12.

[Influences of acetagastrodin on fetuses of mice and rats].

Xiong JM, Mo YQ, Liang B, Chen ZH, Deng SX.

Zhongguo Yao Li Xue Bao. 1987 Jan;8(1):57-9. Chinese. No abstract available.

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