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Reply to Gleicher and Barad: Noninvasive preimplantation genetic testing may provide the solution to the problem of embryo mosaicism.

Huang L, Lu S, Racowsky C, Xie XS.

Proc Natl Acad Sci U S A. 2019 Oct 1. pii: 201912042. doi: 10.1073/pnas.1912042116. [Epub ahead of print] No abstract available.


UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expres7sion of PDK1 through PI3K/AKT signaling.

Lin JX, Xie XS, Weng XF, Qiu SL, Yoon C, Lian NZ, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Yang YH, Huang CM, Zheng CH, Li P.

J Exp Clin Cancer Res. 2019 Sep 18;38(1):410. doi: 10.1186/s13046-019-1416-4.


Diseases Have No Borders, Neither Should Research!

Xie XS.

Cell. 2019 Sep 5;178(6):1275-1276. doi: 10.1016/j.cell.2019.07.053. Epub 2019 Aug 15.


Noninvasive preimplantation genetic testing for aneuploidy in spent medium may be more reliable than trophectoderm biopsy.

Huang L, Bogale B, Tang Y, Lu S, Xie XS, Racowsky C.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14105-14112. doi: 10.1073/pnas.1907472116. Epub 2019 Jun 24.


Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.

Li M, Zhang CS, Zong Y, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC.

Cell Metab. 2019 Sep 3;30(3):508-524.e12. doi: 10.1016/j.cmet.2019.05.018. Epub 2019 Jun 13.


Bayesian model for accurate MARSALA (mutated allele revealed by sequencing with aneuploidy and linkage analyses).

Xiong L, Huang L, Tian F, Lu S, Xie XS.

J Assist Reprod Genet. 2019 Jun;36(6):1263-1271. doi: 10.1007/s10815-019-01451-8. Epub 2019 Jun 11.


Inferring the Evolution and Progression of Small-Cell Lung Cancer by Single-Cell Sequencing of Circulating Tumor Cells.

Su Z, Wang Z, Ni X, Duan J, Gao Y, Zhuo M, Li R, Zhao J, Ma Q, Bai H, Chen H, Wang S, Chen X, An T, Wang Y, Tian Y, Yu J, Wang D, Xie XS, Bai F, Wang J.

Clin Cancer Res. 2019 Aug 15;25(16):5049-5060. doi: 10.1158/1078-0432.CCR-18-3571. Epub 2019 May 21.


[NPM1 High Mutant Allele Burden is an Adverse Prognostic Factor for AML Patients with Mutated NPM1].

Hou JX, Wang SJ, Liu YF, Hao QQ, Wang C, Li T, Bai JJ, Liao LX, Guo CY, Chang YY, Wang M, Sun H, Xie XS, Jiang ZX.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Apr;27(2):365-372. doi: 10.19746/j.cnki.issn.1009-2137.2019.02.009. Chinese.


Three-dimensional genome structures of single sensory neurons in mouse visual and olfactory systems.

Tan L, Xing D, Daley N, Xie XS.

Nat Struct Mol Biol. 2019 Apr;26(4):297-307. doi: 10.1038/s41594-019-0205-2. Epub 2019 Apr 1.


Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3β/cyclin D1 signaling pathway.

Lin JX, Xie XS, Weng XF, Qiu SL, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Li P, Huang CM, Zheng CH.

Oncol Rep. 2019 May;41(5):2739-2752. doi: 10.3892/or.2019.7042. Epub 2019 Mar 5.


The blood transcriptional signature for active and latent tuberculosis.

Deng M, Lv XD, Fang ZX, Xie XS, Chen WY.

Infect Drug Resist. 2019 Jan 30;12:321-328. doi: 10.2147/IDR.S184640. eCollection 2019.


Direct activation of G-protein-gated inward rectifying K+ channels promotes nonrapid eye movement sleep.

Zou B, Cao WS, Guan Z, Xiao K, Pascual C, Xie J, Zhang J, Xie J, Kayser F, Lindsley CW, Weaver CD, Fang J, Xie XS.

Sleep. 2019 Mar 1;42(3). pii: zsy244. doi: 10.1093/sleep/zsy244.


The prognostic value of Cyclin-Dependent Kinase 5 and Protein Phosphatase 2A in Gastric Cancer.

Lin JX, Xie XS, Weng XF, Zheng CH, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Huang CM, Li P.

J Cancer. 2018 Oct 22;9(23):4404-4412. doi: 10.7150/jca.27015. eCollection 2018.


Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma.

Randall EC, Emdal KB, Laramy JK, Kim M, Roos A, Calligaris D, Regan MS, Gupta SK, Mladek AC, Carlson BL, Johnson AJ, Lu FK, Xie XS, Joughin BA, Reddy RJ, Peng S, Abdelmoula WM, Jackson PR, Kolluri A, Kellersberger KA, Agar JN, Lauffenburger DA, Swanson KR, Tran NL, Elmquist WF, White FM, Sarkaria JN, Agar NYR.

Nat Commun. 2018 Nov 21;9(1):4904. doi: 10.1038/s41467-018-07334-3.


Label-free imaging of amyloid plaques in Alzheimer's disease with stimulated Raman scattering microscopy.

Ji M, Arbel M, Zhang L, Freudiger CW, Hou SS, Lin D, Yang X, Bacskai BJ, Xie XS.

Sci Adv. 2018 Nov 16;4(11):eaat7715. doi: 10.1126/sciadv.aat7715. eCollection 2018 Nov.


[Evaluation on safety of puerarin injection in clinical use].

Xie XS, Dong YZ, Mu DP, Pan XL, Zhang FY.

Zhongguo Zhong Yao Za Zhi. 2018 Oct;43(19):3956-3961. doi: 10.19540/j.cnki.cjcmm.20180709.008. Chinese.


[The Role of TSP-1-CD47 in ROS-mediated Pulmonary Fibrosis Induced by Paraquat].

Gao W, Xie XS.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2018 Sep 20;36(9):653-661. doi: 10.3760/cma.j.issn.1001-9391.2018.09.003. Chinese.


Multiregion Sequencing Reveals the Genetic Heterogeneity and Evolutionary History of Osteosarcoma and Matched Pulmonary Metastases.

Wang D, Niu X, Wang Z, Song CL, Huang Z, Chen KN, Duan J, Bai H, Xu J, Zhao J, Wang Y, Zhuo M, Xie XS, Kang X, Tian Y, Cai L, Han JF, An T, Sun Y, Gao S, Zhao J, Ying J, Wang L, He J, Wang J.

Cancer Res. 2019 Jan 1;79(1):7-20. doi: 10.1158/0008-5472.CAN-18-1086. Epub 2018 Nov 2.


CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming.

Liu Y, Yu C, Daley TP, Wang F, Cao WS, Bhate S, Lin X, Still C 2nd, Liu H, Zhao D, Wang H, Xie XS, Ding S, Wong WH, Wernig M, Qi LS.

Cell Stem Cell. 2018 Nov 1;23(5):758-771.e8. doi: 10.1016/j.stem.2018.09.003. Epub 2018 Oct 11.


Chronic intermittent nicotine delivery via lung alveolar region-targeted aerosol technology produces circadian pharmacokinetics in rats resembling human smokers.

Shao XM, Liu S, Lee ES, Fung D, Pei H, Liang J, Mudgway R, Zhang J, Feldman JL, Zhu Y, Louie S, Xie XS.

J Appl Physiol (1985). 2018 Nov 1;125(5):1555-1562. doi: 10.1152/japplphysiol.00357.2018. Epub 2018 Sep 20.


Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer.

Lin JX, Xie XS, Weng XF, Zheng CH, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Li P, Huang CM.

World J Gastroenterol. 2018 Sep 14;24(34):3898-3907. doi: 10.3748/wjg.v24.i34.3898.


Three-dimensional genome structures of single diploid human cells.

Tan L, Xing D, Chang CH, Li H, Xie XS.

Science. 2018 Aug 31;361(6405):924-928. doi: 10.1126/science.aat5641. Epub 2018 Aug 30.


[Long Non Coding RNA RP11-69I8.3 Expression in Acute Leukemia and Its Cinical Significance].

Si JJ, Wang WM, Yu D, Gan SL, Wu FF, Sun L, Wan DM, Xie XS, Liu YF, Wang C, Sun H.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Aug;26(4):978-983. doi: 10.7534/j.issn.1009-2137.2018.04.006. Chinese.


Optimization of Optomotor Response-based Visual Function Assessment in Mice.

Shi C, Yuan X, Chang K, Cho KS, Xie XS, Chen DF, Luo G.

Sci Rep. 2018 Jun 26;8(1):9708. doi: 10.1038/s41598-018-27329-w.


Single cell genomics to study DNA and chromosome changes in human gametes and embryos.

Blanshard RC, Chen C, Xie XS, Hoffmann ER.

Methods Cell Biol. 2018;144:441-457. doi: 10.1016/bs.mcb.2018.03.037. Epub 2018 Apr 24.


A Near-Complete Spatial Map of Olfactory Receptors in the Mouse Main Olfactory Epithelium.

Tan L, Xie XS.

Chem Senses. 2018 Jul 5;43(6):427-432. doi: 10.1093/chemse/bjy030.


Genotyping single-sperm cells by universal MARSALA enables the acquisition of linkage information for combined pre-implantation genetic diagnosis and genome screening.

Wu H, Shen X, Huang L, Zeng Y, Gao Y, Shao L, Lu B, Zhong Y, Miao B, Xu Y, Wang Y, Li Y, Xiong L, Lu S, Xie XS, Zhou C.

J Assist Reprod Genet. 2018 Jun;35(6):1071-1078. doi: 10.1007/s10815-018-1158-9. Epub 2018 May 22.


Computational Fragment-Based Drug Design: Current Trends, Strategies, and Applications.

Bian Y, Xie XS.

AAPS J. 2018 Apr 9;20(3):59. doi: 10.1208/s12248-018-0216-7. Review.


Relatively slow stochastic gene-state switching in the presence of positive feedback significantly broadens the region of bimodality through stabilizing the uninduced phenotypic state.

Ge H, Wu P, Qian H, Xie XS.

PLoS Comput Biol. 2018 Mar 12;14(3):e1006051. doi: 10.1371/journal.pcbi.1006051. eCollection 2018 Mar.


[The roles of TSP-1 and its receptor CD47 in pathogenesis of paraquat-induced pulmonary fibrosis in rats].

Zhang J, Liu KX, Gao W, Xie XS.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2017 Dec 20;35(12):881-887. doi: 10.3760/cma.j.issn.1001-9391.2017.12.001. Chinese.


[Expression of Long-Chain Non-coding RNA RP11-87C12.5 in Acute Lymphocytic Leukemia and Its Cinical Significance].

Yu D, Wang WM, Wu FF, Ma P, Sun L, Wan DM, Liu YF, Xie XS, Wang C, Sun H.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Feb;26(1):26-31. doi: 10.7534/j.issn.1009-2137.2018.01.005. Chinese.


The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population.

Cai MY, Cheng J, Zhou MY, Liang LL, Lian SM, Xie XS, Xu S, Liu X, Xiong XD.

Lipids Health Dis. 2018 Jan 6;17(1):7. doi: 10.1186/s12944-017-0652-x.


Human fibulin-3 protein variant expresses anti-cancer effects in the malignant glioma extracellular compartment in intracranial xenograft models.

Li Y, Hu Y, Liu C, Wang Q, Han X, Han Y, Xie XS, Chen XH, Li X, Siegel ER, Afrasiabi K, Linskey ME, Zhou YX, Zhou YH.

Oncotarget. 2017 Nov 9;8(63):106311-106323. doi: 10.18632/oncotarget.22344. eCollection 2017 Dec 5.


The relationship between stromal cell derived SPARC in human gastric cancer tissue and its clinicopathologic significance.

Gao Y, Yin SP, Xie XS, Xu DD, Du WD.

Oncotarget. 2017 Sep 21;8(49):86240-86252. doi: 10.18632/oncotarget.21133. eCollection 2017 Oct 17.


A risk prediction system of postoperative hemorrhage following laparoscopy-assisted radical gastrectomy with D2 lymphadenectomy for primary gastric cancer.

Xie XS, Lin JX, Li P, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Huang CM, Zheng CH.

Oncotarget. 2017 Sep 11;8(46):81511-81519. doi: 10.18632/oncotarget.20828. eCollection 2017 Oct 6.


Highly accurate fluorogenic DNA sequencing with information theory-based error correction.

Chen Z, Zhou W, Qiao S, Kang L, Duan H, Xie XS, Huang Y.

Nat Biotechnol. 2017 Dec;35(12):1170-1178. doi: 10.1038/nbt.3982. Epub 2017 Nov 6.


Mapping allele with resolved carrier status of Robertsonian and reciprocal translocation in human preimplantation embryos.

Xu J, Zhang Z, Niu W, Yang Q, Yao G, Shi S, Jin H, Song W, Chen L, Zhang X, Guo Y, Su Y, Hu L, Zhai J, Zhang Y, Dong F, Gao Y, Li W, Bo S, Hu M, Ren J, Huang L, Lu S, Xie XS, Sun Y.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8695-E8702. doi: 10.1073/pnas.1715053114. Epub 2017 Sep 27.


Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopy.

Orringer DA, Pandian B, Niknafs YS, Hollon TC, Boyle J, Lewis S, Garrard M, Hervey-Jumper SL, Garton HJL, Maher CO, Heth JA, Sagher O, Wilkinson DA, Snuderl M, Venneti S, Ramkissoon SH, McFadden KA, Fisher-Hubbard A, Lieberman AP, Johnson TD, Xie XS, Trautman JK, Freudiger CW, Camelo-Piragua S.

Nat Biomed Eng. 2017;1. pii: 0027. doi: 10.1038/s41551-016-0027. Epub 2017 Feb 6.


Impact of Different Levels of iPTH on All-Cause Mortality in Dialysis Patients with Secondary Hyperparathyroidism after Parathyroidectomy.

Xi QP, Xie XS, Zhang L, Zhang R, Xiao YF, Jin CG, Li YB, Wang L, Zhang XX, Du ST.

Biomed Res Int. 2017;2017:6934706. doi: 10.1155/2017/6934706. Epub 2017 Jun 5.


Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumor cells.

Gao Y, Ni X, Guo H, Su Z, Ba Y, Tong Z, Guo Z, Yao X, Chen X, Yin J, Yan Z, Guo L, Liu Y, Bai F, Xie XS, Zhang N.

Genome Res. 2017 Aug;27(8):1312-1322. doi: 10.1101/gr.216788.116. Epub 2017 May 9.


The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule.

Maezawa I, Zou B, Di Lucente J, Cao WS, Pascual C, Weerasekara S, Zhang M, Xie XS, Hua DH, Jin LW.

J Alzheimers Dis. 2017;58(2):559-574. doi: 10.3233/JAD-161175.


[Clinical Analysis for 42 Imatinib-resistant Patients with Chronic Myelogenous Leukemia].

Liu X, Gan SL, Ma J, Liu YF, Xie XS, Jiang ZX, Cheng YD, Sun H.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Apr;25(2):377-381. doi: 10.7534/j.issn.1009-2137.2017.02.012. Chinese.


Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.

Castellano JM, Mosher KI, Abbey RJ, McBride AA, James ML, Berdnik D, Shen JC, Zou B, Xie XS, Tingle M, Hinkson IV, Angst MS, Wyss-Coray T.

Nature. 2017 Apr 27;544(7651):488-492. doi: 10.1038/nature22067. Epub 2017 Apr 19.


Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI).

Chen C, Xing D, Tan L, Li H, Zhou G, Huang L, Xie XS.

Science. 2017 Apr 14;356(6334):189-194. doi: 10.1126/science.aak9787.


[Expression of CD146 in Adult and Children's Acute B Cell Lymphoblastic Leukemia and Its Significance].

Xie XQ, Wang WM, Gan SL, Chen SM, Zhang QT, Xie XS, Liu YF, Cheng YD, Liu YF, Xu XJ, Sun H.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Feb;25(1):30-34. doi: 10.7534/j.issn.1009-2137.2017.01.005. Chinese.


Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging.

Zhou Y, Wang P, Tian F, Gao G, Huang L, Wei W, Xie XS.

Cell Res. 2017 Feb;27(2):298-301. doi: 10.1038/cr.2017.9. Epub 2017 Jan 13. No abstract available.


Label-free Imaging of Neurotransmitter Acetylcholine at Neuromuscular Junctions with Stimulated Raman Scattering.

Fu D, Yang W, Xie XS.

J Am Chem Soc. 2017 Jan 18;139(2):583-586. doi: 10.1021/jacs.6b10727. Epub 2016 Dec 30.


Analgesic Microneedle Patch for Neuropathic Pain Therapy.

Xie X, Pascual C, Lieu C, Oh S, Wang J, Zou B, Xie J, Li Z, Xie J, Yeomans DC, Wu MX, Xie XS.

ACS Nano. 2017 Jan 24;11(1):395-406. doi: 10.1021/acsnano.6b06104. Epub 2016 Dec 27.


[Recent advance of cytokines in the pathogenesis of lung injury induced by paraquat poisoning].

Fang WY, Xie XS, Feng SG.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2016 Sep 20;34(9):719-721. doi: 10.3760/cma.j.issn.1001-9391.2016.09.027. Chinese. No abstract available.


Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging.

Tian F, Yang W, Mordes DA, Wang JY, Salameh JS, Mok J, Chew J, Sharma A, Leno-Duran E, Suzuki-Uematsu S, Suzuki N, Han SS, Lu FK, Ji M, Zhang R, Liu Y, Strominger J, Shneider NA, Petrucelli L, Xie XS, Eggan K.

Nat Commun. 2016 Oct 31;7:13283. doi: 10.1038/ncomms13283.

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