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Items: 43

1.

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.

Liu Z, Wang C, Yang J, Zhou B, Yang R, Ramachandran R, Abbott DW, Xiao TS.

Immunity. 2019 Jul 16;51(1):43-49.e4. doi: 10.1016/j.immuni.2019.04.017. Epub 2019 May 13.

PMID:
31097341
2.

Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis.

Rathkey JK, Zhao J, Liu Z, Chen Y, Yang J, Kondolf HC, Benson BL, Chirieleison SM, Huang AY, Dubyak GR, Xiao TS, Li X, Abbott DW.

Sci Immunol. 2018 Aug 24;3(26). pii: eaat2738. doi: 10.1126/sciimmunol.aat2738.

3.

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.

Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, Xiao TS.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797. doi: 10.1073/pnas.1800562115. Epub 2018 Jun 11.

4.

Functional and structural characterization of zebrafish ASC.

Li Y, Huang Y, Cao X, Yin X, Jin X, Liu S, Jiang J, Jiang W, Xiao TS, Zhou R, Cai G, Hu B, Jin T.

FEBS J. 2018 Jul;285(14):2691-2707. doi: 10.1111/febs.14514. Epub 2018 Jun 14.

5.

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.

Liu Z, Wang C, Rathkey JK, Yang J, Dubyak GR, Abbott DW, Xiao TS.

Structure. 2018 May 1;26(5):778-784.e3. doi: 10.1016/j.str.2018.03.002. Epub 2018 Mar 22.

6.

Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction.

Jin T, Huang M, Jiang J, Smith P, Xiao TS.

PLoS One. 2018 Jan 2;13(1):e0190547. doi: 10.1371/journal.pone.0190547. eCollection 2018.

7.

The G-quadruplex (G4) resolvase DHX36 efficiently and specifically disrupts DNA G4s via a translocation-based helicase mechanism.

Yangyuoru PM, Bradburn DA, Liu Z, Xiao TS, Russell R.

J Biol Chem. 2018 Feb 9;293(6):1924-1932. doi: 10.1074/jbc.M117.815076. Epub 2017 Dec 21.

8.

Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase.

Perez JM, Chen Y, Xiao TS, Abbott DW.

J Biol Chem. 2018 Jan 19;293(3):1100-1105. doi: 10.1074/jbc.RA117.000408. Epub 2017 Dec 6.

9.

Live-cell visualization of gasdermin D-driven pyroptotic cell death.

Rathkey JK, Benson BL, Chirieleison SM, Yang J, Xiao TS, Dubyak GR, Huang AY, Abbott DW.

J Biol Chem. 2017 Sep 1;292(35):14649-14658. doi: 10.1074/jbc.M117.797217. Epub 2017 Jul 18.

10.

Design of an expression system to enhance MBP-mediated crystallization.

Jin T, Chuenchor W, Jiang J, Cheng J, Li Y, Fang K, Huang M, Smith P, Xiao TS.

Sci Rep. 2017 Jan 23;7:40991. doi: 10.1038/srep40991.

11.

RAGE Enhances TLR Responses through Binding and Internalization of RNA.

Bertheloot D, Naumovski AL, Langhoff P, Horvath GL, Jin T, Xiao TS, Garbi N, Agrawal S, Kolbeck R, Latz E.

J Immunol. 2016 Nov 15;197(10):4118-4126. Epub 2016 Oct 19.

12.

Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1.

Ni CL, Seth D, Fonseca FV, Wang L, Xiao TS, Gruber P, Sy MS, Stamler JS, Tartakoff AM.

PLoS One. 2016 Sep 22;11(9):e0163359. doi: 10.1371/journal.pone.0163359. eCollection 2016.

13.

Innate immunity and inflammation.

Xiao TS.

Cell Mol Immunol. 2017 Jan;14(1):1-3. doi: 10.1038/cmi.2016.45. Epub 2016 Aug 22. No abstract available.

14.

Post-translational regulation of inflammasomes.

Yang J, Liu Z, Xiao TS.

Cell Mol Immunol. 2017 Jan;14(1):65-79. doi: 10.1038/cmi.2016.29. Epub 2016 Jun 27. Review.

15.

A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.

Waldhuber A, Snyder GA, Römmler F, Cirl C, Müller T, Xiao TS, Svanborg C, Miethke T.

Pathogens. 2016 Feb 29;5(1). pii: E25. doi: 10.3390/pathogens5010025.

16.

STRUCTURAL BIOLOGY. Assembling the wheel of death.

Liu Z, Xiao TS.

Science. 2015 Oct 23;350(6259):376-7. doi: 10.1126/science.aad3981. No abstract available.

17.

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.

Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M.

Nat Immunol. 2015 Oct;16(10):1025-33. doi: 10.1038/ni.3267. Epub 2015 Sep 7.

18.

Structural Mechanisms of Nucleosome Recognition by Linker Histones.

Zhou BR, Jiang J, Feng H, Ghirlando R, Xiao TS, Bai Y.

Mol Cell. 2015 Aug 20;59(4):628-38. doi: 10.1016/j.molcel.2015.06.025. Epub 2015 Jul 23.

19.

The nucleic acid-sensing inflammasomes.

Xiao TS.

Immunol Rev. 2015 May;265(1):103-11. doi: 10.1111/imr.12281. Review.

20.

Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain.

Mistry P, Laird MH, Schwarz RS, Greene S, Dyson T, Snyder GA, Xiao TS, Chauhan J, Fletcher S, Toshchakov VY, MacKerell AD Jr, Vogel SN.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5455-60. doi: 10.1073/pnas.1422576112. Epub 2015 Apr 13.

21.

Three new compounds isolated from the seeds of Vaccaria segetalis.

Zhang YL, Jiang LL, Xiao TS, Chen SQ, Li YB.

J Asian Nat Prod Res. 2015;17(7):717-23. doi: 10.1080/10286020.2014.992887. Epub 2015 Jan 3.

PMID:
25559121
22.

Activation and assembly of the inflammasomes through conserved protein domain families.

Jin T, Xiao TS.

Apoptosis. 2015 Feb;20(2):151-6. doi: 10.1007/s10495-014-1053-5. Review.

23.

Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly.

Abdi K, Singh NJ, Spooner E, Kessler BM, Radaev S, Lantz L, Xiao TS, Matzinger P, Sun PD, Ploegh HL.

J Immunol. 2014 Jun 15;192(12):6028-36. doi: 10.4049/jimmunol.1400159. Epub 2014 May 12.

24.

The catalytic subunit of the SWR1 remodeler is a histone chaperone for the H2A.Z-H2B dimer.

Hong J, Feng H, Wang F, Ranjan A, Chen J, Jiang J, Ghirlando R, Xiao TS, Wu C, Bai Y.

Mol Cell. 2014 Feb 6;53(3):498-505. doi: 10.1016/j.molcel.2014.01.010.

25.

Structures of pattern recognition receptors reveal molecular mechanisms of autoinhibition, ligand recognition and oligomerization.

Chuenchor W, Jin T, Ravilious G, Xiao TS.

Curr Opin Immunol. 2014 Feb;26:14-20. doi: 10.1016/j.coi.2013.10.009. Epub 2013 Nov 13. Review.

26.

Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry.

Snyder GA, Deredge D, Waldhuber A, Fresquez T, Wilkins DZ, Smith PT, Durr S, Cirl C, Jiang J, Jennings W, Luchetti T, Snyder N, Sundberg EJ, Wintrode P, Miethke T, Xiao TS.

J Biol Chem. 2014 Jan 10;289(2):669-79. doi: 10.1074/jbc.M113.523407. Epub 2013 Nov 25.

27.

IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.

Jakobsen MR, Bak RO, Andersen A, Berg RK, Jensen SB, Tengchuan J, Laustsen A, Hansen K, Ostergaard L, Fitzgerald KA, Xiao TS, Mikkelsen JG, Mogensen TH, Paludan SR.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4571-80. doi: 10.1073/pnas.1311669110. Epub 2013 Oct 23. Erratum in: Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19651. Jin, Tengchuan [corrected to Tengchuan, Jin].

28.

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.

Sirois CM, Jin T, Miller AL, Bertheloot D, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Bossaller L, Pelka K, Garbi N, Brewah Y, Tian J, Chang C, Chowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS, Latz E.

J Exp Med. 2013 Oct 21;210(11):2447-63. doi: 10.1084/jem.20120201. Epub 2013 Sep 30. Erratum in: J Exp Med. 2014 May 5;211(5):1001.

29.

Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein.

Jin T, Huang M, Smith P, Jiang J, Xiao TS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Aug;69(Pt 8):855-60. doi: 10.1107/S1744309113015558. Epub 2013 Jul 27.

30.

The cGAS-STING pathway for DNA sensing.

Xiao TS, Fitzgerald KA.

Mol Cell. 2013 Jul 25;51(2):135-9. doi: 10.1016/j.molcel.2013.07.004. Review.

31.

A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C.

Kato H, Jiang J, Zhou BR, Rozendaal M, Feng H, Ghirlando R, Xiao TS, Straight AF, Bai Y.

Science. 2013 May 31;340(6136):1110-3. doi: 10.1126/science.1235532.

32.

Activation and regulation of the inflammasomes.

Latz E, Xiao TS, Stutz A.

Nat Rev Immunol. 2013 Jun;13(6):397-411. doi: 10.1038/nri3452. Review.

33.

The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces.

Jin T, Huang M, Smith P, Jiang J, Xiao TS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 May 1;69(Pt 5):482-7. doi: 10.1107/S1744309113010075. Epub 2013 Apr 27.

34.

Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.

Conlon J, Burdette DL, Sharma S, Bhat N, Thompson M, Jiang Z, Rathinam VA, Monks B, Jin T, Xiao TS, Vogel SN, Vance RE, Fitzgerald KA.

J Immunol. 2013 May 15;190(10):5216-25. doi: 10.4049/jimmunol.1300097. Epub 2013 Apr 12.

35.

Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.

Snyder GA, Cirl C, Jiang J, Chen K, Waldhuber A, Smith P, Römmler F, Snyder N, Fresquez T, Dürr S, Tjandra N, Miethke T, Xiao TS.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6985-90. doi: 10.1073/pnas.1215770110. Epub 2013 Apr 8.

36.

Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly.

Jin T, Perry A, Smith P, Jiang J, Xiao TS.

J Biol Chem. 2013 May 10;288(19):13225-35. doi: 10.1074/jbc.M113.468033. Epub 2013 Mar 25.

37.

Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1.

Jin T, Curry J, Smith P, Jiang J, Xiao TS.

Proteins. 2013 Jul;81(7):1266-70. doi: 10.1002/prot.24287. Epub 2013 Apr 20.

38.

Two distinct binding modes define the interaction of Brox with the C-terminal tails of CHMP5 and CHMP4B.

Mu R, Dussupt V, Jiang J, Sette P, Rudd V, Chuenchor W, Bello NF, Bouamr F, Xiao TS.

Structure. 2012 May 9;20(5):887-98. doi: 10.1016/j.str.2012.03.001. Epub 2012 Apr 5.

39.

Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.

Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam VA, Johnstone RW, Hornung V, Latz E, Bowie AG, Fitzgerald KA, Xiao TS.

Immunity. 2012 Apr 20;36(4):561-71. doi: 10.1016/j.immuni.2012.02.014. Epub 2012 Apr 5.

40.

NLRX1 has a tail to tell.

Xiao TS, Ting JP.

Immunity. 2012 Mar 23;36(3):311-2. doi: 10.1016/j.immuni.2012.03.002.

41.

The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release.

Sette P, Mu R, Dussupt V, Jiang J, Snyder G, Smith P, Xiao TS, Bouamr F.

Structure. 2011 Oct 12;19(10):1485-95. doi: 10.1016/j.str.2011.07.016. Epub 2011 Sep 1.

42.

IFI16 is an innate immune sensor for intracellular DNA.

Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG.

Nat Immunol. 2010 Nov;11(11):997-1004. doi: 10.1038/ni.1932. Epub 2010 Oct 3.

43.

Subversion of innate immune signaling through molecular mimicry.

Xiao TS.

J Clin Immunol. 2010 Sep;30(5):638-42. doi: 10.1007/s10875-010-9435-0. Epub 2010 Jun 30. Review.

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