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Items: 1 to 50 of 153


Renal Dysfunction and In-Hospital Outcomes in Patients With Acute Ischemic Stroke After Intravenous Thrombolytic Therapy.

Rao ZZ, Gu HQ, Wang XW, Xie XW, Yang X, Wang CJ, Zhao X, Xian Y, Wang YL, Li ZX, Xiao RP, Wang YJ; Chinese Stroke Center Alliance investigators.

J Am Heart Assoc. 2019 Oct 15;8(20):e012052. doi: 10.1161/JAHA.119.012052. Epub 2019 Oct 9.


CaMKII-δ9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair.

Zhang M, Gao H, Liu D, Zhong X, Shi X, Yu P, Jin L, Liu Y, Tang Y, Song Y, Liu J, Hu X, Li CY, Song L, Qin J, Wu F, Lan F, Zhang Y, Xiao RP.

Nat Cell Biol. 2019 Sep;21(9):1152-1163. doi: 10.1038/s41556-019-0380-8. Epub 2019 Sep 2.


Response by Wu et al to Letter Regarding Article, "Glucose-Sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis".

Wu HK, Zhang Y, Chen G, Hu X, Lv F, Xiao RP.

Circulation. 2019 Aug 6;140(6):e188-e189. doi: 10.1161/CIRCULATIONAHA.119.041190. Epub 2019 Aug 5. No abstract available.


Atrial Fibrillation Known Before or Detected After Stroke Share Similar Risk of Ischemic Stroke Recurrence and Death.

Yang XM, Rao ZZ, Gu HQ, Zhao XQ, Wang CJ, Liu LP, Liu C, Wang YL, Li ZX, Xiao RP, Wang YJ.

Stroke. 2019 May;50(5):1124-1129. doi: 10.1161/STROKEAHA.118.024176.


Use of Emergency Medical Services and Timely Treatment Among Ischemic Stroke.

Gu HQ, Rao ZZ, Yang X, Wang CJ, Zhao XQ, Wang YL, Liu LP, Wang CY, Liu C, Li H, Li ZX, Xiao RP, Wang YJ; Chinese Stroke Center Alliance Investigators.

Stroke. 2019 Apr;50(4):1013-1016. doi: 10.1161/STROKEAHA.118.024232.


β2-Adrenergic Stimulation Compartmentalizes β1 Signaling Into Nanoscale Local Domains by Targeting the C-Terminus of β1-Adrenoceptors.

Yang HQ, Wang LP, Gong YY, Fan XX, Zhu SY, Wang XT, Wang YP, Li LL, Xing X, Liu XX, Ji GS, Hou T, Zhang Y, Xiao RP, Wang SQ.

Circ Res. 2019 Apr 26;124(9):1350-1359. doi: 10.1161/CIRCRESAHA.118.314322.


A chemical approach for global protein knockdown from mice to non-human primates.

Sun X, Wang J, Yao X, Zheng W, Mao Y, Lan T, Wang L, Sun Y, Zhang X, Zhao Q, Zhao J, Xiao RP, Zhang X, Ji G, Rao Y.

Cell Discov. 2019 Feb 5;5:10. doi: 10.1038/s41421-018-0079-1. eCollection 2019.


Discovery of β-arrestin-biased β2-adrenoceptor agonists from 2-amino-2-phenylethanol derivatives.

Woo AY, Ge XY, Pan L, Xing G, Mo YM, Xing RJ, Li XR, Zhang YY, Wainer IW, Cheng MS, Xiao RP.

Acta Pharmacol Sin. 2019 Aug;40(8):1095-1105. doi: 10.1038/s41401-018-0200-x. Epub 2019 Jan 14.


Glucose-Sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis.

Wu HK, Zhang Y, Cao CM, Hu X, Fang M, Yao Y, Jin L, Chen G, Jiang P, Zhang S, Song R, Peng W, Liu F, Guo J, Tang L, He Y, Shan D, Huang J, Zhou Z, Wang DW, Lv F, Xiao RP.

Circulation. 2019 Feb 12;139(7):901-914. doi: 10.1161/CIRCULATIONAHA.118.037216.


Dynamic changes in insulin and glucagon during disease progression in rhesus monkeys with obesity-related type 2 diabetes mellitus.

Wang C, Xiao Y, Wang J, Hou N, Cui W, Hu X, Zeng F, Yuan Y, Ma D, Sun X, Zhang Y, Zheng W, Liu Y, Shang H, Chen L, Xiao RP, Zhang X.

Diabetes Obes Metab. 2019 May;21(5):1111-1120. doi: 10.1111/dom.13624. Epub 2019 Jan 22.


ADRB2 polymorphism Arg16Gly modifies the natural outcome of heart failure and dictates therapeutic response to β-blockers in patients with heart failure.

Huang J, Li C, Song Y, Fan X, You L, Tan L, Xiao L, Li Q, Ruan G, Hu S, Cui W, Li Z, Ni L, Chen C, Woo AY, Xiao RP, Wang DW.

Cell Discov. 2018 Oct 23;4:57. doi: 10.1038/s41421-018-0058-6. eCollection 2018.


Central role of RIPK1-VDAC1 pathway on cardiac impairment in a non-human primate model of rheumatoid arthritis.

Zeng F, Wen W, Cui W, Zheng W, Liu Y, Sun X, Hou N, Ma D, Yuan Y, Shi H, Wang Z, Li Z, Xiao Y, Wang C, Li Y, Shang H, Li C, Wang J, Zhang Y, Xiao RP, Zhang X.

J Mol Cell Cardiol. 2018 Dec;125:50-60. doi: 10.1016/j.yjmcc.2018.10.015. Epub 2018 Oct 17.


Characterization of spontaneously-developed non-alcoholic fatty liver disease in aged rhesus monkeys.

Zheng W, Liu Y, Shang H, Zhang Y, Ma D, Hou N, Wang J, Sun X, Peng Y, Pan L, Wang Z, Tang X, Xiao RP, Zhang X.

Diabetol Metab Syndr. 2018 Sep 10;10:68. doi: 10.1186/s13098-018-0370-1. eCollection 2018.


Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis.

Dai J, Liang K, Zhao S, Jia W, Liu Y, Wu H, Lv J, Cao C, Chen T, Zhuang S, Hou X, Zhou S, Zhang X, Chen XW, Huang Y, Xiao RP, Wang YL, Luo T, Xiao J, Wang C.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5896-E5905. doi: 10.1073/pnas.1801745115. Epub 2018 Jun 11.


Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders.

Xiao Y, Wang C, Chen JY, Lu F, Wang J, Hou N, Hu X, Zeng F, Ma D, Sun X, Ding Y, Zhang Y, Zheng W, Liu Y, Shang H, Zhu W, Han C, Zhang Y, Ouyang K, Chen L, Chen J, Xiao RP, Li CY, Zhang X.

Nat Commun. 2018 May 22;9(1):2015. doi: 10.1038/s41467-018-04352-z.


RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+ Uptake and Promotes Colorectal Oncogenesis.

Zeng F, Chen X, Cui W, Wen W, Lu F, Sun X, Ma D, Yuan Y, Li Z, Hou N, Zhao H, Bi X, Zhao J, Zhou J, Zhang Y, Xiao RP, Cai J, Zhang X.

Cancer Res. 2018 Jun 1;78(11):2876-2885. doi: 10.1158/0008-5472.CAN-17-3082. Epub 2018 Mar 12.


MG53 and disordered metabolism in striated muscle.

Hu X, Xiao RP.

Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt B):1984-1990. doi: 10.1016/j.bbadis.2017.10.013. Epub 2017 Oct 7. Review.


β-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling.

Wang Y, Jin L, Song Y, Zhang M, Shan D, Liu Y, Fang M, Lv F, Xiao RP, Zhang Y.

Cardiovasc Res. 2017 Nov 1;113(13):1615-1626. doi: 10.1093/cvr/cvx147.


SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway.

Xie N, Chen M, Dai R, Zhang Y, Zhao H, Song Z, Zhang L, Li Z, Feng Y, Gao H, Wang L, Zhang T, Xiao RP, Wu J, Cao CM.

Nat Commun. 2017 Aug 11;8:16016. doi: 10.1038/ncomms16016.


MG53: Biological Function and Potential as a Therapeutic Target.

Zhang Y, Wu HK, Lv F, Xiao RP.

Mol Pharmacol. 2017 Sep;92(3):211-218. doi: 10.1124/mol.117.108241. Epub 2017 Apr 21. Review.


Biased Agonism at the Angiotensin Receptor: Blocker and Calcium Sensitizer at the Same Time.

Woo AY, Komuro I, Xiao RP.

Circulation. 2017 Mar 14;135(11):1071-1074. doi: 10.1161/CIRCULATIONAHA.117.027276. No abstract available.


HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage.

Qian H, Chen Y, Nian Z, Su L, Yu H, Chen FJ, Zhang X, Xu W, Zhou L, Liu J, Yu J, Yu L, Gao Y, Zhang H, Zhang H, Zhao S, Yu L, Xiao RP, Bao Y, Hou S, Li P, Li J, Deng H, Jia W, Li P.

J Clin Invest. 2017 Apr 3;127(4):1353-1369. doi: 10.1172/JCI85963. Epub 2017 Mar 13.


Making An Impact on Clinical Practice and Research in China.

Xiao RP, Wong GW, Prince JM, Gartside M, Zhao J, Wang J, Zhaori G, Drazen JM.

N Engl J Med. 2016 Dec 15;375(24):2391-2392. Epub 2016 Nov 21. No abstract available.


MG53 is a double-edged sword for human diseases.

Zhang Y, Wu HK, Lv FX, Xiao RP.

Sheng Li Xue Bao. 2016 Aug 25;68(4):505-16. Review.


Eplerenone restores 24-h blood pressure circadian rhythm and reduces advanced glycation end-products in rhesus macaques with spontaneous hypertensive metabolic syndrome.

Zhang Y, Zheng W, Liu Y, Wang J, Peng Y, Shang H, Hou N, Hu X, Ding Y, Xiao Y, Wang C, Zeng F, Mao J, Zhang J, Ma D, Sun X, Li C, Xiao RP, Zhang X.

Sci Rep. 2016 Apr 1;6:23957. doi: 10.1038/srep23957.


Interaction of β1-adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling.

Zhu W, Tsang S, Browe DM, Woo AY, Huang Y, Xu C, Liu JF, Lv F, Zhang Y, Xiao RP.

JCI Insight. 2016;1(1):e84969. doi: 10.1172/jci.insight.84969.


CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis.

Zhang T, Zhang Y, Cui M, Jin L, Wang Y, Lv F, Liu Y, Zheng W, Shang H, Zhang J, Zhang M, Wu H, Guo J, Zhang X, Hu X, Cao CM, Xiao RP.

Nat Med. 2016 Feb;22(2):175-82. doi: 10.1038/nm.4017. Epub 2016 Jan 4.


p55γ functional mimetic peptide N24 blocks vascular proliferative disorders.

Guo J, Xie N, Li G, Zhang Y, Lv F, Guo S, Feng Y, Cao CM, Xiao RP.

J Mol Med (Berl). 2015 Oct;93(10):1107-18. doi: 10.1007/s00109-015-1287-x. Epub 2015 Apr 19.


Myocardial glycogen dynamics: new perspectives on disease mechanisms.

Chandramouli C, Varma U, Stevens EM, Xiao RP, Stapleton DI, Mellor KM, Delbridge LM.

Clin Exp Pharmacol Physiol. 2015 Apr;42(4):415-25. doi: 10.1111/1440-1681.12370. Review.


Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor α.

Liu F, Song R, Feng Y, Guo J, Chen Y, Zhang Y, Chen T, Wang Y, Huang Y, Li CY, Cao C, Zhang Y, Hu X, Xiao RP.

Circulation. 2015 Mar 3;131(9):795-804. doi: 10.1161/CIRCULATIONAHA.114.012285. Epub 2015 Jan 30.


Advances in receptor conformation research: the quest for functionally selective conformations focusing on the β2-adrenoceptor.

Woo AY, Song Y, Zhu W, Xiao RP.

Br J Pharmacol. 2015 Dec;172(23):5477-88. doi: 10.1111/bph.13049. Epub 2015 Feb 27. Review.


Identification of PI3K regulatory subunit p55γ as a novel inhibitor of vascular smooth muscle cell proliferation and neointimal formation.

Li G, Xie N, Yao Y, Zhang Y, Guo J, Feng Y, Lv F, Xiao RP, Cao CM.

Cardiovasc Res. 2015 Jan 1;105(1):75-85. doi: 10.1093/cvr/cvu235. Epub 2014 Nov 10.


Biased β2-adrenoceptor signalling in heart failure: pathophysiology and drug discovery.

Woo AY, Song Y, Xiao RP, Zhu W.

Br J Pharmacol. 2015 Dec;172(23):5444-56. doi: 10.1111/bph.12965. Epub 2014 Dec 17. Review.


[Pharmacokinetic study of six aconitine alkaloids in aconiti lateralis radix praeparata in beagle dogs].

Xiao RP, Lai XP, Zhao Y, Yu LW, Zhu YL, Li G.

Zhong Yao Cai. 2014 Feb;37(2):284-7. Chinese.


Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of β2-adrenoceptor.

Woo AY, Jozwiak K, Toll L, Tanga MJ, Kozocas JA, Jimenez L, Huang Y, Song Y, Plazinska A, Pajak K, Paul RK, Bernier M, Wainer IW, Xiao RP.

J Biol Chem. 2014 Jul 11;289(28):19351-63. doi: 10.1074/jbc.M114.558882. Epub 2014 May 15.


Expression of the Pokemon proto-oncogene in nasopharyngeal carcinoma cell lines and tissues.

Jiao W, Liu F, Tang FZ, Lan J, Xiao RP, Chen XZ, Ye HL, Cai YL.

Asian Pac J Cancer Prev. 2013;14(11):6315-9.


Molecular pathological study of the human nasopharyngeal carcinoma CNE3 cell line.

Liu F, Jiao W, Mo XL, Lan J, Xiao RP, Zhou XZ, Huang ZL, Mo XM, Li G.

Oncol Lett. 2013 Oct;6(4):980-984. Epub 2013 Aug 5.


The N-glycoform of sRAGE is the key determinant for its therapeutic efficacy to attenuate injury-elicited arterial inflammation and neointimal growth.

Tae HJ, Kim JM, Park S, Tomiya N, Li G, Wei W, Petrashevskaya N, Ahmet I, Pang J, Cruschwitz S, Riebe RA, Zhang Y, Morrell CH, Browe D, Lee YC, Xiao RP, Talan MI, Lakatta EG, Lin L.

J Mol Med (Berl). 2013 Dec;91(12):1369-81. doi: 10.1007/s00109-013-1091-4. Epub 2013 Oct 17.


Bioimaging for cardiometabolic translational medicine: from cellular messengers to organism function.

Xiao RP.

J Mol Med (Berl). 2013 Aug;91(8):905-6. doi: 10.1007/s00109-013-1072-7. No abstract available.


A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin.

Liu W, Zi M, Tsui H, Chowdhury SK, Zeef L, Meng QJ, Travis M, Prehar S, Berry A, Hanley NA, Neyses L, Xiao RP, Oceandy D, Ke Y, Solaro RJ, Cartwright EJ, Lei M, Wang X.

Circ Heart Fail. 2013 Jul;6(4):833-44. doi: 10.1161/CIRCHEARTFAILURE.112.000123. Epub 2013 Jun 10.


Cardiomyocyte life-death decisions in response to chronic β-adrenergic signaling.

Whelan RS, Konstantinidis K, Xiao RP, Kitsis RN.

Circ Res. 2013 Feb 1;112(3):408-10. doi: 10.1161/CIRCRESAHA.113.300805. No abstract available. Erratum in: Circ Res. 2013 Jun 7;112(12):e181.


Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders.

Song R, Peng W, Zhang Y, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M, Jiang P, Liu F, Meng S, Zhang X, Jiang P, Cao CM, Xiao RP.

Nature. 2013 Feb 21;494(7437):375-9. doi: 10.1038/nature11834. Epub 2013 Jan 27.


[Genetic polymorphism of 16 Y-STR loci in Miao, Yao and Dong nationalities of Guangxi population].

Jiao W, Liu F, Li HL, Wu HX, Lan J, Xiao RP, Qin L, Jiang B.

Fa Yi Xue Za Zhi. 2012 Oct;28(5):355-8. Chinese.


Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy.

Weisleder N, Takizawa N, Lin P, Wang X, Cao C, Zhang Y, Tan T, Ferrante C, Zhu H, Chen PJ, Yan R, Sterling M, Zhao X, Hwang M, Takeshima M, Cai C, Cheng H, Takeshima H, Xiao RP, Ma J.

Sci Transl Med. 2012 Jun 20;4(139):139ra85. doi: 10.1126/scitranslmed.3003921.


mTOR: good, bad, or ugly?

Zhang Y, Zhang T, Cao CM, Xiao RP.

Cardiovasc Res. 2012 Aug 1;95(3):261-2. doi: 10.1093/cvr/cvs201. Epub 2012 Jun 21. No abstract available.


A new era for GPCR research: structures, biology and drug discovery.

Xu HE, Xiao RP.

Acta Pharmacol Sin. 2012 Mar;33(3):289-90. doi: 10.1038/aps.2012.16. No abstract available.


β-Adrenergic receptor subtype signaling in heart: from bench to bedside.

Woo AY, Xiao RP.

Acta Pharmacol Sin. 2012 Mar;33(3):335-41. doi: 10.1038/aps.2011.201. Epub 2012 Jan 30. Review.


Gi-biased β2AR signaling links GRK2 upregulation to heart failure.

Zhu W, Petrashevskaya N, Ren S, Zhao A, Chakir K, Gao E, Chuprun JK, Wang Y, Talan M, Dorn GW 2nd, Lakatta EG, Koch WJ, Feldman AM, Xiao RP.

Circ Res. 2012 Jan 20;110(2):265-74. doi: 10.1161/CIRCRESAHA.111.253260. Epub 2011 Dec 15.


Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.

Liu W, Zi M, Naumann R, Ulm S, Jin J, Taglieri DM, Prehar S, Gui J, Tsui H, Xiao RP, Neyses L, Solaro RJ, Ke Y, Cartwright EJ, Lei M, Wang X.

Circulation. 2011 Dec 13;124(24):2702-15. doi: 10.1161/CIRCULATIONAHA.111.048785. Epub 2011 Nov 14.


Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart.

Chakir K, Depry C, Dimaano VL, Zhu WZ, Vanderheyden M, Bartunek J, Abraham TP, Tomaselli GF, Liu SB, Xiang YK, Zhang M, Takimoto E, Dulin N, Xiao RP, Zhang J, Kass DA.

Sci Transl Med. 2011 Sep 14;3(100):100ra88. doi: 10.1126/scitranslmed.3001909.

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