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Items: 1 to 50 of 63


Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling.

Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, White MF, Drakos SG, Xiang YK, Abel ED.

JCI Insight. 2020 Mar 26;5(6). pii: 134920. doi: 10.1172/jci.insight.134920.


Hyperinsulinemia promotes heterologous desensitization of β2 adrenergic receptor in airway smooth muscle in obesity.

Xu R, Gopireddy RR, Wu Y, Wu L, Tao X, Shao J, Wang W, Li L, Jovanovic A, Xu B, Kenyon NJ, Lu Q, Xiang YK, Fu Q.

FASEB J. 2020 Mar;34(3):3996-4008. doi: 10.1096/fj.201800688RR. Epub 2020 Jan 21.


β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons.

Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, Martinez JM, Man KM, Nieves-Cintron M, Hell JW, Navedo MF, Yu XY, Xiang YK.

Elife. 2019 Oct 14;8. pii: e49464. doi: 10.7554/eLife.49464.


A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes.

Lee J, Taylor CA, Barnes KM, Shen A, Stewart EV, Chen A, Xiang YK, Bao Z, Shen K.

Elife. 2019 Aug 6;8. pii: e46703. doi: 10.7554/eLife.46703.


Phosphodiesterase 5 Associates With β2 Adrenergic Receptor to Modulate Cardiac Function in Type 2 Diabetic Hearts.

West TM, Wang Q, Deng B, Zhang Y, Barbagallo F, Reddy GR, Chen D, Phan KS, Xu B, Isidori A, Xiang YK.

J Am Heart Assoc. 2019 Aug 6;8(15):e012273. doi: 10.1161/JAHA.119.012273. Epub 2019 Jul 17.


[Hypobromite oxidation combined with hydroxylamine hydrochloride reduction method for analyzing ammonium nitrogen isotope in atmospheric samples.]

Xiang YK, Cao F, Yang XY, Zhai XY, Zhang YL.

Ying Yong Sheng Tai Xue Bao. 2019 Jun;30(6):1847-1853. doi: 10.13287/j.1001-9332.201906.011. Chinese.


Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters.

Bers DM, Xiang YK, Zaccolo M.

Physiology (Bethesda). 2019 Jul 1;34(4):240-249. doi: 10.1152/physiol.00002.2019. Review.


Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia.

Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF.

J Clin Invest. 2019 Jun 4;129(8):3140-3152. doi: 10.1172/JCI124705.


A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia.

Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF.

Elife. 2019 Mar 1;8. pii: e42214. doi: 10.7554/eLife.42214.


The gap junction inhibitor INI-0602 attenuates mechanical allodynia and depression-like behaviors induced by spared nerve injury in rats.

Zhang XM, Wang LZ, He B, Xiang YK, Fan LX, Wang Q, Tao L.

Neuroreport. 2019 Mar 20;30(5):369-377. doi: 10.1097/WNR.0000000000001209.


β-adrenergic-mediated dynamic augmentation of sarcolemmal CaV 1.2 clustering and co-operativity in ventricular myocytes.

Ito DW, Hannigan KI, Ghosh D, Xu B, Del Villar SG, Xiang YK, Dickson EJ, Navedo MF, Dixon RE.

J Physiol. 2019 Apr;597(8):2139-2162. doi: 10.1113/JP277283. Epub 2019 Mar 12.


Gut Barrier Dysfunction Induced by Aggressive Fluid Resuscitation in Severe Acute Pancreatitis is Alleviated by Necroptosis Inhibition in Rats.

Cui QR, Ling YH, Wen SH, Liu KX, Xiang YK, Yang WJ, Shen JT, Li YS, Yuan BL, Huang WQ.

Shock. 2019 Nov;52(5):e107-e116. doi: 10.1097/SHK.0000000000001304.


Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes.

Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK.

J Gen Physiol. 2018 Nov 5;150(11):1567-1582. doi: 10.1085/jgp.201812119. Epub 2018 Sep 21.


The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival.

Maeder CI, Kim JI, Liang X, Kaganovsky K, Shen A, Li Q, Li Z, Wang S, Xu XZS, Li JB, Xiang YK, Ding JB, Shen K.

Cell. 2018 Sep 6;174(6):1436-1449.e20. doi: 10.1016/j.cell.2018.07.046. Epub 2018 Aug 23.


Comparative health risk of inhaled exposure to organic solvents, toxic metals, and hexavalent chromium from the use of spray paints in Taiwan.

Lin CH, Lai CH, Peng YP, Wu PC, Chuang KY, Yen TY, Xiang YK.

Environ Sci Pollut Res Int. 2019 Nov;26(33):33906-33916. doi: 10.1007/s11356-018-2669-8. Epub 2018 Jul 4.


Image Gallery: Concomitant eosinophilic angiocentric fibrosis and granuloma faciale.

Xiang YK, Fang RY, Zhang S, Yan Y, Wang B, Qu T.

Br J Dermatol. 2018 Jun;178(6):e395. doi: 10.1111/bjd.16574. No abstract available.


A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching.

Zou W, Dong X, Broederdorf TR, Shen A, Kramer DA, Shi R, Liang X, Miller DM 3rd, Xiang YK, Yasuda R, Chen B, Shen K.

Dev Cell. 2018 May 7;45(3):362-375.e3. doi: 10.1016/j.devcel.2018.04.008.


Image Gallery: Facial sporotrichosis.

Xiang YK, Qu T.

Br J Dermatol. 2018 Apr;178(4):e275. doi: 10.1111/bjd.16358. No abstract available.


Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain.

Blöcher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C, Hammock BD.

J Med Chem. 2018 Apr 26;61(8):3541-3550. doi: 10.1021/acs.jmedchem.7b01804. Epub 2018 Apr 10.


Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell.

Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK.

Nat Commun. 2018 Mar 13;9(1):1050. doi: 10.1038/s41467-018-03459-7.


Nanodelivery of a functional membrane receptor to manipulate cellular phenotype.

Patriarchi T, Shen A, He W, Baikoghli M, Cheng RH, Xiang YK, Coleman MA, Tian L.

Sci Rep. 2018 Feb 23;8(1):3556. doi: 10.1038/s41598-018-21863-3.


Profiling of Differential Expression of Genes in Mice Carrying Both Mutant Presenilin 1 and Amyloid Precursor Protein Transgenes with or without Knockout of B2 Adrenergic Receptor Gene.

Zhou Y, Chen L, Zhou X, Pei Y, Wei S, Mehmood A, Xiang YK, Wang D.

J Appl Bioinforma Comput Biol. 2018;7(3). pii: 155. doi: 10.4172/2329-9533.1000155. Epub 2018 Sep 18.


β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.

Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR.

Science. 2017 Sep 1;357(6354):891-898. doi: 10.1126/science.aaf3934.


β1-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes.

Park M, Reddy GR, Wallukat G, Xiang YK, Steinberg SF.

Sci Rep. 2017 Aug 11;7(1):7890. doi: 10.1038/s41598-017-06607-z.


Heterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes.

Shi Q, Li M, Mika D, Fu Q, Kim S, Phan J, Shen A, Vandecasteele G, Xiang YK.

Cardiovasc Res. 2017 May 1;113(6):656-670. doi: 10.1093/cvr/cvx036.


Cross-Talk Between Insulin Signaling and G Protein-Coupled Receptors.

Fu Q, Shi Q, West TM, Xiang YK.

J Cardiovasc Pharmacol. 2017 Aug;70(2):74-86. doi: 10.1097/FJC.0000000000000481. Review.


Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7.

Pofi R, Fiore D, De Gaetano R, Panio G, Gianfrilli D, Pozza C, Barbagallo F, Xiang YK, Giannakakis K, Morano S, Lenzi A, Naro F, Isidori AM, Venneri MA.

Sci Rep. 2017 Mar 15;7:44584. doi: 10.1038/srep44584.


Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart.

Fu Q, Wang Q, Xiang YK.

Trends Endocrinol Metab. 2017 Jun;28(6):416-427. doi: 10.1016/j.tem.2017.02.002. Epub 2017 Feb 28. Review.


High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts.

Fu Q, Hu Y, Wang Q, Liu Y, Li N, Xu B, Kim S, Chiamvimonvat N, Xiang YK.

J Physiol. 2017 Mar 15;595(6):1973-1986. doi: 10.1113/JP273314. Epub 2017 Feb 2.


Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction.

Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK.

Circulation. 2017 Jan 3;135(1):73-88. doi: 10.1161/CIRCULATIONAHA.116.022281. Epub 2016 Nov 4.


A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans.

Zou W, Shen A, Dong X, Tugizova M, Xiang YK, Shen K.

Elife. 2016 Oct 5;5. pii: e18345. doi: 10.7554/eLife.18345.


With or Without Langendorff: A New Method for Adult Myocyte Isolation to Be Tested With Time.

Chen X, O'Connell TD, Xiang YK.

Circ Res. 2016 Sep 30;119(8):888-90. doi: 10.1161/CIRCRESAHA.116.309734. No abstract available.


Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure.

Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK.

Circ Res. 2016 Sep 30;119(8):931-43. doi: 10.1161/CIRCRESAHA.116.308964. Epub 2016 Aug 30.


Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins.

Skieterska K, Shen A, Clarisse D, Rondou P, Borroto-Escuela DO, Lintermans B, Fuxe K, Xiang YK, Van Craenenbroeck K.

Cell Signal. 2016 Aug;28(8):1001-14. doi: 10.1016/j.cellsig.2016.05.003. Epub 2016 May 5.


Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor.

Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW.

EMBO J. 2016 Jun 15;35(12):1330-45. doi: 10.15252/embj.201593409. Epub 2016 Apr 21.


Three Recombinant Engineered Antibodies against Recombinant Tags with High Affinity and Specificity.

Zhao H, Shen A, Xiang YK, Corey DP.

PLoS One. 2016 Mar 4;11(3):e0150125. doi: 10.1371/journal.pone.0150125. eCollection 2016.


Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.

Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC.

Cell Stem Cell. 2015 Jul 2;17(1):89-100. doi: 10.1016/j.stem.2015.04.020. Epub 2015 Jun 18.


Trafficking of β-Adrenergic Receptors: Implications in Intracellular Receptor Signaling.

Fu Q, Xiang YK.

Prog Mol Biol Transl Sci. 2015;132:151-88. doi: 10.1016/bs.pmbts.2015.03.008. Epub 2015 Apr 29. Review.


Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes.

Isidori AM, Cornacchione M, Barbagallo F, Di Grazia A, Barrios F, Fassina L, Monaco L, Giannetta E, Gianfrilli D, Garofalo S, Zhang X, Chen X, Xiang YK, Lenzi A, Pellegrini M, Naro F.

Cardiovasc Res. 2015 Jun 1;106(3):408-20. doi: 10.1093/cvr/cvv123. Epub 2015 Apr 7.


Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes.

Fu Q, Xu B, Parikh D, Cervantes D, Xiang YK.

Cell Signal. 2015 Mar;27(3):707-15. doi: 10.1016/j.cellsig.2014.11.018. Epub 2014 Nov 25.


A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes.

Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK.

J Biol Chem. 2014 May 23;289(21):14771-81. doi: 10.1074/jbc.M113.542589. Epub 2014 Apr 8.


Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts.

Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK.

Diabetes. 2014 Aug;63(8):2676-89. doi: 10.2337/db13-1763. Epub 2014 Mar 27.


Genetic suppression of β2-adrenergic receptors ameliorates tau pathology in a mouse model of tauopathies.

Wisely EV, Xiang YK, Oddo S.

Hum Mol Genet. 2014 Aug 1;23(15):4024-34. doi: 10.1093/hmg/ddu116. Epub 2014 Mar 13.


Biological techniques: Wrapped around the heart.

Clancy CE, Xiang YK.

Nature. 2014 Mar 6;507(7490):43-4. doi: 10.1038/507043a. No abstract available.


Gadd45β is transcriptionally activated by p53 via p38α-mediated phosphorylation during myocardial ischemic injury.

Kim YA, Kim MY, Yu HY, Mishra SK, Lee JH, Choi KS, Kim JH, Xiang YK, Jung YS.

J Mol Med (Berl). 2013 Nov;91(11):1303-13. doi: 10.1007/s00109-013-1070-9. Epub 2013 Aug 16.


SAP97 controls the trafficking and resensitization of the beta-1-adrenergic receptor through its PDZ2 and I3 domains.

Nooh MM, Naren AP, Kim SJ, Xiang YK, Bahouth SW.

PLoS One. 2013 May 16;8(5):e63379. doi: 10.1371/journal.pone.0063379. Print 2013.


Adenylyl cyclase anchoring by a kinase anchor protein AKAP5 (AKAP79/150) is important for postsynaptic β-adrenergic signaling.

Zhang M, Patriarchi T, Stein IS, Qian H, Matt L, Nguyen M, Xiang YK, Hell JW.

J Biol Chem. 2013 Jun 14;288(24):17918-31. doi: 10.1074/jbc.M112.449462. Epub 2013 May 6.


Compartmentalization of β-adrenergic signals in cardiomyocytes.

Fu Q, Chen X, Xiang YK.

Trends Cardiovasc Med. 2013 Oct;23(7):250-6. doi: 10.1016/j.tcm.2013.02.001. Epub 2013 Mar 23. Review.


β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models.

Wang D, Fu Q, Zhou Y, Xu B, Shi Q, Igwe B, Matt L, Hell JW, Wisely EV, Oddo S, Xiang YK.

J Biol Chem. 2013 Apr 12;288(15):10298-307. doi: 10.1074/jbc.M112.415141. Epub 2013 Feb 19.


Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex.

Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, Xiang YK, Puigserver P.

J Biol Chem. 2013 Mar 8;288(10):7117-26. doi: 10.1074/jbc.M112.415729. Epub 2013 Jan 17.

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