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Nutritional Risks in Adolescents After Bariatric Surgery.

Xanthakos SA, Khoury JC, Inge TH, Jenkins TM, Modi AC, Michalsky MP, Chen MK, Courcoulas AP, Harmon CM, Brandt ML, Helmrath MA, Kalkwarf HJ; Teen Longitudinal Assessment of Bariatric Surgery Consortium.

Clin Gastroenterol Hepatol. 2019 Nov 6. pii: S1542-3565(19)31257-1. doi: 10.1016/j.cgh.2019.10.048. [Epub ahead of print]


Vitamin D deficiency: prevalence and association with liver disease severity in pediatric nonalcoholic fatty liver disease.

Yodoshi T, Orkin S, Arce-Clachar AC, Bramlage K, Liu C, Fei L, El-Khider F, Dasarathy S, Xanthakos SA, Mouzaki M.

Eur J Clin Nutr. 2019 Aug 23. doi: 10.1038/s41430-019-0493-y. [Epub ahead of print]


Relationship between abdominal fat stores and liver fat, pancreatic fat, and metabolic comorbidities in a pediatric population with non-alcoholic fatty liver disease.

Trout AT, Hunte DE, Mouzaki M, Xanthakos SA, Su W, Zhang B, Dillman JR.

Abdom Radiol (NY). 2019 Sep;44(9):3107-3114. doi: 10.1007/s00261-019-02123-y.


GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network.

Namjou B, Lingren T, Huang Y, Parameswaran S, Cobb BL, Stanaway IB, Connolly JJ, Mentch FD, Benoit B, Niu X, Wei WQ, Carroll RJ, Pacheco JA, Harley ITW, Divanovic S, Carrell DS, Larson EB, Carey DJ, Verma S, Ritchie MD, Gharavi AG, Murphy S, Williams MS, Crosslin DR, Jarvik GP, Kullo IJ, Hakonarson H, Li R; eMERGE Network, Xanthakos SA, Harley JB.

BMC Med. 2019 Jul 17;17(1):135. doi: 10.1186/s12916-019-1364-z.


Psychotropic Medications Are Associated With Increased Liver Disease Severity in Pediatric Nonalcoholic Fatty Liver Disease.

Mouzaki M, Yodoshi T, Arce-Clachar AC, Bramlage K, Fei L, Ley SL, Xanthakos SA.

J Pediatr Gastroenterol Nutr. 2019 Sep;69(3):339-343. doi: 10.1097/MPG.0000000000002401.


Five-Year Outcomes of Gastric Bypass in Adolescents as Compared with Adults.

Inge TH, Courcoulas AP, Jenkins TM, Michalsky MP, Brandt ML, Xanthakos SA, Dixon JB, Harmon CM, Chen MK, Xie C, Evans ME, Helmrath MA; Teen–LABS Consortium.

N Engl J Med. 2019 May 30;380(22):2136-2145. doi: 10.1056/NEJMoa1813909. Epub 2019 May 16.


Magnetic resonance imaging T1 relaxation times for the liver, pancreas and spleen in healthy children at 1.5 and 3 tesla.

Gilligan LA, Dillman JR, Tkach JA, Xanthakos SA, Gill JK, Trout AT.

Pediatr Radiol. 2019 Jul;49(8):1018-1024. doi: 10.1007/s00247-019-04411-7. Epub 2019 May 2.


Extremely low levels of low-density lipoprotein potentially suggestive of familial hypobetalipoproteinemia: A separate phenotype of NAFLD?

Mouzaki M, Shah A, Arce-Clachar AC, Hardy J, Bramlage K, Xanthakos SA.

J Clin Lipidol. 2019 May - Jun;13(3):425-431. doi: 10.1016/j.jacl.2019.02.002. Epub 2019 Feb 14.


Change in gastrointestinal symptoms over the first 5 years after bariatric surgery in a multicenter cohort of adolescents.

Dewberry LC, Khoury JC, Ehrlich S, Jenkins TM, Beamish AJ, Kalkwarf HJ, Xanthakos SA, Inge T.

J Pediatr Surg. 2019 Jun;54(6):1220-1225. doi: 10.1016/j.jpedsurg.2019.02.032. Epub 2019 Feb 28.


Clinical Practice Approach to Nonalcoholic Fatty Liver Disease by Pediatric Gastroenterologists in the United States.

Shapiro WL, Yu EL, Arin JC, Murray KF, Ali S, Desai NK, Xanthakos SA, Lin HC, Alkhouri N, Abdou R, Abrams SH, Butler MW, Faasse SA, Gillis LA, Hadley TA, Jain AK, Kavan M, Kordy K, Lee P, Panganiban J, Pohl JF, Potter C, Rudolph B, Sundaram SS, Joshi S, Proudfoot JA, Goyal NP, Harlow KE, Newton KP, Schwimmer JB.

J Pediatr Gastroenterol Nutr. 2019 Feb;68(2):182-189. doi: 10.1097/MPG.0000000000002194.


Serum Immunoglobulin A Levels Do Not Correlate With Liver Disease Severity in Pediatric Nonalcoholic Fatty Liver Disease.

Mouzaki M, Bramlage K, Arce-Clachar AC, Xanthakos SA.

J Pediatr Gastroenterol Nutr. 2018 Nov;67(5):631-634. doi: 10.1097/MPG.0000000000002104.


Putting it all together: established and emerging MRI techniques for detecting and measuring liver fibrosis.

Serai SD, Trout AT, Miethke A, Diaz E, Xanthakos SA, Dillman JR.

Pediatr Radiol. 2018 Aug;48(9):1256-1272. doi: 10.1007/s00247-018-4083-2. Epub 2018 Aug 4. Review.


Alanine Aminotransferase as a Monitoring Biomarker in Children with Nonalcoholic Fatty Liver Disease: A Secondary Analysis Using TONIC Trial Data.

Arsik I, Frediani JK, Frezza D, Chen W, Ayer T, Keskinocak P, Jin R, Konomi JV, Barlow SE, Xanthakos SA, Lavine JE, Vos MB.

Children (Basel). 2018 May 25;5(6). pii: E64. doi: 10.3390/children5060064.


Comparative effectiveness of bariatric procedures among adolescents: the PCORnet bariatric study.

Inge TH, Coley RY, Bazzano LA, Xanthakos SA, McTigue K, Arterburn D, Williams N, Wellman R, Coleman KJ, Courcoulas A, Desai NK, Anau J, Pardee R, Toh S, Janning C, Cook A, Sturtevant J, Horgan C, Zebrick AJ, Michalsky M; PCORnet Bariatric Study Collaborative.

Surg Obes Relat Dis. 2018 Sep;14(9):1374-1386. doi: 10.1016/j.soard.2018.04.002. Epub 2018 Apr 17.


Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease.

Harlow KE, Africa JA, Wells A, Belt PH, Behling CA, Jain AK, Molleston JP, Newton KP, Rosenthal P, Vos MB, Xanthakos SA, Lavine JE, Schwimmer JB; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN).

J Pediatr. 2018 Jul;198:76-83.e2. doi: 10.1016/j.jpeds.2018.02.038. Epub 2018 Apr 13.


Using T1 mapping in cardiovascular magnetic resonance to assess congestive hepatopathy.

Kazour I, Serai SD, Xanthakos SA, Fleck RJ.

Abdom Radiol (NY). 2018 Oct;43(10):2679-2685. doi: 10.1007/s00261-018-1528-x.


Diagnostic Performance of MR Elastography for Liver Fibrosis in Children and Young Adults with a Spectrum of Liver Diseases.

Trout AT, Sheridan RM, Serai SD, Xanthakos SA, Su W, Zhang B, Wallihan DB.

Radiology. 2018 Jun;287(3):824-832. doi: 10.1148/radiol.2018172099. Epub 2018 Feb 22.


Response to the Letters Regarding the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition NAFLD Guidelines.

Vos MB, Abrams SH, Barlow SE, Caprio S, Daniels SR, Kohli R, Mouzaki M, Sathya P, Schwimmer JB, Sundaram SS, Xanthakos SA.

J Pediatr Gastroenterol Nutr. 2017 Nov;65(5):e115-e116. doi: 10.1097/MPG.0000000000001731. No abstract available.


Quantitative Liver MRI-Biopsy Correlation in Pediatric and Young Adult Patients With Nonalcoholic Fatty Liver Disease: Can One Be Used to Predict the Other?

Dillman JR, Trout AT, Costello EN, Serai SD, Bramlage KS, Kohli R, Xanthakos SA.

AJR Am J Roentgenol. 2018 Jan;210(1):166-174. doi: 10.2214/AJR.17.18446. Epub 2017 Oct 18.


Challenges in Screening for Pediatric Nonalcoholic Fatty Liver Disease.

Ferguson AE, Xanthakos SA, Siegel RM.

Clin Pediatr (Phila). 2018 May;57(5):558-562. doi: 10.1177/0009922817733300. Epub 2017 Oct 12.


Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis.

Li H, Canet MJ, Clarke JD, Billheimer D, Xanthakos SA, Lavine JE, Erickson RP, Cherrington NJ.

Drug Metab Dispos. 2017 Dec;45(12):1317-1325. doi: 10.1124/dmd.117.077644. Epub 2017 Oct 6.


Nonalcoholic steatohepatitis in children with severe obesity: A global concern.

Xanthakos SA.

Surg Obes Relat Dis. 2017 Sep;13(9):1609-1611. doi: 10.1016/j.soard.2017.06.003. Epub 2017 Jun 23. No abstract available.


Magnetic resonance elastography assessment of fibrosis in children with NAFLD: Promising but not perfect.

Xanthakos SA, Trout AT, Dillman JR.

Hepatology. 2017 Nov;66(5):1373-1376. doi: 10.1002/hep.29393. Epub 2017 Sep 29. No abstract available.


Changes in Dietary Intake and Eating Behavior in Adolescents After Bariatric Surgery: an Ancillary Study to the Teen-LABS Consortium.

Sarwer DB, Dilks RJ, Spitzer JC, Berkowitz RI, Wadden TA, Moore RH, Chittams JL, Brandt ML, Chen MK, Courcoulas AP, Harmon CM, Helmrath MA, Michalsky MP, Xanthakos SA, Zeller MH, Jenkins TM, Inge TH.

Obes Surg. 2017 Dec;27(12):3082-3091. doi: 10.1007/s11695-017-2764-9.


NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children: Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN).

Vos MB, Abrams SH, Barlow SE, Caprio S, Daniels SR, Kohli R, Mouzaki M, Sathya P, Schwimmer JB, Sundaram SS, Xanthakos SA.

J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):319-334. doi: 10.1097/MPG.0000000000001482.


Long-term outcomes of bariatric surgery in adolescents with severe obesity (FABS-5+): a prospective follow-up analysis.

Inge TH, Jenkins TM, Xanthakos SA, Dixon JB, Daniels SR, Zeller MH, Helmrath MA.

Lancet Diabetes Endocrinol. 2017 Mar;5(3):165-173. doi: 10.1016/S2213-8587(16)30315-1. Epub 2017 Jan 6.


Reversal of Nonalcoholic Steatohepatitis in Adolescents after Metabolic Surgery.

Inge TH, Xanthakos SA.

J Pediatr. 2017 Jan;180:6-7. doi: 10.1016/j.jpeds.2016.10.064. Epub 2016 Nov 4. No abstract available.


In Children With Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but Does Not Reduce Disease Activity Scores.

Schwimmer JB, Lavine JE, Wilson LA, Neuschwander-Tetri BA, Xanthakos SA, Kohli R, Barlow SE, Vos MB, Karpen SJ, Molleston JP, Whitington PF, Rosenthal P, Jain AK, Murray KF, Brunt EM, Kleiner DE, Van Natta ML, Clark JM, Tonascia J, Doo E; NASH CRN.

Gastroenterology. 2016 Dec;151(6):1141-1154.e9. doi: 10.1053/j.gastro.2016.08.027. Epub 2016 Aug 26.


Randomised clinical study: GR-MD-02, a galectin-3 inhibitor, vs. placebo in patients having non-alcoholic steatohepatitis with advanced fibrosis.

Harrison SA, Marri SR, Chalasani N, Kohli R, Aronstein W, Thompson GA, Irish W, Miles MV, Xanthakos SA, Lawitz E, Noureddin M, Schiano TD, Siddiqui M, Sanyal A, Neuschwander-Tetri BA, Traber PG.

Aliment Pharmacol Ther. 2016 Dec;44(11-12):1183-1198. doi: 10.1111/apt.13816. Epub 2016 Oct 24.


Alpha 1-antitrypsin levels can differentiate allelic phenotypes.

Samuel EM, Bernstein K, Xanthakos SA, Kohli R.

Dig Liver Dis. 2016 Dec;48(12):1510-1511. doi: 10.1016/j.dld.2016.09.011. Epub 2016 Sep 23. No abstract available.


Added Sugars and Cardiovascular Disease Risk in Children: A Scientific Statement From the American Heart Association.

Vos MB, Kaar JL, Welsh JA, Van Horn LV, Feig DI, Anderson CAM, Patel MJ, Cruz Munos J, Krebs NF, Xanthakos SA, Johnson RK; American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Functional Genomics and Translational Biology; and Council on Hypertension.

Circulation. 2017 May 9;135(19):e1017-e1034. doi: 10.1161/CIR.0000000000000439. Epub 2016 Aug 22. Review.


Prevalence of Prediabetes and Type 2 Diabetes in Children With Nonalcoholic Fatty Liver Disease.

Newton KP, Hou J, Crimmins NA, Lavine JE, Barlow SE, Xanthakos SA, Africa J, Behling C, Donithan M, Clark JM, Schwimmer JB; Nonalcoholic Steatohepatitis Clinical Research Network.

JAMA Pediatr. 2016 Oct 3;170(10):e161971. doi: 10.1001/jamapediatrics.2016.1971. Epub 2016 Oct 3.


Weight Loss and Health Status after Bariatric Surgery in Adolescents.

Inge TH, Courcoulas AP, Xanthakos SA.

N Engl J Med. 2016 May 19;374(20):1989-90. doi: 10.1056/NEJMc1602007. No abstract available.


Noninvasive Assessment of Nonalcoholic Steatohepatitis and Nonalcoholic Steatohepatitis-Related Fibrosis: Is There a Role for Cytokeratin 18?

Xanthakos SA.

J Pediatr Gastroenterol Nutr. 2016 Aug;63(2):167-8. doi: 10.1097/MPG.0000000000001193. No abstract available.


Pediatric Nonalcoholic Fatty Liver Disease: A Report from the Expert Committee on Nonalcoholic Fatty Liver Disease (ECON).

Kohli R, Sunduram S, Mouzaki M, Ali S, Sathya P, Abrams S, Xanthakos SA, Vos M, Schwimmer JB.

J Pediatr. 2016 May;172:9-13. doi: 10.1016/j.jpeds.2015.12.016. Epub 2016 Jan 1. No abstract available.


Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents.

Inge TH, Courcoulas AP, Jenkins TM, Michalsky MP, Helmrath MA, Brandt ML, Harmon CM, Zeller MH, Chen MK, Xanthakos SA, Horlick M, Buncher CR; Teen-LABS Consortium.

N Engl J Med. 2016 Jan 14;374(2):113-23. doi: 10.1056/NEJMoa1506699. Epub 2015 Nov 6.


Insulin Sensitivity and β-Cell Function Improve after Gastric Bypass in Severely Obese Adolescents.

Inge TH, Prigeon RL, Elder DA, Jenkins TM, Cohen RM, Xanthakos SA, Benoit SC, Dolan LM, Daniels SR, D'Alessio DA.

J Pediatr. 2015 Nov;167(5):1042-8.e1. doi: 10.1016/j.jpeds.2015.08.020. Epub 2015 Sep 9.


High Prevalence of Nonalcoholic Fatty Liver Disease in Adolescents Undergoing Bariatric Surgery.

Xanthakos SA, Jenkins TM, Kleiner DE, Boyce TW, Mourya R, Karns R, Brandt ML, Harmon CM, Helmrath MA, Michalsky MP, Courcoulas AP, Zeller MH, Inge TH; Teen-LABS Consortium.

Gastroenterology. 2015 Sep;149(3):623-34.e8. doi: 10.1053/j.gastro.2015.05.039. Epub 2015 May 28.


Paediatric gastroenterology. On a knife-edge--weight-loss surgery for NAFLD in adolescents.

Xanthakos SA, Schwimmer JB.

Nat Rev Gastroenterol Hepatol. 2015 Jun;12(6):316-8. doi: 10.1038/nrgastro.2015.59. Epub 2015 Apr 14.


Altered regulation of hepatic efflux transporters disrupts acetaminophen disposition in pediatric nonalcoholic steatohepatitis.

Canet MJ, Merrell MD, Hardwick RN, Bataille AM, Campion SN, Ferreira DW, Xanthakos SA, Manautou JE, A-Kader HH, Erickson RP, Cherrington NJ.

Drug Metab Dispos. 2015 Jun;43(6):829-35. doi: 10.1124/dmd.114.062703. Epub 2015 Mar 18.


Severe obesity and comorbid condition impact on the weight-related quality of life of the adolescent patient.

Zeller MH, Inge TH, Modi AC, Jenkins TM, Michalsky MP, Helmrath M, Courcoulas A, Harmon CM, Rofey D, Baughcum A, Austin H, Price K, Xanthakos SA, Brandt ML, Horlick M, Buncher R; Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Consortium.

J Pediatr. 2015 Mar;166(3):651-9.e4. doi: 10.1016/j.jpeds.2014.11.022. Epub 2014 Dec 30.


Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease.

Schwimmer JB, Zepeda A, Newton KP, Xanthakos SA, Behling C, Hallinan EK, Donithan M, Tonascia J; Nonalcoholic Steatohepatitis Clinical Research Network.

PLoS One. 2014 Nov 24;9(11):e112569. doi: 10.1371/journal.pone.0112569. eCollection 2014.


Access to care for adolescents seeking weight loss surgery.

Inge TH, Boyce TW, Lee M, Kollar L, Jenkins TM, Brandt ML, Helmrath M, Xanthakos SA, Zeller MH, Harmon CM, Courcoulas A, Michalsky MP.

Obesity (Silver Spring). 2014 Dec;22(12):2593-7. doi: 10.1002/oby.20898. Epub 2014 Sep 19.


Weight loss maintenance: a hard nut to crack.

Inge TH, Siegel RM, Xanthakos SA.

JAMA Pediatr. 2014 Sep;168(9):796-7. doi: 10.1001/jamapediatrics.2014.672. No abstract available.


Abnormalities in the growth hormone axis and risk of nonalcoholic steatohepatitis: active player or innocent bystander?

Xanthakos SA, Crimmins NA, Chernausek SD.

J Pediatr. 2014 Jul;165(1):12-4. doi: 10.1016/j.jpeds.2014.03.031. Epub 2014 May 3. No abstract available.


High prevalence of hepatitis B non-immunity in paediatric non-alcoholic fatty liver disease patients.

Mehta M, Slaughter C, Xanthakos SA, Kohli R.

Dig Liver Dis. 2014 Aug;46(8):760-1. doi: 10.1016/j.dld.2014.03.014. Epub 2014 Apr 16. No abstract available.


Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study.

Inge TH, Zeller MH, Jenkins TM, Helmrath M, Brandt ML, Michalsky MP, Harmon CM, Courcoulas A, Horlick M, Xanthakos SA, Dolan L, Mitsnefes M, Barnett SJ, Buncher R; Teen-LABS Consortium.

JAMA Pediatr. 2014 Jan;168(1):47-53. doi: 10.1001/jamapediatrics.2013.4296.


IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice.

Harley IT, Stankiewicz TE, Giles DA, Softic S, Flick LM, Cappelletti M, Sheridan R, Xanthakos SA, Steinbrecher KA, Sartor RB, Kohli R, Karp CL, Divanovic S.

Hepatology. 2014 May;59(5):1830-9. doi: 10.1002/hep.26746. Epub 2014 Mar 27.


Perioperative outcome of laparoscopic Roux-en-Y gastric bypass: a children's hospital experience.

Miyano G, Jenkins TM, Xanthakos SA, Garcia VF, Inge TH.

J Pediatr Surg. 2013 Oct;48(10):2092-8. doi: 10.1016/j.jpedsurg.2013.05.019.


Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease.

Xanthakos SA, Podberesky DJ, Serai SD, Miles L, King EC, Balistreri WF, Kohli R.

J Pediatr. 2014 Jan;164(1):186-8. doi: 10.1016/j.jpeds.2013.07.050. Epub 2013 Sep 21.

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