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Items: 1 to 50 of 159

1.

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.

Yousef H, Czupalla CJ, Lee D, Chen MB, Burke AN, Zera KA, Zandstra J, Berber E, Lehallier B, Mathur V, Nair RV, Bonanno LN, Yang AC, Peterson T, Hadeiba H, Merkel T, Körbelin J, Schwaninger M, Buckwalter MS, Quake SR, Butcher EC, Wyss-Coray T.

Nat Med. 2019 Jun;25(6):988-1000. doi: 10.1038/s41591-019-0440-4. Epub 2019 May 13.

PMID:
31086348
2.

Papain-based Single Cell Isolation of Primary Murine Brain Endothelial Cells Using Flow Cytometry.

Yousef H, Czupalla CJ, Lee D, Butcher EC, Wyss-Coray T.

Bio Protoc. 2018 Nov 20;8(22). pii: e3091. doi: 10.21769/BioProtoc.3091.

3.

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.

Pluvinage JV, Haney MS, Smith BAH, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Yang AC, Shuken SR, Gate D, Scott M, Khatri P, Luo J, Bertozzi CR, Bassik MC, Wyss-Coray T.

Nature. 2019 Apr;568(7751):187-192. doi: 10.1038/s41586-019-1088-4. Epub 2019 Apr 3.

PMID:
30944478
4.

Collagenase-based Single Cell Isolation of Primary Murine Brain Endothelial Cells Using Flow Cytometry.

Czupalla CJ, Yousef H, Wyss-Coray T, Butcher EC.

Bio Protoc. 2018 Nov 20;8(22). pii: e3092. doi: 10.21769/BioProtoc.3092.

5.

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing.

Li Q, Cheng Z, Zhou L, Darmanis S, Neff NF, Okamoto J, Gulati G, Bennett ML, Sun LO, Clarke LE, Marschallinger J, Yu G, Quake SR, Wyss-Coray T, Barres BA.

Neuron. 2019 Jan 16;101(2):207-223.e10. doi: 10.1016/j.neuron.2018.12.006. Epub 2018 Dec 31.

PMID:
30606613
6.

Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration.

Bieri G, Lucin KM, O'Brien CE, Zhang H, Villeda SA, Wyss-Coray T.

Mol Neurodegener. 2018 Dec 29;13(1):68. doi: 10.1186/s13024-018-0302-4.

7.

Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy.

Ghaemi MS, DiGiulio DB, Contrepois K, Callahan B, Ngo TTM, Lee-McMullen B, Lehallier B, Robaczewska A, Mcilwain D, Rosenberg-Hasson Y, Wong RJ, Quaintance C, Culos A, Stanley N, Tanada A, Tsai A, Gaudilliere D, Ganio E, Han X, Ando K, McNeil L, Tingle M, Wise P, Maric I, Sirota M, Wyss-Coray T, Winn VD, Druzin ML, Gibbs R, Darmstadt GL, Lewis DB, Partovi Nia V, Agard B, Tibshirani R, Nolan G, Snyder MP, Relman DA, Quake SR, Shaw GM, Stevenson DK, Angst MS, Gaudilliere B, Aghaeepour N.

Bioinformatics. 2019 Jan 1;35(1):95-103. doi: 10.1093/bioinformatics/bty537.

8.

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial.

Sha SJ, Deutsch GK, Tian L, Richardson K, Coburn M, Gaudioso JL, Marcal T, Solomon E, Boumis A, Bet A, Mennes M, van Oort E, Beckmann CF, Braithwaite SP, Jackson S, Nikolich K, Stephens D, Kerchner GA, Wyss-Coray T.

JAMA Neurol. 2019 Jan 1;76(1):35-40. doi: 10.1001/jamaneurol.2018.3288.

PMID:
30383097
9.

Nociceptive and Cognitive Changes in a Murine Model of Polytrauma.

Sahbaie P, Tajerian M, Yang P, Irvine KA, Huang TT, Luo J, Wyss-Coray T, Clark JD.

J Pain. 2018 Dec;19(12):1392-1405. doi: 10.1016/j.jpain.2018.06.004. Epub 2018 Jun 30.

PMID:
29964216
10.

Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics.

Yang AC, du Bois H, Olsson N, Gate D, Lehallier B, Berdnik D, Brewer KD, Bertozzi CR, Elias JE, Wyss-Coray T.

J Am Chem Soc. 2018 Jun 13;140(23):7046-7051. doi: 10.1021/jacs.8b03074. Epub 2018 May 30.

PMID:
29775058
11.

[18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis.

Hoehne A, James ML, Alam IS, Ronald JA, Schneider B, D'Souza A, Witney TH, Andrews LE, Cropper HC, Behera D, Gowrishankar G, Ding Z, Wyss-Coray T, Chin FT, Biswal S, Gambhir SS.

J Neuroinflammation. 2018 Feb 22;15(1):55. doi: 10.1186/s12974-018-1080-1.

12.

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation.

Mathur V, Burai R, Vest RT, Bonanno LN, Lehallier B, Zardeneta ME, Mistry KN, Do D, Marsh SE, Abud EM, Blurton-Jones M, Li L, Lashuel HA, Wyss-Coray T.

Neuron. 2017 Dec 20;96(6):1290-1302.e6. doi: 10.1016/j.neuron.2017.11.032.

13.

OH MYeloid! Immune cells wreaking havoc on brain homeostasis.

Bonanno L, Wyss-Coray T.

EMBO J. 2017 Jul 3;36(13):1803-1805. doi: 10.15252/embj.201797465. Epub 2017 Jun 16. No abstract available.

14.

Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control.

Ruiz-Riol M, Berdnik D, Llano A, Mothe B, Gálvez C, Pérez-Álvarez S, Oriol-Tordera B, Olvera A, Silva-Arrieta S, Meulbroek M, Pujol F, Coll J, Martinez-Picado J, Ganoza C, Sanchez J, Gómez G, Wyss-Coray T, Brander C.

J Virol. 2017 Jul 27;91(16). pii: e00441-17. doi: 10.1128/JVI.00441-17. Print 2017 Aug 15.

15.

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.

Castellano JM, Mosher KI, Abbey RJ, McBride AA, James ML, Berdnik D, Shen JC, Zou B, Xie XS, Tingle M, Hinkson IV, Angst MS, Wyss-Coray T.

Nature. 2017 Apr 27;544(7651):488-492. doi: 10.1038/nature22067. Epub 2017 Apr 19.

16.

Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice.

Tesseur I, Nguyen A, Chang B, Li L, Woodling NS, Wyss-Coray T, Luo J.

J Neurosci. 2017 Apr 26;37(17):4584-4592. doi: 10.1523/JNEUROSCI.2952-16.2017. Epub 2017 Mar 31.

17.

Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.

Zhang Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, Narentuya, Akatsu H, Nishitsuji K, Michikawa M, Wyss-Coray T, Kadomatsu K, Uchimura K.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2947-E2954. doi: 10.1073/pnas.1615036114. Epub 2017 Mar 20.

18.

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.

Czirr E, Castello NA, Mosher KI, Castellano JM, Hinkson IV, Lucin KM, Baeza-Raja B, Ryu JK, Li L, Farina SN, Belichenko NP, Longo FM, Akassoglou K, Britschgi M, Cirrito JR, Wyss-Coray T.

J Exp Med. 2017 Apr 3;214(4):1081-1092. doi: 10.1084/jem.20162011. Epub 2017 Mar 15.

19.

Microglial Barriers to Viral Gene Delivery.

Pluvinage JV, Wyss-Coray T.

Neuron. 2017 Feb 8;93(3):468-470. doi: 10.1016/j.neuron.2017.01.025.

20.

Ageing, neurodegeneration and brain rejuvenation.

Wyss-Coray T.

Nature. 2016 Nov 10;539(7628):180-186. doi: 10.1038/nature20411. Review.

21.

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease.

Middeldorp J, Lehallier B, Villeda SA, Miedema SS, Evans E, Czirr E, Zhang H, Luo J, Stan T, Mosher KI, Masliah E, Wyss-Coray T.

JAMA Neurol. 2016 Nov 1;73(11):1325-1333. doi: 10.1001/jamaneurol.2016.3185.

22.

In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model.

Castellano JM, Palner M, Li SB, Freeman GM Jr, Nguyen A, Shen B, Stan T, Mosher KI, Chin FT, de Lecea L, Luo J, Wyss-Coray T.

Sci Rep. 2016 Jul 1;6:29015. doi: 10.1038/srep29015.

23.

Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore.

Zhang XD, Wang H, Antaris AL, Li L, Diao S, Ma R, Nguyen A, Hong G, Ma Z, Wang J, Zhu S, Castellano JM, Wyss-Coray T, Liang Y, Luo J, Dai H.

Adv Mater. 2016 Aug;28(32):6872-9. doi: 10.1002/adma.201600706. Epub 2016 Jun 2.

24.

Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain.

Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T.

Mol Neurodegener. 2016 May 23;11(1):42. No abstract available.

25.

Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain.

Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T.

Mol Neurodegener. 2016 Apr 26;11:31. doi: 10.1186/s13024-016-0095-2. Erratum in: Mol Neurodegener. 2016;11(1):42.

26.

Beclin 1 regulates neuronal transforming growth factor-β signaling by mediating recycling of the type I receptor ALK5.

O'Brien CE, Bonanno L, Zhang H, Wyss-Coray T.

Mol Neurodegener. 2015 Dec 21;10:69. doi: 10.1186/s13024-015-0065-0.

27.

Combined Plasma and Cerebrospinal Fluid Signature for the Prediction of Midterm Progression From Mild Cognitive Impairment to Alzheimer Disease.

Lehallier B, Essioux L, Gayan J, Alexandridis R, Nikolcheva T, Wyss-Coray T, Britschgi M; Alzheimer’s Disease Neuroimaging Initiative.

JAMA Neurol. 2016 Feb;73(2):203-212. doi: 10.1001/jamaneurol.2015.3135. Epub 2015 Dec 14.

28.

The Role of the Microenvironmental Niche in Declining Stem-Cell Functions Associated with Biological Aging.

DeCarolis NA, Kirby ED, Wyss-Coray T, Palmer TD.

Cold Spring Harb Perspect Med. 2015 Dec 1;5(12). pii: a025874. doi: 10.1101/cshperspect.a025874. Review.

29.

Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice.

Prokop S, Miller KR, Drost N, Handrick S, Mathur V, Luo J, Wegner A, Wyss-Coray T, Heppner FL.

J Exp Med. 2015 Oct 19;212(11):1811-8. doi: 10.1084/jem.20150479. Epub 2015 Oct 12.

30.

Blood-Borne Revitalization of the Aged Brain.

Castellano JM, Kirby ED, Wyss-Coray T.

JAMA Neurol. 2015 Oct;72(10):1191-4. doi: 10.1001/jamaneurol.2015.1616. Review.

31.

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis.

Smith LK, He Y, Park JS, Bieri G, Snethlage CE, Lin K, Gontier G, Wabl R, Plambeck KE, Udeochu J, Wheatley EG, Bouchard J, Eggel A, Narasimha R, Grant JL, Luo J, Wyss-Coray T, Villeda SA.

Nat Med. 2015 Aug;21(8):932-7. doi: 10.1038/nm.3898. Epub 2015 Jul 6.

32.

Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions.

Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K.

Nat Neurosci. 2015 Aug;18(8):1077-80. doi: 10.1038/nn.4054. Epub 2015 Jun 29.

33.

Go with your gut: microbiota meet microglia.

Mosher KI, Wyss-Coray T.

Nat Neurosci. 2015 Jul;18(7):930-1. doi: 10.1038/nn.4051. No abstract available.

34.

CalFluors: A Universal Motif for Fluorogenic Azide Probes across the Visible Spectrum.

Shieh P, Dien VT, Beahm BJ, Castellano JM, Wyss-Coray T, Bertozzi CR.

J Am Chem Soc. 2015 Jun 10;137(22):7145-51. doi: 10.1021/jacs.5b02383. Epub 2015 Jun 2.

35.

Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells.

Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K.

Cell Rep. 2015 Apr 28;11(4):592-604. doi: 10.1016/j.celrep.2015.03.053. Epub 2015 Apr 16.

36.

Neuroinflammation in Alzheimer's disease.

Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP.

Lancet Neurol. 2015 Apr;14(4):388-405. doi: 10.1016/S1474-4422(15)70016-5. Review.

37.

Adult hippocampal neural stem and progenitor cells regulate the neurogenic niche by secreting VEGF.

Kirby ED, Kuwahara AA, Messer RL, Wyss-Coray T.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4128-33. doi: 10.1073/pnas.1422448112. Epub 2015 Mar 16.

38.

PET imaging of translocator protein (18 kDa) in a mouse model of Alzheimer's disease using N-(2,5-dimethoxybenzyl)-2-18F-fluoro-N-(2-phenoxyphenyl)acetamide.

James ML, Belichenko NP, Nguyen TV, Andrews LE, Ding Z, Liu H, Bodapati D, Arksey N, Shen B, Cheng Z, Wyss-Coray T, Gambhir SS, Longo FM, Chin FT.

J Nucl Med. 2015 Feb;56(2):311-6. doi: 10.2967/jnumed.114.141648. Epub 2015 Jan 22.

39.

Geroscience: linking aging to chronic disease.

Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F.

Cell. 2014 Nov 6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039.

40.

Autoimmunity contributes to nociceptive sensitization in a mouse model of complex regional pain syndrome.

Li WW, Guo TZ, Shi X, Czirr E, Stan T, Sahbaie P, Wyss-Coray T, Kingery WS, Clark JD.

Pain. 2014 Nov;155(11):2377-89. doi: 10.1016/j.pain.2014.09.007. Epub 2014 Sep 10.

41.

Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function.

Baruch K, Deczkowska A, David E, Castellano JM, Miller O, Kertser A, Berkutzki T, Barnett-Itzhaki Z, Bezalel D, Wyss-Coray T, Amit I, Schwartz M.

Science. 2014 Oct 3;346(6205):89-93. doi: 10.1126/science.1252945. Epub 2014 Aug 21.

42.

Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.

Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, Miller BL, Kane JP, Kwok PY, Malloy MJ.

JAMA Neurol. 2014 Oct;71(10):1228-36. doi: 10.1001/jamaneurol.2014.2011.

43.

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.

Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, Sánchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Van Broeckhoven C, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C.

Sci Transl Med. 2014 Jul 2;6(243):243ra86. doi: 10.1126/scitranslmed.3009093.

44.

Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.

Nguyen TV, Shen L, Vander Griend L, Quach LN, Belichenko NP, Saw N, Yang T, Shamloo M, Wyss-Coray T, Massa SM, Longo FM.

J Alzheimers Dis. 2014;42(2):459-83. doi: 10.3233/JAD-140036.

45.

ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis.

He Y, Zhang H, Yung A, Villeda SA, Jaeger PA, Olayiwola O, Fainberg N, Wyss-Coray T.

Nat Neurosci. 2014 Jul;17(7):943-52. doi: 10.1038/nn.3732. Epub 2014 May 25.

46.

Stem cells as vehicles for youthful regeneration of aged tissues.

Rando TA, Wyss-Coray T.

J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S39-42. doi: 10.1093/gerona/glu043. Review.

47.

Noninvasive in vivo monitoring of tissue-specific global gene expression in humans.

Koh W, Pan W, Gawad C, Fan HC, Kerchner GA, Wyss-Coray T, Blumenfeld YJ, El-Sayed YY, Quake SR.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7361-6. doi: 10.1073/pnas.1405528111. Epub 2014 May 5. Erratum in: Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11223.

48.

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T.

Nat Med. 2014 Jun;20(6):659-63. doi: 10.1038/nm.3569. Epub 2014 May 4.

49.

Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury.

Luo J, Nguyen A, Villeda S, Zhang H, Ding Z, Lindsey D, Bieri G, Castellano JM, Beaupre GS, Wyss-Coray T.

Front Neurol. 2014 Feb 4;5:12. doi: 10.3389/fneur.2014.00012. eCollection 2014.

50.

A revival of parabiosis in biomedical research.

Eggel A, Wyss-Coray T.

Swiss Med Wkly. 2014 Feb 4;144:w13914. doi: 10.4414/smw.2014.13914. Review.

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