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HER2 signaling regulates HER2 localization and membrane retention.

Jeong J, Kim W, Kim LK, VanHouten J, Wysolmerski JJ.

PLoS One. 2017 Apr 3;12(4):e0174849. doi: 10.1371/journal.pone.0174849. eCollection 2017.


The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2.

Jeong J, VanHouten JN, Kim W, Dann P, Sullivan C, Choi J, Sneddon WB, Friedman PA, Wysolmerski JJ.

J Biol Chem. 2017 Apr 21;292(16):6555-6568. doi: 10.1074/jbc.M116.770883. Epub 2017 Feb 24.


Calcium-Sensing Receptor in Breast Physiology and Cancer.

Kim W, Wysolmerski JJ.

Front Physiol. 2016 Sep 30;7:440. eCollection 2016. Review.


Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein.

Kim W, Takyar FM, Swan K, Jeong J, VanHouten J, Sullivan C, Dann P, Yu H, Fiaschi-Taesch N, Chang W, Wysolmerski J.

Cancer Res. 2016 Sep 15;76(18):5348-60. doi: 10.1158/0008-5472.CAN-15-2614. Epub 2016 Jul 22.


PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.

Jeong J, VanHouten JN, Dann P, Kim W, Sullivan C, Yu H, Liotta L, Espina V, Stern DF, Friedman PA, Wysolmerski JJ.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E282-90. doi: 10.1073/pnas.1516138113. Epub 2016 Jan 4.


OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism.

Ardeshirpour L, Dumitru C, Dann P, Sterpka J, VanHouten J, Kim W, Kostenuik P, Wysolmerski J.

Endocrinology. 2015 Aug;156(8):2762-73. doi: 10.1210/en.2015-1232. Epub 2015 May 11.


Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary gland.

Boras-Granic K, Dann P, Wysolmerski JJ.

Breast Cancer Res. 2014 Dec 3;16(6):487. doi: 10.1186/s13058-014-0487-6.


Deletion of the nuclear localization sequences and C-terminus of PTHrP impairs embryonic mammary development but also inhibits PTHrP production.

Boras-Granic K, Dann P, Vanhouten J, Karaplis A, Wysolmerski J.

PLoS One. 2014 May 1;9(5):e90418. doi: 10.1371/journal.pone.0090418. eCollection 2014.


The calcium-sensing receptor in the breast.

Vanhouten JN, Wysolmerski JJ.

Best Pract Res Clin Endocrinol Metab. 2013 Jun;27(3):403-14. doi: 10.1016/j.beem.2013.02.011. Epub 2013 Mar 28. Review.


Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual.

Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J.

Endocrinology. 2013 Sep;154(9):3031-42. doi: 10.1210/en.2012-2195. Epub 2013 Jun 19.


Parathyroid hormone-related protein specifies the mammary mesenchyme and regulates embryonic mammary development.

Hiremath M, Wysolmerski J.

J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):171-7. doi: 10.1007/s10911-013-9283-7. Epub 2013 May 3. Review.


Attacking breast cancer at the preinvasion stage by targeting autophagy.

Espina V, Wysolmerski J, Edmiston K, Liotta LA.

Womens Health (Lond). 2013 Mar;9(2):157-70. doi: 10.2217/whe.13.5.


Osteocytes remove and replace perilacunar mineral during reproductive cycles.

Wysolmerski JJ.

Bone. 2013 Jun;54(2):230-6. doi: 10.1016/j.bone.2013.01.025. Epub 2013 Jan 23. Review.


Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme.

Hiremath M, Dann P, Fischer J, Butterworth D, Boras-Granic K, Hens J, Van Houten J, Shi W, Wysolmerski J.

Development. 2012 Nov;139(22):4239-49. doi: 10.1242/dev.080671. Epub 2012 Oct 3.


Parathyroid hormone-related protein: an update.

Wysolmerski JJ.

J Clin Endocrinol Metab. 2012 Sep;97(9):2947-56. doi: 10.1210/jc.2012-2142. Epub 2012 Jun 28. Review.


PTHrP and breast cancer: more than hypercalcemia and bone metastases.

Boras-Granic K, Wysolmerski JJ.

Breast Cancer Res. 2012 Apr 25;14(2):307.


Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation.

Qing H, Ardeshirpour L, Pajevic PD, Dusevich V, Jähn K, Kato S, Wysolmerski J, Bonewald LF.

J Bone Miner Res. 2012 May;27(5):1018-29. doi: 10.1002/jbmr.1567.


Osteocytic osteolysis: time for a second look?

Wysolmerski JJ.

Bonekey Rep. 2012 Dec 5;1:229. doi: 10.1038/bonekey.2012.229. Review.


Site-specific changes in bone microarchitecture, mineralization, and stiffness during lactation and after weaning in mice.

Liu XS, Ardeshirpour L, VanHouten JN, Shane E, Wysolmerski JJ.

J Bone Miner Res. 2012 Apr;27(4):865-75. doi: 10.1002/jbmr.1503.


Parathyroid hormone-related protein is not required for normal ductal or alveolar development in the post-natal mammary gland.

Boras-Granic K, VanHouten J, Hiremath M, Wysolmerski J.

PLoS One. 2011;6(11):e27278. doi: 10.1371/journal.pone.0027278. Epub 2011 Nov 8.


Skeletal recovery after weaning does not require PTHrP.

Kirby BJ, Ardeshirpour L, Woodrow JP, Wysolmerski JJ, Sims NA, Karaplis AC, Kovacs CS.

J Bone Miner Res. 2011 Jun;26(6):1242-51. doi: 10.1002/jbmr.339.


Increased PTHrP and decreased estrogens alter bone turnover but do not reproduce the full effects of lactation on the skeleton.

Ardeshirpour L, Brian S, Dann P, VanHouten J, Wysolmerski J.

Endocrinology. 2010 Dec;151(12):5591-601. doi: 10.1210/en.2010-0566. Epub 2010 Nov 3.


PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer.

VanHouten J, Sullivan C, Bazinet C, Ryoo T, Camp R, Rimm DL, Chung G, Wysolmerski J.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11405-10. doi: 10.1073/pnas.0911186107. Epub 2010 Jun 4.


Molecular mechanisms guiding embryonic mammary gland development.

Cowin P, Wysolmerski J.

Cold Spring Harb Perspect Biol. 2010 Jun;2(6):a003251. doi: 10.1101/cshperspect.a003251. Epub 2010 May 19. Review.


Interactions between breast, bone, and brain regulate mineral and skeletal metabolism during lactation.

Wysolmerski JJ.

Ann N Y Acad Sci. 2010 Mar;1192:161-9. doi: 10.1111/j.1749-6632.2009.05249.x. Review.


Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis.

Coletta RD, McCoy EL, Burns V, Kawakami K, McManaman JL, Wysolmerski JJ, Ford HL.

BMC Dev Biol. 2010 Jan 14;10:4. doi: 10.1186/1471-213X-10-4.


The calcium-sensing receptor couples to Galpha(s) and regulates PTHrP and ACTH secretion in pituitary cells.

Mamillapalli R, Wysolmerski J.

J Endocrinol. 2010 Mar;204(3):287-97. doi: 10.1677/JOE-09-0183. Epub 2009 Dec 23.


Analysis of gene expression in PTHrP-/- mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis.

Hens J, Dann P, Hiremath M, Pan TC, Chodosh L, Wysolmerski J.

Dev Dyn. 2009 Nov;238(11):2713-24. doi: 10.1002/dvdy.22097.


Wnt signaling in breast organogenesis.

Boras-Granic K, Wysolmerski JJ.

Organogenesis. 2008 Apr;4(2):116-22.


Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells.

Mamillapalli R, VanHouten J, Zawalich W, Wysolmerski J.

J Biol Chem. 2008 Sep 5;283(36):24435-47. doi: 10.1074/jbc.M801738200. Epub 2008 Jul 11.


Transcellular calcium transport in mammary epithelial cells.

VanHouten JN, Wysolmerski JJ.

J Mammary Gland Biol Neoplasia. 2007 Dec;12(4):223-35. Epub 2007 Nov 13.


Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice.

Ardeshirpour L, Dann P, Adams DJ, Nelson T, VanHouten J, Horowitz MC, Wysolmerski JJ.

Endocrinology. 2007 Aug;148(8):3875-86. Epub 2007 May 10.


BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.

Hens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J.

Development. 2007 Mar;134(6):1221-30. Epub 2007 Feb 14.


The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland.

Ardeshirpour L, Dann P, Pollak M, Wysolmerski J, VanHouten J.

Bone. 2006 Jun;38(6):787-93. Epub 2005 Dec 27.


Hypercalcemia of malignancy due to ectopic transactivation of the parathyroid hormone gene.

VanHouten JN, Yu N, Rimm D, Dotto J, Arnold A, Wysolmerski JJ, Udelsman R.

J Clin Endocrinol Metab. 2006 Feb;91(2):580-3. Epub 2005 Nov 1.


Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D.

Horwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia-Ocaña A, Bisello A, Hollis BW, Rosen CJ, Wysolmerski JJ, Dann P, Gundberg C, Stewart AF.

J Bone Miner Res. 2005 Oct;20(10):1792-803. Epub 2005 Jun 6.


Hypercalcemia in breast cancer: an echo of bone mobilization during lactation?

DeMauro S, Wysolmerski J.

J Mammary Gland Biol Neoplasia. 2005 Apr;10(2):157-67. Review.


Calcium handling by the lactating breast and its relationship to calcium-related complications of breast cancer.

Wysolmerski J.

J Mammary Gland Biol Neoplasia. 2005 Apr;10(2):101-3. No abstract available.


TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro.

Hens JR, Wilson KM, Dann P, Chen X, Horowitz MC, Wysolmerski JJ.

J Bone Miner Res. 2005 Jul;20(7):1103-13. Epub 2005 Feb 14.


Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.

Chu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, Glick A, Wysolmerski JJ, Millar SE.

Development. 2004 Oct;131(19):4819-29. Epub 2004 Sep 1.


The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport.

VanHouten J, Dann P, McGeoch G, Brown EM, Krapcho K, Neville M, Wysolmerski JJ.

J Clin Invest. 2004 Feb;113(4):598-608.


Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation.

VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ.

J Clin Invest. 2003 Nov;112(9):1429-36.


The evolutionary origins of maternal calcium and bone metabolism during lactation.

Wysolmerski JJ.

J Mammary Gland Biol Neoplasia. 2002 Jul;7(3):267-76. Review.


A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor.

Kifor O, Moore FD Jr, Delaney M, Garber J, Hendy GN, Butters R, Gao P, Cantor TL, Kifor I, Brown EM, Wysolmerski J.

J Clin Endocrinol Metab. 2003 Jan;88(1):60-72.


Overexpression of parathyroid hormone-related protein causes hypercalcemia but not bone metastases in a murine model of mammary tumorigenesis.

Wysolmerski JJ, Dann PR, Zelazny E, Dunbar ME, Insogna KL, Guise TA, Perkins AS.

J Bone Miner Res. 2002 Jul;17(7):1164-70.


Treatment of osteoporosis and osteopenia in long-term renal transplant patients with alendronate.

Cruz DN, Brickel HM, Wysolmerski JJ, Gundberg CG, Simpson CA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ.

Am J Transplant. 2002 Jan;2(1):62-7.


Nipple connective tissue and its development: insights from the K14-PTHrP mouse.

Abdalkhani A, Sellers R, Gent J, Wulitich H, Childress S, Stein B, Boissy RE, Wysolmerski JJ, Foley J.

Mech Dev. 2002 Jul;115(1-2):63-77.

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